ALEXIS Biochemicals: Teniposide

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ALX-270-201

Revised 18-Sep-07

Aurintricarboxylic acid
SYNONYMS	ATA
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Topoisomerase Inhibitors Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-201-G001		1 g	15.00 USD

Product Specification

FORMULA:	C₂₂H₁₄O₉
MW:	422.4
CAS NUMBER:	4431-00-9
PURITY:	~85%
APPEARANCE:	Red solid.
SOLUBILITY:	Soluble in aqueous alkali.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	IRRITANT.

Product Description

Potent inhibitor of DNA topoisomerase II in vitro and protein-nucleic acid interactions. Stimulates the tyrosine phosphorylation of MAP kinases. Inhibits both major calpain isoforms. Potent and selective inhibitor of SARS coronavirus replication. Apoptosis inhibitor.

Product Specific Literature References

Mechanism of action of polymeric aurintricarboxylic acid, a potent inhibitor of protein--nucleic acid interactions: R.G. Gonzalez, et al.; Biochemistry 19, 4299 (1980) Abstract
Delayed application of aurintricarboxylic acid reduces glutamate- induced cortical neuronal injury: C.A. Csernansky, et al.; J. Neurosci. Res. 38, 101 (1994) Abstract
Inhibition of topoisomerase II by aurintricarboxylic acid: implications for mechanisms of apoptosis: D.R. Catchpoole & B.W. Stewart; Anticancer Res. 14, 853 (1994) Abstract
Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells: Y. Benchokroun, et al.; Biochem. Pharmacol. 49, 305 (1995) Abstract
A neuroprotective compound, aurin tricarboxylic acid, stimulates the tyrosine phosphorylation cascade in PC12 cells: N. Okada & S. Koizumi; J. Biol. Chem. 270, 16464 (1995) Abstract; Full Text
Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid: R. He, et al.; BBRC 320, 1199 (2004) Abstract

Further Categories Containing This Product:

Apoptosis Inducers & Inhibitors Other Products

ALX-400-050

Revised 07-Apr-08

Mitoxantrone . dihydrochloride
SYNONYMS	1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione . dihydrochloride
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Agents (DNA Interaction & Gene Regulation)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-050-M010		10 mg	25.00 USD
ALX-400-050-M050		50 mg	80.00 USD

Product Specification

FORMULA:	C₂₂H₂₈N₄O₆. 2HCl
MW:	444.5 . 73.0
CAS NUMBER:	70476-82-3
MERCK INDEX:	14: 6217
RTECS:	CB5748500
SOURCE/HOST:	Synthetic.
PURITY:	≥97%
APPEARANCE:	Blue to black crystalline solid.
SOLUBILITY:	Soluble in water; slightly soluble in 100% ethanol or methanol; insoluble in acetonitrile or acetone.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC. MAY BE TERATOGENIC. MAY BE CARCINOGENIC.

Product Description

Antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Has recently been shown to be an inhibitor of DNA methylation.

Product Specific Literature References

Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer: D. Faulds, et al.; Drugs 41, 400 (1991) Abstract
Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells: A. Skladanowski & J. Konopa; Br. J. Cancer 82, 1300 (2000) Abstract
A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone: J. Blasiak, et al.; Acta Biochim. Pol. 49, 145 (2002) Abstract; Full Text
A molecular understanding of mitoxantrone-DNA adduct formation: effect of cytosine methylation and flanking sequences: B.S. Parker, et al.; J. Biol. Chem. 279, 18814 (2004) Abstract; Full Text

Further Categories Containing This Product:

Topoisomerase Inhibitors Other Products

ALX-400-053

Revised 21-Apr-08

Teniposide
SYNONYMS	(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3’,4’:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one 4’-Demethylepipodophyllotoxin-β-D-thenylidine glucoside
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Agents (DNA Interaction & Gene Regulation)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-053-M025		25 mg	55.00 USD
ALX-400-053-M100		100 mg	165.00 USD

Product Specification

FORMULA:	C₃₂H₃₂O₁₃S
MW:	656.7
CAS NUMBER:	29767-20-2
MERCK INDEX:	14: 9145
SOURCE/HOST:	Semisynthetic derivative of podophyllotoxin.
PURITY:	≥97% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in acetone or dimethyl formamide; slightly soluble in methanol; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC. MAY BE CARCINOGENIC.

Product Description

Glycoside-derivative of podophyllotoxin. Has cytostatic effect. Inhibits topoisomerase II. Induces apoptosis.

Product Specific Literature References

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage: W. Ross, et al.; Cancer Res. 44, 5857 (1984) Abstract; Full Text
Human cytochrome P450 metabolism of teniposide and etoposide: M.V. Relling, et al.; J. Pharmacol. Exp. Ther. 261, 491 (1992) Abstract
Topoisomerase II as a target of VM-26 and 4’-(9-acridinylamino)methanesulfon-m-aniside in atypical multidrug resistant human small cell lung carcinoma cells: S de Jong, et al.; Cancer Res. 53, 1064 (1993) Abstract; Full Text
Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma: J. Li, et al.; World J. Surg. Oncol. 4, 41 (2006) Abstract; Full Text