• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Cytochrome P450 [CYP450] / Related Products
You are here: Product Lines > Cancer > Cytochrome P450 [CYP450] / Related Products
Toolbar - View Selection
 
Items 19 of 19
ALX-350-220 Revised 05-May-08
Cafestol
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-220-M050   50 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C20H28O3
MW: 316.4
CAS NUMBER: 469-83-0
MERCK INDEX: 14: 1634
SOURCE/HOST: Isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Inducer of glutathione S-transferases. Has chemoprotective activity, reducing the genotoxicity of several carcinogens.
Product Specific Literature References
R.O. Bengis and R.J. Anderson; J. Biol. Chem. 47, 99 (1932)
K.H. Slotta and K. Neisser; Ber. 71, 1991 (1938)
Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse: L.K.T. Lam, et al.; Cancer Res. 42, 1193 (1982)
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism: C. Cavin, et al.; Carcinogenesis 19, 1369 (1998) Abstract
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity: C. Cavin, et al.; Food Chem. Toxicol. 40, 1155 (2002) Abstract
Further Categories Containing This Product:
Cytochrome P450 [CYP450] / Related Products • Glutathione S-Transferase • Active Substances from Fruit and Vegetables
 
 
ALX-270-256 Revised 28-Apr-05
Clofibrate
Add to Clipboard
SYNONYMS 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Agonists
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-256-M500   500 mg 15.00 USD Add To Cart
ALX-270-256-G001   1 g 25.00 USD Add To Cart
Product Specification
FORMULA: C12H15ClO3
MW: 242.7
CAS NUMBER: 637-07-0
MERCK INDEX: 14: 2377
PURITY: ≥98%
APPEARANCE: Colorless oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Solutions are stable for up to 6 months when stored at –20°C.

Product Description
Activates PPARα and induces cytochrome P450 4A1 and 4A3.
Product Specific Literature References
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor: M. Göttlicher, et al.; PNAS 89, 4653 (1992) Abstract
Related Products
Further Categories Containing This Product:
Cytochrome P450 [CYP450] / Related Products • Carcinogens & Tumor Promoters Other Products • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-350-370 Revised 22-Apr-08
3,3’-Diindolylmethane
Add to Clipboard
SYNONYMS DIM
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-370-M100   100 mg 20.00 USD Add To Cart
ALX-350-370-M500   500 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C17H14N2
MW: 246.3
CAS NUMBER: 1968-05-4
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (200mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Dimer of indole-3-carbinol (Prod. No. ALX-350-347). Anticancer and antineoplastic agent. Induces apoptosis in human cancer cells. Activator of cytochrome P450. Partial agonist of aryl hydrocarbon receptor (AhR).
Product Specific Literature References
Oligomerization of indole-3-carbinol in aqueous acid: K.R. Grose & L.F. Bjeldanes; Chem. Res. Toxicol. 5, 188 (1992) Abstract
The anticarcinogen 3,3'-diindolylmethane is an inhibitor of cytochrome P-450: D.M. Stresser, et al.; J. Biochem. Toxicol. 10, 191 (1995) Abstract
3,3’-Diindolylmethane induces apoptosis in human cancer cells: X. Ge, et al.; BBRC 228, 153 (1996) Abstract
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells: I. Chen, et al.; Biochem. Pharmacol. 51, 1069 (1996) Abstract
3,3’-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices: B.G. Lake, et al.; Xenobiotica 28, 803 (1998) Abstract
Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor: E.V. Hestermann & M. Brown; Mol. Cell. Biol. 23, 7920 (2003) Abstract; Full Text
Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines: L. Mulvey, et al.; Mol. Med. 13, 69 (2007) Abstract; Full Text
3,3’-Diindolylmethane stimulates murine immune function in vitro and in vivo: L. Xue, et al.; J. Nutr. Biochem. 19, 336 (2008) Abstract
3,3’-diindolylmethane reduces levels of HIF-1alpha and HIF-1 activity in hypoxic cultured human cancer cells: J.E. Riby, et al.; Biochem. Pharmacol. 75, 1858 (2008) Abstract
Indole-3-carbinol as a chemopreventive and anti-cancer agent: J.R. Weng, et al.; Cancer Lett. 262, 153 (2008) Abstract
Related Products
Further Categories Containing This Product:
Cytochrome P450 [CYP450] / Related Products • Chemopreventive Agents Other Products • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-270-003 Revised 08-Aug-08
Diphenyleneiodonium chloride
Add to Clipboard
SYNONYMS Dibenziodolium chloride
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-003-M025   25 mg 85.00 USD Add To Cart
ALX-270-003-M100   100 mg 255.00 USD Add To Cart
Product Specification
FORMULA: C12H8ICl
MW: 314.5
CAS NUMBER: 4673-26-1
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: 10mg/ml soluble in DMSO (warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Binds strongly to flavoproteins and is thus a powerful and specific inhibitor of several important enzymes, including nitric oxide synthase (NOS), NADPH-ubiquinone oxidoreductase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Nitric oxide synthase, which shows significant homology with cytochrome P450 reductase, has shown to be irreversibly inhibited by this compound.
Product Specific Literature References
Specific labelling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone reductase by the inhibitor diphenyleneiodonium: C.I. Ragan & D.P. Bloxham; Biochem. J. 163, 605 (1977) Abstract
The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages: J.T. Hancock & O.T.G. Jones; Biochem. J. 242, 103 (1987) Abstract
Indications to an NADPH oxidase as a possible pO2 sensor in the rat carotid body: H. Acker, et al.; FEBS Lett. 256, 75 (1989) Abstract
Purification and some properties of the 45 kDa diphenylene iodonium- binding flavoprotein of neutrophil NADPH oxidase: C.M. Yea, et al.; Biochem. J. 265, 95 (1990) Abstract
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs: D.J. Stuehr, et al.; FASEB J. 5, 98 (1991) Abstract
Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications: D.G. Tew; Biochemistry 32, 10209 (1993) Abstract
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat: H. Kono, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 280, G1005 (2001) Abstract
Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species: A.F. Mendes, et al.; Mediators Inflamm. 10, 209 (2001) Abstract
Preferential inhibition of the plasma membrane NADH oxidase (NOX) activity by diphenyleneiodonium chloride with NADPH as donor: D.J. Morre; Antioxid. Redox Signal 4, 207 (2002) Abstract
G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium: R.M. Scaife; Mol. Cancer Ther. 3, 1229 (2004) Abstract
Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium: A. Balcerczyk, et al.; Biochem. Pharmacol. 69, 1263 (2005) Abstract
Selective and irreversible cell cycle inhibition by diphenyleneiodonium: R.M. Scaife; Mol. Cancer Ther. 4, 876 (2005) Abstract
Further Categories Containing This Product:
Oxygenases Other Products • Cytochrome P450 [CYP450] / Related Products • Respiratory Chain Other Products
 
 
ALX-340-010 Revised 28-Feb-07
ETYA
Add to Clipboard
SYNONYMS 5,8,11,14-Eicosatetraynoic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipoxygenases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-010-M005   5 mg 40.00 USD Add To Cart
ALX-340-010-M025   25 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C20H24O2
MW: 296.5
CAS NUMBER: 1191-85-1
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, DMSO, acetone or acetonitrile.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing the solutions for more than one day.
HANDLING: Protect from light and oxygen.
HAZARD: TOXIC.

Product Description
Inhibits arachidonic acid uptake. Inhibitor of lipoxygenases, cyclooxygenases (COX), phospholipase A2 and cytochrome P450. Modulates Ca2+ entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells. PPAR agonist.
Product Specific Literature References
Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthetase: D.T. Downing, et al.; Biochim. Biophys. Acta 280, 343 (1972) Abstract
The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism: L.D. Tobias & J.G. Hamilton; Lipids 14, 181 (1979) Abstract
An inhibitor of arachidonic acid metabolism stimulates luteinizing hormone (LH) release from cultured pituitary cells: P.M. Conn, et al.; Prostaglandins 19, 873 (1980) Abstract
Evidence for inhibition of leukotriene A4 synthesis by 5,8,11,14-eicosatetraynoic acid in guinea pig polymorphonuclear leukocytes: G.M. Bokoch & P.W. Reed; J. Biol. Chem. 256, 4156 (1981) Abstract; Full Text
Phospholipase A2-induced rat mast cell secretion. Role of arachidonic acid metabolites: E.Y. Chi, et al.; Lab. Invest. 47, 579 (1982) Abstract
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets: J.R. Falck, et al.; BBRC 114, 743 (1983) Abstract
The mechanism of inactivation of lipoxygenases by acetylenic fatty acids: H. Kühn, et al.; Eur. J. Biochem. 139, 577 (1984) Abstract
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostagl. Leukotr. Med. 13, 53 (1984) Abstract
Incorporation of 5,8,11,14-eicosatetraynoic acid (ETYA) into cell lipids: competition with arachidonic acid for esterification: A.S. Taylor, et al.; Prostaglandins 29, 449 (1985) Abstract
Inhibition of U937 eicosanoid and DNA synthesis by 5,8,11,14- eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism and its partial reversal by leukotriene C4: F. Ondrey, et al.; Cancer Res. 49, 1138 (1989) Abstract
Effects of 5,8,11,14-eicosatetraynoic acid on thapsigargin-induced calcium entry, and intracellular pH in thyroid FRTL-5 cells: E. Ekokoski & K. Tornquist; Biochim. Biophys. Acta 1223, 274 (1994) Abstract
Further Categories Containing This Product:
Cytochrome P450 [CYP450] / Related Products • PPAR Agonists • PLA2 Inhibitors • Ca2+ Modulators • COX Inhibitors
 
 
ALX-350-227 Revised 28-Apr-08
Myristicin
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-227-M100   100 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C11H12O3
MW: 192.2
CAS NUMBER: 607-91-0
MERCK INDEX: 14: 6334
SOURCE/HOST: Isolated from Petroselinium hortense Hoffmann.
PURITY: ≥98% (HPLC)
APPEARANCE: Colorless to slightly yellow liquid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Natural product isolated from parsley oil. Inducer of glutathione S-transferases. Also inhibits chemical carcinogenesis. Induces rat and human cytochrome P450 enzymes. Has very potent hepatoprotective activity. Induces apoptosis.
Product Specific Literature References
Myristicin: a potential cancer chemopreventive agent from parsley leaf oil: G.-Q. Zheng, et al.; J. Agri. Food Chem. 40, 107 (1992)
Inhibition of benzo[a]pyrene-induced tumorigenesis by myristicin, a volatile aroma constituent of parsley leaf oil: G.-Q. Zheng, et al.; Carcinogenesis 13, 1921 (1992) Abstract
Induction of rat hepatic cytochrome P450 enzymes by myristicin: H.G. Jeong & C.H. Yun; BBRC 217, 966 (1995) Abstract
Toxicological evaluation of myristicin: H. Hallstrom & A. Thuvander; Nat. Toxins 5, 186 (1997), Review Abstract
Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin: C.H. Yun, et al.; Toxicol. Lett. 137, 143 (2003) Abstract
Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/ d-galactosamine-induced liver injury: T. Morita, et al.; J. Agric. Food Chem. 51, 1560 (2003) Abstract
Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells: B.K. Lee, et al.; Toxicol. Lett. 157, 49 (2005) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Cytochrome P450 [CYP450] / Related Products • Glutathione S-Transferase • Active Substances from Fruit and Vegetables • Natural Products - Apoptosis Inducers & Inhibitors • Lipopolysaccharides [LPS] / Related Products
 
 
ALX-210-242 Revised 18-Jan-05
Polyclonal Antibody to Cytochrome P450 (1A1 Isoform) (human)
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Cytochrome P450 [CYP450] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-242-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Purified IgG in PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified full length human cytochrome P450 (isoform 1A1).
SPECIFICITY: Recognizes human cytochrome P450 (1A1 isoforms). Weakly cross-reacts with other P450 isoforms. Detects a band of ~54kDa by Western blot.
APPLICATION: Western Blot (1:500)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Description
The cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid Arachadonic Acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as mNADPH and P-450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and ω-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). Cytochrome P450 1A1 (Cyp1A1) is expressed in many tissues and Cyp1A1 expression has been shown to be induced through the aryl-hydrocarbon receptor (AhR) pathway for gene expression.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-274 Revised 28-Apr-08
Polyclonal Antibody to Cytochrome P450 (1A2 Isoform) (human)
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Cytochrome P450 [CYP450] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-274-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified full length human cytochrome P450 (isoform 1A2).
SPECIFICITY: Recognizes human cytochrome P450 (1A2 isoforms). Weakly cross-reacts with other P450 isoforms. Detects a band of ~56kDa by Western blot.
APPLICATION: Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-275 Revised 07-Dec-06
Polyclonal Antibody to Cytochrome P450 (2A6 Isoform)
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Cytochrome P450 [CYP450] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-275-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Purified full length human cytochrome P450 (isoform 2A6).
SPECIFICITY: Recognizes human, mouse and rat cytochrome P450 (2A6 isoforms). Weakly cross-reacts with other P450 isoforms. Detects a band of ~49kDa by Western blot.
APPLICATION: Western Blot (1:2'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-106 Revised 15-Aug-05
Polyclonal Antibody to Cytochrome P450 (2C11 Isoform) (rat)
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Cytochrome P450 [CYP450] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-106-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
Others
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum in PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptides corresponding to N-terminal aa 49-60 (D49IGQSIKKFSKV60) and C-terminal aa 491-500 (Q491RADSLSSHL500) of rat cytochrome P450.
SPECIFICITY: Recognizes rat and feline cytochrome P450 (2C11 isoforms). Detects a band of ~50kDa by Western blot.
APPLICATION: Immunohistochemistry (frozen sections (1:100))
Western Blot (1:1'500)
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References