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ALX-380-302 Revised 15-Aug-08 New product
Sparfloxacin
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SYNONYMS rel-5-Amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
AT-4140
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-302-G001   1 g 70.00 USD Add To Cart
ALX-380-302-G005   5 g 280.00 USD Add To Cart
Product Specification
FORMULA: C19H22F2N4O3
MW: 392.4
CAS NUMBER: 110871-86-8
MERCK INDEX: 14: 8735
RTECS: VB1986500
PURITY: ≥98% (Assay)
APPEARANCE: White to yellow crystalline solid.
SOLUBILITY: Soluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Mycobacterium tuberculosis. Shows photosensitizing effects.
Product Specific Literature References
In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone: S. Nakamura, et al.; Antimicrob. Agents Chemother. 33, 1167 (1989) Abstract; Full Text
Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency: T. Miyamoto, et al.; J. Med. Chem. 33, 1645 (1990) Abstract
Pharmacokinetics of a novel quinolone, AT-4140, in animals: S. Nakamura, et al.; Antimicrob. Agents Chemother. 34, 89 (1990) Abstract; Full Text
Mechanism of action of sparfloxacin against and mechanism of resistance in gram-negative and gram-positive bacteria: L.J. Piddock & M. Zhu; Antimicrob. Agents Chemother. 35, 2423 (1991) Abstract; Full Text
The link between sunshine and phototoxicity of sparfloxacin: C. Pierfitte, et al.; Br. J. Clin. Pharmacol. 49, 609 (2000) Abstract; Full Text
Sparfloxacin: a review: J.J. Schentag; Clin. Ther. 22, 372 (2000), (Review) Abstract
Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother. 51, 576 (2007) Abstract; Full Text
Further Categories Containing This Product:
Antibiotics - Topoisomerase Inhibitors • Antibiotics - DNA Replication Inhibitors
 
 
ALX-306-009 Revised 17-Jan-06
D-erythro-Sphingosine, N,N-Dimethyl-
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SYNONYMS N,N-Dimethyl-D-erythro-sphingosine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Ceramides/Cerebrosides/Sphingolipids/Related Products
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ALX-306-009-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C20H41NO2
MW: 327.6
CAS NUMBER: 119567-63-4
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent and specific inhibitor of sphingosine kinase (IC50=5µM) which blocks conversion of sphingosine to sphingosine-1-phosphate (Prod. No. ALX-306-010). Inhibitor of protein kinase C (PKC) which also stimulates Src-kinase. May affect expression of cell surface selectins, which in turn mediate leukocyte or tumor cell adhesion to endothelial cells and platelets. Induces apoptosis.
Product Specific Literature References
A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells: Y. Igarashi, et al.; J. Biol. Chem. 265, 5385 (1990) Abstract; Full Text
Downregulation of GMP-140 (CD62 or PADGEM) expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine: K. Handa, et al.; Biochemistry 30, 11682 (1991) Abstract
Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils: S. Kimura, et al.; Biochem. Pharmacol. 44, 1585 (1992) Abstract
Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation: H. Ohta, et al.; Cancer Res. 55, 691 (1995) Abstract
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide: L.C. Edsall, et al.; Biochemistry 37, 12892 (1998) Abstract
D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells: C.B. Xu, et al.; Atherosclerosis 164, 237 (2002) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Angiogenesis Modulators Other Products • PKC Inhibitors
 
 
ALX-306-010 Revised 31-Jan-07
D-erythro-Sphingosine 1-phosphate (high purity)
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SYNONYMS 1-SPP
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Ceramides/Cerebrosides/Sphingolipids/Related Products
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ALX-306-010-M001   1 mg 80.00 USD Add To Cart
ALX-306-010-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C18H38NO5P
MW: 379.5
CAS NUMBER: 26993-30-6
SOURCE/HOST: Synthetic.
PURITY: ≥96%
APPEARANCE: White to off-white powder.
SOLUBILITY: Sparingly soluble in 1:1 ethanol:water. Addition of small amounts of acetic acid may help to dissolve this product.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Packaged under inert gas. Hygroscopic.
HAZARD: IRRITANT.

Product Description
Sphingosine 1-phosphate (1-SPP) regulates a variety of cellular responses, including survival, cytoskeletal remodeling, chemotaxis etc. via the activation of cell surface EDG receptors. 1-SPP also promotes angiogenesis.
Product Specific Literature References
Sphingosine-1-phosphate in cell growth and cell death: S. Spiegel, et al.; Ann. NY Acad. Sci. 845, 11 (1998) Abstract
Roles of sphingosine-1-phosphate in cell growth, differentiation, and death: S. Spiegel, et al.; Biochemistry 63, 69 (1998) Abstract
Extracellular actions of sphingosine I-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis: S. Pyne, et al.; Biochem. Soc. Trans. 27, 404 (1999) Abstract
Sphingosine 1-phosphate signalling in mammalian cells: S. Pyne & N.J. Pyne; Biochem. J. 349, 385 (2000) Abstract
Sphingosine-1-phosphate: signaling inside and out: S. Spiegel & S. Milstien; FEBS Lett. 476, 55 (2000) Abstract
Further Categories Containing This Product:
Angiogenesis Modulators Other Products
 
 
ALX-306-022 Revised 07-Feb-05
D-erythro-Sphingosine chloride, N,N,N-Trimethyl-
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SYNONYMS N,N,N-Trimethyl-D-erythro-sphingosine chloride
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Ceramides/Cerebrosides/Sphingolipids/Related Products
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ALX-306-022-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C21H44ClNO2
MW: 378.0
SOURCE/HOST: Synthetic.
APPEARANCE: White crystalline solid.
SOLUBILITY: Soluble in water, methanol or DMSO; slightly soluble in chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep under inert gas. Hygroscopic.

Product Description
Stable N-methylated derivative of sphingosine that exhibits antitumor and anti-inflammatory properties and inhibits platelet activating factor (PAF) activation and protein kinase C (PKC) activity. Inhibits IL-1β-induced NF-κB activation and cell surface expression of crucial selectins which promote adhesion of Lex- or sialosyl-Lex-expressing cells with platelets and endothelial cells.
Product Specific Literature References
Downregulation of GMP-140 (CD62 or PADGEM) expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine: K. Handa, et al.; Biochemistry 30, 11682 (1991) Abstract
Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line: H. Okoshi, et al.; Cancer Res. 51, 6019 (1991) Abstract
Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils: S. Kimura, et al.; Biochem. Pharmacol. 44, 1585 (1992) Abstract
Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III: Y.S. Park, et al.; Cancer Res. 54, 2213 (1994) Abstract
N,N,N-trimethylsphingosine inhibits interleukin-1 beta-induced NF-kappa B activation and consequent E-selectin expression in human umbilical vein endothelial cells: A. Masamune, et al.; FEBS Lett. 367, 205 (1995) Abstract
Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells. Possible involvement of protein kinase C activation and its inhibition by nitric oxide donors: T. Murohara, et al.; Circ. Res. 78, 780 (1996) Abstract; Full Text
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors) • PKC Inhibitors • NF-kB Pathway Inhibitors • Anti-inflammatory Agents Other Products
 
 
ALX-380-220 Revised 13-Nov-07
Steffimycin B
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SYNONYMS Antibiotic U 40615
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics - DNA Regulation/Transcription
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ALX-380-220-M001   1 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C29H32O13
MW: 588.6
CAS NUMBER: 54526-94-2
RTECS: QI9450000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5455.
PURITY: ≥99% (HPLC)
APPEARANCE: Orange to red solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
DNA-binding agent. Displays antibacterial and antineoplastic properties. Potential antitumor agent.
Product Specific Literature References
Steffimycin B, a new member of the steffimycin family: isolation and characterization: T.F. Brodasky and F. Reusser; J. Antibiot. (Tokyo) 27, 809 (1974) Abstract
Steffimycin B, a DNA binding agent: F. Reusser; Biochim. Biophys. Acta 383, 266 (1975) Abstract
Screening of antibiotics preferentially active against ras oncogene-expressed cells: K. Suzukake-Tsuchiya, et al.; J. Antibiot. (Tokyo) 43, 1489 (1990) Abstract
Molecular structure of antitumor drug steffimycin and modelling of its binding to DNA: M. Sriram, et al.; J. Biomol. Struct. Dyn. 9, 251 (1991) Abstract
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Antibiotics
 
 
ALX-380-010 Revised 21-Feb-08
Streptozotocin
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SYNONYMS Streptozocin
2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
STZ
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Nitric Oxide Pathway Modulators
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ALX-380-010-M100   100 mg 25.00 USD Add To Cart
ALX-380-010-5100   5x100 mg 65.00 USD Add To Cart
ALX-380-010-G001   1 g 74.00 USD Add To Cart
Product Specification
FORMULA: C8H15N3O7
MW: 265.2
CAS NUMBER: 18883-66-4
MERCK INDEX: 14: 8832
RTECS: LZ5775000
PURITY: ≥97%
APPEARANCE: White to pale yellow solid.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC. CARCINOGENIC.

Product Description
Widely used diabetes inducer in rodents. Inhibition of β-cell O-GlcNAcase by streptozotocin is the mechanism that accounts for its diabetogenic toxicity. N-nitroso-containing antibiotic, acting as a nitric oxide (NO) donor. Potent methylating agent for DNA.
Product Specific Literature References
Studies on the diabetogenic action of streptozotocin: N. Rakieten, et al.; Cancer Chemother. Rep. 29, 91 (1963)
The structure of streptozotocin: R.R. Herr, et al.; JACS 89, 4808 (1967) Abstract
Alkylation of DNA in rat tissues following administration of streptozotocin: R.A. Bennett & A.E. Pegg; Cancer Res. 41, 2786 (1981) Abstract
Streptozotocin: a nitric oxide carrying molecule and its effect on vasodilation: G. Thomas & P. Ramwell; Eur. J. Pharmacol. 161, 279 (1989) Abstract
NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta: K.C. Chang, et al.; BBRC 191, 509 (1993) Abstract
Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets: J. Turk, et al.; BBRC 197, 1458 (1993) Abstract
Nitric oxide generation from streptozotocin: N.S. Kwon, et al.; FASEB J. 8, 529 (1994) Abstract
Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage: K.-D. Kroncke, et al.; Biol. Chem. Hoppe Seyler 376, 179 (1995) Abstract
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas: T. Szkudelski; Physiol. Res. 50, 537 (2001), (Review) Abstract
Genotoxicity of streptozotocin: A.D. Bolzan & M.S. Bianchi; Mutat. Res. 512, 121 (2002), (Review) Abstract
Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo: A.P. Johnston, et al.; Am. J. Physiol. Cell Physiol. 292, C1033 (2007) Abstract
Further Categories Containing This Product:
Nitric Oxide Donors • Antitumor Antibiotics • Obesity & Diabetes Other Products
 
 
ALX-270-400 Revised 31-Mar-05
SU 9516
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SYNONYMS 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-270-400-M005   5 mg 80.00 USD Add To Cart
ALX-270-400-M025   25 mg 320.00 USD Add To Cart
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Product Specification
FORMULA: C13H11N3O2
MW: 241.3
PURITY: ≥95%
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Packaged under inert gas.

Product Description
Cell permeable, potent, selective and ATP-competitive inhibitor of CDK2/cyclin A (IC50=22nM), CDK1/cyclin B (IC50=40nM) and CDK4/cyclin D1 (IC50=200nM). Has no effect on the activity of PKC, p38, PDGFRβ and EGFR (IC50>10µM). Displays anti-proliferative and pro-apoptotic properties in tumor cells. Inhibits proliferation of growth factor-stimulated colon carcinoma cells by binding to CDK2 and thus preventing the phosphorylation of pRb and its dissociation from E2F.
Product Specific Literature References
A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells: M.E. Lane, et al.; Cancer Res. 61, 6170 (2001) Abstract
SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells: B. Yu, et al.; Biochem Pharmacol. 64, 1091 (2002) Abstract
SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2: D.J. Moshinsky, et al.; BBRC 310, 1026 (2003) Abstract
Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-dependent kinase 2 inhibitors: X. Li, et al.; Bioorg. Med. Chem. Lett. 13, 1939 (2003) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Apoptosis Inducers) • Antitumor Agents (Anti-proliferative)
 
 
ALX-430-114 Revised 28-Aug-07
(±)-Sulfinpyrazone
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SYNONYMS 1,2-Diphenyl-4-(phenylsulfinylethyl)-3,5-pyrazolidinedione
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Antioxidants, Flavonoids & Free Radical Scavengers Other Products
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ALX-430-114-G001   1 g 16.00 USD Add To Cart
Product Specification
FORMULA: C23H20N2O3S
MW: 404.5
CAS NUMBER: 57-96-5
MERCK INDEX: 14: 8949
RTECS: UQ8575000
PURITY: ≥99% (Sodium Hydroxide Titration)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: HARMFUL.
IDENTITY: Determined by IR.

Product Description
Potent uricosuric drug. Inhibitor of organic anion transporters. Substrate for MRP2. Has free radical scavenging properties.
Product Specific Literature References
Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export: R. Evers, et al.; Br. J. Cancer 83, 375 (2000) Abstract
Free radical scavenging properties of sulfinpyrazone: M.L. Yang, et al.; Free Radic. Res. 36, 685 (2002) Abstract
Further Categories Containing This Product:
MDR Other Products
 
 
ALX-350-232 Revised 17-Jul-08
DL-Sulforaphane
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SYNONYMS R,S-Sulforaphane
1-Isothiocyanato-4-methylsulfinyl-butane
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-232-M025   25 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C6H11NOS2
MW: 177.3
CAS NUMBER: 142825-10-3; 4478-93-7 (unspecified stereo)
MERCK INDEX: 14: 8962
SOURCE/HOST: Synthetic.
PURITY: ≥98% (UPLC)
APPEARANCE: Slightly yellowish liquid.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats. Inhibits LPS-induced HMGB1 (high mobility group box 1) secretion.
Product Specific Literature References
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS 89, 2399 (1992)