ALEXIS Biochemicals: Trifluoperazine . dihydrochloride

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ALX-350-016

Revised 31-Jul-08

(+)-Aphidicolin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Cell Cycle Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-016-M001		1 mg	65.00 USD
ALX-350-016-M005		5 mg	260.00 USD
ALX-350-016-M025		25 mg	890.00 USD

Product Specification

FORMULA:	C₂₀H₃₄O₄
MW:	338.5
CAS NUMBER:	38966-21-1
MERCK INDEX:	14: 727
RTECS:	PB9185000
SOURCE/HOST:	Isolated from Nigrospora oryzae.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (50mg/ml), methanol (10mg/ml) or 100% ethanol; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at early S phase. Prolongs the half life of DNA methyltransferase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer.

Product Specific Literature References

X-Ray crystallographic determination of the structure of the antibiotic aphidicolin: a tetracyclic diterpenoid containing a new ring system: K.M. Brundret, et al.; J. C. S. Chem. Commun. 1027 (1972)
The production of aphidicolin by Nigrospora sphaerica: A.N. Starratt and S.R Loschiavo; Can. J. Microbiol. 20, 416 (1974)
Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha: S. Ikegami, et al.; Nature 275, 458 (1978) Abstract
Inhibition by aphidicolin of cell cycle progression and DNA replication in sea urchin embryos: S. Ikegami, et al.; J. Cell. Physiol. 100, 439 (1979) Abstract
New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha: J.A. Huberman; Cell 23, 647 (1981) Abstract
Aphidicolin: a specific inhibitor of nuclear DNA replication in eukaryotes: S. Spadari, et al.; TIBS 7, 29 (1982)
Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in human myeloid leukemia cell lines: K. Kuwakado, et al.; Biochem. Pharmacol. 46, 1909 (1993) Abstract
Life, death and genomic change in perturbed cell cycles: R.T. Schimke, et al.; Philos. Trans. R. Soc. London B Biol. Sci. 345, 311 (1994) Abstract
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization: L. Urbani, et al.; Exp. Cell. Res. 219, 159 (1995) Abstract
Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3: M.M. Borner, et al.; Cancer Res. 55, 2122 (1995) Abstract
TrkA neurogenic receptor regulates differentiation of neuroblastoma cells: W. Poluha, et al.; Oncogene 10, 185 (1995) Abstract
Coordinate regulation of G- and C strand length during new telomere synthesis: X. Fan and C.M. Price; Mol. Biol. Cell 8, 2145 (1997) Abstract; Full Text
Effect of aphidicolin on DNA methyltransferase in the nucleus: I. Suetake, et al.; Cell Struct. Funct. 23, 137 (1998) Abstract
Cytotoxicity of aphidicolin and its derivatives against neuroblastoma cells in vitro: synergism with doxorubicin and vincristine: M. Michaelis, et al.; Anticancer Drugs 11, 479 (2000) Abstract
Aphidicolin and bleomycin induced chromosome damage as biomarker of mutagen sensitivity: a twin study: B. Tedeschi, et al.; Mutat. Res. 546, 55 (2004) Abstract

Further Categories Containing This Product:

Cell Cycle Blockers & Inhibitors/Related Products • Natural Products - Other Tumor Promoters • DNA Replication Inhibitors • Carcinogens & Tumor Promoters Other Products • Natural Products - DNA Replication Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors

ALX-380-089

Revised 29-Jul-08

Blasticidin S . hydrochloride
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - DNA Replication Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-089-M100		100 mg	280.00 USD

Product Specification

FORMULA:	C₁₇H₂₆N₈O₅. HCl
MW:	422.4 . 36.5
CAS NUMBER:	3513-03-9
MERCK INDEX:	14: 1316
SOURCE/HOST:	Isolated from Streptomyces griseochromogenes.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water; insoluble in organic solvents.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from moisture.
HAZARD:	VERY TOXIC.

Product Description

Antibiotic. Inhibitor of DNA and protein synthesis.

Product Specific Literature References

Blasticidin S, a new antibiotic: S. Takeuchi, et al.; J. Antibiot. (Tokyo) 11, 1 (1958) Abstract
The blasticidin S resistance gene (bsr) selectable in a single copy state in the Bacillus subtilis chromosome: M. Itaya, et al.; J. Biochem. 107, 799 (1990) Abstract
Cloning and characterization of the gene encoding a blasticidin S acetyltransferase from Streptoverticillum sp: J.A. Perez-Gonzalez, et al.; Gene 86, 129 (1990) Abstract
Blasticidin S-resistance gene (bsr): a novel selectable marker for mammalian cells: M. Izumi, et al.; Exp. Cell Res. 197, 229 (1991) Abstract
Cloning of the blasticidin S deaminase gene (BSD) from Aspergillus terreus and its use as a selectable marker for Schizosaccharomyces pombe and Pyricularia oryzae: M. Kimura, et al.; Mol. Gen. Genet. 242, 121 (1994) Abstract
Blasticidin S deaminase gene from Aspergillus terreus (BSD): a new drug resistance gene for transfection of mammalian cells: M. Kimura, et al.; Biochim. Biophys. Acta 1219, 653 (1994) Abstract

Further Categories Containing This Product:

DNA Replication Inhibitors • Antibiotics - Antifungal • Reporter Gene Markers/Related Products • Translation Inhibitors

ALX-270-286

Revised 18-Sep-07

C75
SYNONYMS	trans-4-Carboxy-5-octyl-3-methylene-butyrolactone
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Fatty Acid Synthase [FAS]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-286-M001		1 mg	65.00 USD
ALX-270-286-M005		5 mg	240.00 USD

Product Specification

FORMULA:	C₁₄H₂₂O₄
MW:	254.3
CAS NUMBER:	191282-48-1
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in dichloromethane, methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	HARMFUL.

Product Description

Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of fatty acid synthase. Downregulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant in vivo antitumor activity in human breast cancer cells. Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to a dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.

Product Specific Literature References

Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines: E.S. Pizer, et al.; Cancer Res. 58, 4611 (1998) Abstract
Synthesis and antitumor activity of an inhibitor of fatty acid synthase: F.P. Kuhajda, et al.; PNAS 97, 3450 (2000) Abstract
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors: T.M. Loftus, et al.; Science 288, 2379 (2000) Abstract
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts: E.S. Pizer, et al.; Cancer Res. 60, 213 (2000) Abstract
Increased fatty acid synthase is a therapeutic target in mesothelioma: E.W. Gabrielson, et al.; Clin. Cancer Res. 7, 153 (2001) Abstract
Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53: J.N. Li, et al.; Cancer Res. 61, 1493 (2001) Abstract
Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase: X. Wang & W. Tian; BBRC 288, 1200 (2001) Abstract
Comparison of central and peripheral administration of c75 on food intake, body weight, and conditioned taste aversion: D.J. Clegg, et al.; Diabetes 51, 3196 (2002) Abstract
Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment: E.K. Kim, et al.; Am. J. Physiol. Endocrinol. Metab. 283, E867 (2002) Abstract
Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice: M.V. Kumar, et al.; PNAS 99, 1921 (2002) Abstract; Full Text
Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides: T. Shimokawa, et al.; PNAS 99, 66 (2002) Abstract
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity: J.N. Thupari, et al.; PNAS 99, 9498 (2002) Abstract
Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem: S. Gao and M.D. Lane; PNAS 100, 10 (2003) Abstract
Hypothalamic malonyl-CoA as a mediator of feeding behavior: Z. Hu, et al.; PNAS 100, 12624 (2003) Abstract
C75 inhibits food intake by increasing CNS glucose metabolism: M.D. Wortman, et al.; Nat. Med. 9, 483 (2003) Abstract
Fatty Acid Synthase Inhibition Triggers Apoptosis during S Phase in Human Cancer Cells: W. Zhou, et al.; Cancer Res. 63, 7330 (2003) Abstract
Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides, and UCP3: S.H. Cha, et al.; BBRC 317, 301 (2004) Abstract
C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism: L.E. Landree, et al.; J. Biol. Chem. 279, 3817 (2004) Abstract
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells: J.A. Menendez, et al.; Oncogene 23, 4945 (2004) Abstract
C75 activates malonyl-CoA sensitive and insensitive components of the CPT system: C. Nicot, et al.; BBRC 325, 660 (2004) Abstract
The anorexigenic fatty acid synthase inhibitor, C75, is a non-specific neuronal activator: K.A. Takahashi, et al.; Endocrinology 145, 184 (2004) Abstract

Further Categories Containing This Product:

Antitumor Agents (Enzyme Activators & Inducers) • Apoptosis Inducers & Inhibitors Other Products • DNA Replication Inhibitors • Antitumor Agents (DNA Interaction & Gene Regulation)

ALX-350-092

Revised 03-Apr-08

Emetine . dihydrochloride
SYNONYMS	6’,7’,10,11-Tetramethoxyemetan . 2HCl
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - DNA Replication Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-092-M050		50 mg	10.00 USD

Product Specification

FORMULA:	C₂₉H₄₀N₂O₄ . 2HCl
MW:	480.7 . 73.0
CAS NUMBER:	316-42-7
MERCK INDEX:	14: 3559
SOURCE/HOST:	Isolated from ground roots of Uragoga ipecacuanha.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light. Hygroscopic.
HAZARD:	TOXIC.

Product Description

Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Antiamebic.

Product Specific Literature References

Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells: A.P. Grollman; J. Biol. Chem. 243, 4089 (1968) Abstract
Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A:: A: T. Schweighoffer, et al.; Histochemistry 96, 93 (1991) Abstract
Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation: W.C. Burhans, et al.; EMBO J. 10, 4351 (1991) Abstract
Role of newly synthesized MHC class II molecules in antigen-specific antigen presentation by B cells: T. Kokuho, et al.; Immunobiology 193, 42 (1995) Abstract
Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells: Y.D. Zhou, et al.; J. Nat. Prod. 68, 947 (2005) Abstract
The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells: M. Moller, et al.; Oncol. Rep. 18, 737 (2007) Abstract
Characteristics of apoptosis induction by the alkaloid emetine in human tumour cell lines: M. Moller & M. Wink; Planta Med. 73, 1389 (2007) Abstract

Further Categories Containing This Product:

Other Toxins • Hypoxia-inducible Factor [HIF]/Related Products • Alkaloids • Parasitic Diseases Other Products • Adrenergics & Adrenergic Receptors/Related Products • DNA Replication Inhibitors • Translation Inhibitors • Natural Products - Other Anti-infective Agents • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products for Neurological Research

ALX-440-045

Revised 17-Jul-07

Methotrexate
SYNONYMS	(+)-Amethopterin 4-Amino-10-methylfolic acid Methylaminopterin MTX
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Agents (Enzyme Inhibitors)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-440-045-M050		50 mg	25.00 USD
ALX-440-045-M100		100 mg	45.00 USD
ALX-440-045-M500		500 mg	135.00 USD
ALX-440-045-G001		1 g	240.00 USD

Product Specification

FORMULA:	C₂₀H₂₂N₈O₅
MW:	454.5
CAS NUMBER:	59-05-2
MERCK INDEX:	14: 5985
PURITY:	≥98%
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in alkaline solution; insoluble in water, 100% ethanol or ether.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	TOXIC. MAY BE CARCINOGENIC. MAY BE TERATOGENIC.

Product Description

Folic acid antagonist. Potent inhibitor of dihydrofolate reductase. Induces apoptosis. Inhibits DNA synthesis. Anticancer agent.

Product Specific Literature References

Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells: L. Genestier, et al.; J. Clin. Invest. 102, 322 (1998) Abstract
Methotrexate induces apoptotic cell death in human keratinocytes: M. Heenen, et al.; Arch. Dermatol. Res. 290, 240 (1998) Abstract
Activation-dependent lymphocyte apoptosis induced by methotrexate: R. Paillot, et al.; Transplant. Proc. 30, 2348 (1998) Abstract
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?: L.D. Fairbanks, et al.; Biochem. J. 342, 143 (1999) Abstract
Antiproliferative and antiinflammatory effects of methotrexate on cultured differentiating myeloid monocytic cells (THP-1) but not on synovial macrophages from patients with rheumatoid arthritis: M. Cutolo, et al.; J. Rheumatol. 27, 2551 (2000) Abstract
Mechanisms of action of methotrexate: L. Genestier, et al.; Immunopharmacology 47, 247 (2000) Abstract

Further Categories Containing This Product:

Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Agents (Apoptosis Inducers) • MDR Other Products • DNA Replication Inhibitors • Folic Acid & Folate Receptors/Related Products

ALX-380-023

Revised 19-Oct-07

Mitomycin C
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - DNA Replication Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-023-M005		5 mg	98.00 USD
ALX-380-023-M010		10 mg	185.00 USD

Product Specification

FORMULA:	C₁₅H₁₈N₄O₅
MW:	334.3
CAS NUMBER:	50-07-7
MERCK INDEX:	14: 6215
RTECS:	CN0700000
SOURCE/HOST:	Isolated from Streptomyces caespitosus.
PURITY:	≥98%
APPEARANCE:	Blue-violet crystals.
SOLUBILITY:	Soluble in water or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	TOXIC. MAY BE CARCINOGENIC.

Product Description

Antitumor antibiotic. Inhibitor of DNA synthesis, nuclear division and cancer cells. DNA intercalating agent. Apoptosis inducer.

Product Specific Literature References

Mitomycin, a new antibiotic from Streptomyces. I: T. Hata, et al.; J. Antibiot. (Tokyo) 9, 141 (1956) Abstract
S.K. Carter & S.T. Crooke ; 'Mitomycin C. Current Status and New Developments', Academic Press, New York (1979)
Revised absolute configuration of mitomycin C. X-ray analysis of 1-N-(p-bromobenzoyl)mitomycin C: K. Shirahata & N. Hirayama; JACS 105, 7199 (1983)
Sequence-specific DNA damage induced by reduced mitomycin C and 7-N-(p- hydroxyphenyl)mitomycin C: K. Ueda and T. Komano; Nucl. Acids Res. 12, 6673 (1984) Abstract
Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA: M. Tomasz, et al.; Science 235, 1204 (1987) Abstract
The chemistry of DNA modification by antitumor antibiotics: J.F. Fisher & P.A. Aristoff; Prog. Drug Res. 32, 411 (1988) Abstract
DNA sequence specificity of mitomycin cross-linking: S.P. Teng, et al.; Biochemistry 28, 3901 (1989) Abstract
Polyoxyethylene-modified superoxide dismutase reduces side effects of adriamycin and mitomycin C: S. Kawasaki, et al.; J. Cancer Res. 83, 899 (1992) Abstract
Genetic evidence for an activator required for induction of pectin lyase in Erwinia carotovora subsp. carotovora by DNA-damaging agents: J.L. McEvoy, et al.; J. Bacteriol. 174, 5471 (1992) Abstract
Elevated DT-diaphorase activity and messenger RNA content in human non- small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cl: A.M. Malkinson, et al.; Cancer Res. 52, 4752 (1992) Abstract
Mitomycins: J. Verweij, et al.; Cancer Chemother. Biol. Response Modif. 18, 46 (1999) Abstract
Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95- independent manner in human gastric adenocarcinoma cells: I.C. Park, et al.; Cancer Lett. 158, 125 (2000) Abstract
Selective inhibition of cyclooxygenase-2 enhances mitomycin-C-induced apoptosis: C.T. Hsueh, et al.; Cancer Chemother. Pharmacol. 45, 389 (2000) Abstract
DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling: A.R. Tee & C.G. Proud; Oncogene 19, 3021 (2000) Abstract
Re-evaluation of tumor-specific cytotoxicity of mitomycin C, bleomycin and peplomycin: M. Sasaki, et al.; Anticancer Res. 26, 3373 (2006) Abstract
Activation of the S phase DNA damage checkpoint by mitomycin C: E. Mladenov, et al.; J. Cell. Physiol. 211, 468 (2007) Abstract

Further Categories Containing This Product:

DNA Replication Inhibitors • Antitumor Agents (Apoptosis Inducers) • Antitumor Antibiotics • Antibiotics - Apoptosis Inducers & Inhibitors • Antitumor Agents (DNA Interaction & Gene Regulation)

ALX-350-146

Revised 03-Oct-07

Neobavaisoflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-146-M001		1 mg	170.00 USD

Product Specification

FORMULA:	C₂₀H₁₈O₄
MW:	322.4
CAS NUMBER:	41060-15-5
SOURCE/HOST:	Isolated from plant Psoralea corylifolia.
PURITY:	≥97% (HPLC)
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
IDENTITY:	Determined by ¹H-NMR, ¹³C-NMR and MS.

Product Description

Inhibits platelet aggregation. DNA polymerase inhibitor. Shows antifungal activity.

Product Specific Literature References

Prenylated isoflavanone from the roots of Erythrina sigmoidea: A.E. Nkengfack, et al.; Phytochemistry 36, 1047 (1994) Abstract
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998) Abstract
Studies on the chemical constituents of Psoralea corylifolia L.: B. Ruan, et al.; J. Asian Nat. Prod. Res. 9, 41 (2007) Abstract

Further Categories Containing This Product:

Natural Products - Topoisomerase Inhibitors • Natural Products - DNA Replication Inhibitors • DNA Replication Inhibitors • Natural Products - Antifungal Agents • Flavonoids/Related Products

ALX-630-116

Revised 15-Aug-08

Sterigmatocystin
SYNONYMS	3a,12c-Dihydro-8-hydroxy-6-methoxy-7H-furol[3’,2’:4,5]furo[2,3-c]xanthen-7-one
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Mycotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-630-116-M001		1 mg	35.00 USD
ALX-630-116-M005		5 mg	120.00 USD

Product Specification

FORMULA:	C₁₈H₁₂O₆
MW:	324.3
CAS NUMBER:	10048-13-2
RTECS:	LV1750000
SOURCE/HOST:	Isolated from Aspergillus versicolor.
PURITY:	≥98% (TLC, HPLC)
APPEARANCE:	Pale yellow solid.
SOLUBILITY:	Soluble in DMSO, 100% ethanol, methanol or acetone.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC. MAY BE CARCINOGENIC.

Product Description

Mycotoxin produced by strains of the common molds. Inhibitor of DNA synthesis. Induces sister chromatid exchanges in bone marrow cells of mice. Causes necrosis.

Product Specific Literature References

Effect of sterigmatocystin on rat liver nuclear RNA: W. Nel & H.E. Pretorius; Biochem. Pharmacol. 19, 957 (1970) Abstract
Massive and single cell necrosis in the rat liver induced by aflatoxin B1 and sterigmatocystin: K. Terao; Acta Pathol. Jpn. 23, 647 (1973) Abstract
Induction of sister-chromatid exchanges in vivo in mice by the mycotoxins sterigmatocystin and griseofulvin: P.T. Curry, et al.; Mutat. Res. 137, 111 (1984) Abstract
Cytotoxicity of occupationally and environmentally relevant mycotoxins: J. Bünger, et al.; Toxicology 202, 199 (2004) Abstract
An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin: K.C. Ehrlich, et al.; Appl. Environ. Microbiol. 71, 8963 (2005) Abstract; Full Text
Aspergillus mycotoxins and their effect on the host: K. Kamei & A. Watanabe; Med. Mycol. 43, S95 (2005) Abstract
A novel biosensor for sterigmatocystin constructed by multi-walled carbon nanotubes (MWNT) modified with aflatoxin-detoxifizyme (ADTZ): D.S. Yao, et al.; Bioelectrochemistry 68, 126 (2006) Abstract

Further Categories Containing This Product:

DNA Replication Inhibitors • Non-apoptotic Cell Death/Necrosis

ALX-550-310

Revised 03-Jun-08

Trifluoperazine . dihydrochloride
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Calmodulin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-310-G001		1 g	20.00 USD
ALX-550-310-G005		5 g	75.00 USD

Product Specification

FORMULA:	C₂₁H₂₄F₃N₃S . 2HCl
MW:	407.5 . 73.0
CAS NUMBER:	440-17-5
MERCK INDEX:	14: 9680
RTECS:	SP1750000
PURITY:	≥99%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light and moisture.
HAZARD:	HARMFUL.

Product Description

Calmodulin inhibitor. Antipsychotic and sedative dopamine antagonist. Potent and irreversible inhibitor of cAMP-gated cationic channels. Inhibits DNA repair. Potent neurotoxin.

Product Specific Literature References

New drug evaluations amiloride (Midamor, Merck, Sharp and Dohme): H.L. Macfie, et al.; Drug Intel. Clin. Pharm. 15, 94 (1981) Abstract
Trifluoperazine binding to porcine brain calmodulin and skeletal muscle troponin C: J. Massom, et al.; Biochemistry 29, 671 (1990) Abstract
Inhibition of olfactory cyclic nucleotide-activated c