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Benzodiazepines / Related Products
You are here: Product Lines > Cancer > Antitumor Reagents > Benzodiazepines / Related Products
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ALX-380-126 Revised 17-Jul-08 New product
Asperloxine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-126-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C21H19N3O5
MW: 393.4
SOURCE/HOST: Isolated from Aspergillus ochraceus.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR.

Product Description

Natural benzodiazepine. Anti-inflammatory.
Product Specific Literature References
Big effects from small changes: possible ways to explore nature’s chemical diversity: H.B. Bode, et al.; Chembiochem. 3, 619 (2002) Abstract
Further Categories Containing This Product:
Benzodiazepines / Related Products • Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
 
 
ALX-550-144 Revised 09-Dec-04
Buspirone . hydrochloride
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SYNONYMS 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-550-144-G001   1 g 48.00 USD Add To Cart
Product Specification
FORMULA: C21H31N5O2 . HCl
MW: 385.5 . 36.5
CAS NUMBER: 33386-08-2
MERCK INDEX: 14: 1504
PURITY: ≥96%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
5-HT1A serotonin receptor agonist.
Product Specific Literature References
The discovery and development of buspirone: a new approach to the treatment of anxiety: J.S. New; Med. Res. Rev. 10, 283 (1990), (Review) Abstract
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products • Benzodiazepines / Related Products • Adrenergics & Adrenergic Receptors / Related Products
 
 
ALX-550-084 Revised 13-Dec-04
Carbamazepine
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SYNONYMS 5H-Dibenz[b,f]azepine-5-carboxamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Benzodiazepines / Related Products
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ALX-550-084-G001   1 g 10.00 USD Add To Cart
ALX-550-084-G005   5 g 30.00 USD Add To Cart
Product Specification
FORMULA: C15H12N2O
MW: 236.3
CAS NUMBER: 298-46-4
MERCK INDEX: 14: 1781
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in ethanol. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Anticonvulsant and analgesic.
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products • Autophagy Other Products
 
 
ALX-550-079 Revised 13-Jan-05
FGIN-1-27
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SYNONYMS N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Benzodiazepines / Related Products
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ALX-550-079-M005   5 mg 20.00 USD Add To Cart
ALX-550-079-M025   25 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C28H37N2OF
MW: 436.6
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Binds specifically and with high affinity to the peptide benzodiazepine receptors.

For the fluorescent probe see NBD FGIN-1-27 (Prod. No. ALX-620-045).
Product Specific Literature References
A.P. Kozikowski, et al.; Angew. Chem. Int. Ed. 31, 1060 (1992)
2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR): E. Romeo, et al.; J. Pharmacol. Exp. Ther. 262, 971 (1992) Abstract
Further Categories Containing This Product:
GABA-ergics & GABA Receptors / Related Products
 
 
ALX-620-045 Revised 05-Jul-06
NBD FGIN-1-27 Analog
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SYNONYMS N3'-[6-((7-Nitro-2,1,3-benzoxadiol-4-yl)amino)hexyl]2-phenylindole-3-acetamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Benzodiazepines / Related Products
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ALX-620-045-MC05   0.5 mg 45.00 USD Add To Cart
ALX-620-045-M001   1 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C28H28N6O4
MW: 512.6
PURITY: ≥96%
APPEARANCE: Red solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
New fluorescent probe for the peripheral-type benzodiazepine receptor (PBR) (Ex(max): 470nm, Em(max): 530nm). The only available tool for imaging PBRs in cellular systems.
Product Specific Literature References
Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function: V. Papadopoulos; Endocr. Rev. 14, 222 (1993) Abstract
Synthesis and biology of a 7-nitro-2,1,3-benzoxadiazol-4-yl derivative of 2-phenylindole-3-acetamide: a fluorescent probe for the peripheral-type benzodiazepine receptor: A.P. Kozikowski, et al.; J. Med. Chem. 40, 2435 (1997) Abstract
Evidence in favour of a role for peripheral-type benzodiazepine receptor ligands in amplification of neuronal apoptosis: E.G. Jorda, et al.; Apoptosis 10, 91 (2005) Abstract
Further Categories Containing This Product:
Dyes / Stains / Fluorescent Probes / Fluorescent Labels
 
 
ALX-550-114 Revised 08-Jan-03
NF 49
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SYNONYMS 5-(4-Methoxyphenyl)pyrrolo[2,1-d][1,5]benzothiazepin-4-ol acetate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Benzodiazepines / Related Products
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ALX-550-114-M001   1 mg 45.00 USD Add To Cart
ALX-550-114-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C21H17NO3S
MW: 363.4
PURITY: ≥98%
APPEARANCE: Greenish solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
New specific ligand for mitochondrial benzodiazepine receptors.
Product Specific Literature References
Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies: I. Fiorini, et al.; J. Med. Chem. 37, 1427 (1994) Abstract
 
 
ALX-550-113 Revised 08-Jan-03
NF 51
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SYNONYMS 5-(4-Methoxyphenyl)pyrrolo[2,1-d][1,5]benzothiazepin-4-ol N,N-dimethylcarbamate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Benzodiazepines / Related Products
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ALX-550-113-M001   1 mg 50.00 USD Add To Cart
ALX-550-113-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C22H20N2O3S
MW: 392.5
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
New specific ligand for mitochondrial benzodiazepine receptors.
Product Specific Literature References
Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies: I. Fiorini, et al.; J. Med. Chem. 37, 1427 (1994) Abstract
 
 
ALX-550-112 Revised 23-Nov-05
NF 115
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SYNONYMS 5-Phenylpyrrolo[2,1-d][1,5]-benzothiazepin-4-ol hexanoate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Benzodiazepines / Related Products
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ALX-550-112-M001   1 mg 48.00 USD Add To Cart
ALX-550-112-M005   5 mg 192.00 USD Add To Cart
Product Specification
FORMULA: C24H23NO2S
MW: 389.5
CAS NUMBER: 155909-06-1
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
New specific ligand for mitochondrial benzodiazepine receptors.
Product Specific Literature References
Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies: I. Fiorini, et al.; J. Med. Chem. 37, 1427 (1994) Abstract
 
 
ALX-550-346 Revised 17-Apr-07
PK 11195
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SYNONYMS 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Benzodiazepines / Related Products
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ALX-550-346-M010   10 mg 40.00 USD Add To Cart
ALX-550-346-M050   50 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C21H21ClN2O
MW: 352.9
CAS NUMBER: 85532-75-8
PURITY: ≥98%
APPEARANCE: White to tan solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, DMSO or dichloromethane; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 2 years after receipt when stored at +4°C. Stock solutions are stable for up to 3 months when stored at -20°C.

Product Description
Selective peripheral benzodiazepine antagonist.
Product Specific Literature References
Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies: G. Le Fur, et al.; Life Sci. 33, 449 (1983) Abstract
Dihydropyridine and peripheral type benzodiazepine binding sites: subcellular distribution and molecular size determination: A. Doble, et al.; Eur. J. Pharmacol. 119, 153 (1985) Abstract
Photoaffinity labeling of peripheral-type benzodiazepine-binding sites: A. Doble, et al.; Mol. Pharmacol. 31, 42 (1987) Abstract
Differential binding properties of the peripheral-type benzodiazepine ligands [3H]PK 11195 and [3H]Ro 5-4864 in trout and mouse brain membranes: A.J. Eshleman & T.F. Murray; J. Neurochem. 53, 494 (1989) Abstract
Pharmacokinetics and effects on exercise heart rate of PK 11195 (52028 RP), an antagonist of peripheral benzodiazepine receptors, in healthy volunteers: A. Ferry, et al.; Fundam. Clin. Pharmacol. 3, 383 (1989) Abstract
 
 
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