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Cyclin-dependent Kinases [CDKs] & Cyclins / Related Products
You are here: Product Lines > Cell Cycle > Kinases in Cell Cycle Regulation > Cyclin-dependent Kinases [CDKs] & Cyclins / Related Products
 
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ALX-153-012 Revised 04-Mar-05
Cyclin-dependent Kinase 2 Inhibitor
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SYNONYMS CDK2/Cyclin Inhibitor
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-153-012-M001   1 mg 120.00 USD Add To Cart
ALX-153-012-M005   5 mg 480.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Ser-Phe-Val-His-His-Gly-Phe-Phe-Asn-Phe-Arg-Val-Ser-Trp-Arg-Glu-Met-Leu-Ala-OH
FORMULA: C121H164N32O27S
MW: 2530.9
PEPTIDE CONTENT: 75-95%
PURITY: ≥97%
APPEARANCE: White to off-white lyophilized solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Inhibitor of cyclin-dependent kinase 2 (CDK2).
Product Specific Literature References
Genetic selection of peptide aptamers that recognize and inhibit cyclin- dependent kinase 2: P. Colas, et al.; Nature 380, 548 (1996) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-153-041 Revised 04-Mar-05
Cyclin-dependent Kinase 2 Inhibitory Peptide I
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SYNONYMS CDK2/Cyclin Inhibitory Peptide I
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-153-041-C500   500 µg 145.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly-OH
FORMULA: C111H196N48O23
MW: 2571.1
PURITY: ≥98% (HPLC)
APPEARANCE: Solid.
FORMULATION: Lyophilized. Counter Ion: Trifluoroacetate salt.
SOLUBILITY: Soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Following reconstitution, aliquot and freeze (-20°C). Product is stable for 2 years as supplied. Stock solutions are stable for 3 months at -20°C.
HANDLING: Hygroscopic.
Product Description
Cell permeable inhibitor of CDK2/cyclin complexes. Blocks phosphorylation of substrates by CDK2/cyclin A and CDK/cyclin E complexes. Preferentially induces apoptosis only in transformed cells and not in non-transformed cells.

Chimeric peptide consisting of the N-terminal sequence of the HIV-TAT protein (directing uptake across the cell membrane) and the consensus sequence PVKRRLFG that serves as the docking site for CDK2/cyclin complexes.
Product Specific Literature References
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists: Y.N. Chen, et al.; PNAS 96, 4325 (1999) Abstract; Full Text
Further Categories Containing This Product:
Peptides • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-153-042 Revised 04-Mar-05
Cyclin-dependent Kinase 2 Inhibitory Peptide II
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SYNONYMS CDK2/Cyclin Inhibitory Peptide II
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-153-042-C500   500 µg 145.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Pro-Val-Lys-Arg-Arg-Leu-Asp-Leu-OH
FORMULA: C110H200N48O25
MW: 2595.1
PURITY: ≥98%
APPEARANCE: Lyophilized solid.
SOLUBILITY: Soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic.
Product Description
Cell permeable inhibitor of CDK2/cyclin complexes. Blocks phosphorylation of substrates by CDK2/cyclin A and CDK/cyclin E complexes. Preferentially induces apoptosis only in transformed cells and not in non-transformed cells.
Product Specific Literature References
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists: Y.N. Chen, et al.; PNAS 96, 4325 (1999) Abstract; Full Text
Further Categories Containing This Product:
Peptides • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-165-018 Revised 09-Dec-04
Protein Kinase p34cdc2 Substrate
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDKs & Cyclins Other Products
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ALX-165-018-M001   1 mg 130.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ala-Asp-Ala-Gln-His-Ala-Thr-Pro-Pro-Lys-Lys-Lys-Arg-Lys-Val-Glu-Asp-Pro-Lys-Asp-Phe-OH
FORMULA: C106H172N32O32
MW: 2406.7
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Highly specific substrate for p34cdc2 protein kinase, an enzyme involved in mitosis and onset of the S phase.
Product Specific Literature References
Characterization of synthetic peptide substrates for p34cdc2 protein kinase: D.R. Marshak, et al.; J. Cell. Biochem. 45, 391 (1991) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-202-036 Revised 04-Mar-05
p34cdc2/Cyclin B (starfish Marthasterias glacialis) (purified)
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDKs and Cyclins
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ALX-202-036-R050   50 µl 360.00 USD Add To Cart
Product Specification
SOURCE/HOST: Isolated from starfish oocytes (Marthasterias glacialis).
PURITY: Affinity-purified
FORMULATION: Liquid. 50µl in 200mM sodium bicarbonate (pH 8.2), 0.2M sodium chloride and 10% glycerol.
SPECIFIC ACTIVITY: ~6,000U/ml. One unit is defined as the amount of enzyme that catalyzes the transfer of 1.0pmol of phosphate to histone H1 per minute at 30°C, pH 7.2. Recommended buffer for assay: 60mM β-glycerophosphate, 15mM p-nitrophenylphosphate, 25mM MOPS (pH 7.2), 5mM EGTA, 15mM MgCl2, 1mM DTT, 1mM sodium vanadate. Use 1mg histone H1/ml.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
Product Specific Literature References
MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B: J.C. Labbé; EMBO J. 8, 3053 (1989) Abstract
Cyclin B targets p34cdc2 for tyrosine phosphorylation: L. Meijer, et al.; EMBO J. 10, 1545 (1991) Abstract
Interaction between the cell-cycle-control proteins p34cdc2 and p9CKShs2. Evidence for two cooperative binding domains in p9CKShs2: L. Azzi, et al.; Eur. J. Biochem. 203, 353 (1992) Abstract
Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase: B. Baratte, et al.; Anticancer Res. 12, 873 (1992) Abstract
Inhibition of cyclin-dependent kinases by purine analogues: J. Veselý, et al.; Eur. J. Biochem. 224, 771 (1994) Abstract
General Information
p34cdc2/cyclin B is a serine/threonine protein kinase. Consists of the catalytic cdc2 subunit (MW 32kDa) and the activating regulatory subunit cyclin B (MW 47kDa). Major regulator of the eukaryotic cell cycle, at the G2/M transition level.
Further Categories Containing This Product:
Natural Proteins
 
 
ALX-210-705 Revised 13-Sep-05
Polyclonal Antibody to CDK2 (human)
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SYNONYMS anti-Cyclin-dependent Kinase 2 (human) PAb
anti-Cell Division Cycle Protein Kinase 2 (human) PAb
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Antibodies
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ALX-210-705-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Contains 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to the C-terminal 12 aa of human CDK2 [9].
SPECIFICITY: Recognizes human CDK2.
APPLICATION: Immunoprecipitation (1:500)
Western Blot (1:500)
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
[1] Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase: L.H. Tsai, et al.; Nature 353, 174 (1991) Abstract
[2] CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle: S.J. Elledge, et al.; PNAS 89, 2907 (1992) Abstract
[3] The cdk2 kinase is required for the G1-to-S transition in mammalian cells: L.H. Tsai, et al.; Oncogene 8, 1593 (1993) Abstract
[4] Cell cycle-specific induction of Cdk2 expression in B lymphocytes following antigen receptor cross-linking: D.A. Tanguay & T.C. Chiles; Mol. Immunol. 31, 643 (1994) Abstract
[5] Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15: Y. Gu, et al.; EMBO J. 11, 3995 (1992) Abstract
[6] Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts: M. Pagano, et al.; J. Cell. Biol. 121, 101 (1993) Abstract
[7] Distinct roles of cdk2 and cdc2 in RP-A phosphorylation during the cell cycle: F. Fang & J.W. Newport; J. Cell. Sci. 106, 983 (1993) Abstract
[8] Phosphorylation of the retinoblastoma protein by cdk2: T. Akiyama, et al.; PNAS 89, 7900 (1992) Abstract
[9] Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation: Y. Xiong, et al.; Genes Dev. 7, 1572 (1993) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-270-143 Revised 20-Feb-08
Tyrphostin AG 494
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SYNONYMS Tyrphostin B48
N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-phenylcinnamamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
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ALX-270-143-M005   5 mg 25.00 USD Add To Cart
ALX-270-143-M025   25 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C16H12N2O3
MW: 280.3
CAS NUMBER: 133550-35-3
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Blocks CDK2 activation and causes cells to arrest at late G1 and during S phase.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases: A. Gazit, et al.; J. Med. Chem. 34, 1896 (1991) Abstract
Tyrphostin AG 494 blocks Cdk2 activation: N. Osherov & A. Levitzki; FEBS Lett. 410, 187 (1997) Abstract
Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase: N. Kleinberger-Doron, et al.; Exp. Cell Res. 241, 340 (1998) Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors • CDK & Cyclin Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products
 
 
ALX-270-168 Revised 18-May-06
Tyrphostin AG 490
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SYNONYMS Tyrphostin B42
N-Benzyl-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-]N-benzylcinnamamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
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ALX-270-168-M005   5 mg 45.00 USD Add To Cart
ALX-270-168-M025   25 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C17H14N2O3
MW: 294.3
CAS NUMBER: 133550-30-8
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO and acetone; slightly soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selectively inhibits CDK2 activation leading to a potent cell cycle arrest at late G1 and S phase. Cell permeable inhibitor of JAK-2 tyrosine kinase. Does not significantly inhibit other kinases, such as Lck, Lyn, Btk, Syk or Src. Blocks IL-7 induced JAK kinase activity in T cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. Valuable tool for studying the cellular role of JAK kinases in signal transduction.
Product Specific Literature References
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989) Abstract
Tyrosine phosphorylation is an obligatory event in IL-2 secretion [published erratum appears in J Immunol 1991 May 1;146(9):3260]: A. Levitzki; Biochem. Pharmacol. 40, 913 (1990) Abstract
Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity: H. Dadi, et al.; Blood 84, 1579 (1994) Abstract; Full Text
JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3’ kinase: N. Sharfe, et al.; Blood 86, 2077 (1995) Abstract; Full Text
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor: N. Meydan, et al.; Nature 379, 645 (1996) Abstract
Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells: R.A. Kirken, et al.; J. Leukoc. Biol. 65, 891 (1999) Abstract
JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response: L.H. Wang, et al.; J. Immunol. 162, 3897 (1999) Abstract
JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells: J. De Vos, et al.; Br. J. Haematol. 109, 823 (2000) Abstract
Further Categories Containing This Product:
Janus Kinases [JAKs] / Related Products • Tyrosine Kinase Inhibitors • CDK & Cyclin Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products
 
 
ALX-270-246 Revised 28-Sep-07
Purvalanol A
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SYNONYMS 6-[(3-Chloro)anilino]-2(1R)-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-270-246-M001   1 mg 55.00 USD Add To Cart
ALX-270-246-M005   5 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C19H25N6OCl
MW: 388.9
PURITY: ≥99%
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in DMSO, methanol or dichloromethane.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry. Keep under inert gas.

Product Description
Inhibitor of human CDK1 (IC50=4nM), CDK2/cyclin A (IC50=70nM), Cdc2/cyclin B, CDK2/cyclin E (IC50=35nM), CDK4/cyclin D1 (IC50=850nM) as well as CDK5/p35 (IC50=75nM). More membrane permeable than purvalanol B.
Product Specific Literature References
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors: N.S. Gray, et al.; Science 281, 533 (1998) Abstract
Up-regulation of cdc2 protein during paclitaxel-induced apoptosis: P. Chadebech, et al.; Int. J. Cancer 87, 779 (2000) Abstract
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons: E.A. Monaco, 3rd, et al.; Biochem. Pharmacol. 67, 1947 (2004) Abstract
 
 
ALX-270-248 Revised 17-Jul-07
Compound 52
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SYNONYMS 2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-270-248-M001   1 mg 55.00 USD Add To Cart
Product Specification
FORMULA: C16H19ClN6O
MW: 346.8
PURITY: ≥99%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent, cell permeable and selective inhibitor of CDK1 (IC50=340nM) the cell cycle-regulating kinase Cdc28p (IC50=7µM) and the related Pho85p kinase (IC50=2µM).
Product Specific Literature References
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors: N.S. Gray, et al.; Science 281, 533 (1998) Abstract
 
 
ALX-270-249 Revised 11-Sep-08
Aminopurvalanol A
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SYNONYMS (2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-
9H-purin-2-yl)amino)-3-methyl-1-butanol
NG-97
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-270-249-M001   1 mg 45.00 USD Add To Cart
ALX-270-249-M005   5 mg 135.00 USD Add To Cart
Product Specification
FORMULA: C19H26N7OCl
MW: 403.9
CAS NUMBER: 220792-57-4
PURITY: ≥97% (1H-NMR)
APPEARANCE: