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ALX-270-264

Revised 17-Apr-08

Carnosic acid
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-264-M010		10 mg	45.00 USD
ALX-270-264-M050		50 mg	140.00 USD

Product Specification

FORMULA:	C₂₀H₂₈O₄
MW:	332.4
CAS NUMBER:	3650-09-7
SOURCE/HOST:	Isolated from Rosmarinus officinalis.
PURITY:	≥95%
APPEARANCE:	Yellow powder.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Naturally occurring phenolic compound with antioxidant properties. Inhibits lipid peroxidation induced by NADH or NADPH oxidation. Peroxisome proliferator-activated receptor γ (PPARγ) activator. Anti-inflammatory. Antimicrobial.

Product Specific Literature References

Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes: K. Schwarz & W. Ternes; Z. Lebensm. Unters. Forsch. 195, 99 (1992) Abstract
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid: O.I. Aruoma, et al.; Xenobiotica 22, 257 (1992) Abstract
Radical intermediates and antioxidants: an ESR study of radicals formed on carnosic acid in the presence of oxidized lipids: M. Geoffroy, et al.; Free Radic. Res. 21, 247 (1994) Abstract
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis: H. Haraguchi, et al.; Planta Med. 61, 333 (1995) Abstract
Rosemary components inhibit benzo[a]pyrene-induced genotoxicity in human bronchial cells: E.A. Offord, et al.; Carcinogenesis 16, 2057 (1995) Abstract
Chemiluminescence determination of the in vivo and in vitro antioxidant activity of RoseOx and carnosic acid: A.I. Kuzmenko, et al.; J. Photochem. Photobiol. B 48, 63 (1999) Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma: O. Rau, et al.; Planta Med. 72, 881 (2006) Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis: K. Horiuchi, et al.; Biol. Pharm. Bull. 30, 287 (2007) Abstract

Further Categories Containing This Product:

Lipid Peroxidation • Active Substances from Fruit and Vegetables • Natural Products - Anti-inflammatory Agents • Natural Products with Antibiotic Activity • PPAR Agonists

ALX-270-254

Revised 22-Sep-08

Carnosol
SYNONYMS	1,3,4,9,10,10aS-Hexahydro-5,6-dihydroxy-1,1-dimethyl-7-isopropyl-2H-9S,4aR-(epoxymethano)phenanthren-12-one
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-254-M001		1 mg	60.00 USD
ALX-270-254-M005		5 mg	269.00 USD

Product Specification

FORMULA:	C₂₀H₂₆O₄
MW:	330.4
CAS NUMBER:	5957-80-2
SOURCE/HOST:	Isolated from Rosmarinus officinalis.
PURITY:	≥96%
APPEARANCE:	White to beige solid.
SOLUBILITY:	Soluble in 100% ethanol (8mg/ml), DMSO (250mg/ml) or dimethyl formamide (35mg/ml); sparingly soluble in aqueous PBS, pH 7.2 (<30μg/ml).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:	Protect from light.

Product Description

Naturally occurring phenolic compound with antioxidant and anti-inflammatory properties. Suppresses nitric oxide (NO) production and inducible nitric oxide synthase (iNOS; NOS II) gene expression by inhibiting NF-κB activation. Inhibits lipid peroxidation. Antimicrobial. Anticarcinogenic. Inhibits cyclooxygenase-2 (COX-2).

Product Specific Literature References

Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid: O.I. Aruoma, et al.; Xenobiotica 22, 257 (1992) Abstract
Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production: M.M. Chan, et al.; Cancer Lett. 96, 23 (1995) Abstract
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis: H. Haraguchi, et al.; Planta Med. 61, 333 (1995) Abstract
Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation: K. Singletary, et al.; Cancer Lett. 104, 43 (1996) Abstract
Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention: K. Macé, et al.; Arch. Toxicol. Suppl. 20, 227 (1998) Abstract
Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages: A.H. Lo, et al.; Carcinogenesis 23, 983 (2002) Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma: O. Rau, et al.; Planta Med. 72, 881 (2006) Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis: K. Horiuchi, et al.; Biol. Pharm. Bull. 30, 287 (2007) Abstract

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • Lipid Peroxidation • Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Anti-inflammatory Agents • COX Inhibitors • Natural Products - Nitric Oxide Pathway Modulators

ALX-460-004

Revised 11-Jul-07

β-Carotene
SYNONYMS	Provitamin A
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Retinol [Vitamin A] & Retinol Derivatives / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-460-004-G005		5 g	65.00 USD

Product Specification

FORMULA:	C₄₀H₅₆
MW:	536.9
CAS NUMBER:	7235-40-7
MERCK INDEX:	14: 1853
SOURCE/HOST:	Synthetic.
PURITY:	≥97%
APPEARANCE:	Red powder.
SOLUBILITY:	Soluble in DMSO, n-hexane, carbon disulfide, benzene or vegetable oils; slightly soluble in ether, petroleum ether or oils; almost insoluble in 100% ethanol, methanol, water, diluted acidic or alkaline solutions.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light. Absorbs oxygen from air. Keep under inert gas.

Further Categories Containing This Product:

Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Vitamins

ALX-270-160

Revised 27-Sep-07

Castanospermine
SYNONYMS	(1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizine
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-160-M010		10 mg	60.00 USD
ALX-270-160-M050		50 mg	180.00 USD

Product Specification

FORMULA:	C₈H₁₅NO₄
MW:	189.2
CAS NUMBER:	79831-76-8
MERCK INDEX:	14: 1896
SOURCE/HOST:	Isolated from Castanospermum australe seeds.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from moisture.

Product Description

Plant alkaloid. Potent inhibitor of α- and β-glucosidase activity in fibroblast extracts; inhibits the glycoprotein processing cycle. Exhibits antiviral properties. Prevents angiogenesis.

Product Specific Literature References

Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin: Y.T. Pan, et al.; Biochemistry 22, 3975 (1983) Abstract
Glycoproteins: their structure, biosynthesis and possible clinical implications: H. Schachter; Clin. Biochem. 17, 3 (1984) Abstract
The effects of processing inhibitors of N-linked oligosaccharides on the intracellular migration of glycoprotein E2 of mouse hepatitis virus and the maturation of coronavirus particles: R. Repp, et al.; J. Biol. Chem. 260, 15873 (1985) Abstract; Full Text
Effects of the anti-inflammatory compounds castanospermine, mannose-6- phosphate and fucoidan on allograft rejection and elicited peritoneal exudates: M.R. Bartlett, et al.; Immunol. Cell Biol. 72, 367 (1994) Abstract
Antiviral activity and metabolism of the castanospermine derivative MDL 28,574, in cells infected with herpes simplex virus type 2: S.P. Ahmed, et al.; BBRC 208, 267 (1995) Abstract
The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth: R. Pili, et al.; Cancer Res. 55, 2920 (1995) Abstract
Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells: C. Durrant & S.E. Moore; Biochem. J. 365, 239 (2002) Abstract

Further Categories Containing This Product:

Natural Products for Angiogenesis Research • Alkaloids • Glycosidases / Related Products • Natural Products - Antiviral / anti-HIV Agents

ALX-385-017

Revised 01-Apr-08

(+)-Catechin . monohydrate
SYNONYMS	(+)-3,3',4',5,7-Flavanpentol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-017-G001		1 g	20.00 USD

Product Specification

FORMULA:	C₁₅H₁₄O₆ . H₂O
MW:	290.3 . 18.0
CAS NUMBER:	88191-48-4, 225937-10-0
MERCK INDEX:	14: 1902
PURITY:	≥98% (TLC)
APPEARANCE:	Off-white to yellow powder.
SOLUBILITY:	Soluble in 100% ethanol (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	IRRITANT.

Product Description

Antioxidant flavonoid. Free radical scavenger. Has chemopreventive and antitumor properties.

Product Specific Literature References

Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models: M.A. Azuine & S.V. Bhide; J. Ethnopharmacol. 44, 211 (1994) Abstract
Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products: S.V. Bhide, et al.; Breast Cancer Res. Treat. 30, 233 (1994) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002), (Review) Abstract
In vitro biological properties of flavonoid conjugates found in vivo: G. Williamson, et al.; Free Radic. Res. 39, 457 (2005), (Review) Abstract
(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006) Abstract
Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007) Abstract

Further Categories Containing This Product:

Free Radical Scavengers • Active Substances from Fruit and Vegetables • Flavonoids / Related Products • Natural Products - Antitumor Reagents • Natural Products - Chemopreventive Agents

ALX-385-002

Revised 19-Nov-07

(±)-Catechin
SYNONYMS	(±)-3,3',4',5,7-Flavanpentol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-002-G001		1 g	80.00 USD

Product Specification

FORMULA:	C₁₅H₁₄O₆
MW:	290.3 (anhydrous basis)
CAS NUMBER:	7295-85-4
MERCK INDEX:	14: 1902
PURITY:	≥98% (HPLC)
APPEARANCE:	White to yellow powder.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	IRRITANT.

Product Description

Antioxidant flavonoid. Free radical scavenger. Has chemopreventive and antitumor properties.

Product Specific Literature References

Further Categories Containing This Product:

Active Substances from Fruit and Vegetables • Free Radical Scavengers • Flavonoids / Related Products • Natural Products - Antitumor Reagents • Natural Products - Chemopreventive Agents

ALX-350-101

Revised 03-Apr-08

Catharanthine . tartrate
SYNONYMS	3,4-Didehydroibogamine-18-carboxylic acid methyl ester . tartrate 7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1’,2’:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester . tartrate
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Cytoskeletal Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-101-M100		100 mg	160.00 USD
ALX-350-101-G001		1 g	430.00 USD

Product Specification

FORMULA:	C₂₁H₂₄N₂O₂ . C₄H₆O₆
MW:	336.4 . 150.1
CAS NUMBER:	2648-21-5
MERCK INDEX:	14: 1904
SOURCE/HOST:	Isolated from Catharanthus roseus.
PURITY:	≥90%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Very hygroscopic. Keep cool and dry.

Product Description

Starting material for the synthesis of the antitumor drugs vinblastine and vincristine. It is less active as an inhibitor of tubulin self-assembly into microtubules than the latter two compounds.

Product Specific Literature References

Photochemical one-pot synthesis of vinblastine and vincristine: S. Pennanen & A. Huhtikangas; Photochem. Photobiol. 51, 515 (1990) Abstract
Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline: V. Prakash & S.N. Timasheff; Biochemistry 30, 873 (1991) Abstract

ALX-350-257	Vinblastine . sulfate
ALX-350-069	Vincristine . sulfate
ALX-350-102	Vindoline

FORMULA:	C₁₅H₁₄ClN₃O₄S
MW:	367.8
CAS NUMBER:	53994-73-3
MERCK INDEX:	14: 1912
PURITY:	≥97%
APPEARANCE:	Light yellow powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

FORMULA:	C₁₄H₁₃N₈O₄S₃ . Na
MW:	453.5 . 23.0
CAS NUMBER:	27164-46-1
MERCK INDEX:	14: 1917
SOURCE/HOST:	Semisynthetic.
PURITY:	≥98%
APPEARANCE:	Off-white powder.
SOLUBILITY:	Soluble in water; slightly soluble in methanol and 100% ethanol; insoluble in acetone, chloroform and benzene.
ACTIVITY:	≥900units/mg.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	TOXIC.