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erbB-2/Related Products
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ALX-350-292 Revised 26-Mar-05
Kahalalide F - Discontinued Due to Patent Restrictions
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-292-C500   500 µg Inquire
Product Specification
FORMULA: C75H124N14O16
MW: 1477.9
CAS NUMBER: 149204-42-2
SOURCE/HOST: Isolated from marine mollusc Elysia rufescens.
PURITY: ≥95%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Highly selective activity against prostate tumors in vitro. Disrupts lysosomal membranes. Inhibitor of c-erbB-2 (ErbB2).
Product Specific Literature References
The antitumoral compound Kahalalide F acts on cell lysosomes: M. Garcia-Rocha, et al.; Cancer Lett. 99, 43 (1996) Abstract
Synthesis and structure determination of kahalalide F (1,2): Synthesis and structure determination of kahalalide F (1,2); J. Am. Chem. Soc. 123, 11398 (2001) Abstract
Chemical and enzymatic stability of a cyclic depsipeptide, the novel, marine-derived, anti-cancer agent kahalalide F: R.W. Sparidans, et al.; Anticancer Drugs 12, 575 (2001) Abstract
Preclinical toxicity studies of kahalalide F, a new anticancer agent: single and multiple dosing regimens in the rat: A.P. Brown, et al.; Cancer Chemother. Pharmacol. 50, 333 (2002) Abstract
Quantitative analysis of the novel depsipeptide anticancer drug Kahalalide F in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray ionization tandem mass spectrometry: E. Stokvis, et al.; J. Mass. Spectrom. 37, 992 (2002) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Protein Kinase Inhibitors • erbB-2/Related Products
 
 
ALX-804-573 Revised 23-Apr-08
Monoclonal Antibody to c-erbB-2 (human) (MGR2)
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SYNONYMS anti-ErbB2 (human) MAb (MGR2)
anti-HER-2 (human) MAb (MGR2)
anti-neu (human) MAb (MGR2)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY erbB-2/Related Products
Ordering Information
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ALX-804-573-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MGR2
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In 150mM sodium chloride, pH 7.4, containing 0.02% sodium azide.
IMMUNOGEN: CaLu 3 lung carcinoma cell line.
SPECIFICITY: Recognizes an epitope present in the extracellular domain of human c-erbB-2 (HER-2; neu).
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections)
Immunoprecipitation: Detects a band of ~185kDa.
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Do not freeze.
Product Specific Literature References
Selection of monoclonal antibodies which induce internalization and phosphorylation of p185HER2 and growth inhibition of cells with HER2/NEU gene amplification: E. Tagliabue, et al.; Int. J. Cancer 47, 933 (1991) Abstract
p185 HER2/neu epitope mapping with murine monoclonal antibodies: F. Centis, et al.; Hybridoma 11, 267 (1992) Abstract
Antigenic and immunogenic mimicry of the HER2/neu oncoprotein by phage-displayed peptides: R. Orlandi, et al.; Eur. J. Immunol. 24, 2868 (1994) Abstract
General Information
The epidermal growth factor type II receptor, c-erbB2 (HER-2; neu), is a transmembrane tyrosine kinase receptor known to play an important role in coordinating the complex ErbB signalling network and to be involved in the development of breast cancer. When c-erbB-2 is overexpressed at high levels, ligand-independent activation of the c-erbB-2 receptor results in an increased mitogen-activated protein kinase and PI(3)K cell signalling, leading to increased cell proliferation. Overexpression of c-erbB-2 has been associated with resistance to chemotherapy and poor survival in several human tumors.
Further Categories Containing This Product:
Tumor Markers • Monoclonal Antibodies
 
 
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