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Netrins & Receptors / Related Products
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ALX-522-109 Revised 14-Apr-08
DCC (Fibronectin Domain 5) (human) (recombinant)
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SYNONYMS Deleted in Colorectal Cancer Protein (Fibronectin Domain 5) (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-109-C050   50 µg 360.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The fibronectin domain 5 (FBN5) of human DCC (aa 841-941) is fused to a N-terminal tag.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human netrin-1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer: J. Fitamant, et al.; PNAS 105, 4850 (2008) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q16218: Deleted in Colorectal Cancer Protein (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin: B.V. Geisbrecht, et al.; J. Biol. Chem. 278, 32561 (2003) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Fibronectin / Related Products
 
 
ALX-804-853 Revised 31-Jul-07
Monoclonal Antibody to DCC (human) (Axel-1)
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SYNONYMS anti-Deleted in Colorectal Cancer Protein (human) MAb (Axel-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-853-C100   100 µg 340.00 USD Add To Cart
ALX-804-853PF-C100 Preservative Free 100 µg 340.00 USD Add To Cart
ALX-804-853TD-T100 ATTO 488 100 tests 380.00 USD Add To Cart
ALX-804-853TS-T100 ATTO 647N 100 tests 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Axel-1
ISOTYPE: Mouse IgG2aλ
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: ALX-804-853: Liquid. In PBS containing 0.02% sodium azide.
ALX-804-853PF: Liquid. In PBS.
ALX-804-853TD: Liquid. In PBS containing 0.02% sodium azide.
ALX-804-853TS: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human DCC fibronectin domain 5 (Prod. No. ALX-522-109).
SPECIFICITY: Recognizes human DCC.
APPLICATION: Flow Cytometry
Functional Application: Blocking
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-838 Revised 02-Jul-07
Monoclonal Antibody to Netrin-1 (Nora-1)
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SYNONYMS anti-Netrin-1 MAb (Nora-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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ALX-804-838-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Nora-1
ISOTYPE: Mouse IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 0.5mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human, mouse and chicken netrin-1 (aa 28-264).
SPECIFICITY: Recognizes human, mouse and chicken netrin-1.
APPLICATION: ELISA
Immunohistochemistry
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
POSITIVE CONTROL: Prod. No. ALX-522-100
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Netrin-1 controls colorectal tumorigenesis by regulating apoptosis: L. Mazelin, et al.; Nature 431, 80 (2004) Abstract
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Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-860 Revised 12-Dec-07
Monoclonal Antibody to Netrin-4 (human) (Netry-1)
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SYNONYMS anti-β-Netrin (human) MAb (Netry-1)
anti-Hepar-derived Netrin-like Protein (human) MAb (Netry-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-860-C100   100 µg 360.00 USD Add To Cart
ALX-804-860B-C100 Biotin 100 µg 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Netry-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human netrin-4 (Prod. No. ALX-522-113).
SPECIFICITY: Recognizes human netrin-4.
APPLICATION: ELISA
Immunoprecipitation (1:200)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
POSITIVE CONTROL: Prod. No. ALX-522-113
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-862 Revised 28-May-08
Monoclonal Antibody to Netrin-4 (Netry-2)
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SYNONYMS anti-β-Netrin MAb (Netry-2)
anti-Hepar-derived Netrin-like Protein MAb (Netry-2)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-862-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Netry-2
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human netrin-4 (Prod. No. ALX-522-113).
SPECIFICITY: Recognizes human and mouse netrin-4.
APPLICATION: ELISA
Immunoprecipitation (1:200)
Western Blot (1:1´000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Prod. No. ALX-522-113
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-846 Revised 04-Jan-07
Monoclonal Antibody to UNC5B (Guido-1)
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SYNONYMS anti-UNC-5 Homolog B MAb (Guido-1)
anti-UNC5H2 MAb (Guido-1)
anti-UNC-5 Homolog 2 MAb (Guido-1)
anti-p53-regulated Receptor For Death And Life Protein 1 MAb (Guido-1)
anti-P53RDL1 MAb (Guido-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-846-C100   100 µg 370.00 USD Add To Cart
ALX-804-846TD-T100 ATTO 488 100 tests 390.00 USD Add To Cart
ALX-804-846TS-T100 ATTO 647N 100 tests 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Guido-1
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human UNC5B (aa 28-363) (Prod. No. ALX-522-095).
SPECIFICITY: Recognizes human and mouse UNC5B.
APPLICATION: Flow Cytometry
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
Product Description
New ATTO-fluorescent antibodies show increased photostability, outstanding brightness and intense signals. ATTO dyes are thermally stable, resistant to environmental changes and show no significant isomerization. ATTO 488 shows bright green fluorescence (λabs (max): 501nm, λem (max): 523nm, εmax: 90’000).
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment: K. Thiebault, et al.; PNAS 100, 4173 (2003) Abstract
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system: X. Lu, et al.; Nature 432, 179 (2004) Abstract
p53, apoptosis and axon-guidance molecules: H. Arakawa; Cell Death Differ. 12, 1057 (2005) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-864 Revised 25-Mar-08
Monoclonal Antibody to UNC5A (human) (Dettwy-1)
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SYNONYMS anti-Netrin Receptor UNC5A Precursor (human) MAb (Dettwy-1)
anti-UNC-5 Homolog A (human) MAb (Dettwy-1)
anti-UNC5H1 (human) MAb (Dettwy-1)
anti-UNC-5 Homolog 1 (human) (Dettwy-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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ALX-804-864-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Dettwy-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Extracellular domain of human UNC5A (aa 26-306) fused to the Fc portion of human IgG1 (Prod. No. ALX-522-121)
SPECIFICITY: Recognizes human UNC5A.
APPLICATION: ELISA
Flow Cytometry
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-522-136 Revised 26-May-08
Netrin-4 (mouse) (recombinant)
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SYNONYMS β-Netrin (mouse) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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ALX-522-136-2010   2x10 µg 390.00 USD Add To Cart
Product Specification
MW: ~65kDa
SOURCE/HOST: Produced in HEK 293 cells. Mouse netrin-4 (aa 21-628) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9JI33: Netrin-4 (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-106 Revised 19-Jun-08
Netrin-1 (chicken) (recombinant)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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ALX-522-106-2010   2x10 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~80kDa
SOURCE/HOST: Produced in HEK 293 cells. Chicken netrin-1 (aa 27-606) is fused at the C-terminus to a linker peptide (6 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
RECONSTITUTION: Reconstitute with 100µl sterile distilled water. Resuspended protein should be used immediately upon reconstitution to avoid loss in activity due to non-specific binding to the vial. Further dilutions should be made with medium containing 5% fetal calf serum or 0.5% BSA.
SPECIFICITY: Binds to human receptor UNC5B.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
The Netrins (whose name means “one who guides” in Sanskrit) are a family of laminin-related secreted protein. In mice, human and rat, netrin-1, netrin-3/NTL2, netrin-4 and G-netrins have been cloned. Netrin-1 is predominantly expressed by floor plate cells as commissural axons extend toward the ventral midline. Netrin-1 induces axonal outgrowth, axon orientation and neuronal migration in neuronal development. It is chemoattractive for some neurons and chemorepellent for others.
To carry its functions, netrin-1 interacts with specific receptors: DCC/neogenin and UNC-5. These receptors belong to the family of “dependence receptors” that induce apoptosis in the absence of their respective ligand, and promote survival when bound to their ligand. The Netrin-1 mediated survival signal inhibits p53-induced apoptosis.
Netrin-1 is also expressed in organs such as pancreas, lung, bowel, bone and mammary gland. In these tissues, netrin-1 has different roles such as invasion of epithelial cells, leukocytes migration, cell adhesion or angiogenesis. Netrin-1, as a survival factor, also contributes to the control of tumorigenesis.
Chicken netrin-1 shares 87% aa identity with mouse and human netrin-1.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q90922: Netrin-1 (chicken)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Netrin-1 and its receptors in tumorigenesis: H. Arakawa; Nat. Rev. Cancer 4, 978 (2004), (Review) Abstract
Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis: P. Mehlen & C. Furne; Cell. Mol. Life Sci. 62, 2599 (2005), (Review) Abstract
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