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ALX-260-136
Revised 16-Jun-05
H-Arg-Lys-Leu-Leu-Trp-NH2
SYNONYMS
RKLLW-NH
2
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-136-M001
1 mg
30.00 USD
ALX-260-136-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
35
H
59
N
11
O
5
MW:
713.9
PURITY:
≥98%
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Highly potent peptide inhibitor of human cathepsin L.
Product Specific Literature References
Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections::
A. Brinker, et al.; Eur. J. Biochem.
267
, 5085 (2000)
Abstract
ALX-260-164
Revised 24-Sep-07
H-LVK-CHO
SYNONYMS
H-Leu-Val-Lys-CHO
Cathepsin B Inhibitor (Aldehyde)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-260-164-M001
1 mg
70.00 USD
ALX-260-164-M005
5 mg
280.00 USD
Product Specification
FORMULA:
C
19
H
36
N
4
O
4
MW:
384.5
PURITY:
≥95%
APPEARANCE:
White to beige solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
May form cyclic isomers.
Product Description
Inhibitor of cathepsin B (IC
50
=4nM). More potent than to leupeptin (IC
50
=310nM) (Prod. No.
ALX-260-009
).
Product Specific Literature References
Inhibition studies of some serine and thiol proteinases by new leupeptin analogues:
R.M. McConnell, et al.; J. Med. Chem.
36
, 1084 (1993)
Abstract
ALX-270-103
Revised 28-Jan-05
NCO-700 . hemisulfate
SYNONYMS
Calpain Inhibitor
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calpains / Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-270-103-M001
1 mg
75.00 USD
ALX-270-103-M005
5 mg
300.00 USD
Product Specification
FORMULA:
(C
26
H
39
N
3
O
8
)
2
. H
2
SO
4
MW:
1141.3 . 98.0
PURITY:
≥98%
APPEARANCE:
White crystalline solid.
SOLUBILITY:
Soluble in 100% ethanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Specific thiol (cysteine) protease inhibitor. Active against calpains, cathepsin B and L and papain. Inhibits fMLP-stimulated PMN oxidant production; scavenges reactive oxygen species.
Product Specific Literature References
K. Hara & K. Takahashi; Biomed. Res.
4
, 121 (1983)
Purification and characterization of cathepsin B from monkey skeletal muscle:
T. Hirao, et al.; J. Biochem.
95
, 871 (1984)
Abstract
Ca overload and the action of calcium sensitive proteases, phospholipases and prostaglandin E2 in myocardial cell degradation:
T. Toyo-oka, et al.; Basic Res. Cardiol.
80
, 303 (1985)
Abstract
Suppression of myocardial protein degradation by the protease inhibitor bis[ethyl(2R,3R)-3-[(S)-methyl-1-[4-(2,3,4-tri-methoxy-phenyl-methyl) piperazine-1-ylcarbonyl]butyl-carbonyl]oxiran-2-carboxylat e]sulfate under hypoxia:
T. Toyo-oka, et al.; Drug Res.
36
, 190 (1986)
Abstract
Effect of NCO-700, an inhibitor of thiol protease, on reactive oxygen production by chemotactic peptide-stimulated rabbit peripheral granulocytes:
K. Tawara, et al.; Experientia
44
, 346 (1988)
Abstract
A protease inhibitor, NCO-700, improves the contractile function in stunned canine myocardium:
H. Ikeda, et al.; Jpn. Cir. J.
58
, 713 (1994)
Abstract
Further Categories Containing This Product:
Cathepsin Inhibitors
•
Proteases Other Products
ALX-270-280
Revised 07-Apr-08
clasto-Lactacystin β-lactone (synthetic)
SYNONYMS
Omuralide
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Proteasome / Ubiquitin Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-280-C200
200 µg
280.00 USD
ALX-270-280-M001
1 mg
1'295.00 USD
Product Specification
FORMULA:
C
10
H
15
NO
4
MW:
213.2
CAS NUMBER:
155975-72-7
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
20mg/ml soluble in DMSO or acetonitrile.
ACTIVITY:
K
obs
/[I]=20’000M
-1
s
-1
versus 20S:PA28 complex.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Subject to hydrolysis in aqueous buffers. We do not recommend storing the aqueous solutions for more than one day.
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR.
Product Description
Highly specific, cell permeable, and irreversible 20S proteasome inhibitor. Inhibits ubiquitin proteasome pathway in cell culture (IC
50
=1µM). It has been suggested that the natural product lactacystin acts as a precursor for
clasto
-lactacystin β-lactone and that the latter is the sole species that interacts with the proteasome. Inhibits cathepsin A. Leads to a reduction of adipogenesis.
Product Specific Literature References
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin:
G. Fenteany, et al.; Science
268
, 726 (1995)
Abstract
Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone:
L.R. Dick, et al.; J. Biol. Chem.
271
, 7273 (1996)
Abstract
Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells:
L.R. Dick, et al.; J. Biol. Chem.
272
, 182 (1997)
Abstract
;
Full Text
Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation:
A. Craiu, et al.; J. Biol. Chem.
272
, 13437 (1997)
Abstract
;
Full Text
Lactacystin, proteasome function, and cell fate:
G. Fenteany & S.L. Schreiber; J. Biol. Chem.
273
, 8545 (1998)
Abstract
;
Full Text
Total synthesis and biological activity of lactacystin, omuralide and analogs:
E.J. Corey & W.D. Li; Chem. Pharm. Bull.
47
, 1 (1999)
Abstract
Lactacystin, a proteasome inhibitor: discovery and its application in cell biology:
H. Tomoda & S. Omura; Yakugaku Zasshi
120
, 935 (2000), Review
Abstract
Lactacystin inhibits cathepsin A activity in melanoma cell lines:
L. Kozlowski, et al.; Tumour Biol.
22
, 211 (2001)
Abstract
Inhibition of human preadipocyte proteasomal activity by HIV protease inhibitors or specific inhibitor lactacystin leads to a defect in adipogenesis, which involves matrix metalloproteinase-9:
S. De Barros, et al.; J. Pharmacol. Exp. Ther.
320
, 291 (2007)
Abstract
Effect of proteasome inhibitor clasto-lactacystin-beta-lactone on the proteome of the haloarchaeon Haloferax volcanii:
P.A. Kirkland, et al.; Microbiology
153
, 2271 (2007)
Abstract
Further Categories Containing This Product:
Cathepsin Inhibitors
•
Proteasome / Related Products
•
MMP Inhibitors
ALX-620-080
Revised 23-May-06
bADA
SYNONYMS
Dibenzyl-1-[(R)-biotin-6-aminohexanoyl-aziridine]-2,3-(S,S+R,R)-dicarboxylate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Proteases Other Products
Ordering Information
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ALX-620-080-M002
2 mg
540.00 USD
Product Specification
FORMULA:
C
34
H
42
N
4
O
7
S
MW:
650.8
CAS NUMBER:
744207-03-02
PURITY:
≥98% (HPLC)
APPEARANCE:
White to yellow solid.
SOLUBILITY:
Soluble in DMSO (50mg/ml), 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Irreversible, cell permeable, biotin-labelled inhibitor of cysteine proteases.
Product Specific Literature References
Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate:
C. Gelhaus, et al.; Biol. Chem.
385
, 435 (2004)
Abstract
Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells:
C. Gelhaus, et al.; Biol. Chem.
386
, 499 (2005)
Abstract
Further Categories Containing This Product:
Cathepsin Inhibitors
ALX-804-289
Revised 07-Feb-06
Monoclonal Antibody to Procathepsin L (human) (CPLH 2D4)
SYNONYMS
anti-Cathepsin L Precursor (human) MAb (CPLH 2D4)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Antibodies
Ordering Information
Product Numbers:
Format:
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ALX-804-289-C200
200 µg
460.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
CPLH 2D4
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Protein G purified antibody in PBS containing 0.01% thimerosal.
IMMUNOGEN:
Purified human procathepsin L (from culture supernatant of non-small cell lung cancer cell line EPLC 32 M1).
SPECIFICITY:
Recognizes the epitope T
67
SEEFRQVMNGFQ
79
of the propeptide of human procathepsin L. Does not cross-react with mature single or two chain cathepsin L or with mature cathepsins B, D, H, K, S and procathepsins B, D, F, S, W.
APPLICATION:
ELISA (capture antibody)
Immunohistochemistry (paraffin sections after microwave treatment)Western Blot
Optimal conditions must be determined individually for each application. Dilutions given in the figures below may be used as guidelines.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth
:
E. Weber, et al.; J. Cancer. Res. Clin. Oncol.
120
, 564 (1994)
Abstract
Monoclonal antibodies against cathepsin L and procathepsin L of different species
:
E. Weber, et al.; Hybridoma
16
, 159 (1997)
Abstract
Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas
:
P. Wurl, et al.; Virchows Arch.
430
, 221 (1997)
Abstract
General Information
Cathepsin L [EC 3.4.22.15] is a lysosomal endopeptidase belonging to the papain family of the closely related cysteine proteases superfamily. The enzyme is ubiquitously distributed in the lysosomes of all cells and seems to be involved in a variety of disorders in which the pathological destruction of the extracellular matrix is one of the main characteristics.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-290
Revised 01-Nov-05
Monoclonal Antibody to Cathepsin L/Procathepsin L (human) (CPLH 33/1)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-804-290-C100
100 µg
460.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
CPLH 33/1
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.01% thimerosal.
IMMUNOGEN:
Purified human procathepsin L (from culture supernatant of non-small cell lung cancer cell line EPLC 32 M1).
SPECIFICITY:
Recognizes the epitope F
241
YKE
244
of human procathepsin L. Recognizes mature human single or two chain cathepsin L (heavy chain) and human procathepsin L. Does not cross-react with mature cathepsins B, D, H, K, S and procathepsins B, D, F, S, W.
APPLICATION:
ELISA (capture antibody)
Immunohistochemistry (paraffin sections after microwave treatment)
Western Blot
Optimal conditions must be determined individually for each application. Dilutions given in the figures below may be used as guidelines.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth:
E. Weber, et al.; J. Cancer. Res. Clin. Oncol.
120
, 564 (1994)
Abstract
Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas:
P. Wurl, et al.; Virchows Arch.
430
, 221 (1997)
Abstract
Monoclonal antibodies against cathepsin L and procathepsin L of different species:
E. Weber, et al.; Hybridoma
16
, 159 (1997)
Abstract
General Information
Cathepsin L [
EC 3.4.22.15
] is a lysosomal endopeptidase belonging to the papain family of the closely related cysteine proteases superfamily. The enzyme is ubiquitously distributed in the lysosomes of all cells and seems to be involved in a variety of disorders in which the pathological destruction of the extracellular matrix is one of the main characteristics.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-291
Revised 01-Nov-05
Monoclonal Antibody to Cathepsin L/Procathepsin L (CPLH 33/2)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Antibodies
Ordering Information
Product Numbers:
Format:
Size:
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Quantity:
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ALX-804-291-C100
100 µg
460.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
CLONE:
CPLH 33/2
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.01% thimerosal.
IMMUNOGEN:
Purified human procathepsin L (from culture supernatant of non-small cell lung cancer cell line EPLC 32 M1).
SPECIFICITY:
Recognizes the epitope G
265
YGFEST
271
of human procathepsin L. Recognizes mature human single or two chain cathepsin L (heavy chain) and human procathepsin L. Cross-reacts with rat cathepsin L and weakly with mouse procathepsin L. Does not cross-react with mature cathepsins B, D, H, K, S and procathepsins B, D, F, S, W.
APPLICATION:
ELISA (capture antibody)
Immunohistochemistry (paraffin sections after microwave treatment
Western blot
Optimal conditions must be determined individually for each application. Dilutions given in the figures below may be used as guidelines.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Monoclonal antibodies against cathepsin L and procathepsin L of different species:
E. Weber, et al.; Hybridoma
16
, 159 (1997)
Abstract
Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas:
P. Wurl, et al.; Virchows Arch.
430
, 221 (1997)
Abstract
Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth:
E. Weber, et al.; J. Cancer. Res. Clin. Oncol.
120
, 564 (1994)
Abstract
General Information
Cathepsin L [
EC 3.4.22.15
] is a lysosomal endopeptidase belonging to the papain family of the closely related cysteine proteases superfamily. The enzyme is ubiquitously distributed in the lysosomes of all cells and seems to be involved in a variety of disorders in which the pathological destruction of the extracellular matrix is one of the main characteristics.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-292
Revised 01-Nov-05
Monoclonal Antibody to Cathepsin L/Procathepsin L (human) (CLP 1/36)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-804-292-C200
200 µg
460.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
CLP 1/36
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.01% thimerosal.
IMMUNOGEN:
Synthetic peptide corresponding to aa 200-217 (Y
200
SVANDTGFVDIPKQEKA
217
) of human procathepsin L.
SPECIFICITY:
Recognizes the epitope I
211
PKQ
214
of human procathepsin L. Recognizes mature human single or two chain cathepsin L (heavy chain) and human procathepsin L. Does not cross react with mature cathepsins B, D, H, K, S and procathepsins B, D, F, S, W.
APPLICATION:
Immunohistochemistry (paraffin sections after microwave treatment)
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth:
E. Weber, et al.; J. Cancer. Res. Clin. Oncol.
120
, 564 (1994)
Abstract
Monoclonal antibodies against cathepsin L and procathepsin L of different species:
E. Weber, et al.; Hybridoma
16
, 159 (1997)
Abstract
Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas:
P. Wurl, et al.; Virchows Arch.
430
, 221 (1997)
Abstract
General Information
Cathepsin L [
EC 3.4.22.15
] is a lysosomal endopeptidase belonging to the papain family of the closely related cysteine proteases superfamily. The enzyme is ubiquitously distributed in the lysosomes of all cells and seems to be involved in a variety of disorders in which the pathological destruction of the extracellular matrix is one of the main characteristics.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-293
Revised 08-Feb-05
Monoclonal Antibody to Cathepsin L/Procathepsin L (CPLH 3G10)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-293-C200
200 µg
460.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE:
CPLH 3G10
