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ALX-201-433
Revised 06-Aug-08
Klotho (Extracellular Domain) (human):Fc (human) (recombinant)
SYNONYMS
KL (Extracellular Domain) (human):Fc (human) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Fibroblast Growth Factors [FGFs] & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-201-433-C010
10 µg
320.00 USD
Product Specification
SOURCE/HOST:
Produced in HEK 293 cells. The signal peptide and the extracellular domain of human Klotho (aa 1-981) are fused at the C-terminus to the Fc portion of human IgG.
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT:
<1EU/µg protein (LAL-test).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q9UEF7:
Klotho (human)
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
•
Insulin & Insulin Receptor/Related Products
ALX-201-434
Revised 06-Aug-08
βKlotho (Extracellular Domain) (human):Fc (human) (recombinant)
SYNONYMS
BKL (Extracellular Domain) (human):Fc (human) (recombinant)
Klotho beta-like Protein(Extracellular Domain) (human):Fc (human) (recombinant)
KLB (Extracellular Domain) (human):Fc (human) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Fibroblast Growth Factors [FGFs] & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-434-C010
10 µg
320.00 USD
Product Specification
SOURCE/HOST:
Produced in HEK 293 cells. The extracellular domain of human βKlotho (aa 1-996) is fused at the C-terminus to the Fc portion of human IgG.
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT:
<1EU/µg protein (LAL-test).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q86Z14:
βKlotho (human)
MANUFACTURER
Manufactured by AdipoGen, Inc.
General Literature References
BetaKlotho is required for metabolic activity of fibroblast growth factor 21:
Y. Ogawa, et al.; PNAS
104
, 7432 (2007)
Abstract
;
Full Text
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
•
Insulin & Insulin Receptor/Related Products
ALX-202-030
Revised 26-May-08
COX-1 (sheep)
SYNONYMS
Cyclooxygenase 1 (sheep)
Prostaglandin H Synthase 1 (sheep)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
COX
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-202-030-UT50
5 KU
259.00 USD
Product Specification
MW:
~70kDa.
EC:
1.14.99.1
SOURCE/HOST:
Isolated from sheep seminal vesicles.
CONCENTRATION:
PURITY:
≥95%
FORMULATION:
Liquid. In 80mM TRIS/HCl, pH 8.0, containing 0.1% Tween 20 and 300µM DDC.
ACTIVITY:
~20'
000U/ml.
SPECIFIC ACTIVITY:
≥45,000U/mg protein. One unit is defined as the amount of enzyme that consumes 1nmol oxygen per min. at 37°C in 0.1M TRIS/HCl, pH 8.0, containing 100µM arachidonate, 5mM EDTA, 2mM phenol and 1µM hematin.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Enzyme is extremely unstable in the absence of preservative and should be used within 1 hour.
Product Specific Literature References
Prostaglandin H synthase
:
L.J. Marnett & K.R. Maddipati; 'Peroxidases in Biology, vol 1' (J. Everse, et al. eds.), CRC Press, Inc., Boca Raton 293 (1991)
Prostaglandin endoperoxide synthase: structure and catalysis:
W.L. Smith & L.J. Marnett; Biochim. Biophys. Acta
1083
, 1 (1991)
Abstract
Prostaglandin endoperoxide synthase: regulation of enzyme expression:
D.L. DeWitt; Biochim. Biophys. Acta
1083
, 121 (1991)
Abstract
Mitogen-Inducible Prostaglandin G/H Synthase: A New Target for Nonsteroidal Antiinflammatory Drugs:
W. Xie, et al.; Drug Development Research
25
, 249 (1992)
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P05979:
COX-1 (sheep) (precursor)
AfCS Signalling Gateway link A000738:
COX-1 (mouse)
Further Categories Containing This Product:
Enzymes
•
Natural Proteins
ALX-202-032
Revised 24-Apr-06
COX-2 (sheep)
SYNONYMS
Cyclooxygenase 2 (sheep)
Prostaglandin H Synthase 2 (sheep)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
COX
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-202-032-UT10
1 KU
176.00 USD
Product Specification
MW:
~72kDa/subunit.
EC:
1.14.99.1
SOURCE/HOST:
Isolated from sheep placenta.
CONCENTRATION:
PURITY:
~70%
FORMULATION:
Liquid. In 80mM TRIS-HCl, pH 8.0 with 0.1% Tween 20 and 300µM DDC.
ACTIVITY:
~4'000U/ml
SPECIFIC ACTIVITY:
~4'500U/mg protein. One unit is defined as the amount of enzyme that consumes 1nmol oxygen per min. at 37°C in 0.1M TRIS/HCl, pH 8.0, containing 100µM arachidonate, 5mM EDTA, 2mM phenol and 1µM hematin.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Enzyme is extremely unstable after removal of preservative and should be used within 1 hour.
HANDLING:
Keep stock on ice while handling. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s):
J.H. Capdevila, et al.; Biochemistry
34
, 3325 (1995)
Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons:
J.L. Johnson, et al.; Arch. Biochem. Biophys.
324
, 26 (1995)
Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro:
N. Futaki, et al.; Prostaglandins
47
, 55 (1994)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P79208:
COX-2 (sheep) (precursor)
AfCS Signalling Gateway link A000739:
COX-2 (mouse)
Further Categories Containing This Product:
Enzymes
•
Natural Proteins
ALX-210-069
Revised 16-Jul-08
Polyclonal Antibody to HIF-1α
SYNONYMS
anti-Hypoxia-inducible Factor 1α PAb
anti-ARNT-interacting Protein PAb
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Hypoxia-inducible Factor [HIF]/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-069-C050
50 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2.8mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
IMMUNOGEN:
Recombinant HIF-1α (hypoxia-inducible factor-1a) (aa 609-826).
SPECIFICITY:
Recognizes human and mouse HIF-1α.
APPLICATION:
Immunohistochemistry (1:200)
Immunoprecipitation (1-5µg)
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis:
N. Tang, et al.; Cancer Cell
6
, 485 (2004)
Abstract
Epidermal sensing of oxygen is essential for systemic hypoxic response:
A.T. Boutin, et al.; Cell
133
, 206 (2008)
Abstract
Critical Role of HIF-1alpha in Keratinocyte Defense against Bacterial Infection:
C. Peyssonnaux, et al.; J. Invest. Dermatol.
128
, 1964 (2008)
Abstract
General Literature References
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
:
C. C. Hudson, et al.; Mol. Cell Biol.
22
, 7004 (2002)
Abstract
;
Full Text
Further Categories Containing This Product:
Aryl Hydrocarbon Receptor/Related Products
•
Polyclonal Antibodies
ALX-210-150
Revised 15-Oct-07
Polyclonal Antibody to Ah Receptor Nuclear Translocator (mouse)
SYNONYMS
anti-ARNT (mouse) PAb
anti-HIF-1β (mouse) PAb
anti-Hypoxia-inducible Factor 1β (mouse) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Aryl Hydrocarbon Receptor/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-150-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 771-789 (N
771
SYNNEEFPDLTMFPPFSE
789
) of human ARNT (Ah receptor nuclear translocator).
SPECIFICITY:
Recognizes mouse ARNT.
APPLICATION:
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Literature References
Cloning of a factor required for activity of the Ah (Dioxin) receptor
:
E. Hoffman, et al.; Science
252
, 954 (1991)
Abstract
Physiochemical and immunocytochemical analysis of the aryl hydrocarbon receptor nuclear translocation: characterization of two monoclonal antibodies to the ARNT
:
N.G. Hord and G. Perdew; Mol. Pharmacol.
46
, 618 (1994)
Abstract
cDNA cloning and tissue-specific expression of a novel basic helix/loop/helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear transporter
:
K. Hirose, et al.; Mol. Cell. Biol.
16
, 1706 (196)
Abstract
Expression of the aryl hydrocarbon receptor is regulated by serum and mitogenic growth factors in murine 3T3 fibroblasts
:
C. Vaziri, et al.; J. Biol. Chem.
271
, 25921 (1996)
Abstract
;
Full Text
Further Categories Containing This Product:
Hypoxia-inducible Factor [HIF]/Related Products
•
Polyclonal Antibodies
ALX-210-151
Revised 19-Mar-08
Polyclonal Antibody to Androgen Receptor
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Androgens & Androgen Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-151-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human androgen receptor (aa 331-572).
SPECIFICITY:
Recognizes human, mouse, rat and monkey androgen receptor. Detects a band of ~110kDa by Western blot.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (paraffin sections, frozen sections) (1:100)
Immunoprecipitation
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
•
Tumor Markers
ALX-210-152/1
Revised 28-Feb-08
Polyclonal Antibody to Androgen Receptor
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Androgens & Androgen Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-152/1-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope affinity-purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to N-terminal aa 1-21 (M
1
EVQLGLGRVYPRPPSKTYRG
21
C) of human, mouse and rat androgen receptor.
SPECIFICITY:
Recognizes human androgen receptor. Detects a band of ~110kDa by Western blot. Does not cross-react with estrogen, progesterone, or glucocorticoid receptors.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-151-033
.
Product Specific Literature References
Immunocytochemical analysis of androgen receptor along the ducts of the separate rat prostate lobes after androgen withdrawal and replacement:
G.S. Prins, et al.; Endocrinology
132
, 169 (1993)
Abstract
Androgen receptor localization in different cell types of the adult rat prostate:
G.S. Prins, et al.; Endocrinology
129
, 3187 (1991)
Abstract
Related Products
ALX-151-033
Blocking Peptide for PAb to Androgen Receptor (Prod. No.
ALX-210-152/1
)
Further Categories Containing This Product:
Polyclonal Antibodies
•
Tumor Markers
ALX-210-209/1
Revised 07-Feb-08
Polyclonal Antibody to Glutathione S-transferase
SYNONYMS
anti-GST PAb
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Glutathione S-Transferase
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-209/1-C100
100 µg
234.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
GST (glutathione S-transferase)-tagged fusion proteins.
SPECIFICITY:
Recognizes GST and GST-tagged proteins.
CROSSREACTIVITY PROTEINS:
GST and GST-tagged proteins.
APPLICATION:
Western Blot (1:5’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Glutathione/Related Products
•
Polyclonal Antibodies
ALX-210-230
Revised 10-Oct-06
Polyclonal Antibody to Nerve Growth Factor Receptor
SYNONYMS
anti-NGFR PAb
anti-TNFRSF 16 PAb
anti-p75
NTR
PAb
anti-p75 Neurotrophin Receptor PAb
anti-CD271 PAb
anti-Low-affinity Nerve Growth Factor Receptor PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Nerve Growth Factors [NGF] & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-230-R100
100 µl
280.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to a portion of C-terminal human NGFR (nerve growth factor receptor; p75
NTR
).
SPECIFICITY:
Recognizes human, rat and chicken NGFR.
APPLICATION:
Immunoprecipitation (2µl/sample)
Western Blot (1:250-1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-232
Revised 01-Jul-08
Polyclonal Antibody to VE-cadherin
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Cadherin Antibodies
Ordering Information
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Format:
Size:
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ALX-210-232-C100
Purified
100 µg
308.00 USD
ALX-210-232B-T100
Biotin
100 tests
355.00 USD
ALX-210-232F-T100
FITC
100 tests
355.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
