ALEXIS Biochemicals: Cantharidin

ALX-270-063

Revised 03-Apr-08

Cantharidin
SYNONYMS	Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-063-M025		25 mg	50.00 USD
ALX-270-063-M100		100 mg	160.00 USD

Product Specification

FORMULA:	C₁₀H₁₂O₄
MW:	196.2
CAS NUMBER:	56-25-7
MERCK INDEX:	14: 1752
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in acetone, DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Potent protein phosphatase 2A (PP2A) inhibitor. At higher concentrations, also inhibits protein phosphatase 1 (PP1).

Product Specific Literature References

Partial characterization of specific cantharidin binding sites in mouse tissues: M.J. Graziano, et al.; Mol. Pharmacol. 33, 706 (1988) Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A: Y.-M. Li and J.E. Casida; PNAS 89, 11867 (1992) Abstract
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues: Y.-M. Li, et al.; Biochem. Pharmacol. 46, 1435 (1993) Abstract

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