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Cancer
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ALX-270-256 Revised 28-Apr-05
Clofibrate
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SYNONYMS 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Agonists
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-256-M500   500 mg 15.00 USD Add To Cart
ALX-270-256-G001   1 g 25.00 USD Add To Cart
Product Specification
FORMULA: C12H15ClO3
MW: 242.7
CAS NUMBER: 637-07-0
MERCK INDEX: 14: 2377
PURITY: ≥98%
APPEARANCE: Colorless oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Solutions are stable for up to 6 months when stored at –20°C.

Product Description
Activates PPARα and induces cytochrome P450 4A1 and 4A3.
Product Specific Literature References
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor: M. Göttlicher, et al.; PNAS 89, 4653 (1992) Abstract
Related Products
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Cytochrome P450 [CYP450] / Related Products • Apoptosis Inducers & Inhibitors Other Products
 
 
AG-CC06H2 Revised 11-Jan-08
Clusterin (human) Competitive ELISA Kit
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SYNONYMS TRPM-2 (human) Competitive ELISA Kit
Apolipoprotein J (human) Competitive ELISA Kit
APO-J (human) Competitive ELISA Kit
CLI (human) Competitive ELISA Kit
CLU (human) Competitive ELISA Kit
SGP-2 (human) Competitive ELISA Kit
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Clusterin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
AG-CC06H2EK-KI01   96 wells 550.00 USD Add To Cart
AG-CC06H2TP-KI01 Twin Plex 2x96 wells 890.00 USD Add To Cart
AG-CC06H2PP-KI01 Penta Plex 5x96 wells 1'870.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 1ng/ml
APPLICATION: For the quantitative determination of clusterin in human serum, plasma or cell culture supernatant.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-201-355 Revised 18-Mar-08
Clusterin (nuclear form) (human) (recombinant) (His)
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SYNONYMS TRPM-2 (nuclear form) (human) (recombinant) (His)
Apolipoprotein J (nuclear form) (human) (recombinant) (His)
APO-J (nuclear form) (human) (recombinant) (His)
CLI (nuclear form) (human) (recombinant) (His)
CLU (nuclear form) (human) (recombinant) (His)
SGP-2 (nuclear form) (human) (recombinant) (His)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Clusterin / Related Products
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ALX-201-355-C050   50 µg 395.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Mature human nuclear clusterin (aa 23-449) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P10909: Clusterin (human) [Precursor]
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Inhibition of post-ischemic brain injury by clusterin overexpression: P. Wehrli, et al.; Nat. Med. 7, 977 (2001) Abstract
Clusterin/apolipoprotein J in human aging and cancer: I.P. Trougakos and E.S. Gonos; Int. J. Biochem. Cell Biol. 34, 1430 (2002) Abstract
Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer: B. Shannan, et al.; Cell Death Differ. 13, 12 (2006) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-365 Revised 18-Mar-08
Clusterin (nuclear form) (mouse) (recombinant) (His)
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SYNONYMS TRPM-2 (nuclear form) (mouse) (recombinant) (His)
Apolipoprotein J (nuclear form) (mouse) (recombinant) (His)
APO-J (nuclear form) (mouse) (recombinant) (His)
CLI (nuclear form) (mouse) (recombinant) (His)
CLU (nuclear form) (mouse) (recombinant) (His)
SGP-2 (nuclear form) (mouse) (recombinant) (His)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Clusterin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-365-C050   50 µg 395.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Mature mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q549A5: Clusterin (mouse) [Precursor]
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Inhibition of post-ischemic brain injury by clusterin overexpression: P. Wehrli, et al.; Nat. Med. 7, 977 (2001) Abstract
Clusterin/apolipoprotein J in human aging and cancer: I.P. Trougakos and E.S. Gonos; Int. J. Biochem. Cell Biol. 34, 1430 (2002) Abstract
Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer: B. Shannan, et al.; Cell Death Differ. 13, 12 (2006) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-358 Revised 18-Mar-08
Clusterin (secretory form) (human) (recombinant)
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SYNONYMS TRPM-2 (secretory form) (human) (recombinant)
Apolipoprotein J (secretory form) (human) (recombinant)
APO-J (secretory form) (human) (recombinant)
CLI (secretory form) (human) (recombinant)
CLU (secretory form) (human) (recombinant)
SGP-2 (secretory form) (human) (recombinant)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Clusterin / Related Products
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ALX-201-358-C010   10 µg 230.00 USD Add To Cart
ALX-201-358-C050   50 µg 480.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide sequence and the mature human secretory clusterin (aa 1-449) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2 µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P10909: Clusterin (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-350-316 Revised 16-Jun-08
Cochliodinol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-350-316-MC05   0.5 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C32H30N2O4
MW: 506.6
CAS NUMBER: 11051-88-0
RTECS: DK3529000
SOURCE/HOST: Isolated from Chaetomium globosum.
PURITY: ≥97% (HPLC)
APPEARANCE: White to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antibiotic. Displays antibacterial and antitumor activity.
Product Specific Literature References
The toxicity of cochliodinol, an antibiotic metabolite of Chaetomium spp: D. Brewer, et al.; Can. J. Microbiol. 16, 433 (1970) Abstract
The Chemistry of Cochliodinol, a Metabolite of Chaetomium spp.: W.A. Jerram, et al.; Can. J. Chem. 53, 727 (1975)
The antibacterial activity of some naturally occurring 2,5-dihydroxy-1,4-benzoquinones: D. Brewer, et al.; Can. J. Microbiol. 30, 1068 (1984) Abstract
 
 
ALX-350-335 Revised 14-Nov-07
Cochlioquinone A
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SYNONYMS Luteoleersin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Angiogenesis Research
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ALX-350-335-MC05   0.5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C30H44O8
MW: 532.7
CAS NUMBER: 32450-25-2
SOURCE/HOST: Isolated from Bipolaris leersia MST-FP107.
PURITY: ≥99% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Shows antiangiogenic and nematocidal activities. Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of diacylglycerol acyltransferase, diacylglycerol kinase and NADH-ubiquinone reductase.
Product Specific Literature References
Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites: J.M. Schaeffer, et al.; J. Antibiot. (Tokyo) 43, 1179 (1990) Abstract
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi: T. Fujioka, et al.; J. Antibiot. (Tokyo) 49, 409 (1996) Abstract
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola: H.J. Jung, et al.; Bioorg. Med. Chem. 11, 4743 (2003) Abstract
Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1: H.B. Lee, et al.; J. Antibiot. (Tokyo) 56, 967 (2003) Abstract
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum: K. Yoganathan, et al.; J. Antibiot. (Tokyo) 57, 59 (2004) Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products • NAD+ Metabolism / Related Products • Vitamins
 
 
ALX-350-341 Revised 14-Nov-07
Cochlioquinone B
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Angiogenesis Research
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ALX-350-341-MC05   0.5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C28H40O6
MW: 472.6
CAS NUMBER: 32450-26-3
SOURCE/HOST: Isolated from Bipolaris leersia MST-FP107.
PURITY: ≥99% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of NADH-ubiquinone reductase. Phytotoxic agent inhibiting root growth.
Product Specific Literature References
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum: K. Yoganathan, et al.; J. Antibiot. (Tokyo) 57, 59 (2004) Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products • NAD+ Metabolism / Related Products • Vitamins
 
 
ALX-270-316 Revised 12-Jan-07
Compound 56
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SYNONYMS 4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Inhibitors
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ALX-270-316-C500   500 µg 135.00 USD Add To Cart
Product Specification
FORMULA: C18H18BrN3O2
MW: 388.3
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: MAY BE MUTAGENIC. HARMFUL.

Product Description
Potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC50=6pM).
Product Specific Literature References
Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor: A.J. Bridges, et al.; J. Med. Chem. 39, 267 (1996) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
 
 
ALX-550-516 Revised 21-May-08
Compound A
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SYNONYMS CpdA
2-((4-Acetophenyl)-2-chloro-N-methyl)ethylammonium chloride
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-550-516-M005   5 mg 40.00 USD Add To Cart
ALX-550-516-M025   25 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C11H14ClNO2 . HCl
MW: 227.7 . 36.5
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or water.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stock solutions in ethanol are stable for up to 1 month when stored at -80°C.
HANDLING: Protect from moisture. After reconstitution, prepare aliquots and store at -80°C.

Product Description
Cell permeable, nonsteroidal glucocorticoid receptor modulator with high binding affinity. Exerts anti-inflammatory potential by down-modulating TNF-induced pro-inflammatory gene expression, such as IL-6 and E-selectin. Unlike dexamethasone (Prod. No. ALX-370-002) it does not enhance glucocorticoid response element (GRE)-driven gene expression or induce glucocorticoid receptor (GR) binding to GRE-dependent genes in vivo.
Product Specific Literature References
A fully dissociated compound of plant origin for inflammatory gene repression: K. De Bosscher, et al.; PNAS 102, 15827 (2005) Abstract
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis: P. Dewint, et al.; J. Immunol. 180, 2608 (2008) Abstract
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Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • GITR & GITRL Other Products • Glucocorticoids & Glucocorticoid Receptors / Related Products • RANK & RANKL / OPG Other Products • DNA & RNA Methyl & Alkyl Transferases / Related Products • Antitumor Agents (Hormone-related) • Natural Products for Cell Cycle Research • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Chemopreventive Agents</