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ALX-430-001 Revised 30-Nov-06
Carboxy-PTIO
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SYNONYMS 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide . potassium salt
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Scavengers
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-001-M010   10 mg 40.00 USD Add To Cart
ALX-430-001-M050   50 mg 160.00 USD Add To Cart
ALX-430-001-M250   250 mg 580.00 USD Add To Cart
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Product Specification
FORMULA: C14H16N2O4 . K
MW: 276.3 . 39.1
CAS NUMBER: 148819-94-7
PURITY: ≥98%
APPEARANCE: Blue solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, DMSO or dimethyl formamide. Highly soluble in water or aqueous buffers, e. g. PBS, pH 7.2.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Water soluble and stable nitric oxide radical scavenger that shows in chemical and biological systems antagonistic action against the free nitric oxide radical (NO·). The inhibitory effects were almost 2-fold stronger than those of NMMA (Prod. No. ALX-106-001) and NOARG (Prod. No. ALX-105-001). Reacts with nitric oxide in a stoichometric manner. Can be used for an improved detection of nitric oxide in activated macrophage cultures in combination with the Griess reagent (Prod. No. ALX-400-004).
Product Specific Literature References
Antagonistic action of imidazolineoxyl N-oxides against endothelium- derived relaxing factor/.NO through a radical reaction: T. Akaike, et al.; Biochemistry 32, 827 (1993) Abstract
Pronounced enhancement of .NO-dependent antimicrobial action by an .NO- oxidizing agent, imidazolineoxyl N-oxide: K. Yoshida, et al.; Infect. Immun. 61, 3552 (1993) Abstract
Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity: M. Yoshida, et al.; BBRC 202, 923 (1994) Abstract
Improved detection of nitric oxide radical (NO.) production in an activated macrophage culture with a radical scavenger, carboxy PTIO and Griess reagent: F. Amano & T. Noda; FEBS Lett. 368, 425 (1995) Abstract
Nitric oxide activation of guanylyl cyclase in cells revisited: B. Roy & J. Garthwaite; PNAS 103, 12185 (2006) Abstract
 
 
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