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Items 16 of 16
ALX-350-092
Revised 03-Apr-08
Emetine . dihydrochloride
SYNONYMS
6’,7’,10,11-Tetramethoxyemetan . 2HCl
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - DNA Replication Inhibitors
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ALX-350-092-M050
50 mg
10.00 USD
Product Specification
FORMULA:
C
29
H
40
N
2
O
4
. 2HCl
MW:
480.7 . 73.0
CAS NUMBER:
316-42-7
MERCK INDEX:
14:
3559
SOURCE/HOST:
Isolated from ground roots of
Uragoga ipecacuanha
.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Hygroscopic.
HAZARD:
TOXIC.
Product Description
Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Antiamebic.
Product Specific Literature References
Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells:
A.P. Grollman; J. Biol. Chem.
243
, 4089 (1968)
Abstract
Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A::
A: T. Schweighoffer, et al.; Histochemistry
96
, 93 (1991)
Abstract
Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation:
W.C. Burhans, et al.; EMBO J.
10
, 4351 (1991)
Abstract
Role of newly synthesized MHC class II molecules in antigen-specific antigen presentation by B cells:
T. Kokuho, et al.; Immunobiology
193
, 42 (1995)
Abstract
Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells:
Y.D. Zhou, et al.; J. Nat. Prod.
68
, 947 (2005)
Abstract
The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells:
M. Moller, et al.; Oncol. Rep.
18
, 737 (2007)
Abstract
Characteristics of apoptosis induction by the alkaloid emetine in human tumour cell lines:
M. Moller & M. Wink; Planta Med.
73
, 1389 (2007)
Abstract
Further Categories Containing This Product:
Other Toxins
•
Adrenergics & Adrenergic Receptors / Related Products
•
Translation Inhibitors
•
Hypoxia-inducible Factor [HIF] / Related Products
•
Natural Products - Other Anti-infective Agents
•
Parasitic Diseases Other Products
•
Natural Products for Neurological Research
•
Alkaloids
•
DNA Replication Inhibitors
•
Natural Products - Apoptosis Inducers & Inhibitors
ALX-350-104
Revised 10-May-07
Aaptamine
SYNONYMS
8,9-Dimethoxy-1
H
-benzo[
de
][1,6]naphtyridine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
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ALX-350-104-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
13
H
12
N
2
O
2
MW:
228.3
CAS NUMBER:
85547-22-4
SOURCE/HOST:
Isolated from the sponge
Aaptos aaptos
.
PURITY:
≥97%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Competitive antagonist of α-adrenoceptors in vascular smooth muscle cells. Inhibits cancer cell growth.
Product Specific Literature References
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle
:
Y. Ohizumi, et al.; J. Pharm. Pharmacol.
36
, 785 (1984)
Abstract
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine:
G.R. Pettit, et al.; J. Org. Chem.
69
, 2251 (2004)
Abstract
Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner:
S. Aoki, et al.; BBRC
342
, 101 (2006)
Abstract
Further Categories Containing This Product:
Adrenergics & Adrenergic Receptors / Related Products
•
Natural Products - Antitumor Reagents
•
Alkaloids
•
Antitumor Agents (Anti-proliferative)
•
Marine Natural Products
ALX-350-111
Revised 04-Mar-05
Sibutramine . hydrochloride . monohydrate
SYNONYMS
1-(4-Chlorophenyl-
N,N
-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine . HCl . H
2
O
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
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ALX-350-111-M250
250 mg
25.00 USD
ALX-350-111-G001
1 g
60.00 USD
Product Specification
FORMULA:
C
17
H
26
ClN . HCl . H
2
O
MW:
279.9 . 36.5 . 18.0
CAS NUMBER:
125494-59-9
MERCK INDEX:
14:
8485
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline powder.
SOLUBILITY:
Soluble in methanol or water (2.9mg/ml at pH 5.2).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
MELTINGPOINT:
193-198°C
Product Description
Anti-obesity agent. Prevents resorption of the messenger substances serotonin and noradrenalin in the brain, allowing them to act at higher concentration on nerve cells and increasing the feeling of satiety.
Further Categories Containing This Product:
Serotonergics & Serotonin Receptors / Related Products
•
Obesity & Diabetes Other Products
ALX-550-076
Revised 29-Apr-08
L-Norepinephrine . bitartrate . monohydrate
SYNONYMS
L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol . C
4
H
6
O
6
. H
2
O
L-Noradrenaline . C
4
H
6
O
6
. H
2
O
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
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ALX-550-076-G001
1 g
60.00 USD
Product Specification
FORMULA:
C
8
H
11
NO
3
. C
4
H
6
O
6
. H
2
O
MW:
169.2 . 150.1 . 18.0
CAS NUMBER:
69815-49-2
MERCK INDEX:
14:
6695
PURITY:
≥98% (Assay)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Solutions may oxidize when exposed to air.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Adrenergic neurotransmitter.
ALX-550-077
Revised 26-Apr-07
Clenbuterol . hydrochloride
SYNONYMS
4-Amino-3,5-dichloro-α-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol . HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
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ALX-550-077-M050
50 mg
20.00 USD
ALX-550-077-M250
250 mg
50.00 USD
ALX-550-077-G001
1 g
150.00 USD
Product Specification
FORMULA:
C
12
H
18
Cl
2
N
2
O . HCl
MW:
277.2 . 36.5
CAS NUMBER:
21898-19-1
MERCK INDEX:
14:
2347
RTECS:
DN3180000
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water, methanol or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
TOXIC.
Product Description
β
2
-Adrenergic receptor agonist. Bronchodilator.
Product Specific Literature References
Thiokynurenates: a new group of antagonists of the glycine modulatory site of the NMDA receptor:
F. Moroni, et al.; Eur. J. Pharmacol.
199
, 227 (1991)
Abstract
Function and regulation of the beta 3-adrenoceptor:
A.D. Strosberg & F. Pietri-Rouxel; TIPS
17
, 373 (1996), (Review)
Abstract
ALX-550-087
Revised 15-Sep-08
Clonidine . hydrochloride
SYNONYMS
2
-
(2,6
-
Dichloroanilino)
-
2
-
imidazoline . hydrochloride
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
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ALX-550-087-M050
50 mg
23.00 USD
Product Specification
FORMULA:
C
9
H
9
Cl
2
N
3
. HCl
MW:
230.1 . 36.5
CAS NUMBER:
4205-91-8
MERCK INDEX:
14:
2390
RTECS:
NJ2490000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (50mg/ml) or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
VERY TOXIC.
Product Description
α
2
-Adrenergic receptor agonist. Antihypertensive.
Further Categories Containing This Product:
Imidazoline Binding Site Ligands
ALX-550-097
Revised 04-Mar-05
Spiroxatrine
SYNONYMS
(±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]-decane-4-one
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Serotonergics & Serotonin Receptors / Related Products
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ALX-550-097-M005
5 mg
70.00 USD
Product Specification
FORMULA:
C
22
H
25
N
3
O
3
MW:
379.5
CAS NUMBER:
1054-88-2
PURITY:
≥98%
APPEARANCE:
Off-white powder.
SOLUBILITY:
Slightly soluble in DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Neuroleptic agent for receptor binding studies.
Product Specific Literature References
Spiroxamide (R 5188) : A new compound producing morphine-like and chlorpromazine-like effects in animals
:
C.J.E. Niemegeers, et al.; Int. J. Neuropharmacol.
2
, 349 (1964)
Spiroxatrine: a selective serotonin1A receptor antagonist:
D.L. Nelson & E.W. Taylor; Eur. J. Pharmacol.
124
, 207 (1986)
Abstract
Further Categories Containing This Product:
Adrenergics & Adrenergic Receptors / Related Products
ALX-550-144
Revised 09-Dec-04
Buspirone . hydrochloride
SYNONYMS
8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione . HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Serotonergics & Serotonin Receptors / Related Products
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ALX-550-144-G001
1 g
48.00 USD
Product Specification
FORMULA:
C
21
H
31
N
5
O
2
. HCl
MW:
385.5 . 36.5
CAS NUMBER:
33386-08-2
MERCK INDEX:
14:
1504
PURITY:
≥96%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
TOXIC.
Product Description
5-HT
1A
serotonin receptor agonist.
Product Specific Literature References
The discovery and development of buspirone: a new approach to the treatment of anxiety
:
J.S. New; Med. Res. Rev.
10
, 283 (1990), (Review)
Abstract
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products
•
Benzodiazepines / Related Products
•
Adrenergics & Adrenergic Receptors / Related Products
ALX-550-274
Revised 03-Mar-05
(±)-Niguldipine . hydrochloride
SYNONYMS
(±)-1,4-Dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(4',4'-diphenyl-1'-piperidinyl)propylmethyl ester . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
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ALX-550-274-M005
5 mg
35.00 USD
ALX-550-274-M025
25 mg
110.00 USD
Product Specification
FORMULA:
C
36
H
39
N
3
O
6
. HCl
MW:
609.7 . 36.5
CAS NUMBER:
113317-61-6
PURITY:
≥95%
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in DMSO or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Adsorbs strongly to plastic.
Product Description
Extremely potent (picomolar range) inhibitor of α
1A
-adrenergic receptors and L-type Ca
2+
channels.
Product Specific Literature References
Stereoselective binding of niguldipine enantiomers to alpha 1A- adrenoceptors labeled with [3H]5-methyl-urapidil:
I. Graziadei, et al.; Eur. J. Pharmacol.
172
, 329 (1989)
Abstract
Niguldipine discriminates between alpha 1-adrenoceptor-mediated second messenger responses in rat cerebral cortex slices:
J.P. Robinson & D.A. Kendall; Br. J. Pharmacol.
100
, 3 (1990)
Abstract
Further Categories Containing This Product:
Adrenergics & Adrenergic Receptors / Related Products
ALX-550-276
Revised 03-Mar-05
S-(+)-Niguldipine . hydrochloride
SYNONYMS
S-(+)-1,4-Dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(4',4'-diphenyl-1'-piperidinyl)propylmethyl ester . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
Ordering Information
Product Numbers:
Format:
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ALX-550-276-M005
5 mg
160.00 USD
Product Specification
FORMULA:
C
36
H
39
N
3
O
6
. HCl
MW:
609.7 . 36.5
CAS NUMBER:
113165-32-5
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Adsorbs strongly to plastic.
Product Description
Extremely potent (picomolar range) inhibitor of α
1A
-adrenergic receptors and L-type Ca
2+
channels.
Product Specific Literature References
(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors:
R. Boer, et al.; Eur. J. Pharmacol.
172
, 131 (1989)
Abstract
Stereoselective binding of niguldipine enantiomers to alpha 1A- adrenoceptors labeled with [3H]5-methyl-urapidil:
I. Graziadei, et al.; Eur. J. Pharmacol.
172
, 329 (1989)
Abstract
Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells:
U. Klockner, et al.; Arzneimittelforschung
39
, 120 (1989)
Abstract
Niguldipine discriminates between alpha 1-adrenoceptor-mediated second messenger responses in rat cerebral cortex slices:
J.P. Robinson & D.A. Kendall; Br. J. Pharmacol.
100
, 3 (1990)
Abstract
Further Categories Containing This Product:
Adrenergics & Adrenergic Receptors / Related Products
ALX-550-306
Revised 09-Nov-07
(±)-Verapamil . hydrochloride
SYNONYMS
5-[(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-valeronitrile . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
Ordering Information
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ALX-550-306-G001
1 g
24.00 USD
ALX-550-306-G005
