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ALX-445-028
Revised 08-Apr-08
Phorbol 13-acetate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-445-028-M001
1 mg
40.00 USD
ALX-445-028-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
22
H
30
O
7
MW:
406.5
CAS NUMBER:
32752-29-7
RTECS:
QH4377000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT. MAY BE CARCINOGENIC.
Product Description
Reference compound for studying 12-deacylation of phorbol 12-myristate 13-acetate (PMA; TPA) (Prod. No.
ALX-445-004
).
Product Specific Literature References
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
ALX-445-003
Revised 08-Apr-08
Phorbol 12,13-diacetate
SYNONYMS
PDA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-445-003-M001
1 mg
20.00 USD
ALX-445-003-M005
5 mg
65.00 USD
Product Specification
FORMULA:
C
24
H
32
O
8
MW:
448.5
CAS NUMBER:
24928-15-2
PURITY:
≥99%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
HIGHLY IRRITANT. TUMOR PROMOTER.
Product Description
Less potent than phorbol 12,13-dibutyrate (PDBu) (Prod. No.
ALX-445-001
), but also less hydrophobic.
Product Specific Literature References
Modulation of high-threshold Ca current and spontaneous postsynaptic transient currents by phorbol 12,13-diacetate, 1-(5-isoquinolinesulfonyl)-2-methyl piperazine (H-7), and monosialoganglioside (GM1) in CA1 pyramidal neurons of rat hippocampus in vitro:
N. Agopyan, et al.; Hippocampus
3
, 67 (1993)
Abstract
Effects of phorbol 12,13-diacetate on human isolated bronchus:
B. Sarria, et al.; Eur. J. Pharmacol.
399
, 65 (2000)
Abstract
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-445-001
Revised 08-Apr-08
Phorbol 12,13-dibutyrate
SYNONYMS
PDBu
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-445-001-M001
1 mg
20.00 USD
ALX-445-001-M005
5 mg
50.00 USD
Product Specification
FORMULA:
C
28
H
40
O
8
MW:
504.6
CAS NUMBER:
37558-16-0
RTECS:
EK7767000
PURITY:
≥99%
APPEARANCE:
Off-white to yellowish oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC. TUMOR PROMOTER. HIGHLY IRRITANT.
Product Description
Widely used protein kinase C (PKC) activator. Less potent than phorbol 12-myristate 13-acetate (PMA; TPA) (Prod. No.
ALX-445-004
), but also less hydrophobic.
Product Specific Literature References
Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets:
D.E. MacIntyre, et al.; FEBS Lett.
180
, 160 (1985)
Abstract
Phorbol-12,13-dibutyrate-induced vasoconstriction in vivo: characterization of response in genetic hypertension:
G.E. Bilder, et al.; J. Pharmacol. Exp. Ther.
252
, 526 (1990)
Abstract
Protein kinase C activator phorbol 12, 13-dibutyrate inhibits platelet activating factor-stimulated Ca2+ mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells:
T.L. Yue, et al.; Neurochem. Res.
17
, 997 (1992)
Abstract
Raf-1 and ERK2 kinases are required for phorbol 12,13-dibutyrate-stimulated proliferation of rat lymphoblasts. ERK2 activation precedes Raf-1 hyperphosphorylation:
C. Lisbona, et al.; Eur. J. Immunol.
24
, 2746 (1994)
Abstract
Effect of phorbol 12, 13-dibutyrate on ligand binding, enzyme activity and translocation of protein kinase C isoforms in the alpha T3-1 gonadotrope-derived cell line:
M.S. Johnson, et al.; Mol. Cell. Biochem.
165
, 65 (1996)
Abstract
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-445-038
Revised 08-Apr-08
4α-Phorbol 12,13-dibutyrate
SYNONYMS
4α-PDBu
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-445-038-M001
1 mg
30.00 USD
ALX-445-038-M005
5 mg
95.00 USD
Product Specification
FORMULA:
C
28
H
40
O
8
MW:
504.6
CAS NUMBER:
93781-54-5
PURITY:
≥99%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TUMOR PROMOTER. HIGHLY IRRITANT.
Product Description
Negative control for phorbol 12,13-dibutyrate (PDBu) (Prod. No.
ALX-445-001
).
Product Specific Literature References
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
ALX-445-002
Revised 03-Dec-07
Phorbol 12,13-didecanoate
SYNONYMS
PDD
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-445-002-M001
1 mg
20.00 USD
ALX-445-002-M005
5 mg
65.00 USD
Product Specification
FORMULA:
C
40
H
64
O
8
MW:
672.9
CAS NUMBER:
24928-17-4
RTECS:
GZ0653000
PURITY:
≥99% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HIGHLY IRRITANT. VERY TOXIC.
Product Description
Very potent and hydrophobic protein kinase C (PKC) activator.
Product Specific Literature References
Altered growth properties of normal human cells induced by phorbol 12,13-didecanoate:
R. W. Trewyn & H. B. Gatz; In Vitro
20
, 409 (1984)
Abstract
Inhibition of queuine uptake in diploid human fibroblasts by phorbol-12,13-didecanoate. Requirement for a factor derived from early passage cells::
M. S. Elliott & J. R. Katze; J. Biol. Chem.
261
, 13019 (1986)
Abstract
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-445-006
Revised 03-Dec-07
4α-Phorbol 12,13-didecanoate
SYNONYMS
4α-PDD
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-445-006-M001
1 mg
35.00 USD
ALX-445-006-M005
5 mg
110.00 USD
Product Specification
FORMULA:
C
40
H
64
O
8
MW:
672.9
CAS NUMBER:
27536-56-7
PURITY:
≥98% (HPLC)
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solution cannot be made in aqueous media. Compound must be dissolved in an organic solvent prior to dilution into aqueous media. Add calculated volume of organic solvent to vial to prepare concentrated stock solution. Intermediate dilutions into the same organic solvent are recommended prior to final dilution into aqueous media.
HANDLING:
Protect from light.
HAZARD:
HIGHLY IRRITANT. VERY TOXIC. MAY BE CARCINOGENIC.
Product Description
Activator of TRPV4. Negative control for phorbol 12,13-didecanoate (PDD) (Prod. No.
ALX-445-002
).
Product Specific Literature References
TRPV4 calcium entry channel: a paradigm for gating diversity
:
B. Nilius, et al.; Am. J. Physiol. Cell Physiol.
286
, C195 (2004)
Abstract
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
:
H. Watanabe, et al.; J. Biol. Chem.
277
, 13569 (2002)
Abstract
Related Products
ALX-445-002
Phorbol 12,13-didecanoate
Further Categories Containing This Product:
TRPV2, TRPV3, TRPV4 / Related Products
•
Natural Products for Neurological Research
ALX-445-044
Revised 03-Dec-07
Phorbol 13-myristate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-445-044-M001
1 mg
60.00 USD
ALX-445-044-M005
5 mg
180.00 USD
Product Specification
FORMULA:
C
34
H
54
O
7
MW:
574.8
CAS NUMBER:
115905-51-6
PURITY:
≥97% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT. MAY BE MUTAGENIC.
Product Specific Literature References
Influence of side chains on phorbol ester binding to protein kinase C:
E. Yeh, et al.; Phytotherapy Res.
1
, 135 (1987)
ALX-445-004
Revised 08-Oct-08
Phorbol 12-myristate 13-acetate
SYNONYMS
PMA
12-O-Tetradecanoylphorbol 13-acetate
TPA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-445-004-M001
1 mg
18.00 USD
ALX-445-004-M005
5 mg
60.00 USD
ALX-445-004-M010
10 mg
110.00 USD
ALX-445-004-M025
25 mg
210.00 USD
Product Specification
FORMULA:
C
36
H
56
O
8
MW:
616.8
CAS NUMBER:
16561-29-8
MERCK INDEX:
14:
7332
RTECS:
QH4377000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Dissolve in an organic solvent prior to dilution into aqueous buffers. Add calculated volume of organic solvent to vial to prepare concentrated stock solution. Intermediate dilutions into the same organic solvent are recommended prior to final dilution into aqueous buffer.
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HARMFUL. MAY BE MUTAGENIC.
Product Description
Most commonly used phorbol ester. Binds to and activates protein kinase C (PKC). Causes an extremely wide range of effects in cells and tissues. Very potent mouse skin tumor promoter. Inhibits apoptosis induced by Fas, but induces apoptosis in HL-60 promyelocytic leukemia cells.
Product Specific Literature References
Autoxidation of phorbol esters under normal storage conditions:
R. Schmidt & E. Hecker; Cancer Res.
35
, 1375 (1975)
Abstract
Phorbol esters as signal transducers and tumor promoters:
M. Castagna; Biol. Cell
59
, 3 (1987), Review
Abstract
P.M. Blumberg; CRC Crit. Rev. Toxicol
8
, 153 (1988)
Differential irreversible insertion of protein kinase C into phospholipid vesicles by phorbol esters and related activators:
M.G. Kazanietz, et al.; J. Biol. Chem.
267
, 20878 (1992)
Abstract
Phorbol esters induce nitric oxide synthase activity in rat hepatocytes. Antagonism with the induction elicited by lipopolysaccharide:
S. Hortelano, et al.; J. Biol. Chem.
267
, 24937 (1992)
Abstract
;
Full Text
Phorbol ester induces apoptosis in HL-60 promyelocytic leukemia cells but not in HL-60 PET mutant:
D.E. Macfarlane & P.S. O'Donnel; Leukemia
7
, 1846 (1993)
Abstract
Effect of phorbol 12-myristate 13-acetate on Ca2+-ATPase activity in rat liver nuclei:
K. Oishi & M. Yamaguchi; J. Cell. Biochem.
55
, 168 (1994)
Abstract
Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity:
C.G. Tepper, et al.; PNAS
92
, 8443 (1995)
Abstract
Evidence for different mechanisms of growth inhibition of T-cell lymphoma by phorbol esters and concanavalin A:
S. Desrivieres, et al.; J. Biol. Chem.
272
, 2470 (1997)
Abstract
Phorbol esters and synthetic diacylglycerols inhibit gamma-aminobutyric acid uptake in human spermatozoa: an effect mediated by protein kinase C?:
A. Aanesen, et al.; Mol. Hum. Reprod.
4
, 339 (1998)
Abstract
Gene expression of TPA induced differentiation in HL-60 cells by DNA microarray analysis:
X. Zheng, et al.; Nucleic Acids Res.
30
, 4489 (2002)
Abstract
;
Full Text
Phorbol esters and neurotransmitter release: more than just protein kinase C?:
E.M. Silinsky and T.J. Searl; Br. J. Pharmacol.
138
, 1191 (2003), Review
Abstract
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
Further Categories Containing This Product:
PKC Activators
•
Natural Products - Apoptosis Inducers & Inhibitors
ALX-445-005
Revised 08-Apr-08
4α-Phorbol 12-myristate 13-acetate
SYNONYMS
4α-PMA
4α-12-O-Tetradecanoylphorbol 13-acetate
4α-TPA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-445-005-M001
1 mg
45.00 USD
ALX-445-005-M005
5 mg
145.00 USD
Product Specification
FORMULA:
C
36
H
56
O
8
MW:
616.8
CAS NUMBER:
63597-44-4
PURITY:
≥98%
APPEARANCE:
Off-white to yellow powder.
SOLUBILITY:
Soluble in DMSO; also soluble in methanol, 100% ethanol or ethyl acetate.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
HIGHLY IRRITANT. TUMOR PROMOTER.
Product Description
Negative control for phorbol 12-myristate 13-acetate (PMA; TPA) (Prod. No.
ALX-445-004
).
Product Specific Literature References
Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin:
Van Duuren, et al.; Cancer Res.
39
, 2644 (1979)
Abstract
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
ALX-550-355
Revised 30-Jun-08
PPAHV
SYNONYMS
Phorbol 12-phenylacetate 13-acetate 20-homovanillate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-355-M001
1 mg
65.00 USD
ALX-550-355-M005
5 mg
260.00 USD
