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ALX-630-093 Revised 23-Jul-08
Aflatoxin B1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-093-M001   1 mg 28.00 USD Add To Cart
ALX-630-093-M005   5 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C17H12O6
MW: 312.3
CAS NUMBER: 1162-65-8
MERCK INDEX: 14: 180
RTECS: GY1925000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in DMSO (20mg/ml) or methylene chloride (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: VERY TOXIC. MAY BE CARCINOGENIC. MAY BE TERATOGENIC.

Product Description
Naturally occuring mycotoxin produced by many species of Aspergillus. Metabolized by the liver to the reactive intermediate aflatoxin M1. Exposure may produce acute necrosis, cirrhosis and carcinoma of the liver. Induces DNA damage.
Product Specific Literature References
Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus: C.P. Wild, et al.; Environ. Health Perspect. 99, 115 (1993) Abstract
A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China: G.S. Qian, et al.; Cancer Epidemiol. Biomarkers Prev. 3, 3 (1994) Abstract
Aflatoxin B1 induced lacI mutation in liver and kidney of transgenic mice C57BL/6N: effect of phorone: H. Autrup, et al.; Mutagenesis 11, 69 (1996) Abstract
Activation and detoxication of aflatoxin B1: F.P. Guengerich, et al.; Mutat. Res. 402, 121 (1998), (Review) Abstract
Hyperplasia, partial hepatectomy, and the carcinogenicity of aflatoxin B1: B.D. Roebu; J. Cell. Biochem. 91, 242 (2004), (Review) Abstract
Aflatoxin B1-induced DNA damage and its repair: L. L. Bedard & T. E. Massey; Cancer Lett. 241, 174 (2006), (Review) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Plant Research Reagents / Related Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis
 
 
ALX-630-103 Revised 04-Sep-08
Aflatoxin B2
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-103-M001   1 mg 55.00 USD Add To Cart
ALX-630-103-M005   5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C17H14O6
MW: 314.3
CAS NUMBER: 7220-81-7
MERCK INDEX: 14: 180
RTECS: GY1722000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methylene chloride (5mg/ml), DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. VERY TOXIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Aflatoxin B2: Chemical Identity and Biological Activity: S.B. Chang, et al.; Science 142, 1191 (1963) Abstract
Accumulation of only aflatoxin B2 by a strain of Aspergillus flavus: H.W. Schroeder & W.W. Carlton; Appl. Microbiol. 25, 146 (1973) Abstract
In vitro metabolism of aflatoxin B2 by animal and human liver: B.D. Roebuck, et al.; Cancer Res. 38, 999 (1978) Abstract
Interaction of aflatoxin B2 with rat liver DNA and histones in vivo: J.D. Groopman, et al.; Carcinogenesis 2, 1371 (1981) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Plant Research Reagents / Related Products • Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis
 
 
ALX-630-104 Revised 20-Mar-08
Aflatoxin G1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-104-M001   1 mg 65.00 USD Add To Cart
ALX-630-104-M005   5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C17H12O7
MW: 328.3
CAS NUMBER: 1165-39-5
MERCK INDEX: 14: 181
RTECS: LV1720000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in DMSO (10mg/ml), methylene chloride (5mg/ml) or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. VERY TOXIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Mutagenic effect of aflatoxin G1 in comparison with B1: M.M. el-Zawahri, et al.; J. Environ. Pathol. Toxicol. Oncol. 10, 45 (1990) Abstract
Identification of an aflatoxin G1-serum albumin adduct and its relevance to the measurement of human exposure to aflatoxins: G. Sabbioni & C.P. Wild; Carcinogenesis 12, 97 (1991) Abstract
Effects of sterigmatocystin, deoxynivalenol and aflatoxin G1 on apoptosis of human peripheral blood lymphocytes in vitro: X.M. Sun, et al.; Biomed. Environ. Sci. 15, 145 (2002) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Plant Research Reagents / Related Products • Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis
 
 
ALX-630-106 Revised 20-Jun-08
Aflatoxin G2
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-106-M001   1 mg 150.00 USD Add To Cart
ALX-630-106-M005   5 mg 600.00 USD Add To Cart
Product Specification
FORMULA: C17H14O7
MW: 330.3
CAS NUMBER: 7241-98-7
MERCK INDEX: 14: 181
RTECS: LV1700000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in methylene chloride (5mg/ml), DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: VERY TOXIC. MAY BE CARCINOGENIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Combining Ability for Resistance to Field Aflatoxin Accumulation in Maize Grain: D.P. Gorman, et al.; Plant Breeding 109, 296 (1992)
Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential: J.J. Wong & D.P. Hsieh; PNAS 73, 2241 (1976) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Plant Research Reagents / Related Products • Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis
 
 
ALX-630-114 Revised 13-Jun-08
Aflatoxin M2
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SYNONYMS 4-Hydroxyaflatoxin B2
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-630-114-MC01   0.1 mg 250.00 USD Add To Cart
Product Specification
FORMULA: C17H14O7
MW: 330.3
CAS NUMBER: 6885-57-0
MERCK INDEX: 14: 182
RTECS: GY1720000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC, TLC)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in DMSO or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC. MAY BE CARCINOGENIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin. Metabolite of aflatoxin B2. DNA-damaging agent.
Product Specific Literature References
Milk of mammals fed an aflatoxin-containing diet.: H. De Iongh, et al.; Nature 202, 466 (1964) Abstract
Isolation and structure of aflatoxins M1 and M2: C.W. Holzapfel, et al.; Tetrahedron Lett. 25, 2799 (1966) Abstract
Acute toxicity of aflatoxins M1 and M2 in one-day-old ducklings: I.F. Purchase; Food Cosmet. Toxicol. 5, 339 (1967) Abstract
Occurrence of aflatoxins M(1) and M(2) in milk commercialized in Ribeirăo Preto-SP, Brazil: N.S. Garrido, et al.; Food Addit. Contam. 20, 70 (2003) Abstract
Further Categories Containing This Product:
Plant Research Reagents / Related Products • Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters
 
 
ALX-630-095 Revised 03-Apr-08
Aflatoxin M1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-630-095-MC01   0.1 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C17H12O7
MW: 328.3
CAS NUMBER: 6795-23-9
MERCK INDEX: 14: 182
RTECS: GY1880000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methylene chloride (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE MUTAGENIC. MAY BE CARCINOGENIC. VERY TOXIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin. Hydroxylated metabolite of aflatoxin B1.
Product Specific Literature References
Production and characterization of monoclonal antibodies against aflatoxin M1: N.A. Woychik, et al.; Appl. Environ. Microbiol. 48, 1096 (1984) Abstract; Full Text
Comparative binding and sequence interaction specificities of aflatoxin B1, aflatoxicol, aflatoxin M1, and aflatoxicol M1 with purified DNA: K. Marien, et al.; J. Biol. Chem. 262, 7455 (1987) Abstract; Full Text
Presence of aflatoxin M1 in commercial ultra-high-temperature-treated milk.: J.L. Blanco, et al.; Appl. Environ. Microbiol. 54, 1622 (1988) Abstract; Full Text
Distribution and stability of aflatoxin M1 during processing, ripening and storage of Telemes cheese: A. Govaris, et al.; Food Addit. Contam. 18, 437 (2001) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Plant Research Reagents / Related Products • Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis
 
 
ALX-430-063 Revised 10-Oct-07
Anthralin
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SYNONYMS Dithranol
PRODUCT LINE Inflammation
PRODUCT CATEGORY Leukotrienes Other Products
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ALX-430-063-G001   1 g 25.00 USD Add To Cart
Product Specification
FORMULA: C14H10O3
MW: 226.2
CAS NUMBER: 1143-38-0
MERCK INDEX: 14: 684
RTECS: CB8927000
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. IRRITANT.

Product Description
Leukotriene biosynthesis inhibitor. Inhibits LTB4 ω-oxidation.
Product Specific Literature References
Anthralin (1,8-dihydroxyanthrone) is a potent inhibitor of leukotriene production and LTB4-omega oxidation by human neutrophils: J.M. Schröder; J. Invest. Dermatol. 87, 624 (1986) Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Cancer Other Products
 
 
ALX-350-016 Revised 31-Jul-08
(+)-Aphidicolin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cell Cycle Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-016-M001   1 mg 65.00 USD Add To Cart
ALX-350-016-M005   5 mg 260.00 USD Add To Cart
ALX-350-016-M025   25 mg 890.00 USD Add To Cart
Product Specification
FORMULA: C20H34O4
MW: 338.5
CAS NUMBER: 38966-21-1
MERCK INDEX: 14: 727
RTECS: PB9185000
SOURCE/HOST: Isolated from Nigrospora oryzae.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (50mg/ml), methanol (10mg/ml) or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at early S phase. Prolongs the half life of DNA methyltransferase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer.
Product Specific Literature References
X-Ray crystallographic determination of the structure of the antibiotic aphidicolin: a tetracyclic diterpenoid containing a new ring system: K.M. Brundret, et al.; J. C. S. Chem. Commun. 1027 (1972)
The production of aphidicolin by Nigrospora sphaerica: A.N. Starratt and S.R Loschiavo; Can. J. Microbiol. 20, 416 (1974)
Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha: S. Ikegami, et al.; Nature 275, 458 (1978) Abstract
Inhibition by aphidicolin of cell cycle progression and DNA replication in sea urchin embryos: S. Ikegami, et al.; J. Cell. Physiol. 100, 439 (1979) Abstract
New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha: J.A. Huberman; Cell 23, 647 (1981) Abstract
Aphidicolin: a specific inhibitor of nuclear DNA replication in eukaryotes: S. Spadari, et al.; TIBS 7, 29 (1982)
Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in human myeloid leukemia cell lines: K. Kuwakado, et al.; Biochem. Pharmacol. 46, 1909 (1993) Abstract
Life, death and genomic change in perturbed cell cycles: R.T. Schimke, et al.; Philos. Trans. R. Soc. London B Biol. Sci. 345, 311 (1994) Abstract
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization: L. Urbani, et al.; Exp. Cell. Res. 219, 159 (1995) Abstract
Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3: M.M. Borner, et al.; Cancer Res. 55, 2122 (1995) Abstract
TrkA neurogenic receptor regulates differentiation of neuroblastoma cells: W. Poluha, et al.; Oncogene 10, 185 (1995) Abstract
Coordinate regulation of G- and C strand length during new telomere synthesis: X. Fan and C.M. Price; Mol. Biol. Cell 8, 2145 (1997) Abstract; Full Text
Effect of aphidicolin on DNA methyltransferase in the nucleus: I. Suetake, et al.; Cell Struct. Funct. 23, 137 (1998) Abstract
Cytotoxicity of aphidicolin and its derivatives against neuroblastoma cells in vitro: synergism with doxorubicin and vincristine: M. Michaelis, et al.; Anticancer Drugs 11, 479 (2000) Abstract
Aphidicolin and bleomycin induced chromosome damage as biomarker of mutagen sensitivity: a twin study: B. Tedeschi, et al.; Mutat. Res. 546, 55 (2004) Abstract
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors / Related Products • Natural Products - Other Tumor Promoters • DNA Replication Inhibitors • Carcinogens & Tumor Promoters Other Products • Natural Products - DNA Replication Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-270-047 Revised 26-Sep-07
Aristolochic acid
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SYNONYMS 8-Methoxy-6-nitrophenanthrol(3,4-d)-1,3-dioxide-5-carboxylic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-047-M025   25 mg 25.00 USD Add To Cart
ALX-270-047-M100   100 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C17H11NO7
MW: 341.3
CAS NUMBER: 313-67-7
MERCK INDEX: 14: 786
RTECS: CF3325000
SOURCE/HOST: Isolated from Aristolochia clematis.
PURITY: ≥97% (~1:1 mixture of aristolochic acids I (A) and II (B))
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE CARCINOGENIC. TOXIC. MAY BE MUTAGENIC.

Product Description
Phospholipase A2 (PLA2) inhibitor active against the enzymes found in many snake venoms as well as those of human platelets and synovial fluids. Inhibits ionophore-stimulated PLA2 activity in human neutrophils. Has been shown to be nephropathic and carcinogenic.
Product Specific Literature References
Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid: B.S. Vishwanath, et al.; Toxicon 25, 501 (1987) Abstract
Interaction of aristolochic acid with Vipera russelli phospholipase A2: its effect on enzymatic and pathological activities: B.S. Vishwanath & T.V. Gowda; Toxicon 25, 929 (1987) Abstract
Interaction of phospholipase A2 from Vipera russelli venom with aristolochic acid: a circular dichroism study: B.S. Vishwanath, et al.; Toxicon 25, 939 (1987) Abstract
Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid: B.S. Vishwanath, et al.; Inflammation 12, 549 (1988) Abstract
Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils: M.D. Rosenthal, et al.; Biochim. Biophys. Acta 1001, 3 (1989) Abstract
Suramin alters phosphoinositide synthesis and inhibits growth factor receptor binding in HT-29 cells: R. Kopp & A. Pfeiffer; Cancer Res. 50, 6490 (1990) Abstract
The effects of the phospholipase A2 inhibitors aristolochic acid and PGBx on A23187-stimulated mobilization of arachidonate in human neutrophils are overcome by diacylglycerol or phorbol ester: M.D. Rosenthal, et al.; Biochim. Biophys. Acta 1126, 319 (1992) Abstract
Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils: J.D. Winkler, et al.; Biochem. Pharmacol. 44, 2055 (1992) Abstract
Selective inhibition of group II phospholipase A2 by quercetin: M. Lindahl & C. Tagesson; Inflammation 17, 573 (1993) Abstract
Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy: H.H. Schmeiser, et al.; Cancer Res. 56, 2025 (1996) Abstract
Aristolochic acid and ’Chinese herbs nephropathy’: a review of the evidence to date: J.P. Cosyns; Drug Saf. 26, 33 (2003), Review Abstract
Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells: Y.H. Hsin, et al.; Apoptosis 11, 2167 (2006) Abstract
Further Categories Containing This Product:
PLA2 Inhibitors • Carcinogens & Tumor Promoters Other Products • Natural Products - Other Tumor Promoters • Alkaloids • Other Toxins
 
 
ALX-350-014 Revised 03-Apr-08
Calyculin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-014-C010   10 µg 65.00 USD Add To Cart
ALX-350-014-C025   25 µg 110.00 USD Add To Cart
ALX-350-014-C050   50 µg 190.00 USD Add To Cart
ALX-350-014-C100   100 µg 320.00 USD Add To Cart
Product Specification
FORMULA: C50H81N4O15P