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ALX-804-838 Revised 02-Jul-07
Monoclonal Antibody to Netrin-1 (Nora-1)
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SYNONYMS anti-Netrin-1 MAb (Nora-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-838-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Nora-1
ISOTYPE: Mouse IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 0.5mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human, mouse and chicken netrin-1 (aa 28-264).
SPECIFICITY: Recognizes human, mouse and chicken netrin-1.
APPLICATION: ELISA
Immunohistochemistry
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
POSITIVE CONTROL: Prod. No. ALX-522-100
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Netrin-1 controls colorectal tumorigenesis by regulating apoptosis: L. Mazelin, et al.; Nature 431, 80 (2004) Abstract
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-860 Revised 12-Dec-07
Monoclonal Antibody to Netrin-4 (human) (Netry-1)
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SYNONYMS anti-β-Netrin (human) MAb (Netry-1)
anti-Hepar-derived Netrin-like Protein (human) MAb (Netry-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-860-C100   100 µg 360.00 USD Add To Cart
ALX-804-860B-C100 Biotin 100 µg 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Netry-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human netrin-4 (Prod. No. ALX-522-113).
SPECIFICITY: Recognizes human netrin-4.
APPLICATION: ELISA
Immunoprecipitation (1:200)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
POSITIVE CONTROL: Prod. No. ALX-522-113
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-862 Revised 28-May-08
Monoclonal Antibody to Netrin-4 (Netry-2)
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SYNONYMS anti-β-Netrin MAb (Netry-2)
anti-Hepar-derived Netrin-like Protein MAb (Netry-2)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-862-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Netry-2
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human netrin-4 (Prod. No. ALX-522-113).
SPECIFICITY: Recognizes human and mouse netrin-4.
APPLICATION: ELISA
Immunoprecipitation (1:200)
Western Blot (1:1´000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Prod. No. ALX-522-113
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-186 Revised 04-Sep-07
Monoclonal Antibody to p53 (phosphorylated) (pSer392) (9F4)
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY p53 Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-186-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 9F4
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.1% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1 ml distilled water (15 min, RT).
IMMUNOGEN: Synthetic peptide corresponding to a portion of p53 phosphorylated at Ser392.
SPECIFICITY: Recognizes activated human p53 phosphorylated at Ser392. Does not cross-react with the non-phosphorylated form of p53 or with unrelated serine-phosphorylated proteins.
APPLICATION: Western Blot: 1µg/ml for AP/BCIP/NBT (MTT) detection; 0.1µg/ml for HRPO/ECL detection. Do not use milk/casein for blocking and dilution! Replace by BSA!
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and freeze in liquid nitrogen.
Further Categories Containing This Product:
Phospho-specific Antibodies • Tumor Markers • Monoclonal Antibodies
 
 
ALX-801-060 Revised 20-May-08
Monoclonal Antibody to p53 (human) (BP53-12)
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SYNONYMS anti-p53 (human) MAb (BP53-12)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY p53 Antibodies
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ALX-801-060-C100   100 µg 210.00 USD Add To Cart
ALX-801-060F-C100 FITC 100 µg 315.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Monkey
CLONE: BP53-12
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant human wild-type p53 protein.
SPECIFICITY: Antibody BP53-12 detects a denaturation resistant epitope (aa 16-25) in the human p53 protein.
APPLICATION: BP53-12:
ELISA
Immunocytochemistry
Immunohistochemistry (paraffin sections)
Immunoprecipitation
Western Blot (1-2µg/ml)
BP53-12-FITC:
Flow Cytometry
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
Product Specific Literature References
Immunohistochemical analysis of the p53 oncoprotein on paraffin sections using a series of novel monoclonal antibodies: J. Bartek, et al.; J. Pathol. 169, 27 (1993) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-803-300 Revised 31-Oct-06
Monoclonal Antibody to p130Cas (1H9)
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SYNONYMS anti-CRK-associated Substrate MAb (1H9)
anti-CRKAS MAb (1H9)
anti-Breast Cancer anti-estrogen Resistance 1 Protein MAb (1H9)
anti-BCAR1 MAb (1H9)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adaptor Proteins & Interaction Domains Other Products
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ALX-803-300-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: 1H9
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.2mg/ml
PURITY: Liquid. In PBS containing 0.05% sodium azide.
PURITY DETAIL: Protein A-affinity purified.
IMMUNOGEN: Recombinant mouse p130Cas (CRK-associated substrate; BCAR1) C-terminal portion (aa 375-630).
SPECIFICITY: Recognizes human, mouse and rat p130Cas.
APPLICATION: ELISA
Immunocytochemistry
Immunohistochemistry (frozen section, paraffin sections)
Immunoprecipitation (5µl per 5x106 cells)
Western Blot (1:20’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells: S. Cabodi, et al.; J. Cell Sci. 117, 1603 (2004) Abstract
Further Categories Containing This Product:
Cancer Other Products • Tyrosine Kinases Other Products • Monoclonal Antibodies
 
 
ALX-801-002 Revised 16-Jun-08
Monoclonal Antibody to P-glycoprotein (C219)
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SYNONYMS anti-ABCB1 MAb (C219)
anti-CD243 MAb (C219)
PRODUCT LINE Cancer
PRODUCT CATEGORY P-glycoprotein [Pgp] / Related Products
Ordering Information
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ALX-801-002-C100   100 µg 690.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE: C219
ISOTYPE: Mouse IgG1
CONCENTRATION: 100µg/ml
FORMULATION: Liquid. In 0.01M PBS containing 1% BSA and 0.1% sodium azide.
IMMUNOGEN: SDS-solubilized plasma membranes of an MDR (multidrug resistant) Chinese hamster ovary (CHO) cell line and a human cell line.
SPECIFICITY: Recognizes an internal, highly conserved amino acid sequence (VQEALD and VQAALD) found in both protein isoforms, P-glycoprotein and MDR3 P-glycoprotein; not species specific.
CROSSREACTIVITY PROTEINS: Cross-reacts with a ~200kDa protein which migrates in the same position as myosin and with C-erbB2 protein (p185c-erbB2).
APPLICATION: Flow Cytometry (cell permeabilization required)
Immunocytochemistry (cytospin preparations)
Immunohistochemistry (frozen sections, paraffin sections)
Immunoprecipitation
Western Blot (1:50-1:100).
Optimal conditions must be determined individually for each application.

Recommendations for Immunohistochemistry on paraffin sections:
- For optimal staining, the sections should be pretreated with an antigen unmasking solution.
- The antibody may be diluted to ≥1:25 for biotin based detection systems.
- For optimal staining, the primary antibody should be incubated 60 minutes at room temperature.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies: N. Kartner, et al.; Nature 316, 820 (1985) Abstract
A sensitive method for immunocytochemical detection of P-glycoprotein in multidrug-resistant human ovarian carcinoma cell lines: H.S. Chan, et al.; Lab. Invest. 59, 870 (1988) Abstract
Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies: A.H. Schinkel, et al.; Cancer Res. 51, 2628 (1991) Abstract
Comparison of an immunoperoxidase "sandwich" staining method and western blot detection of P-glycoprotein in human cell lines and sarcomas: K. Toth, et al.; Am. J. Pathol. 140, 1009 (1992) Abstract
New immunohistochemical "sandwich" staining method for mdr1 P-glycoprotein detection with JSB-1 monoclonal antibody in formalin-fixed, paraffin-embedded human tissues: K. Toth et al.; Am. J. Pathol. 144, 227 (1994) Abstract
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations: W.T. Beck, et al.; Cancer Res. 56, 3010 (1996) Abstract
MRP and MDR1 gene expression in primary breast carcinomas: M. Filipits, et al.; Clin. Cancer Res. 2, 1231 (1996) Abstract
P-glycoprotein expression and prognostic value in acute myeloid leukemia: L. Senent, et al.; Haematologica 83, 783 (1998) Abstract
Transport of doxorubicin in mast cell granules and the effect of the calcium antagonist verapamil: L. Candussio, et al.; Anticancer Res. 19, 1101 (1999) Abstract
Kinetics of doxorubicin handling in the LLC-PK1 kidney epithelial cell line is mediated by both vesicle formation and P-glycoprotein drug transport: E. Crivellato, et al.; Histochem. J. 31, 635 (1999) Abstract
Clinical significance of P-glycoprotein (P-gp) expression in childhood acute lymphoblastic leukemia. Results of a 6-year prospective study: C. Dhooge & B. De Moerloose; Adv. Exp. Med. Biol. 457, 11 (1999) Abstract
The effects of anticancer drugs in combination with nimodipine and verapamil on cultured cells of glioblastoma multiforme: R. Durmaz, et al.; Clin. Neurol. Neurosurg. 101, 238 (1999) Abstract
Interferon α2b differentially affects proliferation of two human renal cell carcinoma cell lines differing in the P-glycoprotein-associated multidrug-resistant phenotype: M.H. Frank & S. Pomer; J. Cancer. Res. Clin. Oncol. 125, 117 (1999) Abstract
A multidrug-resistant breast cancer cell line induced by weekly exposure to doxorubicin: S.M. Hahn, et al.; Int. J. Oncol. 14, 273 (1999) Abstract
Characterization of cyclosporin A transport in cultured rabbit corneal epithelial cells: P-glycoprotein transport activity and binding to cyclophilin: K. Kawazu, et al.; Invest. Ophtalmol. Vis. Sci. 40, 1738 (1999) Abstract
Antibody C219 recognizes an alpha-helical epitope on P-glycoprotein: J.M. van Den Elsen, et al.; PNAS 96, 13679 (1999) Abstract; Full Text
Selectively induced high MRP gene expression in multidrug-resistant human HL60 leukemia cells: H. Wada, et al.; Exp. Hematol. 27, 99 (1999) Abstract
Immunohistochemical evidence that P-glycoprotein in non-small cell lung cancers is associated with shorter survival: H. Yokoyama, et al.; Surg. Today 29, 1141 (1999) Abstract
P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries: M. Demeule, et al.; FEBS Lett. 466, 219 (2000) Abstract
Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity: M. Julien & P. Gros; Biochemistry 39, 4559 (2000) Abstract
Expression of P-glycoprotein in hepatocellular carcinoma. A determinant of chemotherapy response: I.O. Ng, et al.; Am. J. Clin. Pathol. 113, 355 (2000) Abstract
Activation of the human P-glycoprotein ATPase by trypsin: S.L. Nuti, et al.; Biochemistry 39, 3424 (2000) Abstract
Cytofluorimetric analysis of a renal tubular cell line and its resistant counterpart: A. Rosati, et al.; Anticancer Res. 20, 3403 (2000) Abstract
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000) Abstract; Full Text
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis: F. Thevenod, et al.; J. Biol. Chem. 275, 1887 (2000) Abstract; Full Text
Characterization of multidrug transporters in a normal renal tubular cell line resistant to doxorubicin. Multidrug transporters in the LLC-PK(1) cell line and its resistant counterpart: G. Decorti, et al.; Biochem. Pharmacol. 61, 61 (2001) Abstract
Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone: R. Yumoto, et al.; Drug. Metab. Dispos. 29, 145 (2001) Abstract; Full Text
Further Categories Containing This Product:
Tumor Markers • Monoclonal Antibodies • CD Antibodies
 
 
ALX-801-001 Revised 22-Feb-05
Monoclonal Antibody to P-glycoprotein (human) (4E3.16)
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SYNONYMS anti-ABCB1 (human) MAb (4E3.16)
anti-CD243 (human) MAb (4E3.16)
PRODUCT LINE Cancer
PRODUCT CATEGORY P-glycoprotein [Pgp] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-801-001-C050   50 µg 790.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 4E3.16
ISOTYPE: Mouse IgG2a
CONCENTRATION: ~0.05mg/ml
FORMULATION: Liquid. In 0.01M PBS containing 1% BSA and 0.1% sodium azide.
IMMUNOGEN: MDR (multidrug resistant) human squamous lung cancer cell line SW-1573/500 (doxorubicin resistant) and MDR human uterine adenocarcinoma cell line ME180/DOX 500 (doxorubicin resistant).
SPECIFICITY: Recognizes an external epitope of human P-glycoprotein. Does not cross-react with human MDR3 P-glycoprotein.
APPLICATION: Flow Cytometry
Immunocytochemistry
Immunohistochemistry (frozen sections; not recommended for paraffin sections)
Immunoprecipitation.
Note: Not recommended for Western blot.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
POSITIVE CONTROL: Cell lines: Appropriate drug-sensitive parental cell lines and their multidrug resistant derivatives prepared by the same methods as the test specimens can be used as control materials.
Tissue: Liver (positive staining detected along luminal surfaces of bile canaliculi) or colon (positive staining localized to luminal surface of secretory epithelium).
Product Specific Literature References
Monoclonal antibody to an external epitope of the human mdr1 P-glycoprotein: R.J. Arceci, et al.; Cancer Res. 53, 310 (1993) Abstract
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations: W.T. Beck, et al.; Cancer Res. 56, 3010 (1996) Abstract
Reference method for detection of Pgp mediated multidrug resistance in human hematological malignancies: a method validated by the laboratories of the French Drug Resistance Network: S. Huet, et al.; Cytometry 34, 248 (1998) Abstract
Identification of a multidrug resistance-like system in Tetrahymena pyriformis: evidence for a new detoxication mechanism in freshwater ciliates: M. Bamdad, et al.; FEBS Lett. 456, 389 (1999) Abstract
Discordance of P-glycoprotein expression and function in acute leukemia: B. De Moerloose, et al.; Adv. Exp. Med. Biol. 457, 107 (1999) Abstract
Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines: V. Nuessler, et al.; Leukemia 13, 1864 (1999) Abstract
Conformational heterogeneity of P-glycoprotein: K. Goda, et al.; Cancer Detect. Prevent. 24, 415 (2000) Abstract
Functional characterization of glycosylation-deficient human P-glycoprotein using A vaccinia virus expression system: J.J. Gribar, et al.; J. Membr. Biol. 173, 203 (2000) Abstract
Simultaneous measurement of cellular P-glycoprotein content and function by multiparametric flow-cytometry: M.R. Muller, et al.; Int. J. Clin. Pharmacol. Ther. 38, 180 (2000) Abstract
Further Categories Containing This Product:
Tumor Markers • Monoclonal Antibodies • CD Antibodies
 
 
ALX-801-003 Revised 21-Dec-06
Monoclonal Antibody to P-glycoprotein (human) (C494)
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SYNONYMS anti-ABCB1 (human) MAb (C494)
anti-CD243 (human) MAb (C494)
PRODUCT LINE Cancer
PRODUCT CATEGORY P-glycoprotein [Pgp] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-801-003-C100   100 µg 790.00 USD Add To Cart
Product Specification