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NF-kB Pathway Inhibitors
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ALX-350-140 Revised 22-Aug-07
Rocaglamide AL 
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SYNONYMS 3’-4’-Methylenedioxyrocaglamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-140-C050   50 µg 160.00 USD Add To Cart
Product Specification
FORMULA: C26H24O7
MW: 448.5
CAS NUMBER: 201212-33-1
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000)
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000) Abstract
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001)
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006)
Related Products
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • Natural Products - Immunomodulators • Other Natural Products - DNA Regulation / Transcription • Nuclear Factor of Activated T Cells [NF-AT] • NF-kB Pathway Inhibitors
 
 
ALX-350-141 Revised 22-Aug-07
Rocaglamide C
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SYNONYMS 3’-Hydroxyrocaglamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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ALX-350-141-C050   50 µg 160.00 USD Add To Cart
Product Specification
FORMULA: C29H31NO8
MW: 521.6
CAS NUMBER: 189322-67-6
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000)
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000)
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001)
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006)
Related Products
Further Categories Containing This Product:
Natural Products - Immunomodulators • TNF-alpha & TNF Receptors Other Products • Other Natural Products - DNA Regulation / Transcription • Nuclear Factor of Activated T Cells [NF-AT] • NF-kB Pathway Inhibitors
 
 
ALX-350-142 Revised 22-Aug-07
Rocaglamide I
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SYNONYMS 1-Acetyl-3’-hydroxyrocaglamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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ALX-350-142-C050   50 µg 160.00 USD Add To Cart
Product Specification
FORMULA: C31H33NO9
MW: 563.6
CAS NUMBER: 189322-68-7
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000)
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000)
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001)
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006)
Related Products
Further Categories Containing This Product:
Natural Products - Immunomodulators • TNF-alpha & TNF Receptors Other Products • Other Natural Products - DNA Regulation / Transcription • Nuclear Factor of Activated T Cells [NF-AT] • NF-kB Pathway Inhibitors
 
 
ALX-350-143 Revised 22-Aug-07
Rocaglamide J
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SYNONYMS Aglafolin
2-Methylrocaglate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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ALX-350-143-C050   50 µg 160.00 USD Add To Cart
Product Specification
FORMULA: C28H28O8
MW: 492.5
CAS NUMBER: 147059-47-0
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000) Abstract
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000) Abstract
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001) Abstract
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Natural Products - Immunomodulators • TNF-alpha & TNF Receptors Other Products • Other Natural Products - DNA Regulation / Transcription • Nuclear Factor of Activated T Cells [NF-AT] • NF-kB Pathway Inhibitors
 
 
ALX-350-135 Revised 04-Dec-07
Rocaglaol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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ALX-350-135-C100   100 µg 220.00 USD Add To Cart
Product Specification
FORMULA: C26H26O6
MW: 434.5
CAS NUMBER: 147059-46-9
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description

Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties. Induces apoptosis.
Product Specific Literature References
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000) Abstract
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Rocaglaol induces apoptosis and cell cycle arrest in LNCaP cells: Q. Mi, et al.; Anticancer Res. 26, 947 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. (Tokyo) 54, 1344 (2006) Abstract
Related Products
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • Natural Products - Immunomodulators • Nuclear Factor of Activated T Cells [NF-AT] • NF-kB Pathway Inhibitors • Other Natural Products - DNA Regulation / Transcription • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-116 Revised 29-Nov-07
Sauchinone
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-116-M001   1 mg 70.00 USD Add To Cart
ALX-350-116-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C20H20O6
MW: 356.4
SOURCE/HOST: Isolated from Saururus chinensis.
PURITY: ≥95%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Diastereomeric lignan with cytoprotective and antioxidant activities in cultured hepatocytes. Inhibitor of LPS-inducible iNOS (NOS II), TNF-α and COX-2 expression in macrophages through suppression of IκBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Suppressor of NF-κB by inhibiting transactivation activity of the RelA subunit. Inhibits staurosporine (Prod. No. ALX-380-014)-induced apoptosis. Inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.
Product Specific Literature References
Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes: S.H. Sung, et al.; Biol. Pharm. Bull. 23, 666 (2000) Abstract
Hepatoprotective diastereomeric lignans from Saururus chinensis herbs: S.H. Sung & Y.C. Kim; J. Nat. Prod. 63, 1019 (2000) Abstract
Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation: A.K. Lee, et al.; Br. J. Pharmacol. 139, 11 (2003) Abstract
Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells: H. Song, et al.; Biol. Pharm. Bull. 26, 1428 (2003) Abstract
Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB: B.Y. Hwang, et al.; Planta Med. 69, 1096 (2003) Abstract
Inhibition of osteoclast differentiation and bone resorption by sauchinone: K.Y. Han, et al.; Biochem. Pharmacol. 74, 911 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Bone Metabolism Other Products • NF-kB Pathway Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-167-024 Revised 17-May-06
SN50
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Inhibitors
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ALX-167-024-C500   500 µg 125.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
FORMULA: C129H230N36O29S
MW: 2781.5
PEPTIDE CONTENT: 50-75%
PURITY: ≥96% (HPLC)
APPEARANCE: White to off-white solid.
FORMULATION: Counter Ion: Trifluoroacetate salt.
SOLUBILITY: Soluble in distilled water, 100% ethanol or ethanol:water 1:1.
RECONSTITUTION: Reconstitute in sterile distilled water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Peptides in solution have limited stability.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Description
Inhibits translocation of the NF-κB active complex into the nucleus. In mouse endothelial LE-II cells induced with LPS, inhibition of NF-κB nuclear translocation was 88% at 50µg/ml (18µM). In human monocytic THP-1 cells induced by LPS or TNF-α there was 85% inhibition at 100µg/ml. For control peptide, see SN50M (Prod. No. ALX-167-025).
Product Specific Literature References
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence: Y.Z. Lin, et al.; J. Biol. Chem. 270, 14255 (1995) Abstract; Full Text
p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism: K.K. Meja, et al.; Br. J. Pharmacol. 131, 1143 (2000) Abstract
Nuclear factor-kappaB activates dual inhibition sites in the regulation of tumor necrosis factor-alpha-induced neutrophil apoptosis: M. Niwa, et al.; Eur. J. Pharmacol 407, 211 (2000) Abstract
Activation of nuclear factor kappaB and induction of apoptosis by tumor necrosis factor-alpha in the mouse uterine epithelial WEG-1 cell line: S. Pampfer, et al.; Biol. Reprod. 63, 879 (2000) Abstract
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells: Y. Dai, et al.; Blood 103, 2761 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Nuclear localization sequence (NLS) aa 360-369 (AAVALLPAVLLALLAPVQRKRQKLMP) of the transcription factor NF-κB p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF).
Further Categories Containing This Product:
Peptides • Nuclear Envelope & Nuclear Transport
 
 
ALX-167-025 Revised 17-May-06
SN50M Control Peptide
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-167-025-C500   500 µg 125.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Pro-Val-Gln-Arg-Asn-Gly-Gln-Lys-Leu-Met-Pro-OH
FORMULA: C123H215N33O30S
MW: 2668.4
PEPTIDE CONTENT: 70-90%
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
FORMULATION: Counter Ion: Trifluoroacetate salt.
SOLUBILITY: Soluble in water.
RECONSTITUTION: Reconstitute in sterile distilled water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Peptides in solution have limited stability.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Inactive control peptide for SN50 (Prod. No. ALX-167-024). In mouse endothelial LE-II cells, induced with LPS, 50µg/ml SN50M had no measurable effect on NF-κB translocation. In human monocytic THP-1 cells induced by LPS or TNF-α there was slight inhibition at 100µg/ml.
Product Specific Literature References
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence: Y.Z. Lin, et al.; J. Biol. Chem. 270, 14255 (1995) Abstract; Full Text
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells: Y. Dai, et al.; Blood 103, 2761 (2004) Abstract
Further Categories Containing This Product:
Nuclear Envelope & Nuclear Transport • Peptides
 
 
ALX-430-116 Revised 04-Mar-05
Sodium salicylate