ALEXIS Biochemicals: Baccatin III, 10-Deacetyl-

Advanced Search

You are here: Product Lines > Cancer > Antitumor Reagents > Taxol / Related Products

ALX-350-124

Revised 05-Apr-08

Ferulenol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products with Antibiotic Activity

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-124-M001		1 mg	45.00 USD
ALX-350-124-M005		5 mg	135.00 USD
ALX-350-124-M010		10 mg	230.00 USD

Product Specification

FORMULA:	C₂₄H₃₀O₃
MW:	366.5
CAS NUMBER:	6805-34-1
SOURCE/HOST:	Isolated from Ferula communis.
PURITY:	≥96%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in DMSO, 100% ethanol and methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Prenylated 4-hydroxycoumarin. Antitubercular antibiotic with potent activity against Mycobacteria. Exerts taxol-like and dose-dependent cytotoxicity against various human tumor cell lines. Stimulator of tubulin polymerisation in vitro and inhibitor of colchicine binding to tubulin. Antithrombotic, depressing the activity of all vitamin K-dependent coagulation factors. Shows lower acute toxicity and higher activity than warfarin. Shows hepatocyte toxicity.

Product Specific Literature References

Experimental studies on the toxicity of some compounds isolated from Ferula communis in the rat: S. Tagliapietra, et al.; Res. Commun. Chem. Pathol. Pharmacol. 66, 333 (1989) Abstract
Plasma ferulenol concentration and activity of clotting factors in sheep with Ferula communis variety brevifolia intoxication: N. Tligui, et al.; Am. J. Vet. Res. 55, 1564 (1994) Abstract
Antibacterial constituents from the rhizomes of Ferula communis: M.A. Al-Yahya, et al.; Phytother. Res. 12, 335 (1998)
Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol: C. Bocca, et al.; Planta Med. 68, 1135 (2002) Abstract
Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L: O. Fraigui, et al.; Vet. Hum. Toxicol. 44, 5 (2002) Abstract
Characterization of anti-coagulant properties of prenylated coumarin ferulenol: M. Monti, et al.; Biochim. Biophys. Acta 1770, 1437 (2007) Abstract

Further Categories Containing This Product:

ALX-351-001

Revised 08-Apr-08

Paclitaxel
SYNONYMS	Taxol^®
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-351-001-M001		1 mg	20.00 USD
ALX-351-001-M005		5 mg	50.00 USD
ALX-351-001-M025		25 mg	150.00 USD

Product Specification

FORMULA:	C₄₇H₅₁NO₁₄
MW:	853.9
CAS NUMBER:	33069-62-4
MERCK INDEX:	14: 6982
RTECS:	DA8340700
SOURCE/HOST:	Isolated from Taxus brevifolia.
PURITY:	≥98%
APPEARANCE:	Off-white crystalline powder.
SOLUBILITY:	Soluble in acetonitrile, DMSO or methanol; sparingly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep cool and dry.
HAZARD:	MAY BE MUTAGENIC. HARMFUL. MAY BE TERATOGENIC.
IDENTITY:	Determined by IR.

Product Description

Antitumor agent. Binds to tubulin. Promotes assembly and inhibits disassembly of microtubules. Blocks the cell cycle at the mitotic phase and induces apoptosis. The checkpoint of mitotic spindle assembly, aberrant activation of cyclin-dependent kinases (CDKs) and the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) are involved in paclitaxel-induced apoptosis.

Product Specific Literature References

CDK4 down-regulation induced by paclitaxel is associated with G1 arrest in gastric cancer cells: Y.D. Yoo, et al.; Clin Cancer Res 4, 3063 (1998) Abstract
Molecular effects of paclitaxel: myths and reality (a critical review): M.V. Blagosklonny & T. Fojo; Int. J. Cancer 83, 151 (1999) Abstract
Paclitaxel-induced cell death: where the cell cycle and apoptosis come together: T.H. Wang, et al.; Cancer 88, 2619 (2000) Abstract
Disruption of Cell Adhesion and Caspase-Mediated Proteolysis of beta- and gamma-Catenins and APC Protein in Paclitaxel-Induced Apoptosis:: Y.H. Ling, et al.; Mol. Pharmaco. 59, 593 (2001) Abstract; Full Text
Taxol: biosynthesis, molecular genetics, and biotechnological applications: S. Jennewein and R. Croteau; Appl. Microbiol. Biotechnol. 57, 13 (2001) Abstract
Chemistry and chemical biology of taxane anticancer agents: M.L. Miller and I. Ojima; Chem. Rec. 1, 195 (2001) Abstract
Paclitaxel and its formulations: A.K. Singla, et al.; Int. J. Pharm. 235, 179 (2002) Abstract
Paclitaxel in cancer therapy: T.M. Mekhail and M. Markman; Expert. Opin. Pharmacother. 3, 755 (2002) Abstract
Taxol reactions: K.S. Price and M.C. Castells; Allergy Asthma Proc. 23, 205 (2002) Abstract
The chemistry of taxol and related taxoids: D.G. Kingston, et al.; Fortschr. Chem. Org. Naturst. 84, 53 (2002) Abstract
Overcoming multidrug resistance in taxane chemotherapy: R. Geney, et al.; Clin. Chem. Lab. Med. 40, 918 (2002) Abstract
Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action: M. Abal, et al.; Curr. Cancer Drug Targets 300, 193 (2003) Abstract
Paclitaxel: as adjuvant or neoadjuvant therapy in early breast cancer: D. Simpson & G.L. Plosker; Drugs 64, 1839 (2004), Review Abstract
Paclitaxel for AIDS-associated Kaposi’s sarcoma: T. Dhillon, et al.; Expert Rev. Anticancer Ther. 5, 215 (2005), Review Abstract
Microtubule Associated Protein (MAP)-Tau: a novel mediator of paclitaxel sensitivity in vitro and in vivo: P. Wagner, et al.; Cell Cycle 4, 1149 (2005), Review Abstract

Further Categories Containing This Product:

ALX-351-005

Revised 07-Jan-08

Baccatin III
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-351-005-M005		5 mg	85.00 USD
ALX-351-005-M025		25 mg	360.00 USD

Product Specification

FORMULA:	C₃₁H₃₈O₁₁
MW:	586.6
CAS NUMBER:	27548-93-2
SOURCE/HOST:	Semisynthetic.
PURITY:	≥95%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in DMSO or 100 % ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light and moisture. Avoid strong oxidizing agents, acids and bases.

Product Description

Starting material for the synthesis of taxol analogs. Shows antitumor properties.

Product Specific Literature References

Recent advances in the chemistry of taxol: D.G. Kingston; J. Nat. Prod. 63, 726 (2000) Abstract

Further Categories Containing This Product:

Taxol / Related Products

ALX-351-006

Revised 07-Jan-08

Baccatin III, 10-Deacetyl-
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-351-006-M005		5 mg	190.00 USD
ALX-351-006-M025		25 mg	590.00 USD

Product Specification

FORMULA:	C₂₉H₃₆O₁₀
MW:	544.6
CAS NUMBER:	32981-86-5
SOURCE/HOST:	Isolated from Taxus baccata.
PURITY:	≥95%
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light and moisture. Avoid strong oxidizing agents, acids and bases.

Product Description

Intermediate for the preparation of taxol analogs.

Product Specific Literature References

Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules: H. Lataste, et al.; PNAS 81, 4090 (1984) Abstract
Chemical Studies of 10-Deacetyl Baccatin III. Hemisynthesis of Taxol Derivatives: F. Gueritte-Voegelein, et al.; Tetrahedron Letters 42, 4451 (1986)
A highly efficient, practical approach to natural taxol: J.-N. Denis, et al.; JACS 110, 5917 (1988)
Preclinical evaluation of docetaxel (Taxotere): F. Lavelle, et al.; Semin. Oncol. 22, 3 (1995) Abstract

Further Categories Containing This Product:

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.