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ALX-270-441 Revised 26-Jun-06
NU6140
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SYNONYMS 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-441-M005   5 mg 185.00 USD Add To Cart
Product Specification
FORMULA: C23H30N6O2
MW: 422.5
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING: Packaged under inert gas. Protect from light.
HAZARD: HARMFUL. MAY BE CARCINOGENIC.

Product Description
Highly cell permeable purine compound that acts as a selective and ATP-competitive inhibitor of CDKs (IC50=6.6µM, 0.41µM, 5.5µM, 15µM and 3.9µM for CDK1/cyclin B, CDK2/cyclin A, CDK4/cyclin D, CDK5/p25 and CDK7/cyclin H) and displays anticancer properties. Causes cell cycle arrest at the G2/M phase and induces apoptosis by activating caspases and downregulating survivin.
Product Specific Literature References
Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation: M. Pennati, et al.; Mol. Cancer Ther. 4, 1328 (2005) Abstract
Further Categories Containing This Product:
Survivin [TIAP] • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-430-128 Revised 21-Feb-08
Nutlin-3
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SYNONYMS (±)-4-[4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-piperazin-2-one
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY p53 Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-128-M001   1 mg 35.00 USD Add To Cart
ALX-430-128-M005   5 mg 160.00 USD Add To Cart
ALX-430-128-M025   25 mg 560.00 USD Add To Cart
Product Specification
FORMULA: C30H30Cl2N4O4
MW: 581.5
CAS NUMBER: 548472-68-0
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in methanol, 100% ethanol, DMSO, dimethyl formamide or acetonitrile; sparingly soluble in a 1:10 solution of ethanol:PBS, pH 7.2.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least one year after receipt when stored at -20°C.

We do not recommend storing the aqueous solution for more than one day.
HAZARD: IRRITANT.

Product Description
Inhibitor of p53/MDM2 interaction (IC50=0.09µM).
Product Specific Literature References
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2: L.T. Vassilev, et al.; Science 303, 844 (2004) Abstract
Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas: G. Sarek, et al.; J. Clin. Invest. 117, 1019 (2007) Abstract; Full Text
General Literature References
Drug discovery and p53: D.P. Lane, et al.; Drug Discov. Today 8, 347 (2003) Abstract
Further Categories Containing This Product:
Ubiquitin Ligases [E3]
 
 
ALX-350-013 Revised 23-Oct-07
Olomoucine (high purity)
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SYNONYMS 6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-013-M005   5 mg 65.00 USD Add To Cart
ALX-350-013-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C15H18N6O
MW: 298.4
CAS NUMBER: 101622-51-9
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent and very selective inhibitor of cdc2, CDK and other cyclin-related kinases by competing for the ATP-binding domain of the kinase. Inhibits CDK1/cyclin B (IC50=7µM), CDK2 (IC50=7µM) and CDK5/p35 (IC50=3µM). Also inhibits DNA synthesis in interleukin-2 stimulated T lymphocytes and triggers G1 arrest similar to that observed in interleukin-2 deprived cells. Can be used to synchronize cells in G1. Triggers apoptosis in target tumor cells in vitro and in vivo and in maturing cerebellar granule neurons.
Product Specific Literature References
Inhibition of cyclin-dependent kinases by purine analogues: J. Vesely, et al.; Eur. J. Biochem. 224, 771 (1994) Abstract
Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases: R.T. Abraham, et al.; Biol. Cell 83, 105 (1995) Abstract
Mitotic disassembly of the Golgi apparatus in vivo: T. Mistelli & G. Warren; J. Cell Sci. 108, 2715 (1995) Abstract
Chemical inhibitors of cyclin-dependent kinases: L. Meijer, et al.; Meth. Enzymol. 283, 113 (1997) Abstract
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds: L. Havlicek, et al.; J. Med. Chem. 40, 408 (1997) Abstract
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity: F. Alessi, et al.; Exp. Cell Res. 245, 8 (1998) Abstract
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons: E.A. Monaco, 3rd, et al.; Biochem. Pharmacol. 67, 1947 (2004) Abstract
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors/Related Products • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-350-054 Revised 23-Oct-07
Olomoucine, Dimethylamino-
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SYNONYMS 6-Benzylamino-2-(2-dimethyl aminoethyl)amino-9-methylpurine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-350-054-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C17H23N7
MW: 325.4
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Negative control for olomoucine (Prod. No. ALX-350-013).
Product Specific Literature References
The clam 3’ UTR masking element-binding protein p82 is a member of the CPEB family: J. Walker, et al.; RNA 5, 14 (1999) Abstract
Further Categories Containing This Product:
CDKs & Cyclins Other Products
 
 
ALX-350-090 Revised 10-Mar-08
Olomoucine, Iso-
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SYNONYMS 6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-350-090-M005   5 mg 70.00 USD Add To Cart
ALX-350-090-M025   25 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C15H18N6O
MW: 298.4
CAS NUMBER: 101622-50-8
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inactive negative control for use in studies involving olomoucine (Prod. No. ALX-350-013).
Product Specific Literature References
Inhibition of cyclin-dependent kinases by purine analogues: J. Vesely, et al.; Eur. J. Biochem. 224, 771 (1994) Abstract
The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker: N.A. Krucher, et al.; Cell. Mol. Neurobiol. 17, 495 (1997) Abstract
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity: F. Alessi, et al.; Exp. Cell Res. 245, 8 (1998) Abstract
Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine: J.R. Taylor, et al.; PNAS 104, 4147 (2007) Abstract
Further Categories Containing This Product:
CDKs & Cyclins Other Products
 
 
ALX-270-397 Revised 09-Jan-08
Olomoucine, N9-Isopropyl-
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SYNONYMS 6-Benzylamino-2-(2-hydroxyethylamino)-9-Isopropylpurine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-270-397-M001   1 mg 40.00 USD Add To Cart
ALX-270-397-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C17H22N6O
MW: 326.4
CAS NUMBER: 158982-15-1
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; sparingly soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for 3 months when stored at -20°C.

Product Description
Inhibitor of CDK1/cyclin B (IC50=2µM) and CDK5/p35 (IC50=3µM).
Product Specific Literature References
Inhibition of cyclin-dependent kinases by purine analogues: J. Vesely, et al.; Eur. J. Biochem. 224, 771 (1994) Abstract
Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis: F.I. Raynaud, et al.; Mol. Cancer Ther. 3, 353 (2004) Abstract
 
 
ALX-270-396 Revised 07-Mar-08
Olomoucine II
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SYNONYMS 6-(2-Hydroxybenzylamino)-2(R)-[[1-hydroxymethyl)propyl]amino]-9-isopropylpurine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-270-396-M001   1 mg 42.00 USD Add To Cart
ALX-270-396-M005   5 mg 145.00 USD Add To Cart
Product Specification
FORMULA: C19H26N6O2
MW: 370.5
CAS NUMBER: 500735-47-7
PURITY: ≥98%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Selective inhibitor of CDK1/cyclin B (IC50=20nM). Potent cytotoxin in tumor cells: IC50=5.3µM against MCF7 cells, IC50=11.1µM against K562 cells, IC50=3.0µM against CEM cells, IC50=6.3µM against HOS cells, and IC50=6.3µM against G361 cells.
Product Specific Literature References
Synthesis and biological activity of olomoucine II: V. Krystof, et al.; Bioorg. Med. Chem. Lett. 12, 3283 (2002) Abstract
Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor: V. Krystof, et al.; Cell Mol. Life Sci. 62, 1763 (2005) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-380-210 Revised 08-Apr-08 New product
7-Oxostaurosporine
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SYNONYMS Antibiotic BMY 41950
Antibiotic RK 1409
LCM76-L
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Protein Kinase Inhibitors
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ALX-380-210-M001   1 mg 330.00 USD Add To Cart
Product Specification
FORMULA: C28H24N4O4
MW: 480.5
CAS NUMBER: 141196-69-2
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5345.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, methanol or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Antibiotic. Potent inhibitor of protein kinase C (PKC). Inhibits the cell cycle at the G2 stage.
Product Specific Literature References
A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity: H. Osada, et al.; J. Antibiot. 45, 189 (1992) Abstract
A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure: H. Koshino, et al.; J. Antibiot. 45, 195 (1992) Abstract
Further Categories Containing This Product:
PKC Inhibitors • Cell Cycle Blockers & Inhibitors/Related Products • Staurosporine/Related Products • Antibiotics for Cell Cycle Research • Alkaloids
 
 
ALX-202-036 Revised 04-Mar-05
p34cdc2/Cyclin B (starfish Marthasterias glacialis) (purified)
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDKs and Cyclins
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ALX-202-036-R050   50 µl 360.00 USD Add To Cart
Product Specification
SOURCE/HOST: Isolated from starfish oocytes (Marthasterias glacialis).
PURITY: Affinity-purified
FORMULATION: Liquid. 50µl in 200mM sodium bicarbonate (pH 8.2), 0.2M sodium chloride and 10% glycerol.
SPECIFIC ACTIVITY: ~6,000U/ml. One unit is defined as the amount of enzyme that catalyzes the transfer of 1.0pmol of phosphate to histone H1 per minute at 30°C, pH 7.2. Recommended buffer for assay: 60mM β-glycerophosphate, 15mM p-nitrophenylphosphate, 25mM MOPS (pH 7.2), 5mM EGTA, 15mM MgCl2, 1mM DTT, 1mM sodium vanadate. Use 1mg histone H1/ml.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
Product Specific Literature References
MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B: J.C. Labbé; EMBO J. 8, 3053 (1989) Abstract
Cyclin B targets p34cdc2 for tyrosine phosphorylation: L. Meijer, et al.; EMBO J. 10, 1545 (1991) Abstract
Interaction between the cell-cycle-control proteins p34cdc2 and p9CKShs2. Evidence for two cooperative binding domains in p9CKShs2: L. Azzi, et al.; Eur. J. Biochem. 203, 353 (1992) Abstract
Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase: B. Baratte, et al.; Anticancer Res. 12, 873 (1992) Abstract
Inhibition of cyclin-dependent kinases by purine analogues: J. Veselý, et al.; Eur. J. Biochem. 224, 771 (1994) Abstract
General Information
p34cdc2/cyclin B is a serine/threonine protein kinase. Consists of the catalytic cdc2 subunit (MW 32kDa) and the activating regulatory subunit cyclin B (MW 47kDa). Major regulator of the eukaryotic cell cycle, at the G2/M transition level.
Further Categories Containing This Product:
Natural Proteins
 
 
ALX-850-057 Revised 24-Feb-05
p53 (human) ELISA Kit
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY p53 Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-057-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.5U/ml
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human p53 in cell culture supernatants, human serum, plasma and other biological fluids.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-270-270 Revised 17-Mar-08
Pifithrin-α . hydrobromide
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