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CDKs & Cyclins Other Products
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ALX-380-116 Revised 07-Apr-08
Hypothemycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-116-C250   250 µg 140.00 USD Add To Cart
ALX-380-116-M001   1 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C19H22O8
MW: 378.4
CAS NUMBER: 76958-67-3
SOURCE/HOST: Isolated from Phoma sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or acetone; insoluble in methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Exhibits antifungal and cytotoxic activity against some tumor cell lines partly attributed to inhibition of Ras-inducible genes. Inhibits proliferation of mouse and human T cells and modulates production of cytokines during T cell activation. Facilitates the ubiquitinylation process of cyclin D1. Has been identified as a potent and selective inhibitor of threonine/tyrosine-specific kinase, MEK, and other protein kinases that contain a conserved cysteine residue in the ATP-binding site in both in vitro and in vivo studies.
Product Specific Literature References
Metabolites of pyrenomycetes XIII: Structure of (+) hypothemycin, an antibiotic macrolide from hypomyces trichothecoides: M.S.R. Nair & S.T. Carey; Tetrahedron Lett. 21, 2011 (1980)
Metabolites of pyrenomycetes. XIV: Structure and partial stereochemistry of the antibiotic macrolides hypothemycin and dihydrohypothemycin: M.S.R. Nair, et al.; Tetrahedron 37, 2445 (1981)
Revised structure and stereochemistry of hypothemycin: T. Agatsuma et al.; Chem. Pharm. Bull. 41, 373 (1993)
Antitumor efficacy of hypothemycin, a new Ras-signaling inhibitor: H. Tanaka, et al.; Jpn. J. Cancer Res. 90, 1139 (1999) Abstract
Hypothemycin inhibits the proliferative response and modulates the production of cytokines during T cell activation: R. Camacho, et al.; Immunopharmacology 44, 255 (1999) Abstract
Suppression of oncogenic transformation by hypothemycin associated with accelerated cyclin D1 degradation through ubiquitin-proteasome pathway: H. Sonoda, et al.; Life Sci. 65, 381 (1999) Abstract
Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK: A. Zhao, et al.; J. Antibiot. 52, 1086 (1999) Abstract
Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides: A. Schirmer, et al.; PNAS 103, 4234 (2006) Abstract; Full Text
Chemistry and biology of resorcylic acid lactones: N. Winssinger, et al.; Chem. Commun. (Camb). 1, 22 (2007), (Review) Abstract
Further Categories Containing This Product:
MAPK Pathway Inhibitors • Antibiotics - Protein Kinase Inhibitors • CDKs & Cyclins Other Products • Tyrosine Kinase Inhibitors • Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Antibiotics • Antibiotics - Proteasome/Ubiquitin Modulators • Ubiquitination Other Products • Ras Signalling Pathway Other Products
 
 
ALX-804-046 Revised 25-Oct-04
Monoclonal Antibody to p16 (human) (DCS-50.1/H4)
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDKs & Cyclins Other Products
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ALX-804-046-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: DCS-50.1/H4
ISOTYPE: Mouse IgG1
FORMULATION: Lyophilized. 100µg of purified antibody in 1ml sodium phosphate buffer containing 0.1% sodium azide and 0.2% gelatin.
IMMUNOGEN: Human p16 protein.
SPECIFICITY: Recognizes human p16.
APPLICATION: Immunohistochemistry (paraffin sections)
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-645 Revised 05-Mar-07
Monoclonal Antibody to TRIP-Br1 (TB1-27/2)
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SYNONYMS anti-SERTA Domain-containing Protein 1 MAb (TB1-27/2)
anti-SEI-1 MAb (TB1-27/2)
anti-CDK4-binding Protein p34SEI1 MAb (TB1-27/2)
anti-Transcriptional Regulator Interacting with the PHD-bromodomain 1 MAb (TB1-27/2)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDKs & Cyclins Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-645-C050   50 µg 240.00 USD Add To Cart
ALX-804-645-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Pig
Monkey
CLONE: TB1-27/2
ISOTYPE: Mouse IgG2a.
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 27-42 (D27PGHAAVAQAPPAVAS42) of human TRIP-Br1 [SEI-1].
SPECIFICITY: Recognizes human, mouse, pig and monkey TRIP-Br1.
APPLICATION: Immunohistochemistry (1:200)
Immunoprecipitation
Western Blot (1:1’000-1:5’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Specific Literature References
Exploiting the TRIP-Br family of cell cycle regulatory proteins as chemotherapeutic drug targets in human cancer: Z.J. Zang, et al.; (ahead of print), (2007)
General Information
TRIP-Br1 [SEI-1] functions as physiological integrator of transcriptional regulatory signals at E2F-responsive promoters to ensure proper execution of E2F-dependent cell cycle progression. TRIP-Br1 was recently defined as an oncogene.
General Literature References
RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A: J.M. Cho, et al.; Nucl. Acids Res. 28, 3478 (2000) Abstract; Full Text
TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1: S.I. Hsu, et al.; EMBO J. 20, 2273 (2001) Abstract; Full Text
The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus: S. Calgaro, et al.; Genetics 160, 547 (2002) Abstract; Full Text
Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP: T. Hirose, et al.; Int. J. Mol. Med. 11, 705 (2003) Abstract
TRIP-Br links E2F to novel functions in the regulation of cyclin E expression during cell cycle progression and in the maintenance of genomic stability: K.G. Sim, et al.; Cell Cycle 3, 1296 (2004) Abstract
The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner: J. Li, et al.; Biochemistry 43, 4394 (2004) Abstract
Expression of a human SOCS protein, HSOCP-1, in peripheral blood eosinophils from patients with atopic dermatitis: K. Ogawa, et al.; Int. Arch. Allergy Immunol. 134 Suppl 1, 2 (2004) Abstract
Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A): J. Li, et al.; Biochemistry 44, 13246 (2005) Abstract
SEI family of nuclear factors regulates p53-dependent transcriptional activation: R. Watanabe-Fukunaga, et al.; Genes Cells 10, 851 (2005) Abstract; Full Text
CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation: R. Hayashi, et al.; J. Biol. Chem. 281, 35633 (2006) Abstract; Full Text
Further Categories Containing This Product:
Tumor Suppressors/Related Products • Monoclonal Antibodies • Transcription Regulators Other Products
 
 
ALX-350-054 Revised 23-Oct-07
Olomoucine, Dimethylamino-
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SYNONYMS 6-Benzylamino-2-(2-dimethyl aminoethyl)amino-9-methylpurine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-350-054-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C17H23N7
MW: 325.4
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Negative control for olomoucine (Prod. No. ALX-350-013).
Product Specific Literature References
The clam 3’ UTR masking element-binding protein p82 is a member of the CPEB family: J. Walker, et al.; RNA 5, 14 (1999) Abstract
Further Categories Containing This Product:
CDKs & Cyclins Other Products
 
 
ALX-350-090 Revised 10-Mar-08
Olomoucine, Iso-
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SYNONYMS 6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-350-090-M005   5 mg 70.00 USD Add To Cart
ALX-350-090-M025   25 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C15H18N6O
MW: 298.4
CAS NUMBER: 101622-50-8
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inactive negative control for use in studies involving olomoucine (Prod. No. ALX-350-013).
Product Specific Literature References
Inhibition of cyclin-dependent kinases by purine analogues: J. Vesely, et al.; Eur. J. Biochem. 224, 771 (1994) Abstract
The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker: N.A. Krucher, et al.; Cell. Mol. Neurobiol. 17, 495 (1997) Abstract
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity: F. Alessi, et al.; Exp. Cell Res. 245, 8 (1998) Abstract
Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine: J.R. Taylor, et al.; PNAS 104, 4147 (2007) Abstract
Further Categories Containing This Product:
CDKs & Cyclins Other Products
 
 
ALX-165-018 Revised 09-Dec-04
Protein Kinase p34cdc2 Substrate
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDKs & Cyclins Other Products
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ALX-165-018-M001   1 mg 130.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ala-Asp-Ala-Gln-His-Ala-Thr-Pro-Pro-Lys-Lys-Lys-Arg-Lys-Val-Glu-Asp-Pro-Lys-Asp-Phe-OH
FORMULA: C106H172N32O32
MW: 2406.7
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Highly specific substrate for p34cdc2 protein kinase, an enzyme involved in mitosis and onset of the S phase.
Product Specific Literature References
Characterization of synthetic peptide substrates for p34cdc2 protein kinase: D.R. Marshak, et al.; J. Cell. Biochem. 45, 391 (1991) Abstract
Further Categories Containing This Product:
Peptides
 
 
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