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Polyclonal Antibodies
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ALX-215-024 Revised 21-Jul-06
Polyclonal Antibody to 14-3-3γ
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SYNONYMS anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY 14-3-3 Proteins / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-024-R100   100 µl 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-10 (V1DREQLVQKA10C) of 14-3-3γ.
SPECIFICITY: Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3γ.
APPLICATION: ELISA
Immunohistochemistry (1:800)
Western Blot (1:6’000-1:12’000)
Optimal condition must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein: H. Martin, et al.; FEBS Lett. 331, 296 (1993) Abstract; Full Text
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies: H. Martin, et al.; J. Neurochem. 63, 2259 (1994) Abstract
Purification of 14-3-3 protein and analysis of isoforms in chicken brain: Y. Patel, et al.; Biochim. Biophys. Acta 1222, 405 (1994) Abstract
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins: D.H. Jones, et al.; FEBS Lett. 368, 55 (1995) Abstract; Full Text
Expression and structural analysis of 14-3-3 proteins: D.H. Jones, et al.; J. Mol. Biol. 245, 375 (1995) Abstract
Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation: C.P. Wheeler-Jones, et al.; Biochem. J. 315, 41 (1996) Abstract; Full Text
14-3-3 inhibits the Dictyostelium myosin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain: M. Matto-Yelin, et al.; Mol. Biol. Cell 8, 1889 (1997) Abstract; Full Text
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease: J. Wiltfang, et al.; J. Neurochem. 73, 2485 (1999) Abstract
Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants: A. Aitken; Plant Mol. Biol. 50, 993 (2002) Abstract
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain: H.C. Baxter, et al.; Neuroscience 109, 5 (2002) Abstract
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1: H.K. Chen, et al.; Cell 113, 457 (2003) Abstract
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein: P. Steinacker, et al.; Mol. Cell. Biol. 25, 1339 (2005) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-215-027 Revised 21-Jul-06
Polyclonal Antibody to 14-3-3σ
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SYNONYMS anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
anti-Stratifin PAb
anti-SFN PAb
anti-Epithelial Cell Marker Protein 1 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY 14-3-3 Proteins / Related Products
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ALX-215-027-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-10 (M1ERASLIQKA10C) of 14-3-3σ.
SPECIFICITY: Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3σ.
APPLICATION: Western Blot (1:3000)
Optimal condition must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo: M.L. Henriksson, et al.; Eur. J. Biochem. 269, 4921 (2002) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-419 Revised 30-Oct-06
Polyclonal Antibody to 53BP1
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SYNONYMS anti-Tumor Protein p53 Binding Protein 1 PAb
anti-TP53BP1 PAb
anti-p202 PAb
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY p53 Other Products
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ALX-210-419-R050   50 µl 180.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN: Recombinant human 53BP1 (tumor protein p53 binding protein 1) (aa 1308-1824).
SPECIFICITY: Recognizes native and denatured forms of full-length human 53BP1. Cross-reacts with mouse 53BP1.
APPLICATION: Immunocytochemistry (1:200);
Immunoprecipitation;
Western blot (1:2'000).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Storage at +4°C is recommended; if freezing is prefered add 50% glycerol.
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Product Description
The 53BP1 protein is implicated in the early response to DNA damage. The residues aa 1308-1824 are central to the antigen sequence recognized by the antibody ALX-210-419.
Product Specific Literature References
Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage: L. Anderson, et al.; Mol. Cell. Biol. 21, 1719 (2001) Abstract
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis: D. Jullien, et al.; J. Cell Sci. 115, 71 (2002) Abstract; Full Text
Further Categories Containing This Product:
DNA Damage Checkpoint Other Products • Polyclonal Antibodies
 
 
ALX-210-001 Revised 29-Jun-05
Polyclonal Antibody to A1 (mouse)
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SYNONYMS anti-Bfl-1 (mouse) PAb
anti-Bcl-2-related Protein A1 (mouse) PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Members Other Products
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ALX-210-001-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 34-51 (C34RVLQRVAFSVQKEVEKN51) of mouse Bcl-2-related protein A1.
SPECIFICITY: Recognizes mouse A1.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation: E.Y. Lin, et al.; Blood 87, 983 (1996) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-370 Revised 07-Aug-06
Polyclonal Antibody to ABIN-2
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SYNONYMS anti-A20-Binding Inhibitor of NF-κB 2 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Other Products
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ALX-210-370-C100   100 µg 267.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptides corresponding to human ABIN-2 (A20-binding inhibitor of NF-κB 2).
SPECIFICITY: Recognizes human and mouse ABIN-2. Detects a band of ~66kDa by Western blot.
APPLICATION: Western Blot (0.5-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
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Further Categories Containing This Product:
TLRs Other Products • Polyclonal Antibodies
 
 
ALX-210-444 Revised 25-Jul-07
Polyclonal Antibody to ACE2 (human)
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SYNONYMS anti-Angiotensin-converting Enzyme 2 (human) PAb
anti-SARS Receptor (human) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin Converting Enzyme [ACE] & ACE2 / Related Products
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ALX-210-444-C100   100 µg 340.00 USD Add To Cart
ALX-210-444B-C050 Biotin 50 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human ACE2 (angiotensin-converting enzyme 2).
SPECIFICITY: Recognizes human ACE2.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:10’000)
Western Blot 1:2’000-1:10’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
SARS Coronavirus / Related Products • Polyclonal Antibodies
 
 
ALX-210-881 Revised 04-Mar-05
Polyclonal Antibody to Acrolein
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-210-881-C100   100 µg 450.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Others
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
IMMUNOGEN: Acrolein conjugated to a carrier protein.
SPECIFICITY: Recognizes acrolein adducts. Slightly cross-reacts with malondialdehyde-BSA (cross-reactivity ratio=1:55 as determined with competitive ELISA test).
APPLICATION: ELISA (1:2'000-1:5'000).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Lyophilized powder is stable at least 2 years if stored at -20°C. Reconstitute with 100µl of distilled water if solution will be used entirely within 8 hours.
If stored at +4°C (stable for 2 months) reconstitute with 100µl distilled water containing 0.1% merthiolate.
If stored at -20°C (stable for at least 1 year) reconstitute with a mixture of distilled water/glycerol (v/v).
Antibody can be prediluted 10x in PBS containing 0.1% merthiolate.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-356 Revised 20-Jun-07
Polyclonal Antibody to α-Actinin-4
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Actin / Related Products
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ALX-210-356-C050   50 µg 490.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Pig
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 250µg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.01% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 28-38 (M28GDYMAQEDDW38) of human and rat actinin-4 and to aa 29-39 of mouse actinin-4.
SPECIFICITY: Recognizes human, mouse, rat, pig, and Chinese hamster actinin-4. Does not cross-react with actinin-1, -2 or -3.
APPLICATION: Immunohistochemistry (frozen sections (1µg/ml), paraffin sections [3])
Immunoprecipitation (25µg/ml)
Western Blot (0.1-0.25µg/ml)
The recommended dilutions refer to the analysis of mouse cells and tissues with intermediate levels of actinin-4 expression and must be viewed as approximate.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
POSITIVE CONTROL: Human platelet protein (500µg) (Prod. No. ALX-840-007), supplied at 5mg/ml in SDS sample buffer (100mM NaCl, 73mM TRIS/HCl pH 6.7, 10mM DTT, 8mM EDTA, 5% glycerol, 2% SDS, 10µg/ml Bromophenol Blue sodium salt).
Use 5µl (25µg) per lane for Western blotting of tricine gels (13% acrylamide) or 15% Laemmli gels.
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Product Specific Literature References
[1] Expression of alpha-actinin-4 in acquired human nephrotic syndrome: a quantitative immunoelectron microscopy study: N.P. Goode, et al.; Nephrol. Dial. Transplant. 19, 844 (2004) Abstract; Full Text
[2] CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling: Q. Yan, et al.; Mol. Biol. Cell 16, 2470 (2005) Abstract; Full Text
[3] Podocyte involvement in human immune crescentic glomerulonephritis: J. Bariety, et al.; Kidney Int. 68, 1109 (2005) Abstract
General Information
α-Actinin-4 is an actin-bundling protein of ~100kDa that is associated with cell motility, endocytosis, and cancer invasion [1, 2]. The α-actinin family comprises two non-muscle isoforms (α-actinin-1 and -4) and two skeletal muscle isoforms (α-actinin-2 and -3), with α-actinin-2 being also expressed in cardiac muscle [3]. While α-actinin-4 is almost ubiquitously expressed, particularly high concentrations are found in glomeruli. On the subcellular level it is associated with actin stress fibers, but in certain cells it also localizes to the nucleus [1]. Mutations in the α-actinin-4 gene cause an autosomal-dominant form of familial focal segmental glomerulosclerosis (FSGS) [4], which is thought to result from a defect in glomerular podocyte function. A point mutation in the α-actinin-4 gene was found to generate an antigenic peptide that is recognized by autologous cytolytic T lymphocytes (CTL) on a human lung carcinoma [5]. α-actinin-4 interacts with a variety of proteins, including the ring finger protein BERP [6], the PDZ-LIM protein CLP-36 [7], the hemidesmosomal and cell-cell contact protein BP180 [8], and the tight junction protein MAGI-1 [9]. Moreover, α-actinin-4 forms a ternary complex with Ca2+ / Calmodulin-dependent protein kinase II and Densin-180, a protein of postsynaptic densities in CNS neurons [10]. Ca2+-dependent association of α-actinin-4 with E3KARP is required for Ca2+-dependent inhibition of the Na+ / H+ exchanger 3 (NHE3) [11].
General Literature References
[1] Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion: K. Honda, et al.; J. Cell Biol. 140, 1383 (1998) Abstract
[2] Alpha-Actinins: D.R. Critchley & G. Flood; in: Guidebook to the Cytoskeletal and Motor Proteins, T. Kreis & R. Vale, Editors, Oxford University Press: Oxford p. 24 (1999)
[3] Actinin-4 is preferentially involved in circular ruffling and macropinocytosis in mouse macrophages: analysis by fluorescence ratio imaging: N. Araki, et al.; J. Cell Sci. 113, 3329 (2000) Abstract
[4] Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis: J.M. Kaplan, et al.; Nat. Genet. 24, 251 (2000) Abstract
[5] BERP, a novel ring finger protein, binds to alpha-actinin-4: A.E. El-Husseini, et al.; BBRC 267, 906 (2000) Abstract
[6] CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4: T. Vallenius, et al.; J. Biol. Chem. 275, 11100 (2000) Abstract
[7] A point mutation in the alpha-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma: H. Echchakir, et al.; Cancer Res. 61, 4078 (2001) Abstract
[8] Interactions of a hemidesmosome component and actinin family members: A.M. Gonzalez, et al.; J. Cell Sci. 114, 4197 (2001) Abstract
[9] Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin: R.S. Walikonis, et al.; J. Neurosci. 21, 423 (2001) Abstract
[10] Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1: K.M. Patrie, et al.; J. Biol. Chem. 277, 30183 (2002) Abstract
[11] Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis: J.H. Kim, et al.; J. Biol. Chem. 277, 23714 (2002) Abstract
Further Categories Containing This Product:
Endocytosis • Polyclonal Antibodies • Tumor Markers
 
 
ALX-210-555 Revised 11-May-07
Polyclonal Antibody to ADAMTS-1 (human)
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY ADAMTS Family / Related Products
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ALX-210-555-1   1 Vial 180.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute in 50µl water or buffer.
IMMUNOGEN: Synthetic peptide corresponding to aa 295-306 of human ADAMTS-1.
SPECIFICITY: Recognizes human ADAMTS-1.
APPLICATION: Immunocytochemistry
Immunoprecipitation (1:500)
Note: Not recommended for Western blot.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and transfer entire antibody solution to new tubes for storage at -20°C.
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Product Description
ADAMTS-1 is a disintegrin and metalloproteinase containing a thrombospondin motif-1. More efficient disruptor of angiogenesis than ADAMTS-8, thrombospondin-1 or endostatin in vivo and in vitro.
Product Specific Literature References
Identification of Prodomain Determinants Involved in ADAMTS-1 Biosynthesis: J.M. Longpre and R. Leduc; J. Biol. Chem. 279, 33237 (2004) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-144/1 Revised 27-Dec-06
Polyclonal Antibody to Adenosine Receptor A1 (rat)
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
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ALX-210-144/1-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to the C-terminal aa 309-326 (C309QPKPPIDEDLPEEKAED326) of rat adenosine receptor A1 (A1AR).
SPECIFICITY: Recognizes rat adenosine receptor A1. Detects a band of ~37kDa by Western blot. Does not cross-react with other adenosine receptors.
APPLICATION: Western Blot: 1:500.
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.