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Neurobiology
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ALX-550-033 Revised 07-Aug-07
D-AP5
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SYNONYMS D(-)-2-Amino-5-phosphonopentanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-033-M005   5 mg 65.00 USD Add To Cart
ALX-550-033-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C5H12NO5P
MW: 197.1
CAS NUMBER: 79055-68-8
PURITY: ≥97%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (acidify for better solubility).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
More active form of DL-AP5 (Prod. No. ALX-550-034). Widely used competitive NMDA receptor antagonist.
Product Specific Literature References
Activity of the enantiomers of 2-amino-5-phosphono-valeric acid as stereospecific antagonists of excitatory aminoacids: T.W. Stone, et al.; Neuroscience 6, 2249 (1981) Abstract
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation: J. Davies, et al.; Neurosci. Lett. 21, 77 (1981) Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982) Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4- phosphonobutyrate in the cat spinal cord: J. Davies & J.C. Watkins; Brain Res. 235, 378 (1982) Abstract
The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro: J. Davis; J. Neurosci. 12, 21 (1992) Abstract
 
 
ALX-550-035 Revised 26-Nov-04
L-AP5
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SYNONYMS L(+)-2-Amino-5-phosphonopentanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-035-M001   1 mg 40.00 USD Add To Cart
ALX-550-035-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C5H12NO5P
MW: 197.1
CAS NUMBER: 79055-67-7
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Specific Literature References
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4- phosphonobutyrate in the cat spinal cord: J. Davies and J.C. Watkins; Brain Res. 235, 378 (1982) Abstract
 
 
ALX-550-034 Revised 25-Jul-08
DL-AP5
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SYNONYMS DL-2-Amino-5-phosphonopentanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-034-M005   5 mg 30.00 USD Add To Cart
ALX-550-034-M025   25 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C5H12NO5P
MW: 197.1
CAS NUMBER: 76326-31-3
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 1M NaOH or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Potent and selective NMDA receptor antagonist.
Product Specific Literature References
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation: J. Davies, et al.; Neurosci. Lett. 21, 77 (1981) Abstract
Excitatory amino acid transmitters: J.C. Watkins and R.H. Evans; Ann. Rev. Pharmacol. Toxicol. 21, 165 (1981), (Review) Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982) Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4- phosphonobutyrate in the cat spinal cord: J. Davies and J.C. Watkins; Brain Res. 235, 378 (1982) Abstract
 
 
ALX-550-030 Revised 16-Dec-04
D-AP6
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SYNONYMS D(-)-2-Amino-6-phosphonohexanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-030-M005   5 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C6H14NO5P
MW: 211.2
CAS NUMBER: 131177-53-2
PURITY: ≥97%
APPEARANCE: White hygroscopic powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Specific Literature References
Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons: M.K. Schulte, et al.; Brain. Res. 649, 203 (1994) Abstract
 
 
ALX-550-032 Revised 16-Dec-04
L-AP6
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SYNONYMS L(+)-2-Amino-6-phosphonohexanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-032-M001   1 mg 50.00 USD Add To Cart
ALX-550-032-M005   5 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C6H14NO5P
MW: 211.2
CAS NUMBER: 78944-89-5
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
QUIS-sensitized L-AP4 receptor agonist.
Product Specific Literature References
Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons: M.K. Schulte, et al.; Brain Res. 649, 203 (1994)
 
 
ALX-550-031 Revised 25-Nov-04
DL-AP6
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SYNONYMS DL-2-Amino-6-phosphonohexanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-031-M005   5 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C6H14NO5P
MW: 211.2
CAS NUMBER: 78944-89-5
PURITY: ≥97%
APPEARANCE: White hygroscopic solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Weak NMDA receptor antagonist.
Product Specific Literature References
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982) Abstract
 
 
ALX-550-027 Revised 26-Nov-04
D-AP7
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SYNONYMS D(-)-2-Amino-7-phosphonoheptanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-027-M005   5 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C7H16NO5P
MW: 225.2
CAS NUMBER: 81338-23-0
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or very soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
More active form of DL-AP7 (Prod. No. ALX-550-028).
Product Specific Literature References
Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants: M.N. Perkins, et al.; Neurosci. Lett. 32, 65 (1982) Abstract
Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist: T. Wieloch; Science 230, 681 (1985) Abstract
Structure-activity analysis of binding kinetics for NMDA receptor competitive antagonists: the influence of conformational restriction: M. Benveniste & M.L. Mayer; Br. J. Pharmacol. 104, 207 (1991) Abstract
 
 
ALX-550-028 Revised 25-Nov-04
DL-AP7
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SYNONYMS DL-2-Amino-7-phosphonoheptanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-028-M005   5 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C7H16NO5P
MW: 225.2
CAS NUMBER: 78966-69-5
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Potent NMDA receptor antagonist.
Product Specific Literature References
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982) Abstract
Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist: T. Wieloch; Science 230, 681 (1985) Abstract
 
 
ALX-151-013 Revised 05-Dec-06
Apamin
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Blockers & Inhibitors
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ALX-151-013-MC05   0.5 mg 150.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2
(Disulfide bonds between Cys1-Cys11and Cys3-Cys15)
FORMULA: C131H131N31O24S4
MW: 2027.3
CAS NUMBER: 24345-16-2
MERCK INDEX: 14: 725
RTECS: CD6899900
SOURCE/HOST: Synthetic.
PURITY: ≥97% (HPLC)
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in 0.05M acetic acid; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker.
Product Specific Literature References
Toxins in the characterization of potassium channels: N.A. Castle, et al.; TINS 12, 59 (1989), (Review) Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-550-178 Revised 10-Feb-05
(2R,4R)-APDC
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SYNONYMS LY-314,593
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-178-M001   1 mg 70.00 USD Add To Cart
ALX-550-178-M005   5 mg 315.00 USD Add To Cart
Product Specification
FORMULA: C6H10N2O4
MW: 174.2
CAS NUMBER: 169209-63-6
PURITY: ≥98%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Selective agonist for group II mGluRs.
Product Specific Literature References
Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4- dicarboxylate: D.D. Schoepp, et al.; Neuropharmacology 34, 843 (1995) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase: J.A. Monn, et al.; J. Med. Chem. 39, 2990 (1996) Abstract
Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II- selective metabotropic glutamate receptor agonists: R. Mistry, et al.; Br. J. Pharmacol. 123, 581 (1998) Abstract
Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death: G. Battaglia, et al.; Eur. J. Pharmacol. 356, 271 (1998) Abstract
Modulation of sensory inhibition in the ventrobasal thalamus via activation of group II metabotropic glutamate receptors by 2R,4R-aminopyrrolidine-2,4-dicarboxylate: T.E. Salt & J.P. Turner; Exp. Brain Res. 121, 181 (1998) Abstract
Specific group II metabotropic glutamate receptor activation inhibits the development of kindled epilepsy in rats: P.J. Atwell, et al.; Brain Res. 787, 286 (1998) Abstract
Effect of the group II metabotropic glutamate agonist, 2R,4R-APDC, varies with age, layer, and visual experience in the visual cortex: C.J. Beaver, et al.; J. Neurophysiol. 82, 86 (1999) Abstract
D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-380-207 Revised 03-Apr-08
Apoptolidin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-380-207-MC01   0.1 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C58H96O21
MW: 1129.4
CAS NUMBER: 194874-06-1
SOURCE/HOST: Isolated from Amicolatopsis sp. MST-AS5912.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Originally isolated from Nocardiopsis sp. Antibiotic. Potent and highly selective apoptosis inducer in several cancer cell lines. F0F1-ATPase inhibitor.
Product Specific Literature References
Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp: J.W. Kim, et al.; J. Antibiot. (Tokyo) 50, 6628 (1997) Abstract
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase: A.R. Salomon, et al.; PNAS 97, 14766 (2000) Abstract; Full Text
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase: A.R. Salomon, et al.; Chem. Biol. 8, 71 (2001) Abstract; Full Text
Apoptolidin: induction of apoptosis by a natural product: P.T. Daniel, et al.; Ange