ALEXIS Biochemicals: MMP-3 (Catalytic Domain) (human) (recombinant)

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ALX-350-334

Revised 03-Apr-08

Ascochlorin
SYNONYMS	LL-Z 1272 γ
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-334-MC05		0.5 mg	320.00 USD

Product Specification

FORMULA:	C₂₃H₂₉ClO₄
MW:	404.9
CAS NUMBER:	26166-39-2
RTECS:	VH3707560
SOURCE/HOST:	Isolated from Acremonium sp. MST-FP1890.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to light grey powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Antitumor antibiotic. Shows antiviral activity. Inhibitor or matrix metalloproteinase 9 (MMP-9). Reduces the inflammatory response to TNF-α in rat vascular smooth muscle cells. May be useful as an antiatherogenic agent.

Product Specific Literature References

Ascochlorin, a new antibiotic, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics. I): G. Tamura, et al.; J. Antibiot. (Tokyo) 21, 539 (1968) Abstract
Ascochlorin derivatives as ligands for nuclear hormone receptors: M. Togashi, et al.; J. Med. Chem. 46, 4113 (2003) Abstract
Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells: S. Hong, et al.; J. Biol. Chem. 280, 25202 (2005) Abstract; Full Text
Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines: K. Sakaguchi, et al.; BBRC 329, 46 (2005) Abstract
Ascochlorin suppresses oxLDL-induced MMP-9 expression by inhibiting the MEK/ERK signaling pathway in human THP-1 macrophages: J.H. Kang, et al.; J. Cell. Biochem. 102, 506 (2007) Abstract

Further Categories Containing This Product:

Antibiotics - Antiviral / Anti-HIV • MMP Inhibitors • Antibiotics for Cytoskeletal Research • Antibiotics for Inflammation Research

ALX-260-120

Revised 12-Dec-07

Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH
PRODUCT LINE	Cytoskeleton
PRODUCT CATEGORY	MMP Substrates

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-120-M005		5 mg	250.00 USD

Product Specification

SEQUENCE:	2,4-Dinitrophenyl-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH
FORMULA:	C₄₄H₆₁N₁₃O₁₃S
MW:	1012.1
PURITY:	≥95% (HPLC)
APPEARANCE:	Yellow solid
SOLUBILITY:	Soluble in DMSO; dilute with distilled water or buffer.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Fluorogenic substrate for MMP-2 and MMP-9. Excitation: 280nm; emission 360nm.

Product Specific Literature References

Continuously recording fluorescent assays optimized for five human matrix metalloproteinases: S. Netzel-Arnett, et al.; Anal. Biochem. 195, 86 (1991) Abstract

ALX-380-273

Revised 03-Apr-08

Doxycycline . hyclate
SYNONYMS	Doxycycline . hydrochloride . hemiethanolate . hemihydrate
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics for Angiogenesis Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-273-G001		1 g	20.00 USD
ALX-380-273-G005		5 g	60.00 USD

Product Specification

FORMULA:	C₂₂H₂₄N₂O₈ . HCl . 0.5C₂H₆O . 0.5H₂O
MW:	444.4 . 36.5 . 23.0 . 9.0
CAS NUMBER:	24390-14-5
MERCK INDEX:	14: 3440
RTECS:	QI8925000
SOURCE/HOST:	Semisynthetic from oxytetracycline.
PURITY:	≥98% (Assay on dry basis)
APPEARANCE:	Yellow crystalline solid.
SOLUBILITY:	Soluble in water (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Hygroscopic.
HAZARD:	HARMFUL. MAY BE TERATOGENIC. MAY BE CARCINOGENIC.

Product Description

Broad spectrum antibiotic and bacteriostatic. Shows antiprotozoal properties. Potent inhibitor of MMPs (matrix metalloproteinases) in vivo. Inhibits collagen synthesis.

Product Specific Literature References

Alpha-6-deoxyoxytetracycline. I. Some biological properties: A.R. English; Proc. Soc. Exp. Biol. Med. 122, 1107 (1966) Abstract
A compilation of LD50 values in newborn and adult animals: E.I. Goldenthal; Toxicol. Appl. Pharmacol. 18, 185 (1971) Abstract
An efficacy trial of doxycycline chemoprophylaxis against leptospirosis: E.T. Takafuji, et al.; N. Engl. J. Med. 310, 497 (1984) Abstract
Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential: K. Suomalainen, et al.; Antimicrob. Agents Chemother. 36, 227 (1992) Abstract
Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline: R. Hanemaaijer, et al.; J. Biol. Chem. 272, 31504 (1997) Abstract; Full Text
Doxycycline and tissue repair in rats: S. Lamparter, et al.; J. Lab. Clin. Med. 139, 295 (2002) Abstract
Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry: R.A. Garcia, et al.; Mol. Pharmacol. 67, 1128 (2005) Abstract; Full Text
Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices: C. Franco, et al.; Am. J. Pathol. 168, 1697 (2006) Abstract; Full Text
Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia: D. Burggraf, et al.; Neurobiol. Dis. 25, 506 (2007) Abstract

Further Categories Containing This Product:

MMP Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Anti-proliferative) • Antitumor Antibiotics

ALX-420-039

Revised 14-Aug-08

Imiquimod
SYNONYMS	1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine R-837
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLR Agonists Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-039-M100		100 mg	55.00 USD
ALX-420-039-M250		250 mg	120.00 USD

Product Specification

FORMULA:	C₁₄H₁₆N₄
MW:	240.3
CAS NUMBER:	99011-02-6
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO (3mg/ml) or dimethyl formamide; slightly soluble in water (warm to 37°C, vortex); insoluble in 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C.

Product Description

Topical immune response modifier that inhibits angiogenesis. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway.

Product Specific Literature References

Imiquimod applied topically: a novel immune response modifier and new class of drug: R.L. Miller, et al.; Int. J. Immunopharmacol. 21, 1 (1999) Abstract
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway: H. Hemmi, et al.; Nat. Immunol. 3, 196 (2002) Abstract
In vivo and in situ modulation of the expression of genes involved in metastasis and angiogenesis in a patient treated with topical imiquimod for melanoma skin metastases: C. Hesling, et al.; Br. J. Dermatol. 150, 761 (2004) Abstract
Imiquimod as an antiangiogenic agent: V.W. Li, et al.; J. Drugs Dermatol. 4, 708 (2005) Abstract
Imiquimod is a strong inhibitor of tumor cell-induced angiogenesis: S. Majewski, et al.; Int. J. Dermatol. 44, 14 (2005) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Stimulation of TLR7 can be achieved with 1-10µg/ml of the compound for 6 to 24 hours.

Related Products:
- ddWater (endotoxin-free) (Prod. No. ALX-505-008)
- PBS (endotoxin-free) (Prod. No. ALX-505-007)

Related Products

ALX-505-007	PBS (endotoxin-free)
ALX-505-008	ddWater (endotoxin-free)

Further Categories Containing This Product:

Antitumor Agents (Apoptosis Inducers) • Angiogenesis Modulators Other Products • MMPs Other Products • Inflammasome

ALX-350-145

Revised 28-Mar-07

Isobavachalcone
SYNONYMS	2’,4’,4-Trihydroxy-3’-[3’’-methylbut-3’’-enyl]chalcone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-145-M001		1 mg	190.00 USD

Product Specification

FORMULA:	C₂₀H₂₀O₄
MW:	324.4
CAS NUMBER:	20784-50-3
SOURCE/HOST:	Isolated from plant Psoralea corylifolia.
PURITY:	≥97% (HPLC)
APPEARANCE:	Yellow oil.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
IDENTITY:	Determined by ¹H-NMR, ¹³C-NMR and MS.

Product Description

Inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Shows antifungal activity.

Product Specific Literature References

Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects: T. Akihisa, et al.; Cancer Lett. 201, 133 (2003) Abstract
Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa: N.O. Omisore, et al.; Braz. J. Med. Biol. Res. 38, 1087 (2005) Abstract
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects: T. Akihisa, et al.; J. Nat. Prod. 69, 38 (2006) Abstract
Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau.: B. Ngameni, et al.; Arkivoc ix, 91 (2007) Full Text

Further Categories Containing This Product:

Other Natural Products - DNA Regulation / Transcription • Chalcones • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • MMP Inhibitors • Epstein Barr Virus / Related Products • Antitumor Agents (Anti-proliferative) • Natural Products - Antifungal Agents

ALX-270-280

Revised 07-Apr-08

clasto-Lactacystin β-lactone (synthetic)
SYNONYMS	Omuralide
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Proteasome / Ubiquitin Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-280-C200		200 µg	280.00 USD
ALX-270-280-M001		1 mg	1'295.00 USD

Product Specification

FORMULA:	C₁₀H₁₅NO₄
MW:	213.2
CAS NUMBER:	155975-72-7
SOURCE/HOST:	Synthetic.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	20mg/ml soluble in DMSO or acetonitrile.
ACTIVITY:	K_obs/[I]=20’000M^-1s^-1 versus 20S:PA28 complex.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Subject to hydrolysis in aqueous buffers. We do not recommend storing the aqueous solutions for more than one day.
HANDLING:	Protect from light.
IDENTITY:	Determined by ¹H-NMR.

Product Description

Highly specific, cell permeable, and irreversible 20S proteasome inhibitor. Inhibits ubiquitin proteasome pathway in cell culture (IC₅₀=1µM). It has been suggested that the natural product lactacystin acts as a precursor for clasto-lactacystin β-lactone and that the latter is the sole species that interacts with the proteasome. Inhibits cathepsin A. Leads to a reduction of adipogenesis.

Product Specific Literature References

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin: G. Fenteany, et al.; Science 268, 726 (1995) Abstract
Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone: L.R. Dick, et al.; J. Biol. Chem. 271, 7273 (1996) Abstract
Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells: L.R. Dick, et al.; J. Biol. Chem. 272, 182 (1997) Abstract; Full Text
Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation: A. Craiu, et al.; J. Biol. Chem. 272, 13437 (1997) Abstract; Full Text
Lactacystin, proteasome function, and cell fate: G. Fenteany & S.L. Schreiber; J. Biol. Chem. 273, 8545 (1998) Abstract; Full Text
Total synthesis and biological activity of lactacystin, omuralide and analogs: E.J. Corey & W.D. Li; Chem. Pharm. Bull. 47, 1 (1999) Abstract
Lactacystin, a proteasome inhibitor: discovery and its application in cell biology: H. Tomoda & S. Omura; Yakugaku Zasshi 120, 935 (2000), Review Abstract
Lactacystin inhibits cathepsin A activity in melanoma cell lines: L. Kozlowski, et al.; Tumour Biol. 22, 211 (2001) Abstract
Inhibition of human preadipocyte proteasomal activity by HIV protease inhibitors or specific inhibitor lactacystin leads to a defect in adipogenesis, which involves matrix metalloproteinase-9: S. De Barros, et al.; J. Pharmacol. Exp. Ther. 320, 291 (2007) Abstract
Effect of proteasome inhibitor clasto-lactacystin-beta-lactone on the proteome of the haloarchaeon Haloferax volcanii: P.A. Kirkland, et al.; Microbiology 153, 2271 (2007) Abstract

Further Categories Containing This Product:

Cathepsin Inhibitors • Proteasome / Related Products • MMP Inhibitors

ALX-201-415

Revised 09-Jul-08

Lipocalin-2 (mouse) (recombinant)
SYNONYMS	NGAL (mouse) (recombinant) Neutrophil Gelatinase-associated Lipocalin (mouse) (recombinant) Siderocalin (mouse) (recombinant) Oncogene 24p3 (mouse) (recombinant)
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Adipokines Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-415-C010		10 µg	150.00 USD
ALX-201-415-C050		50 µg	320.00 USD

Product Specification

SOURCE/HOST:	Produced in HEK 293 cells. The mature peptide of mouse lipocalin-2 (aa 1-200) is fused to a FLAG^®-tag at the C-terminus.
CONCENTRATION:	0.3mg/ml
PURITY:	≥90% (SDS-PAGE)
FORMULATION:	Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT:	<1EU/µg protein (LAL-test).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

Product Images

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General Information

BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link P11672: Lipocalin-2 (mouse) FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER	Manufactured by AdipoGen, Inc.

ALX-201-417	Lipocalin-2 (rat) (recombinant)
ALX-201-411	Lipocalin-2 (human) (recombinant)

BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link P30152: Lipocalin-2 (rat) FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER	Manufactured by AdipoGen, Inc.

BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link P80188: Lipocalin-2 (human) FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER	Manufactured by AdipoGen, Inc.