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Immunology
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ALX-350-329 Revised 21-May-08
Allicin
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SYNONYMS 2-Propene-1-sulfinothioic acid S-2-propenyl ester
Diallyl thiosulfinate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-329-M001   1 mg 200.00 USD Add To Cart
ALX-350-329-M005   5 mg 690.00 USD Add To Cart
Product Specification
FORMULA: C6H10OS2
MW: 162.3
CAS NUMBER: 539-86-6
MERCK INDEX: 14: 261
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Clear to slightly yellow liquid.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Active metabolite of garlic. Exhibits antimicrobial, antioxidant, antiproliferative, chemopreventive, antihyperlipidaemic and antihypertensive effects. Inhibits telomerase activity. Induces apoptosis. Also inhibits inducible nitric oxide synthase (iNOS; NOS II) expression.
Product Specific Literature References
Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica: S. Ankri, et al.; Antimicrob. Agents Chemother. 41, 2286 (1997) Abstract
Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase: V.M. Dirsch, et al.; Atherosclerosis 139, 333 (1998) Abstract
Antimicrobial properties of allicin from garlic: S. Ankri & D. Mirelman; Microbes Infect. 1, 125 (1999), Review Abstract
Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation: K. Hirsch, et al.; Nutr. Cancer 38, 245 (2000) Abstract
The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats: A. Elkayam, et al.; Am. J. Hypertens. 14, 377 (2001) Abstract
Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells: L. Sun & X. Wang; World J. Gastroenterol. 9, 1930 (2003) Abstract
Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells: S. Oommen, et al.; Eur. J. Pharmacol. 485, 97 (2004) Abstract
Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus: R.R. Cutler & P. Wilson; Br. J. Biomed. Sci. 61, 71 (2004) Abstract
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin: L.J. Macpherson, et al.; Curr. Biol. 15, 929 (2005) Abstract
An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic: S.R. Davis; Mycoses 48, 95 (2005), Review Abstract
Thiolsulfinate allicin from garlic: inspiration for a new antimicrobial agent: R. Hunter, et al.; Ann. N.Y. Acad. Sci. 1056, 234 (2005), Review Abstract
The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide: L.Y. Chung; J. Med. Food 9, 205 (2006) Abstract
Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial: C.D. Gardner, et al.; Arch. Intern. Med. 167, 346 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Chemopreventive Agents • Antitumor Agents (Anti-proliferative) • Natural Products with Antibiotic Activity • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Apoptosis Inducers & Inhibitors • TRPV1 Agonists and Antagonists / Related Products
 
 
ALX-350-158 Revised 13-May-08
Aloesin
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SYNONYMS Aloeresin B
NSC 631262
8-β-D-Glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-1-benzopyran-4-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-158-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C19H22O9
MW: 394.4
CAS NUMBER: 30861-27-9
SOURCE/HOST: Isolated from Aloe sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Pale yellow to brown powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
C-glycosylated chromone compound. Competitive inhibitor of tyrosinase. Shows weak free radical scavenging activity. Anti-inflammatory. Modulates melanogenesis (pigmentation-altering agent). Used in the cosmetic industry.
Product Specific Literature References
The distribution of aloesin in some South African Aloe species: T.J. McCarthy & L.J. Haynes; Planta Med. 15, 342 (1967) Abstract
Chromones in aloe species. I. Aloesin--a C-glucosyl-7-hydroxychromone: D.K. Holdsworth; Planta Med. 19, 322 (1971) Abstract
Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells: K.Y. Lee, et al.; Biochem. Mol. Biol. Int. 41, 285 (1997) Abstract
Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase: K. Jones, et al.; Pigment Cell Res. 15, 335 (2002) Abstract
Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera: A. Yagi, et al.; Planta Med. 68, 957 (2002) Abstract
Mushroom tyrosinase inhibition activity of some chromones: L.Z. Piao, et al.; Chem. Pharm. Bull. (Tokyo) 50, 309 (2002) Abstract
Aloesin inhibits hyperpigmentation induced by UV radiation: S. Choi, et al.; Clin. Exp. Dermatol. 27, 513 (2002) Abstract
Determination of aloesin and aloeresin A for the detection of aloe in beverages: M. Dell Agli, et al.; J. Agric. Food Chem. 55, 3363 (2007) Abstract
Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe: G. Speranza, et al.; Planta Med. 71, 79 (2005) Abstract
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ALX-270-385 Revised 17-Jul-07
Aloisine A
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SYNONYMS RP107
7-n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-270-385-M001   1 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C16H17N3O
MW: 267.3
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Packaged under inert gas.

Product Description
Cell permeable, potent, selective, reversible and ATP-competitive inhibitor of CDK1/cyclin B (IC50=150nM), CDK2/cyclin A (IC50=120nM), CDK2/cyclin E (IC50=400nM), CDK5/p25
(IC50=200nM), CDK5/p35 (IC50=160nM) and GSK-3α (IC50=500nM). Also inhibits GSK-3β (IC50=650nM) and c-Jun N-terminal kinase (JNK) (IC50~3-10µM). Poor inhibitor of CK1, CK2, CDK4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC50≥100µM). Blocks cell cycle in both G1 and G2 phase.
Product Specific Literature References
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects: Y. Mettey, et al.; J. Med. Chem. 46, 222 (2003) Abstract
Further Categories Containing This Product:
GSK-3 Inhibitors • JNK [SAPK1] / Related Products • Cell Cycle Blockers & Inhibitors / Related Products
 
 
ALX-350-325 Revised 25-Jun-07
Altenusin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-350-325-M001   1 mg 110.00 USD Add To Cart
ALX-350-325-M005   5 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C15H14O6
MW: 290.3
CAS NUMBER: 31186-12-6
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antifungal penicillide. Non-competitive, specific neutral sphingomyelinase (N-SMase) and strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light chain kinase inhibitor. Exhibits anti-HIV-1 integrase activity.
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 103. Metabolites of Alternaria tenuis Auct.: Culture filtrate products: T. Rosett, et al.; Biochem. J. 67, 390 (1957) Full Text
Studies in the biosynthesis of fungal metabolites. 4. Alternariol monomethyl ether and its relation to other phenolic metabolites of Alternaria tenuis: R. Thomas; Biochem. J. 80, 234 (1961) Abstract; Full Text
Metabolites of some Alternaria species. The structures of altenusin and dehydroaltenusin: R. G. Coombe, et al.; Aus. J. Chem. 23, 2343 (1970)
Host-specific toxins and chemical structures from alternaria species: S. Nishimura, et al.; Ann. Rev. Phytopathol. 21, 87 (1983)
The metabolites of Talaromycesflavus: Part 1. Metabolites of the organic extracts : W. A. Ayer, et al.; Can. J. Chem. 68, 2085 (1990)
Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur: S. Nakanishi, et al.; Biosci. Biotechnol. Biochem. 59, 1333 (1995) Abstract
Alutenusin, a specific neutral sphingomyelinase inhibitor, produced by Penicillium sp. FO-7436: R. Uchida, et al.; J. Antibiot. 52, 572 (1999) Abstract
Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites: S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol. 30, 721 (2003) Abstract
Fungal metabolites as potent protein kinase inhibitors: Identification of a novel metabolite and novel activities of known metabolites : M. Oyama, et al.; Lett. Drug Design Discov. 1, 24 (2004)
New penicillide derivatives isolated from Penicillium simplicissimum: S. I. Komai, et al.; J. Nat. Med. 60, 185 (2006)
HIV-1 integrase inhibitors: 2003-2004 update: R. Dayam, et al.; Med. Res. Rev. 26, 271 (2006) Abstract
Further Categories Containing This Product:
Myosin Light Chain Kinase Inhibitors • Tyrosine Kinase Inhibitors • Antibiotics - Antiviral / Anti-HIV
 
 
ALX-350-139 Revised 18-Feb-08
Alternariol
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SYNONYMS AOH
3,7,9-Trihydroxy-1-methyl-6H-dibenzo(b,d)pyran-6-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-350-139-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C14H10O5
MW: 258.2
CAS NUMBER: 641-38-3
RTECS: HP8757000
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC. MAY BE MUTAGENIC.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Mycotoxin contaminant of fruit and cereal products. Exhibits antifungal and phytotoxic activity. Cholinesterase inhibitor.
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 90. Alternariol and alternariol monomethyl ether, metabolic products of Alternaria tenuis: H. Raistrick, et al.; Biochem. J. 55, 421 (1953) Abstract; Full Text
Studies in the biosynthesis of fungal metabolites. 2. The biosynthesis of alternariol and its relation to other fungal phenols: R. Thomas; Biochem. J. 78, 748 (1961) Abstract; Full Text
Effect of substrate on metabolite production of Alternaria alternata: R. Burroughs, et al.; Appl. Environ. Microbiol. 31, 685 (1976) Abstract; Full Text
Light inhibits the production of alternariol and alternariol monomethyl ether in Alternaria alternata: K. Soderhall, et al.; Appl. Environ. Microbiol. 36, 655 (1978) Abstract; Full Text
Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay: G.F. Griffin and F.S. Chu; Appl. Environ. Microbiol. 46, 1420 (1983) Abstract; Full Text
Alternariol, a dibenzopyrone mycotoxin of Alternaria spp., is a new photosensitizing and DNA cross-linking agent: F. DiCosmo and N.A. Straus; Experientia 41, 1188 (1985) Abstract
Nitrogen inhibition of mycotoxin production by Alternaria alternata: M. Orvehed, et al.; Appl. Environ. Microbiol. 54, 2361 (1988) Abstract; Full Text
Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium: V.M. Davis and M.E. Stack; Appl. Environ. Microbiol. 60, 3901 (1994) Abstract; Full Text
The inhibitory effect of extracts from Fructus lycii and Rhizoma polygonati on in vitro DNA breakage by alternariol: D.S. Xu, et al.; Biomed. Environ. 9, 67 (1996) Abstract
Total synthesis of alternariol: K. Koch, et al.; J. Org. Chem. 70, 3275 (2005) Abstract
Mutagenicity of the mycotoxin alternariol in cultured mammalian cells: E.M. Brugger, et al.; Toxicol. Lett. 164, 221 (2006) Abstract
Estrogenic and clastogenic potential of the mycotoxin alternariol in cultured mammalian cells: L. Lehmann, et al.; Food Chem. Toxicol. 44, 398 (2006) Abstract
Further examination of the effects of nitrosylation on Alternaria alternata mycotoxin mutagenicity in vitro: T.J. Schrader, et al.; Mutat. Res. 606, 61 (2006) Abstract
Novel oxidative in vitro metabolites of the mycotoxins alternariol and alternariol methyl ether: E. Pfeiffer, et al.; Mol. Nutr. Food Res. 51, 307 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Antifungal Agents
 
 
ALX-350-162 Revised 11-Aug-08 New product
Altersolanol A
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SYNONYMS As-A 2
NSC 173943
(1R-(1α,2β,3β,4α))-1,2,3,4-Tetrahydro-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-9,10-anthracenedione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-162-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C16H16O8
MW: 336.3
CAS NUMBER: 22268-16-2
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow-orange to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Tetrahydroanthraquinone with phytotoxic and antibacterial activity.
Product Specific Literature References
Metabolites of Dactylaria lutea. The structures of dactylariol and the antiprotozoal antibiotic dactylarin: A.M. Becker, et al.; J. Antibiot. (Tokyo) 31, 324 (1978) Abstract
High-performance liquid chromatographic determination of macrosporin, altersolanol A, alterporriol A, B and C in fermentation of Alternaria porri (Ellis) Ciferri: R. Suemitsu, et al.; J. Chromatogr. 454, 406 (1988) Abstract
Mode of phytotoxic action of altersolanols : H. Haraguchi, et al.; Phytochemistry 43, 989 (1996)
Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium: U. Höller, et al.; J. Nat. Prod. 54, 876 (2002) Abstract
Secondary metabolite profiling of Alternaria dauci, A. porri, A. solani, and A. tomatophila: B. Andersen, et al.; Mycol. Res. 112, 241 (2008) Abstract
 
 
ALX-270-440 Revised 20-Nov-08 New product
AMI-1
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SYNONYMS Arginine N-Methyltransferase Inhibitor-1
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY PRMTs, Mono- & Dimethylarginine / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-440-M005   5 mg 90.00 USD Add To Cart
ALX-270-440-M025   25 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C21H12N2O9S2Na4
MW: 592.4
PURITY: ≥98% (1H-NMR and HPLC)
APPEARANCE: Brown solid.
SOLUBILITY: Soluble in water, 100% ethanol or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Protect from light. Hygroscopic.

Product Description
Potent, cell permeable and specific inhibitor of protein arginine N-methyltransferases (PRMTs) (IC50=8.8µM for human PRMT1 and 3.0µM for yeast Hmt1p). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Exhibits only minimal effects on lysine N-methyltransferases. Suppresses the transcriptional coactivator activity of PRMT1 and PRMT4. Inhibitor of HIV-1 RT polymerase (IC50=5.0µM).
Product Specific Literature References
A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002) Abstract
Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004) Abstract; Full Text
Further Categories Containing This Product:
HIV / AIDS / Related Products
 
 
ALX-380-266 Revised 03-Apr-08
Amikacin . disulfate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-266-M250   250 mg 30.00 USD Add To Cart
ALX-380-266-G001   1 g 70.00 USD Add To Cart
Product Specification
FORMULA: C22H43N5O13 . 2H2SO4
MW: 585.6 . 196.2
CAS NUMBER: 39831-55-5
MERCK INDEX: 14: 405
RTECS: WK1961200
SOURCE/HOST: Semisynthetic from kanamycin A (Prod. No. ALX-380-275).
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (50mg/ml).
ACTIVITY: Potency is 647-786µg/ml (on dry basis).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Aminoglycoside antibiotic. Effective against Gram-negative and Gram-positive bacteria.
Product Specific Literature References
BB-K 8, a new semisynthetic aminoglycoside antibiotic: H. Kawaguchi, et al.; J. Antibiot. 25, 695 (1972) Abstract
Comparative pharmacokinetics of BB-K8 and kanamycin in dogs and humans: B.E. Cabana & J.G. Taggart; Antimicrob. Agents Chemother. 3, 478 (1973) Abstract
Comparative in vitro activity of three aminoglycosidic antibiotics: BB-K8, kanamycin, and gentamicin: P.K. Yu & J.A. Washington; Antimicrob. Agents Chemother. 4, 133 (1973) Abstract
Pharmacology of amikacin in humans: G.P. Bodey, et al.; Antimicrob. Agents Chemother. 5, 508 (1974) Abstract
Aminoglycoside antibiotics. VII. Acute toxicity of aminoglycoside antibiotics: K. Fujisawa, et al.; J. Antibiot. 27, 677 (1974) Abstract
Ototoxicity and pharmacokinetically determined dosages of amikacin in granulocytopenic cancer patients: F.J. Danhauer, et al.; Clin. Pharm. 1, 539 (1982) Abstract
Biological transformation of kanamycin A to amikacin (BBK-8): L.M. Cappelletti & R. Spagnoli; J. Antibiot. 36, 328 (1983) Abstract
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ALX-380-045 Revised 03-Apr-08
Amikacin (free base)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-045-G001   1 g 60.00 USD Add To Cart
Product Specification
FORMULA: C22H43N5O13
MW: 585.6
CAS NUMBER: 37517-28-5
MERCK INDEX: 14: 405
SOURCE/HOST: Semisynthetic from kanamycin A (Prod. No. ALX-380-275).
PURITY: ≥98% (contains ≤5% water)
APPEARANCE: White solid.