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ALX-260-009
Revised 19-Dec-07
Leupeptin (synthetic)
SYNONYMS
Acetyl-L-leucyl-L-leucyl-L-argininal . sulfate
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-009-M005
5 mg
40.00 USD
ALX-260-009-M025
25 mg
95.00 USD
ALX-260-009-M100
100 mg
320.00 USD
Product Specification
FORMULA:
C
20
H
38
N
6
O
4
. 0.5 H
2
SO
4
MW:
426.6 . 49.0
CAS NUMBER:
103476-89-7
MERCK INDEX:
14:
5456
SOURCE/HOST:
Synthetic.
PURITY:
≥95%
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in water, methanol and 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Competitive and reversible inhibitor of serine and cysteine proteinases like calpain, porcine kallikrein, trypsin, plasmin, papain and cathepsin B. Does not inhibit chymotrypsin and thrombin. Also known to inhibit activation-induced programmed cell death and restoration of defective immune responses of HIV
+
donors.
Product Specific Literature References
Isolation and characterization of leupeptins produced by Actinomycetes:
S. Kondo, et al.; Chem. Pharm. Bull.
17
, 1896 (1969)
Abstract
Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts:
J.P. Montenez, et al.; Toxicol. Lett.
73
, 201 (1994)
Abstract
Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors:
A. Sarin, et al.; J. Immunol.
153
, 862 (1994)
Abstract
Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin:
M.A. Belaud-Rotureau, et al.; Cell Death Differ.
6
, 788 (1999)
Abstract
Further Categories Containing This Product:
Calpains / Related Products
•
Proteases Other Products
ALX-260-012
Revised 14-Aug-08
Bestatin . hydrochloride
SYNONYMS
[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Aminopeptidases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-012-M005
5 mg
55.00 USD
ALX-260-012-M025
25 mg
200.00 USD
Product Specification
FORMULA:
C
16
H
24
N
2
O
4
. HCl
MW:
308.4 . 36.5
CAS NUMBER:
65391-42-6
SOURCE/HOST:
Synthetic.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methanol, acetic acid, DMSO, dimethyl formamide or 100% ethanol; slightly soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions in organic solvents are stable for 1 month at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:
Protect from light.
Product Description
Inhibits aminopeptidases like aminopeptidase B, leucine aminopeptidase, tripeptide aminopeptidase, aminopeptidases on the surface of mammalian cells. Does not inhibit carboxypeptidases. May be used in
in vitro
translation system to inhibit the aminopeptidases found in reticulocate or wheat germ lysates. Activates macrophages and T lymphocytes. Has antitumor properties and enhances not only blastogenesis and lymphocytes
in vitro
, but also establishes a delayed-type hypersensitivity
in vivo
.
Product Specific Literature References
Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes:
H. Umezawa, et al.; J. Antibiot.
29
, 97 (1976)
Abstract
Low-molecular-weight enzyme inhibitors of microbial origin:
H. Umezawa; Ann. Rev. Microbiol.
36
, 75 (1982)
Abstract
Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes:
D.H. Rich, et al.; J. Med. Chem.
27
, 417 (1984)
Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors)
ALX-260-014
Revised 19-Aug-08
Calpeptin
SYNONYMS
Z-Leu-norleucinal
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calpains / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-014-M005
5 mg
85.00 USD
ALX-260-014-M010
10 mg
160.00 USD
Product Specification
FORMULA:
C
20
H
30
N
2
O
4
MW:
362.5
CAS NUMBER:
117591-20-5
PURITY:
≥94% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
5mg/ml soluble in DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 2 months when stored at -20°C.
HANDLING:
Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. Protect from light and moisture.
Product Description
Membrane permeable inhibitor of calpain I and II and cathepsin L. Promotes neurite elongation in differentiating PC12 cells. Prevents Ca
2+
-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin (Prod. No.
ALX-450-006
) or thrombin.
Product Specific Literature References
Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins:
T. Sasaki, et al.; J. Enz. Inhib.
3
, 195 (1990)
Abstract
Cell-penetrating inhibitors of calpain:
S. Mehdi; TIBS
16
, 150 (1991)
Abstract
Specificity of calcium-activated neutral proteinase (CANP) inhibitors for human mu CANP and mCANP:
K. Saito and R.A. Nixon; Neurochem. Res.
18
, 231 (1993)
Abstract
Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells:
M. Pinter, et al.; Neurosci. Lett.
170
, 91 (1994)
Abstract
Further Categories Containing This Product:
Cathepsin Inhibitors
ALX-260-017
Revised 07-Jul-08
CA-074
SYNONYMS
N-[L-3-
trans
-Propylcarbamoyloxirane-2-carbonyl]-Ile-Pro-OH
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-260-017-M001
1 mg
210.00 USD
Product Specification
FORMULA:
C
18
H
29
N
3
O
6
MW:
383.5
CAS NUMBER:
134448-10-5
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in ethyl acetate (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent and specific inhibitor of cathepsin B
in vitro
and
in vivo
.
Product Specific Literature References
Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro:
M. Murata, et al.; FEBS Lett.
280
, 307 (1991)
Abstract
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo:
T. Towatari, et al.; FEBS Lett.
280
, 311 (1991)
Abstract
Specific assay method for the activities of cathepsin L-type cysteine proteinases:
T. Inubushi, et al.; J. Biochem.
116
, 282 (1994)
Abstract
ALX-260-037
Revised 30-May-07
Calpain Inhibitor I
SYNONYMS
Ac-LL-Norleucinal
Ac-Leu-Leu-Nle-CHO
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calpains / Related Products
Ordering Information
Product Numbers:
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Size:
Unit Price:
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ALX-260-037-M010
10 mg
80.00 USD
ALX-260-037-M050
50 mg
310.00 USD
Product Specification
FORMULA:
C
20
H
37
N
3
O
4
MW:
383.5
CAS NUMBER:
110044-82-1
SOURCE/HOST:
Synthetic.
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light and moisture.
Product Description
Inhibits calpain I (K
i
=190nM), calpain II (K
i
=220nM), cathepsin B (K
i
=150nM) and cathepsin L (K
i
=0.5nM). Inhibits neutral cysteine proteases and the proteasome. Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with the transcription of inducible nitric oxide synthase (iNOS; NOS II). Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex.
Product Specific Literature References
Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of the inducible NO synthase gene:
J.M. Griscavage, et al.; BBRC
215
, 721 (1995)
Abstract
Further Categories Containing This Product:
Proteasome / Related Products
•
Cathepsin Inhibitors
•
Proteases Other Products
ALX-260-038
Revised 15-Nov-05
Calpain Inhibitor II
SYNONYMS
Ac-LLM-CHO
Ac-Leu-Leu-Met-CHO
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calpains / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-038-M010
10 mg
75.00 USD
ALX-260-038-M050
50 mg
290.00 USD
Product Specification
FORMULA:
C
19
H
35
N
3
O
4
S
MW:
401.6
CAS NUMBER:
110115-07-6
PURITY:
≥96%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 100% ethanol, methanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light and moisture.
Product Description
Inhibitor of calpain I, calpain II, cathepsin B and cathepsin L.
Further Categories Containing This Product:
Cathepsin Inhibitors
ALX-260-085
Revised 23-Jan-07
Pepstatin A (synthetic)
SYNONYMS
i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA
Iva-Val-Val-Sta-Ala-Sta
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-085-M005
5 mg
35.00 USD
ALX-260-085-M025
25 mg
95.00 USD
ALX-260-085-M100
100 mg
290.00 USD
Product Specification
SEQUENCE:
i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA
(AHMHA = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid)
FORMULA:
C
34
H
63
N
5
O
9
MW:
685.9
CAS NUMBER:
26305-03-3
MERCK INDEX:
14:
7147
RTECS:
SC6155000
SOURCE/HOST:
Synthetic.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, methanol or acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 2 years after receipt when stored at -20°C.
HANDLING:
Protect from light.
Product Description
Inhibitor of aspartate (acid) proteases, including pepsin, cathepsin D, renin, chymosin, bacterial aspartic proteinases and HIV proteases. Efficiently inhibits Fcγ receptor induction by IFN-γ. Blocks the endocytic pathway followed by an antibody when it enters the cell at the level of early endosomal compartments, resulting in inhibition of autoantigen presentation or viral transmission.
Product Specific Literature References
Localization of pepstatin's inhibitory action during Fc-mediated antibody internalization: possible implications for antibody-mediated viral transmission:
I. Athanassakis, et al.; Cell. Immunol.
199
, 81 (2000)
Abstract
Pepstatin, a new pepsin inhibitor produced by Actinomycetes:
H. Umezawa, et al.; J. Antibiot.
23
, 259 (1970)
Abstract
Further Categories Containing This Product:
Proteases Other Products
•
Autophagy Other Products
ALX-260-120
Revised 12-Dec-07
Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-260-120-M005
5 mg
250.00 USD
Product Specification
SEQUENCE:
2,4-Dinitrophenyl-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH
FORMULA:
C
44
H
61
N
13
O
13
S
MW:
1012.1
PURITY:
≥95% (HPLC)
APPEARANCE:
Yellow solid
SOLUBILITY:
Soluble in DMSO; dilute with distilled water or buffer.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Fluorogenic substrate for MMP-2 and MMP-9. Excitation: 280nm; emission 360nm.
Product Specific Literature References
Continuously recording fluorescent assays optimized for five human matrix metalloproteinases
:
S. Netzel-Arnett, et al.; Anal. Biochem.
195
, 86 (1991)
Abstract
ALX-260-121
Revised 08-Jul-05
Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-260-121-M001
1 mg
190.00 USD
Product Specification
MW:
1680.0
PURITY:
≥97%
APPEARANCE:
Yellow solid.
SOLUBILITY:
DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry. Protect from light.
Product Description
Fluorogenic substrate for MMP-3 and MMP-9.
ALX-260-122
Revised 12-Jun-03
Mca-Pro-Cha-Gly-Nva-His-Ala-Dap(Dnp)-NH2
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Substrates
Ordering Information
Product Numbers:
Format:
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ALX-260-122-M001
1 mg
190.00 USD
Product Specification
FORMULA:
C
51
H
65
N
13
O
15
MW:
1100.2
PURITY:
≥97%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Fluorogenic substrate for MMP-13.
Product Specific Literature References
Biochemical characterization of human collagenase-3
:
V. Knäuper, et al.; J. Biol. Chem.
271
, 1544 (1996)
Abstract
;
Full Text
ALX-260-123
Revised 14-Dec-04
Mca-Pro-Leu-Ala-Nva-Dap(Dnp)-Ala-Arg-NH2
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Substrates
Ordering Information
Product Numbers:
Format:
Size:
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ALX-260-123-M001
1 mg
190.00 USD
Product Specification
MW:
1093.0
PURITY:
≥97%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry. Protect from light.
Product Description
Fluorogenic substrate for MMP-2.
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