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ALX-350-054
Revised 23-Oct-07
Olomoucine, Dimethylamino-
SYNONYMS
6-Benzylamino-2-(2-dimethyl aminoethyl)amino-9-methylpurine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-350-054-M005
5 mg
70.00 USD
Product Specification
FORMULA:
C
17
H
23
N
7
MW:
325.4
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Negative control for olomoucine (Prod. No.
ALX-350-013
).
Product Specific Literature References
The clam 3’ UTR masking element-binding protein p82 is a member of the CPEB family:
J. Walker, et al.; RNA
5
, 14 (1999)
Abstract
Further Categories Containing This Product:
CDKs & Cyclins Other Products
ALX-350-090
Revised 10-Mar-08
Olomoucine, Iso-
SYNONYMS
6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-090-M005
5 mg
70.00 USD
ALX-350-090-M025
25 mg
280.00 USD
Product Specification
FORMULA:
C
15
H
18
N
6
O
MW:
298.4
CAS NUMBER:
101622-50-8
PURITY:
≥98%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inactive negative control for use in studies involving olomoucine (Prod. No.
ALX-350-013
).
Product Specific Literature References
Inhibition of cyclin-dependent kinases by purine analogues:
J. Vesely, et al.; Eur. J. Biochem.
224
, 771 (1994)
Abstract
The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker:
N.A. Krucher, et al.; Cell. Mol. Neurobiol.
17
, 495 (1997)
Abstract
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity:
F. Alessi, et al.; Exp. Cell Res.
245
, 8 (1998)
Abstract
Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine:
J.R. Taylor, et al.; PNAS
104
, 4147 (2007)
Abstract
Further Categories Containing This Product:
CDKs & Cyclins Other Products
ALX-270-397
Revised 09-Jan-08
Olomoucine, N9-Isopropyl-
SYNONYMS
6-Benzylamino-2-(2-hydroxyethylamino)-9-Isopropylpurine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-397-M001
1 mg
40.00 USD
ALX-270-397-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
17
H
22
N
6
O
MW:
326.4
CAS NUMBER:
158982-15-1
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; sparingly soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for 3 months when stored at -20°C.
Product Description
Inhibitor of CDK1/cyclin B (IC
50
=2µM) and CDK5/p35 (IC
50
=3µM).
Product Specific Literature References
Inhibition of cyclin-dependent kinases by purine analogues
:
J. Vesely, et al.; Eur. J. Biochem.
224
, 771 (1994)
Abstract
Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis:
F.I. Raynaud, et al.; Mol. Cancer Ther.
3
, 353 (2004)
Abstract
ALX-270-396
Revised 07-Mar-08
Olomoucine II
SYNONYMS
6-(2-Hydroxybenzylamino)-2(R)-[[1-hydroxymethyl)propyl]amino]-9-isopropylpurine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-396-M001
1 mg
42.00 USD
ALX-270-396-M005
5 mg
145.00 USD
Product Specification
FORMULA:
C
19
H
26
N
6
O
2
MW:
370.5
CAS NUMBER:
500735-47-7
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Selective inhibitor of CDK1/cyclin B (IC
50
=20nM). Potent cytotoxin in tumor cells: IC
50
=5.3µM against MCF7 cells, IC
50
=11.1µM against K562 cells, IC
50
=3.0µM against CEM cells, IC
50
=6.3µM against HOS cells, and IC
50
=6.3µM against G361 cells.
Product Specific Literature References
Synthesis and biological activity of olomoucine II
:
V. Krystof, et al.; Bioorg. Med. Chem. Lett.
12
, 3283 (2002)
Abstract
Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor:
V. Krystof, et al.; Cell Mol. Life Sci.
62
, 1763 (2005)
Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors)
•
Antitumor Agents (Apoptosis Inducers)
ALX-202-036
Revised 04-Mar-05
p34cdc2/Cyclin B (starfish Marthasterias glacialis) (purified)
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDKs and Cyclins
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ALX-202-036-R050
50 µl
360.00 USD
Product Specification
SOURCE/HOST:
Isolated from starfish oocytes (
Marthasterias glacialis)
.
PURITY:
Affinity-purified
FORMULATION:
Liquid. 50µl in 200mM sodium bicarbonate (pH 8.2), 0.2M sodium chloride and 10% glycerol.
SPECIFIC ACTIVITY:
~6,000U/ml. One unit is defined as the amount of enzyme that catalyzes the transfer of 1.0pmol of phosphate to histone H1 per minute at 30°C, pH 7.2. Recommended buffer for assay: 60mM β-glycerophosphate, 15mM p-nitrophenylphosphate, 25mM MOPS (pH 7.2), 5mM EGTA, 15mM MgCl
2
, 1mM DTT, 1mM sodium vanadate. Use 1mg histone H1/ml.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
Product Specific Literature References
MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B:
J.C. Labbé; EMBO J.
8
, 3053 (1989)
Abstract
Cyclin B targets p34cdc2 for tyrosine phosphorylation:
L. Meijer, et al.; EMBO J.
10
, 1545 (1991)
Abstract
Interaction between the cell-cycle-control proteins p34cdc2 and p9CKShs2. Evidence for two cooperative binding domains in p9CKShs2:
L. Azzi, et al.; Eur. J. Biochem.
203
, 353 (1992)
Abstract
Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase:
B. Baratte, et al.; Anticancer Res.
12
, 873 (1992)
Abstract
Inhibition of cyclin-dependent kinases by purine analogues:
J. Veselý, et al.; Eur. J. Biochem.
224
, 771 (1994)
Abstract
General Information
p34
cdc2
/cyclin B is a serine/threonine protein kinase. Consists of the catalytic cdc2 subunit (MW 32kDa) and the activating regulatory subunit cyclin B (MW 47kDa). Major regulator of the eukaryotic cell cycle, at the G2/M transition level.
Further Categories Containing This Product:
Natural Proteins
ALX-270-398
Revised 06-Feb-05
PNU 112455A . hydrochloride
SYNONYMS
N
4
-(6-Aminopyrimidin-4-yl)-sulfanilamide . HCl
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
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ALX-270-398-M001
1 mg
34.00 USD
ALX-270-398-M005
5 mg
135.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
O
2
S . HCl
MW:
265.3 . 36.5
PURITY:
≥95%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO or water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light and moisture. Packaged under inert gas. Hygroscopic.
Product Description
Selective and ATP-competitive inhibitor of CDK2/cyclin E (K
i
=2µM) and CDK5/p25 (K
i
=2µM). Binds to the ATP-binding pocket of CDK2. Does not affect the activities of c-met, IGF-1 receptor tyrosine kinase, cAMP-dependent kinase and ERK2 at concentrations as high as 100µM.
Product Specific Literature References
The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism
:
P.M. Clare, et al.; J. Biol. Chem.
276
, 48292 (2001)
Abstract
;
Full Text
ALX-210-705
Revised 13-Sep-05
Polyclonal Antibody to CDK2 (human)
SYNONYMS
anti-Cyclin-dependent Kinase 2 (human) PAb
anti-Cell Division Cycle Protein Kinase 2 (human) PAb
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Antibodies
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-210-705-R100
100 µl
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Contains 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to the C-terminal 12 aa of human CDK2 [9].
SPECIFICITY:
Recognizes human CDK2.
APPLICATION:
Immunoprecipitation (1:500)
Western Blot (1:500)
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-20°C
Product Specific Literature References
[1]
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase:
L.H. Tsai, et al.; Nature
353
, 174 (1991)
Abstract
[2]
CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle:
S.J. Elledge, et al.; PNAS
89
, 2907 (1992)
Abstract
[3]
The cdk2 kinase is required for the G1-to-S transition in mammalian cells:
L.H. Tsai, et al.; Oncogene
8
, 1593 (1993)
Abstract
[4]
Cell cycle-specific induction of Cdk2 expression in B lymphocytes following antigen receptor cross-linking:
D.A. Tanguay & T.C. Chiles; Mol. Immunol.
31
, 643 (1994)
Abstract
[5]
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15:
Y. Gu, et al.; EMBO J.
11
, 3995 (1992)
Abstract
[6]
Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts:
M. Pagano, et al.; J. Cell. Biol.
121
, 101 (1993)
Abstract
[7]
Distinct roles of cdk2 and cdc2 in RP-A phosphorylation during the cell cycle:
F. Fang & J.W. Newport; J. Cell. Sci.
106
, 983 (1993)
Abstract
[8]
Phosphorylation of the retinoblastoma protein by cdk2:
T. Akiyama, et al.; PNAS
89
, 7900 (1992)
Abstract
[9]
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation:
Y. Xiong, et al.; Genes Dev.
7
, 1572 (1993)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-165-018
Revised 09-Dec-04
Protein Kinase p34cdc2 Substrate
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDKs & Cyclins Other Products
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ALX-165-018-M001
1 mg
130.00 USD
Product Specification
SEQUENCE:
H-Ala-Asp-Ala-Gln-His-Ala-Thr-Pro-Pro-Lys-Lys-Lys-Arg-Lys-Val-Glu-Asp-Pro-Lys-Asp-Phe-OH
FORMULA:
C
106
H
172
N
32
O
32
MW:
2406.7
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Highly specific substrate for p34
cdc2
protein kinase, an enzyme involved in mitosis and onset of the S phase.
Product Specific Literature References
Characterization of synthetic peptide substrates for p34cdc2 protein kinase:
D.R. Marshak, et al.; J. Cell. Biochem.
45
, 391 (1991)
Abstract
Further Categories Containing This Product:
Peptides
ALX-270-246
Revised 28-Sep-07
Purvalanol A
SYNONYMS
6-[(3-Chloro)anilino]-2(1R)-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-246-M001
1 mg
55.00 USD
ALX-270-246-M005
5 mg
220.00 USD
Product Specification
FORMULA:
C
19
H
25
N
6
OCl
MW:
388.9
PURITY:
≥99%
APPEARANCE:
Off-white to yellow powder.
SOLUBILITY:
Soluble in DMSO, methanol or dichloromethane.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry. Keep under inert gas.
Product Description
Inhibitor of human CDK1 (IC
50
=4nM), CDK2/cyclin A (IC
50
=70nM), Cdc2/cyclin B, CDK2/cyclin E (IC
50
=35nM), CDK4/cyclin D1 (IC
50
=850nM) as well as CDK5/p35 (IC50=75nM). More membrane permeable than purvalanol B.
Product Specific Literature References
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors:
N.S. Gray, et al.; Science
281
, 533 (1998)
Abstract
Up-regulation of cdc2 protein during paclitaxel-induced apoptosis:
P. Chadebech, et al.; Int. J. Cancer
87
, 779 (2000)
Abstract
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons:
E.A. Monaco, 3rd, et al.; Biochem. Pharmacol.
67
, 1947 (2004)
Abstract
ALX-270-463
Revised 22-Apr-08
RO-3306
SYNONYMS
(5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
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Size:
Unit Price:
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ALX-270-463-M001
1 mg
50.00 USD
ALX-270-463-M005
5 mg
200.00 USD
Product Specification
FORMULA:
C
18
H
13
N
3
OS
2
MW:
351.4
CAS NUMBER:
872573-93-8
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
Brown solid.
SOLUBILITY:
Soluble in DMSO (5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C in the dark.
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Inhibitor of CDK1/cyclin B1 and CDK1/cyclin A. Reversibly arrests human cells at the G
2
/M border of the cell cycle. Allows for effective cell synchronisation in early mitosis.
Product Specific Literature References
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1:
L.T. Vassilev, et al.; PNAS
103
, 10660 (2006)
Abstract
;
Full Text
Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1:
L.T. Vassilev; Cell Cycle
5
, 2555 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors / Related Products
ALX-350-251
Revised 23-Oct-07
(R)-Roscovitine
SYNONYMS
6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-251-M001
1 mg
30.00 USD
ALX-350-251-M005
5 mg
110.00 USD
ALX-350-251-M050
50 mg
450.00 USD
