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ALX-385-013 Revised 16-Jun-08
Malvidin chloride
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SYNONYMS 3,4',5,7-Tetrahydroxy-3',5'-dimethoxyflavylium chloride
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Anthocyanidins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-013-M010   10 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C17H15O7Cl
MW: 366.8
CAS NUMBER: 643-84-5
MERCK INDEX: 14: 5715
RTECS: LK9900000
PURITY: ≥97%
APPEARANCE: Reddish brown to black powder.
SOLUBILITY: Soluble in 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Hygroscopic.

Product Description
Antioxidant flavonoid. Antitumor compound. Induces cell cycle arrest in the G2/M-phase.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Biological activities of malvidin, a red wine anthocyanidin: J. Fritz, et al.; Mol. Nutr. Food Res. 50, 390 (2006) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products - Antitumor Reagents • Natural Products - Antioxidants • Natural Products for Cell Cycle Research
 
 
ALX-440-045 Revised 17-Jul-07
Methotrexate
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SYNONYMS (+)-Amethopterin
4-Amino-10-methylfolic acid
Methylaminopterin
MTX
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Enzyme Inhibitors)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-440-045-M050   50 mg 25.00 USD Add To Cart
ALX-440-045-M100   100 mg 45.00 USD Add To Cart
ALX-440-045-M500   500 mg 135.00 USD Add To Cart
ALX-440-045-G001   1 g 240.00 USD Add To Cart
Product Specification
FORMULA: C20H22N8O5
MW: 454.5
CAS NUMBER: 59-05-2
MERCK INDEX: 14: 5985
PURITY: ≥98%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in alkaline solution; insoluble in water, 100% ethanol or ether.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC. MAY BE CARCINOGENIC. MAY BE TERATOGENIC.

Product Description
Folic acid antagonist. Potent inhibitor of dihydrofolate reductase. Induces apoptosis. Inhibits DNA synthesis. Anticancer agent.
Product Specific Literature References
Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells: L. Genestier, et al.; J. Clin. Invest. 102, 322 (1998) Abstract
Methotrexate induces apoptotic cell death in human keratinocytes: M. Heenen, et al.; Arch. Dermatol. Res. 290, 240 (1998) Abstract
Activation-dependent lymphocyte apoptosis induced by methotrexate: R. Paillot, et al.; Transplant. Proc. 30, 2348 (1998) Abstract
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?: L.D. Fairbanks, et al.; Biochem. J. 342, 143 (1999) Abstract
Antiproliferative and antiinflammatory effects of methotrexate on cultured differentiating myeloid monocytic cells (THP-1) but not on synovial macrophages from patients with rheumatoid arthritis: M. Cutolo, et al.; J. Rheumatol. 27, 2551 (2000) Abstract
Mechanisms of action of methotrexate: L. Genestier, et al.; Immunopharmacology 47, 247 (2000) Abstract
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Agents (Apoptosis Inducers) • Folic Acid & Folate Receptors / Related Products • DNA Replication Inhibitors • MDR Other Products
 
 
ALX-380-023 Revised 19-Oct-07
Mitomycin C
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - DNA Replication Inhibitors
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ALX-380-023-M005   5 mg 98.00 USD Add To Cart
ALX-380-023-M010   10 mg 185.00 USD Add To Cart
Product Specification
FORMULA: C15H18N4O5
MW: 334.3
CAS NUMBER: 50-07-7
MERCK INDEX: 14: 6215
RTECS: CN0700000
SOURCE/HOST: Isolated from Streptomyces caespitosus.
PURITY: ≥98%
APPEARANCE: Blue-violet crystals.
SOLUBILITY: Soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC. MAY BE CARCINOGENIC.

Product Description
Antitumor antibiotic. Inhibitor of DNA synthesis, nuclear division and cancer cells. DNA intercalating agent. Apoptosis inducer.
Product Specific Literature References
Mitomycin, a new antibiotic from Streptomyces. I: T. Hata, et al.; J. Antibiot. (Tokyo) 9, 141 (1956) Abstract
S.K. Carter & S.T. Crooke ; 'Mitomycin C. Current Status and New Developments', Academic Press, New York (1979)
Revised absolute configuration of mitomycin C. X-ray analysis of 1-N-(p-bromobenzoyl)mitomycin C: K. Shirahata & N. Hirayama; JACS 105, 7199 (1983)
Sequence-specific DNA damage induced by reduced mitomycin C and 7-N-(p- hydroxyphenyl)mitomycin C: K. Ueda and T. Komano; Nucl. Acids Res. 12, 6673 (1984) Abstract
Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA: M. Tomasz, et al.; Science 235, 1204 (1987) Abstract
The chemistry of DNA modification by antitumor antibiotics: J.F. Fisher & P.A. Aristoff; Prog. Drug Res. 32, 411 (1988) Abstract
DNA sequence specificity of mitomycin cross-linking: S.P. Teng, et al.; Biochemistry 28, 3901 (1989) Abstract
Polyoxyethylene-modified superoxide dismutase reduces side effects of adriamycin and mitomycin C: S. Kawasaki, et al.; J. Cancer Res. 83, 899 (1992) Abstract
Genetic evidence for an activator required for induction of pectin lyase in Erwinia carotovora subsp. carotovora by DNA-damaging agents: J.L. McEvoy, et al.; J. Bacteriol. 174, 5471 (1992) Abstract
Elevated DT-diaphorase activity and messenger RNA content in human non- small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cl: A.M. Malkinson, et al.; Cancer Res. 52, 4752 (1992) Abstract
Mitomycins: J. Verweij, et al.; Cancer Chemother. Biol. Response Modif. 18, 46 (1999) Abstract
Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95- independent manner in human gastric adenocarcinoma cells: I.C. Park, et al.; Cancer Lett. 158, 125 (2000) Abstract
Selective inhibition of cyclooxygenase-2 enhances mitomycin-C-induced apoptosis: C.T. Hsueh, et al.; Cancer Chemother. Pharmacol. 45, 389 (2000) Abstract
DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling: A.R. Tee & C.G. Proud; Oncogene 19, 3021 (2000) Abstract
Re-evaluation of tumor-specific cytotoxicity of mitomycin C, bleomycin and peplomycin: M. Sasaki, et al.; Anticancer Res. 26, 3373 (2006) Abstract
Activation of the S phase DNA damage checkpoint by mitomycin C: E. Mladenov, et al.; J. Cell. Physiol. 211, 468 (2007) Abstract
Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers) • Antibiotics - Apoptosis Inducers & Inhibitors • Antitumor Antibiotics • Antitumor Agents (DNA Interaction & Gene Regulation) • DNA Replication Inhibitors
 
 
ALX-430-094 Revised 04-Jul-07
Monastrol
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SYNONYMS 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic acid ethyl ester
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Cycle Blockers & Inhibitors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-094-M001   1 mg 60.00 USD Add To Cart
ALX-430-094-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C14H16N2O3S
MW: 292.4
CAS NUMBER: 329689-23-8
PURITY: ≥95%
APPEARANCE: White to light yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14µM) by binding to the mitotic kinesin Eg5.
Product Specific Literature References
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen: T.U. Mayer, et al.; Science 286, 971 (1999) Abstract
A combinatorial approach to recognition of chirality: preparation of highly enantioselective aryl-dihydropyrimidine selectors for chiral HPLC: K. Lewandowski, et al.; J. Comb. Chem. 1, 105 (1999) Abstract
Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5: Z. Maliga, et al.; Chem. Biol. 9, 989 (2002) Abstract
Inhibition of a mitotic motor protein: where, how, and conformational consequences: Y. Yan, et al.; J. Mol. Biol. 335, 547 (2004) Abstract
Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures: S.Y. Yoon, et al.; Cell Motil. Cytoskeleton 60, 181 (2005) Abstract
Interaction of the mitotic kinesin Eg5 inhibitor monastrol with P-glycoprotein: T. Peters, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 372, 291 (2006) Abstract
A pathway of structural changes produced by monastrol binding to Eg5: Z. Maliga, et al.; J. Biol. Chem. 281, 7977 (2006) Abstract
Allosteric inhibition of kinesin-5 modulates its processive directional motility: B.H. Kwok, et al.; Nat. Chem. Biol. 2, 480 (2006) Abstract
Further Categories Containing This Product:
Kinesin & Kinesin-like Proteins / Related Products
 
 
ALX-380-026 Revised 26-Jun-08
Monensin . sodium salt
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Ionophores
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ALX-380-026-M100   100 mg 25.00 USD Add To Cart
ALX-380-026-G001   1 g 63.00 USD Add To Cart
Product Specification
FORMULA: C36H61O11 . Na
MW: 669.9 . 23.0
CAS NUMBER: 22373-78-0
MERCK INDEX: 14: 6246
PURITY: ≥90%
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in chloroform or DMSO. Clear solution (5%) in methanol with heat. Slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Antibiotic that functions as Na+ ionophore. Blocks glycoprotein secretion. Inhibits proliferation of several lymphoma cell lines through cell cycle arrest and apoptosis.
Product Specific Literature References
Monensin, a new biologically active compound. I. Discovery and isolation: M. E. Haney, Jr. & M. M. Hoehn; Antimicrobial Agents Chemother. (Bethesda) 7, 349 (1967) Abstract
Solution chemistry of monensin and its alkali metal ion complexes. Potentiometric and spectroscopic studies
: P.G. Gertenbach & A.I. Popov; JACS 97, 4738 (1975)
Undersulfated proteoglycans are secreted by cultured chondrocytes in the presence of the ionophore monensin: K. Tajiri, et al.; J. Biol. Chem. 255, 6036 (1980) Abstract; Full Text
Expression of membrane IGM by a human B lymphoblastoid cell line in the presence of monensin: R.T. Kubo and M.L. Pigeon; Mol. Immunol. 20, 345 (1983) Abstract
Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity: H. H. Mollenhauer, et al.; Biochim. Biophys. Acta 1031, 225 (1990), Review Abstract
Monensin-mediated growth inhibition in human lymphoma cells through cell cycle arrest and apoptosis: W. H. Park, et al.; Br. J. Haematol. 119, 400 (2002) Abstract
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors / Related Products • Vesicles & Membrane Trafficking Other Products • Natural Products for Cell Cycle Research • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
ALX-804-176 Revised 31-Oct-06
Monoclonal Antibody to Cdc37 (C1)
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SYNONYMS anti-Cdc37 MAb (C1)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Co-Chaperones & HSP-interacting Proteins / Related Products
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ALX-804-176-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE: C1
ISOTYPE: Mouse IgG2b
FORMULATION: Liquid. Ascites containing 0.05% sodium azide.
IMMUNOGEN: Recombinant mouse Cdc37.
SPECIFICITY: Recognizes human, mouse, rat and hamster Cdc37. Detects a band of ~50kDa by Western blot.
APPLICATION: Immunocytochemistry  (1:200)
Immunoprecipitation
Western Blot  (1:5'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
CDK & Cyclin Antibodies • Monoclonal Antibodies
 
 
ALX-804-126 Revised 04-May-07
Monoclonal Antibody to Clusterin (human) (CLI-9)
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SYNONYMS anti-TRPM-2 (human) MAb (CLI-9)
anti-Apolipoprotein J (human) MAb (CLI-9)
anti-APO-J (human) MAb (CLI-9)
anti-CLI (human) MAb (CLI-9)
anti-CLU (human) MAb (CLI-9)
anti-SGP-2 (human) MAb (CLI-9)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Clusterin / Related Products
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ALX-804-126-C100   100 µg 280.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: CLI-9
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Purified human clusterin (TRPM-2).
SPECIFICITY: Recognizes human clusterin.
APPLICATION: Immunocytochemistry
Immunohistochemistry (frozen sections, paraffin sections)
Immunoprecipitation
Western Blot (1:2’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C undiluted.
HANDLING: Do not freeze/thaw.
Product Specific Literature References
Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer  : C. D. Hough, et al.; Cancer Res. 60, 6281 (2000) Abstract
Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent: T. Chen, et al.; Cancer Res. 64, 7412 (2004) Abstract; Full Text
General Information
Clusterin (SGP-2/sulfated glycoprotein-2; CLI; Apolipoprotein J (Apo J); TRPM-2) is the first identified extracellular mammalian chaperone and appears to be implicated in such diverse processes as sperm maturation, regulation of complement activation, programmed cell death, tissue remodelling and lipid transport. Increases in clusterin mRNA and protein have been consistently detected in apoptotic cell death paradigms, establishing clusterin gene expression as a prominent marker of apoptotic cell loss. A dual role has been shown for clusterin in that cells can be protected from damage and dead cells can be more easily removed after some types of cellular damage.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Characterization and cloning of androgen-repressed mRNAs from rat ventral prostate: J.G. Leger, et al.; BBRC 147, 196 (1987) Abstract
Apolipoprotein J: structure and tissue distribution: H.V. De Silva, et al.; Biochemistry 29, 5380 (1990) Abstract
Clusterin: the intriguing guises of a widely expressed glycoprotein: D.E. Jenne & J. Tschopp; Trends Biochem. Sci. 17, 154 (1992) Abstract
Clusterin: S.E. Jones and C. Jomary; Int. J. Biochem. Cell Biol. 34, 427 (2002), (Review) Abstract
Clusterin/Apolipoprotein J in human aging and cancer: I. Trougakos and E. Gonos; Int. J. Biochem. Cell Biol. 34, 1430 (2002) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-001 Revised 22-Nov-07
Monoclonal Antibody to Cyclin D1 (DCS-6)
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SYNONYMS anti-Bcl-1 MAb (DCS-6)
anti-PRAD-1 MAb (DCS-6)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-001-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: DCS-6
ISOTYPE: Mouse IgG2a
CONCENTRATION: 0.1mg/ml
FORMULATION: Liquid. In 0.05M sodium phosphate buffer containing 0.2% gelatin and 0.1% sodium azide.
IMMUNOGEN: Recombinant human cyclin D1.
SPECIFICITY: Recognizes human, mouse and rat cyclin D1. Does not cross-react with cyclins D2 or D3.
APPLICATION:

Flow Cytometry (5µg/ml)
Immunocytochemistry (5µg/ml)
Immunohistochemistry (frozen sections, paraffin sections (5µg/ml) - pretreatment with pepsin or trypsin is required)
Immunoprecipitation (see [3])
Western Blot (1µg/ml, see [3])

Functional Application: Neutralization studies (see [3])
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Do not freeze.
Product Specific Literature References
[1] Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining: C. Gillett, et al.; Cancer Res. 54, 1812 (1994) Abstract
[2] Cell cycle-related variation and tissue-restricted expression of human cyclin D1 protein: J. Bartkova, et al.; J. Pathol. 172, 237 (1994) Abstract
[3] Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines: J. Lukas, et al.; Oncogene 9, 707 (1994) Abstract
Further Categories Containing This Product:
Tumor Markers • Monoclonal Antibodies
 
 
ALX-804-539 Revised 30-Nov-04
Monoclonal Antibody to Cyclin D1 (CD1.1)
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-539-C100   100 µg 280.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
CLONE: CD1.1
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. In TBS containing carrier proteins and sodium azide.
IMMUNOGEN: Human cyclin D1.
SPECIFICITY: Recognizes human and rat cyclin D1.
APPLICATION: ELISA
Immunohistochemistry (paraffin sections (0.1-1µg/ml))
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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