ALEXIS Biochemicals: Caspase-10/a (active) (human) (recombinant) (high stability)

ALX-201-193

Revised 15-Dec-04

Caspase-10/a (active) (human) (recombinant) (high stability)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspases

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-193-U050		50 U	320.00 USD

Product Specification

MW:	~17kDa (large subunit); ~12kDa (small subunit).
EC:	3.4.22.-
SOURCE/HOST:	Produced in E. coli.
CONCENTRATION:	~1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. 20µl in 100mM HEPES, pH 7.0, containing 10% sucrose, 10mM DTT, 2mM EDTA and 0.1% CHAPS.
SPECIFIC ACTIVITY:	~2'500U/mg protein. One unit is defined as the amount of enzyme that cleaves 1 nmol of the caspase substrate IETD-pNA per min. at 37°C in a buffered solution.
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Shows excellent freeze-thaw stability (see Figure).

Product Images

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Product Description

The undiluted product has been shown to be stable over several freeze/thaw cycles.

Product Specific Literature References

Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10: P.W. Ng, et al.; J. Biol. Chem. 274, 10301 (1999) Abstract
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases: Y. Shikama, et al.; Eur. J. Immunol. 33, 1998 (2003) Abstract
Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation: M. Leverkus, et al.; Mol. Cell Biol. 23, 777 (2003) Abstract
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8: M.R. Sprick, et al.; EMBO J. 21, 4520 (2002) Abstract

Further Categories Containing This Product:

Recombinant Proteins/Fusion Proteins • Enzymes

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