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ALX-168-003
Revised 02-Apr-03
Tyrosine Phosphorylation Site Inhibitor
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-003-M001
1 mg
60.00 USD
ALX-168-003-M005
5 mg
240.00 USD
Product Specification
SEQUENCE:
H-Gly-Ser-Phe-Leu-Val-Arg-Glu-Ser-OH
FORMULA:
C
39
H
63
N
11
O
13
MW:
894.0
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of EGF receptor binding to SH2. The peptide corresponds to a highly conserved amino acid sequence common in a variety of SH2-containing proteins. It is the minimum essential sequence for recognition of the phosphotyrosine site.
Product Specific Literature References
Highly conserved eight amino acid sequence in SH2 is important for recognition of phosphotyrosine site:
M. Hidaka, et al.; BBRC
180
, 1490 (1991)
Abstract
Further Categories Containing This Product:
Peptides
•
SH2 & SH3 Domains
ALX-168-004
Revised 02-Apr-03
H-Tyr-Ile-Tyr-Gly-Ser-Phe-Lys-OH
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-004-M001
1 mg
90.00 USD
ALX-168-004-M005
5 mg
360.00 USD
Product Specification
FORMULA:
C
44
H
60
N
8
O
11
MW:
877.0
PURITY:
97%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Peptide selected from a random combinatorial peptide library. Specific and efficient substrate for the
Src
-family protein tyrosine kinase than cdc2 (6-20).
Product Specific Literature References
Identification and characterization of a novel synthetic peptide substrate specific for Src-family protein tyrosine kinases:
K.S. Lam, et al.; Int. J. Peptide Protein Res.
45
, 587 (1995)
Abstract
Further Categories Containing This Product:
Peptides
ALX-168-005
Revised 04-Mar-05
Tyrosine Hydroxylase (24-33) (rat)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
MAPK Pathway Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-005-M001
1 mg
85.00 USD
Product Specification
SEQUENCE:
H-Lys-Gln-Ala-Glu-Ala-Val-Thr-Ser-Pro-Arg-OH
FORMULA:
C
45
H
79
N
15
O
16
MW:
1086.2
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Represents consensus site for MAP kinase (MAPK/ERK) phosphorylation. Includes the Ser
31
phosphorylation site.
Product Specific Literature References
ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ:
J.W. Haycock, et al.; PNAS
89
, 2365 (1992)
Abstract
Further Categories Containing This Product:
Peptides
ALX-168-009/1
Revised 07-Nov-08
L-TAT Control Peptide (for Prod. No. ALX-159-600)
SYNONYMS
JNK Inhibitor 1 (L-stereoisomer) Control Peptide (for Prod. No.
ALX-159-600
)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
JNK [SAPK1] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-009/1-R050
50 µl
40.00 USD
Product Specification
SEQUENCE:
GRKKRRQRRR-amide
FORMULA:
C
55
H
109
N
31
O
12
MW:
1396.6
CONCENTRATION:
1mM
PURITY:
≥95% (HPLC)
FORMULATION:
Liquid. Sterile solution in PBS.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. Keep on ice at all times.
Product Description
Control peptide for L-JNKI. For more details see L-JNKI1 (Prod.No.
ALX-159-600
).
Product Specific Literature References
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death:
C. Bonny, et al.; Diabetes
50
, 77 (2001)
Abstract
;
Full Text
Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation:
R. Reinehr, et al.; FASEB J.
17
, 731 (2003)
Abstract
;
Full Text
Related Products
ALX-159-600
JNK Inhibitor 1 (L-stereoisomer)
ALX-152-027
Bim
L
(147-164) (human) (cell permeable)
ALX-152-028
Bax (58-75) (human) (cell permeable)
ALX-152-029
Bok (66-83) (human) (cell permeable)
ALX-163-011
NBD Peptide / NF-κB Blocker (cell permeable)
Further Categories Containing This Product:
Peptides
ALX-168-009F
Revised 28-Jul-08
L-TAT Control Peptide (for Prod. No. ALX-159-600) (FITC)
SYNONYMS
JNK Inhibitor 1 (L-stereoisomer) Control Peptide (for Prod. No.
ALX-159-600
) (FITC)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
JNK [SAPK1] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-168-009F-R050
FITC
50 µl
110.00 USD
Product Specification
SEQUENCE:
FITC-β-A-RKKRRQRRRA-amide
FORMULA:
C
80
H
128
N
34
O
17
S
MW:
1870.2
CONCENTRATION:
1mM
PURITY:
≥90% (HPLC)
FORMULATION:
Liquid. In sterile PBS.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. Keep on ice at all times.
Product Description
Control peptide for L-JNKI. For more details see L-JNKI1 (Prod.No.
ALX-159-600
).
Product Specific Literature References
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death:
C. Bonny, et al.; Diabetes
50
, 77 (2001)
Abstract
;
Full Text
Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation:
R. Reinehr, et al.; FASEB J.
17
, 731 (2003)
Abstract
;
Full Text
Related Products
ALX-159-600
JNK Inhibitor 1 (L-stereoisomer)
ALX-152-028
Bax (58-75) (human) (cell permeable)
ALX-163-011
NBD Peptide / NF-κB Blocker (cell permeable)
ALX-152-027
Bim
L
(147-164) (human) (cell permeable)
ALX-152-029
Bok (66-83) (human) (cell permeable)
Further Categories Containing This Product:
Peptides
ALX-168-010
Revised 14-Aug-06
D-TAT Control Peptide (for Prod. No. ALX-159-601)
SYNONYMS
JNK Inhibitor 1 (D-stereoisomer) Control Peptide (for Prod. No.
ALX-159-601
)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
JNK [SAPK1] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-010-R025
25 µl
95.00 USD
ALX-168-010F-R025
FITC
25 µl
145.00 USD
Product Specification
SEQUENCE:
Unconjugated peptide
: rrrqrrkkr-amide
FITC-conjugated peptide
: FITC-β-a-rkkrrqrrra-amide
FORMULA:
Unconjugated peptide:
C
53
H
107
N
31
O
10
FITC-conjugated peptide:
C
80
H
128
N
34
O
17
S
MW:
Unconjugated peptide:
1338.6
FITC-conjugated peptide:
1870.2
CONCENTRATION:
1mM
PURITY:
≥95% (HPLC)
FORMULATION:
Liquid. In sterile PBS.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Protect from moisture. Avoid freeze/thaw cycles. Keep on ice at all times.
Product Images
Please click on thumbnails to enlarge.
Product Description
Control peptide for D-JNKI. For more details see JNK Inhibitor 1 (D-stereoisomer) (Prod. No.
ALX-159-601
).
Product Specific Literature References
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death:
C. Bonny, et al.; Diabetes
50
, 77 (2001)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Note:
D-TAT consists of D-amino acids. The sequence of unconjugated D-TAT is retro-inverse compared to L-TAT.
Further Categories Containing This Product:
Peptides
ALX-170-001
Revised 16-Dec-03
Vasoactive Intestinal Contractor (mouse)
SYNONYMS
VIC (mouse)
β-Endothelin (mouse)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-170-001-PC01
0.1 mg*
70.00 USD
ALX-170-001-PC05
0.5 mg*
210.00 USD
ALX-170-001-P001
1 mg*
360.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Asn-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
116
H
161
N
27
O
32
S
4
MW:
2574.0
CAS NUMBER:
120928-04-3
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Differential activities of two distinct endothelin family peptides on ileum and coronary artery:
N. Ishida, et al.; FEBS Lett.
247
, 337 (1989)
Abstract
A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity:
K. Saida, et al.; J. Biol. Chem.
264
, 14613 (1989)
Abstract
;
Full Text
Cellular signaling by peptides of the endothelin gene family:
M.S. Simonson & M.J. Dunn; FASEB J.
4
, 2989 (1990)
Abstract
Further Categories Containing This Product:
Peptides
•
Hormones & Hormone Receptors Other Products
ALX-200-005
Revised 12-Apr-07
Calmodulin (human brain) (high purity)
SYNONYMS
CaM (human brain) (high purity)
Phosphodiesterase 3':5'-cyclic Nucleotide Activator (human brain) (high purity)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulins
Ordering Information
Product Numbers:
Format:
Size:
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ALX-200-005-C500
500 µg
135.00 USD
Product Specification
CAS NUMBER:
73298-54-1
MERCK INDEX:
14:
1719
SOURCE/HOST:
Isolated from human brain. Tested negative for infectious diseases.
PURITY:
≥95% (native reducing PAGE in presence of EGTA)
PURITY DETAIL:
Ion-exchange chromatography and gel filtration.
FORMULATION:
Lyophilized. Contains 2mM EDTA.
RECONSTITUTION:
Reconstitute with distilled water.
SPECIFIC ACTIVITY:
~40'000U/mg protein. One unit is defined as the amount of calmodulin that stimulates 0.016 activated units of phosphodiesterase 3':5'-cyclic nucleotide (Prod. No.
ALX-202-035
) to 50% of the maximum activity of the enzyme when saturated with activator, in the presence of 0.01mM Ca
2+
at 30°C, pH 7.5.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P02593:
Calmodulin (human)
AfCS Signalling Gateway link A000452:
Calmodulin I (mouse)
Further Categories Containing This Product:
Natural Proteins
ALX-200-087
Revised 18-Dec-06
Cystatin C (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Cystatins / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-200-087-C100
100 µg
235.00 USD
Product Specification
MW:
~13.3kDa
SOURCE/HOST:
Isolated from human urine.
PURITY:
≥96% (SDS-PAGE)
PURITY DETAIL:
All starting materials used were tested negative for HIV 1 and 2 antibodies, hepatitis B surface antigen and HCV antibodies.
FORMULATION:
Lyophilized from 0.05M acetate buffer, pH 4.5.
RECONSTITUTION:
Reconstitute with 0.1M acetate buffer, pH 4.5.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 2 years after receipt when stored at -20°C.
Further Categories Containing This Product:
Natural Proteins
ALX-200-088
Revised 26-Mar-08
TGF-β1 (human)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-200-088-C002
2 µg
240.00 USD
Product Specification
MW:
12.5kDa for one subunit.
SOURCE/HOST:
Human platelets tested negative for HBsAG-, HCV- and HIV-antibodies.
CONCENTRATION:
10μg/ml (determined by induction of 5-lipoxygenase activity in Mono Mac 6 cells)
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Acid-ethanol extraction of platelets followed by gel filtration and cation exchange column chromatography.
FORMULATION:
Liquid. In 25% actonitrile containing 0.1% BSA and 0.1% trifluoroacetic acid.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 3 months when stored at +4°C.
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Natural Proteins
ALX-200-310
Revised 27-Jun-06
Cathepsin G (human neutrophils)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-200-310-C100
100 µg
190.00 USD
Product Specification
MW:
~23.5kDa.
EC:
3.4.21.20
MERCK INDEX:
14:
1905
SOURCE/HOST:
Isolated from whole human blood (from single donors). Negative for HBSAG-, HCV- and HIV-antibodies.
PURITY:
≥
95% (SDS-PAGE)
PURITY DETAIL:
Essentially salt free.
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with 50mM sodium acetate, pH 5.5, containing 150mM sodium chloride.
SPECIFIC ACTIVITY:
~2-4U/mg protein. One unit is defined as the amount of enzyme that hydrolyzes 1µmol Suc-Ala-Ala-Pro-Phe-pNA (1mM) per min. at 25°C in 160mM TRIS/HCl and 1.6M NaCl, pH 7.4.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
