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ALX-850-039
Revised 20-Dec-07
Cell Counting Kit-8
SYNONYMS
CCKi-8
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Cell Proliferation & Cytotoxicity Assays
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-039-KI01
500 tests
150.00 USD
ALX-850-039-KI02
5x500 tests
450.00 USD
Product Specification
QUANTITY:
500 tests/5ml; 2500 tests/5 x 5ml.
KIT/SET CONTAINS:
5mM WST-8 solution, 0.2mM 1-methoxy-PMS, 150mM sodium chloride.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. Protect from light.
Product Images
Please click on thumbnails to enlarge.
Product Description
Colorimetric kit for simple and accurate cell proliferation and cytotoxicity assays.
Advantages:
One-step, ready-to-use solution, no radioisotopes, no solubilization step, high sensitivity, correlates with the [
3
H]-thymidine incorporation assay. Can be added directly to the cell media for fast, high-throughput screening without a solubilization process obtaining highly reproducible and accurate results.
Product Specific Literature References
A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet:
M. Ishiyama, et al.; Biol. Pharm. Bull.
19
, 1518 (1996)
Abstract
Antenatal hydronephrosis. Fetal and neonatal management:
J.S. Elder; Pediatr. Clin. North Am.
44
, 1299 (1997)
Abstract
A highly water-soluble disulfonated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability:
M. Ishiyama, et al.; Talanta
44
, 1299 (1997)
Enhancement of MTT, a tetrazolium salt, exocytosis by amyloid beta- protein and chloroquine in cultured rat astrocytes:
I. Isobe, et al.; Neurosci. Lett.
266
, 129 (1999)
Abstract
A water-soluble tetrazolium salt useful for colorimetric cell viability assay
:
H. Tominaga, et al.; Anal. Commun.
36
, 47 (1999)
Increased cytotoxicity of cadmium in fibroblasts lacking c-fos:
M. Matsuoka, et al.; Biochem. Pharmacol.
59
, 1573 (2000)
Abstract
Mitogen-activated protein kinases mediate peroxynitrite-induced cell death in human bronchial epithelial cells:
E. Nabeyrat, et al.; Am. J. Physiol. Lung Cell. Mol. Physiol.
284
, L1112 (2003)
Abstract
;
Full Text
Cyclin G2 dysregulation in human oral cancer:
Y. Kim, et al.; Cancer Res.
64
, 8980 (2004)
Abstract
;
Full Text
Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect:
Y. Kim, et al.; J. Biol. Chem.
280
, 23273 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Kits Other Products
ALX-850-245
Revised 03-Feb-05
Cell Counting Kit-F
SYNONYMS
CCKi-F
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Cell Proliferation & Cytotoxicity Assays
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-245-KI01
500 tests
215.00 USD
ALX-850-245-KI02
5x500 tests
790.00 USD
Product Specification
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Fluorometric kit for simple and accurate cell proliferation and cytotoxicity assays.
Advantages:
No radioisotopes, more sensitive than the colorimetric assay, short staining reaction time, no solubilization step, correlates with the [
3
H]-thymidine incorporation assay.
Further Categories Containing This Product:
Kits Other Products
ALX-270-391
Revised 18-Jul-07
CGP 74514A
SYNONYMS
N-(
cis
-
2-Aminocyclohexyl)-N-(3-chlorophenyl)-9-ethyl-9
H
-purine-2,6-diamine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-391-M001
1 mg
35.00 USD
ALX-270-391-M005
5 mg
70.00 USD
ALX-270-391-M025
25 mg
280.00 USD
Product Specification
FORMULA:
C
19
H
24
ClN
7
MW:
385.9
PURITY:
≥95%
APPEARANCE:
White to yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Packaged under inert gas.
Product Description
Cell permeable, potent and selective inhibitor of CDK1/cyclin B (IC
50
=25nM). Reported to affect the activities of other kinases only at much higher concentrations: PKCα (IC
50
=6.1µM), PKA (IC
50
=125µM) and EGFR (IC
50
>10µM). Induces mitochondrial damage and apoptosis in several human leukemia cell lines (>3µM).
Product Specific Literature References
2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors
:
P. Imbach, et al.; Bioorg. Med. Chem. Lett.
9
, 91 (1999)
Abstract
The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process
:
C. Yu, et al.; Cancer Res.
63
, 1822 (2003)
Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
ALX-270-392
Revised 08-Dec-04
3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-392-M001
1 mg
35.00 USD
ALX-270-392-M005
5 mg
130.00 USD
Product Specification
FORMULA:
C
17
H
11
ClN
2
O
MW:
294.7
PURITY:
≥95% (HPLC)
APPEARANCE:
Yellow to orange solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable for 3 years after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. Protect from light.
Product Description
Selective, ATP-competitive inhibitor of CDK1/cyclin B (IC
50
=5.8µM) and CDK5 (IC
50
=25µM). Does not inhibit GSK-3β (IC
50
>100µM). Exhibits potent antiproliferative properties (IC
50
=2µM in HeLa cells).
Product Specific Literature References
Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones
:
A. Andreani, et al.; Anticancer Res.
16
, 3585 (1996)
Abstract
Imidazo[2,1 -b]thiazolylmethylene- and indolylmethylene-2-indolinones: a new class of cyclin-dependent kinase inhibitors. Design, synthesis, and CDK1/cyclin B inhibition
:
A. Andreani, et al.; Anticancer Drug Des.
15
, 447 (2000)
Abstract
Further Categories Containing This Product:
Antitumor Agents (Anti-proliferative)
•
Antitumor Agents (Enzyme Inhibitors)
ALX-270-437
Revised 04-Jun-08
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Sirtuins/Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-270-437-M001
1 mg
110.00 USD
Product Specification
FORMULA:
C
13
H
13
ClN
2
O
MW:
248.7
CAS NUMBER:
49843-98-3
PURITY:
≥95%
APPEARANCE:
White to beige powder.
SOLUBILITY:
Soluble in DMSO (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months when stored at -20°C in the dark.
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Specific cell permeable inhibitor. Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC
50
=98nM
in vivo
/ IC
50
=38nM
in vitro
; compared to hSIRT2: IC
50
=19µM and hSIRT3: IC
50
=48µM) with no effect on human histone deacetylases (HDACs) class I and class II, nor NAD glycohydrolase (IC
50
>100µg). Inhibits the deacetylation of p53 (IC
50
=1µM).
Product Specific Literature References
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1:
A.D. Napper, et al.; J. Med. Chem.
48
, 8045 (2005)
Abstract
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes:
J.C. Milne, et al.; Nature
450
, 712 (2007)
Abstract
Further Categories Containing This Product:
p53 Other Products
AG-CC06H2
Revised 11-Jan-08
Clusterin (human) Competitive ELISA Kit
SYNONYMS
TRPM-2 (human) Competitive ELISA Kit
Apolipoprotein J (human) Competitive ELISA Kit
APO-J (human) Competitive ELISA Kit
CLI (human) Competitive ELISA Kit
CLU (human) Competitive ELISA Kit
SGP-2 (human) Competitive ELISA Kit
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Clusterin/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
AG-CC06H2EK-KI01
96 wells
550.00 USD
AG-CC06H2PP-KI01
Penta Plex
5x96 wells
1'870.00 USD
AG-CC06H2TP-KI01
Twin Plex
2x96 wells
890.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY:
1ng/ml
APPLICATION:
For the quantitative determination of clusterin in human serum, plasma or cell culture supernatant.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
ELISA & EIA Kits
ALX-201-355
Revised 18-Mar-08
Clusterin (nuclear form) (human) (recombinant) (His)
SYNONYMS
TRPM-2 (nuclear form) (human) (recombinant) (His)
Apolipoprotein J (nuclear form) (human) (recombinant) (His)
APO-J (nuclear form) (human) (recombinant) (His)
CLI (nuclear form) (human) (recombinant) (His)
CLU (nuclear form) (human) (recombinant) (His)
SGP-2 (nuclear form) (human) (recombinant) (His)
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Clusterin/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-355-C050
50 µg
395.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
. Mature human nuclear clusterin (aa 23-449) is fused at the C-terminus to a His-tag.
CONCENTRATION:
1mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT:
<1EU/µg protein (LAL-test).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P10909:
Clusterin (human) [Precursor]
MANUFACTURER
Manufactured by AdipoGen, Inc.
General Literature References
Inhibition of post-ischemic brain injury by clusterin overexpression:
P. Wehrli, et al.; Nat. Med.
7
, 977 (2001)
Abstract
Clusterin/apolipoprotein J in human aging and cancer:
I.P. Trougakos and E.S. Gonos; Int. J. Biochem. Cell Biol.
34
, 1430 (2002)
Abstract
Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer:
B. Shannan, et al.; Cell Death Differ.
13
, 12 (2006)
Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
ALX-201-365
Revised 18-Mar-08
Clusterin (nuclear form) (mouse) (recombinant) (His)
SYNONYMS
TRPM-2 (nuclear form) (mouse) (recombinant) (His)
Apolipoprotein J (nuclear form) (mouse) (recombinant) (His)
APO-J (nuclear form) (mouse) (recombinant) (His)
CLI (nuclear form) (mouse) (recombinant) (His)
CLU (nuclear form) (mouse) (recombinant) (His)
SGP-2 (nuclear form) (mouse) (recombinant) (His)
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Clusterin/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-201-365-C050
50 µg
395.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
. Mature mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.
CONCENTRATION:
1mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT:
<1EU/µg protein (LAL-test).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q549A5:
Clusterin (mouse) [Precursor]
MANUFACTURER
Manufactured by AdipoGen, Inc.
General Literature References
Inhibition of post-ischemic brain injury by clusterin overexpression:
P. Wehrli, et al.; Nat. Med.
7
, 977 (2001)
Abstract
Clusterin/apolipoprotein J in human aging and cancer:
I.P. Trougakos and E.S. Gonos; Int. J. Biochem. Cell Biol.
34
, 1430 (2002)
Abstract
Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer:
B. Shannan, et al.; Cell Death Differ.
13
, 12 (2006)
Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
ALX-201-358
Revised 18-Mar-08
Clusterin (secretory form) (human) (recombinant)
SYNONYMS
TRPM-2 (secretory form) (human) (recombinant)
Apolipoprotein J (secretory form) (human) (recombinant)
APO-J (secretory form) (human) (recombinant)
CLI (secretory form) (human) (recombinant)
CLU (secretory form) (human) (recombinant)
SGP-2 (secretory form) (human) (recombinant)
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Clusterin/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-358-C010
10 µg
230.00 USD
ALX-201-358-C050
50 µg
480.00 USD
Product Specification
SOURCE/HOST:
Produced in HEK 293 cells. The signal peptide sequence and the mature human secretory clusterin (aa 1-449) is fused at the C-terminus to a FLAG
®
-tag.
CONCENTRATION:
0.5mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2 µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT:
<0.1EU/µg protein (LAL-test).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P10909:
Clusterin (human) [Precursor]
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
ALX-270-248
Revised 17-Jul-07
Compound 52
SYNONYMS
2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-248-M001
1 mg
55.00 USD
Product Specification
FORMULA:
C
16
H
19
ClN
6
O
MW:
346.8
PURITY:
≥99%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent, cell permeable and selective inhibitor of CDK1 (IC
50
=340nM) the cell cycle-regulating kinase Cdc28p (IC
50
=7µM) and the related Pho85p kinase (IC
50
=2µM).
Product Specific Literature References
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors:
N.S. Gray, et al.; Science
281
, 533 (1998)
Abstract
ALX-550-516
Revised 21-May-08
Compound A
