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Translation Inhibitors
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ALX-430-155 Revised 16-Nov-07
4EGI-1
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SYNONYMS α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Translation Inhibitors
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ALX-430-155-M002   2 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C18H12Cl2N4O4S
MW: 451.3
CAS NUMBER: 315706-13-9
PURITY: ≥95%
APPEARANCE: Brown solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Selective and cell permeable inhibitor of the interaction between the human eukaryotic translation initiation factors 4E (eIF4E) and 4G (eIF4G).
Product Specific Literature References
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G: N.J. Moerke, et al.; Cell 128, 257 (2007) Abstract
 
 
ALX-380-089 Revised 29-Jul-08
Blasticidin S . hydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - DNA Replication Inhibitors
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ALX-380-089-M100   100 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C17H26N8O5 . HCl
MW: 422.4 . 36.5
CAS NUMBER: 3513-03-9
MERCK INDEX: 14: 1316
SOURCE/HOST: Isolated from Streptomyces griseochromogenes.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water; insoluble in organic solvents.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.
HAZARD: VERY TOXIC.

Product Description
Antibiotic. Inhibitor of DNA and protein synthesis.
Product Specific Literature References
Blasticidin S, a new antibiotic: S. Takeuchi, et al.; J. Antibiot. (Tokyo) 11, 1 (1958) Abstract
The blasticidin S resistance gene (bsr) selectable in a single copy state in the Bacillus subtilis chromosome: M. Itaya, et al.; J. Biochem. 107, 799 (1990) Abstract
Cloning and characterization of the gene encoding a blasticidin S acetyltransferase from Streptoverticillum sp: J.A. Perez-Gonzalez, et al.; Gene 86, 129 (1990) Abstract
Blasticidin S-resistance gene (bsr): a novel selectable marker for mammalian cells: M. Izumi, et al.; Exp. Cell Res. 197, 229 (1991) Abstract
Cloning of the blasticidin S deaminase gene (BSD) from Aspergillus terreus and its use as a selectable marker for Schizosaccharomyces pombe and Pyricularia oryzae: M. Kimura, et al.; Mol. Gen. Genet. 242, 121 (1994) Abstract
Blasticidin S deaminase gene from Aspergillus terreus (BSD): a new drug resistance gene for transfection of mammalian cells: M. Kimura, et al.; Biochim. Biophys. Acta 1219, 653 (1994) Abstract
Further Categories Containing This Product:
Reporter Gene Markers / Related Products • Translation Inhibitors • Antibiotics - Antifungal • DNA Replication Inhibitors
 
 
ALX-630-115 Revised 22-May-08
Deoxynivalenol
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SYNONYMS DON
3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one
Vomitoxin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-630-115-M001   1 mg 50.00 USD Add To Cart
ALX-630-115-M005   5 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C15H20O6
MW: 296.3
CAS NUMBER: 51481-10-8
RTECS: YD0167000
SOURCE/HOST: Isolated from Trichoderma viride.
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol or ethyl acetate; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Mycotoxin found in cereals. Binds to the ribosome and inhibits protein synthesis.
Product Specific Literature References
Simultaneous detection of several Fusarium mycotoxins in cereals, grains, and foodstuffs: H. Kamimura, et al.; J. Assoc. Off. Anal. Chem. 64, 1067 (1981) Abstract
Individual and combined effects of low oral doses of deoxynivalenol and nivalenol in mice: M.E. Gouze, et al.; Cell. Mol. Biol. (Noisy-le-grand) 51, OL809 (2005) Abstract
The ability to detoxify the mycotoxin deoxynivalenol colocalizes with a major quantitative trait locus for Fusarium head blight resistance in wheat: M. Lemmens, et al.; Mol. Plant Microbe Interact. 18, 1318 (2005) Abstract
Detection of deoxynivalenol in foods and indoor air using an array biosensor: M.M. Ngundi, et al.; Environ. Sci. Technol. 40, 2352 (2006) Abstract
Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants: J. Pestka & H.R. Zhou; Toxicol. Sci. 92, 445 (2006) Abstract; Full Text
Accumulation of deoxynivalenol and its 15-acetylated form is significantly modulated by oxidative stress in liquid cultures of Fusarium graminearum: N. Ponts, et al.; FEMS Microbiol. Lett. 258, 102 (2006) Abstract
Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes: T. Goyarts, et al.; Toxicol. In Vitro 20, 858 (2006) Abstract
Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations: T. Sergent, et al.; Toxicol. Lett. 164, 167 (2006) Abstract
Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages: Q. Jia, et al.; J. Nutr. 136, 366 (2006) Abstract; Full Text
Effects of feeding deoxynivalenol contaminated wheat on growth performance, organ weights and histological parameters of the intestine of broiler chickens: W.A. Awad, et al.; J. Anim. Physiol. Anim. Nutr. (Berl) 90, 32 (2006) Abstract
The effects of feeding grains naturally contaminated with Fusarium mycotoxins with and without a polymeric glucomannan adsorbent on lactation, serum chemistry, and reproductive performance after weaning of first-parity lactating sows: G. Diaz-Llano & T.K. Smith; J. Anim. Sci. 85, 1412 (2007) Abstract
Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture: M. Königs, et al.; Toxicology 240, 48 (2007) Abstract
Some major mycotoxins and their mycotoxicoses--an overview: J.L. Richard; Int. J. Food Microbiol. 119, 3 (2007), (Review) Abstract
Ribotoxic mycotoxin deoxynivalenol induces G(2)/M cell cycle arrest via p21(Cip/WAF1) mRNA stabilization in human epithelial cells: H. Yang, et al.; Toxicology 243, 145 (2008) Abstract
Further Categories Containing This Product:
Translation Inhibitors
 
 
ALX-350-092 Revised 03-Apr-08
Emetine . dihydrochloride
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SYNONYMS 6’,7’,10,11-Tetramethoxyemetan . 2HCl
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - DNA Replication Inhibitors
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ALX-350-092-M050   50 mg 10.00 USD Add To Cart
Product Specification
FORMULA: C29H40N2O4 . 2HCl
MW: 480.7 . 73.0
CAS NUMBER: 316-42-7
MERCK INDEX: 14: 3559
SOURCE/HOST: Isolated from ground roots of Uragoga ipecacuanha.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Hygroscopic.
HAZARD: TOXIC.

Product Description
Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Antiamebic.
Product Specific Literature References
Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells: A.P. Grollman; J. Biol. Chem. 243, 4089 (1968) Abstract
Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A:: A: T. Schweighoffer, et al.; Histochemistry 96, 93 (1991) Abstract
Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation: W.C. Burhans, et al.; EMBO J. 10, 4351 (1991) Abstract
Role of newly synthesized MHC class II molecules in antigen-specific antigen presentation by B cells: T. Kokuho, et al.; Immunobiology 193, 42 (1995) Abstract
Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells: Y.D. Zhou, et al.; J. Nat. Prod. 68, 947 (2005) Abstract
The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells: M. Moller, et al.; Oncol. Rep. 18, 737 (2007) Abstract
Characteristics of apoptosis induction by the alkaloid emetine in human tumour cell lines: M. Moller & M. Wink; Planta Med. 73, 1389 (2007) Abstract
Further Categories Containing This Product:
Other Toxins • Hypoxia-inducible Factor [HIF] / Related Products • Adrenergics & Adrenergic Receptors / Related Products • Translation Inhibitors • Alkaloids • Natural Products - Other Anti-infective Agents • Parasitic Diseases Other Products • Natural Products for Neurological Research • DNA Replication Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-380-274 Revised 21-May-08
Erythromycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Inflammation Research
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ALX-380-274-G005   5 g 40.00 USD Add To Cart
Product Specification
FORMULA: C37H67NO13
MW: 733.9
CAS NUMBER: 114-07-8
MERCK INDEX: 14: 3681
RTECS: KF4375000
SOURCE/HOST: Isolated from Streptomyces erythreus.
PURITY: ≥85% (Assay on dry basis)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (50mg/ml), 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Macrolide antibiotic. Inhibits protein synthesis (elongation) at the transpeptidation step. Binds to the 23S RNA of the 50S ribosomal subunit. Effective against Gram-negative and Gram-positive bacteria.
Product Specific Literature References
Inducible erythromycin resistance in bacteria: B. Weisblum; Br. Med. Bull. 40, 47 (1984) Abstract
Erythromycin inhibits transcriptional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cells: Y. Aoki & P.N. Kao; Antimicrob. Agents Chemother. 43, 2678 (1999) Abstract; Full Text
Assessment of the potential pharmacokinetic and pharmacodynamic interactions between erythromycin and argatroban: J.Q. Tran, et al.; J. Clin. Pharmacol. 39, 513 (1999) Abstract
Inhibition of the metabolism of brotizolam by erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in brotizolam metabolism: T. Tokairin, et al.; Br. J. Clin. Pharmacol. 60, 172 (2005) Abstract; Full Text
Related Products
Further Categories Containing This Product:
NF-kB Pathway Inhibitors • Anti-inflammatory Agents Other Products • Translation Inhibitors
 
 
ALX-380-060 Revised 11-Jul-08
Tetracycline . hydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics - DNA Regulation / Transcription
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ALX-380-060-G005   5 g 20.00 USD Add To Cart
Product Specification
FORMULA: C22H24N2O8 . HCl
MW: 444.5 . 36.5
CAS NUMBER: 64-75-5
MERCK INDEX: 14: 9196
RTECS: QI9100000
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in water, methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture.
HAZARD: IRRITANT.

Product Description
Broad-spectrum antibiotic with anti-inflammatory activity. Blocks bacterial protein synthesis by inhibiting binding of aminoacyl tRNA to A-site of ribosomes. Tetracycline-controlled systems are used to control gene expression on transgenic mice. Marker of bone formation.
Product Specific Literature References
Clinical and laboratory observations of a new antibiotic, tetracycline: M. Finland, et al.; J. Am. Med. Assoc. 154, 561 (1954) Abstract
Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance: I. Chopra & M. Roberts; Microbiol. Mol. Biol. Rev. 65, 232 (2001) Abstract
Tetracyclines: nonantibiotic properties and their clinical implications: A. N. Sapadin & R. Fleischmajer; J. Am. Acad. Dermatol. 54, 258 (2006) Abstract
A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatide: R. Lindsay, et al.; J. Bone Miner. Res. 21, 366 (2006) Abstract
Tetracycline-controlled genetic switches: R. Sprengel & M. T. Hasan; Handb. Exp. Pharmacol. 178, 49 (2007) Abstract
Anti-inflammatory activity of tetracyclines: G. Webster & J. Q. Del Rosso; Dermatol. Clin. 25, 133 (2007) Abstract
Further Categories Containing This Product:
tRNA / Related Products • Antibiotics for Inflammation Research • Antibiotics - Apoptosis Inducers & Inhibitors • Translation Inhibitors
 
 
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