• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Alzheimer Research Other Products
You are here: Product Lines > Cell Cycle > Alzheimer Research Other Products
Toolbar - View Selection
 
Items 7 of 7
ALX-158-011 Revised 12-Sep-05
Humanin (human)
Add to Clipboard
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Alzheimer Research Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-158-011-MC05   0.5 mg 210.00 USD Add To Cart
ALX-158-011-M001   1 mg 350.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH
FORMULA: C119H204N34O32S2
MW: 2687.3
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Humanin was originally identified as an anti-apoptotic peptide of 24 aa encoded in a cDNA that rescued neuronal cells from apoptosis induced by presenilin mutants associated with familial Alzheimer's disease and by amyloid-β protein [1]. Mutagenesis studies showed that the cysteine at position 8 of the humanin peptide is critical for its anti-apoptotic function [1-3]. It has now been shown that Bax (Bcl-2 associated X protein), an apoptosis-inducing protein, interacts with humanin [4]. Humanin prevents the translocation of Bax from the cytosol to mitochondria. Humanin peptides also block Bax association with isolated mitochondria, and suppress cytochrome c release in vitro.
Product Specific Literature References
[1] A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta: Y. Hashimoto, et al.; PNAS 98, 6336 (2001) Abstract; Full Text
[2] Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults: Y. Hashimoto, et al.; J. Neurosci. 21, 9235 (2001) Abstract; Full Text
[3] Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein: Y. Hashimoto, et al.; BBRC 283, 460 (2001) Abstract
[4] Humanin peptide suppresses apoptosis by interfering with Bax activation: B. Guo, et al.; Nature 423, 456 (2003) Abstract
Further Categories Containing This Product:
Peptides • Bcl-2 Family Interacting Proteins / Related Products
 
 
ALX-201-221 Revised 02-Oct-06
Pin1 (human) (recombinant)
Add to Clipboard
SYNONYMS Peptidyl-prolyl cis-trans Isomerase Pin1 (human) (recombinant)
PPIase Pin1 (human) (recombinant)
Peptidyl-prolyl cis-trans Isomerase NIMA-interacting 1 (human) (recombinant)
PPIase NIMA-interacting 1 (human) (recombinant)
Rotamase Pin1 (human) (recombinant)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Alzheimer Research Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-221-C100   100 µg 325.00 USD Add To Cart
Product Specification
MW: ~18.2kDa
SOURCE/HOST: Recombinant human peptidyl-prolyl cis-trans isomerase (PPIase) Pin1 produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 20mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 5mM DTT and 20% glycerol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Stress & Heat Shock Proteins Other Products • Antiviral Signalling / Related Products • Recombinant Proteins / Fusion Proteins • p53 Other Products
 
 
ALX-210-348 Revised 28-Sep-05
Polyclonal Antibody to Munc-18 Interacting Protein 3
Add to Clipboard
SYNONYMS anti-Mint3 PAb
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Alzheimer Research Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-348-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-19 of rat Mint3 (munc-18 interacting protein 3).
SPECIFICITY: Recognizes mouse and rat Mint3. Detects a band of ~86kDa by Western blot.
APPLICATION: Western Blot (1:500)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-162-028.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-260-087 Revised 17-Jan-06
Proteasome Substrate IV (Fluorogenic)
Add to Clipboard
SYNONYMS Z-VKM-AMC
PRODUCT LINE Ubiquitin & Proteasome
PRODUCT CATEGORY Proteasome / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-087-M001   1 mg 37.00 USD Add To Cart
ALX-260-087-M005   5 mg 143.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Val-Lys-Met-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA: C34H45N5O7S
MW: 667.8
PURITY: ≥98%
APPEARANCE: Colorless amorphous solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Fluorogenic substrate for Alzheimer's Disease amyloid A4-generating enzymes and for the proteasome.
Product Specific Literature References
Distribution of Alzheimer's disease amyloid A4-generating enzymes in rat brain tissue: S. Ishiura, et al.; Neurosci. Lett. 115, 329 (1990) Abstract
Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells: R.C. Gardner, et al.; Biochem. J. 346, 447 (2000) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
Further Categories Containing This Product:
Alzheimer Research Other Products
 
 
ALX-350-106 Revised 29-Nov-07
Ampullosporin A
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-106-M001   1 mg 50.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leucinol
FORMULA: C77H127N19O19
MW: 1623.0
SOURCE/HOST: Antibiotic isolated from Sepedonium ampullosporum.
PURITY: ≥98% (HPLC)
SOLUBILITY: Soluble in alcohols, chloroform or dichloromethane. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.
Product Description
Peptaibol-type polypeptide. Induces pigment formation by the fungus Phoma destructiva, causes hypothermia in mice, displays neuroleptic activity in rats and forms instable pores in artificial bilayer membranes.
Product Specific Literature References
Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice: M. Ritzau, et al.; J. Antibiot. 50, 722 (1997) Abstract
Differences in ion permeability of an artificial bilayer membrane caused by ampullosporin and bergofungin, new 15-membered peptaibol-type antibiotics: P. Grigoriev, et al.; Bioelectrochemistry 44, 155 (1997)
Differences in ion-channel formation by ampullosporins B, C, D and semisynthetic desacetyltryptophanyl ampullosporin A: P. Grigoriev, et al.; Bioelectrochemistry 57, 119 (2002) Abstract
Synthesis and biological evaluation of analogues of the peptaibol ampullosporin A: H.H. Nguyen, et al.; J. Med. Chem. 45, 2781 (2002) Abstract
Crystal structure and conformational analysis of ampullosporin A: M. Kronen, et al.; J. Pept. Sci. 9, 729 (2003) Abstract
Membrane association and activity of 15/16-membered peptide antibiotics: zervamicin IIB, ampullosporin A and antiamoebin I: T.N. Kropacheva, et al.; Biochim. Biophys. Acta 1715, 6 (2005) Abstract
Transcriptional response to the neuroleptic-like compound Ampullosporin A in the rat ketamine model: H. Krugel, et al.; J. Neurochem. 97, Suppl. 1, 74 (2006) Abstract
Further Categories Containing This Product:
Peptides • Alzheimer Research Other Products • Ion Channels & Transporters Other Products
 
 
ALX-550-065 Revised 07-Oct-08
(-)-Huperzine A
Add to Clipboard
SYNONYMS (-)-Selagine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cholinergics / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-065-MC05   0.5 mg 60.00 USD Add To Cart
ALX-550-065-M001   1 mg 100.00 USD Add To Cart
Product Specification
FORMULA: C15H18N2O
MW: 242.3
CAS NUMBER: 102518-79-6
MERCK INDEX: 14: 4755
RTECS: PB9185700
SOURCE/HOST: Isolated from Lycopodium sp.
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: VERY TOXIC.

Product Description
Plant alkaloid. Neurotoxin. Active isomer with acetylcholine esterase activity. Protects cells against hydrogen peroxide, β-amyloid, glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. Prospective agent for the treatment of Alzheimer‘s disease. For the racemic modification, see (±)-Huperzine A (Prod. No. ALX-550-064).
Product Specific Literature References
The effect of the nucleoside transport inhibitor dipyridamole on the incorporation of [3H]thymidine in the rat: J.-S. Liu, et al.; Can. J. Chem. 64, 837 (1986)
Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat: X.C. Tang, et al.; J. Neurosci. Res. 24, 276 (1989) Abstract
A Practical Synthesis of the Chinese "Nootropic" Agent Huperzine A: A Possible Lead in the Treatment of Alzheimer's Disease: Y. Xia & A.P. Kozikowski; JACS 111, 4116 (1989)
Synthesis and Biological Evaluation of (±)-Z-Huperzine A: A.P. Kozikowski, et al.; Tetrahedron Lett. 31, 6159 (1990)
Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase: M. McKinney, et al.; Eur. J. Pharmacol. 203, 303 (1991) Abstract
Mechanism of inhibition of cholinesterases by huperzine A: Y. Ashani; BBRC 184, 719 (1992) Abstract
Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo: I. Hanin, et al.; Ann. N. Y. Acad. Sci. 695, 304 (1993) Abstract
An Improved Synthetic Route to Huperzine A; New Analogues and Their Inhibition of Acetylcholinesterase: A.P. Kozikowski, et al.; J. C. S. Chem. Commun. 860 (1993)
Huperzine A, a potential therapeutic agent for treatment of Alzheimer’s disease: D.L. Bai, et al.; Curr. Med. Chem. 7, 355 (2000), (Review) Abstract
Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine: R. Wang, et al.; Acta Pharmacol. Sin. 27, 1 (2006), (Review) Abstract
Further Categories Containing This Product:
Alzheimer Research Other Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products for Neurological Research • Alkaloids • Acetylcholine Esterase / Related Products
 
 
ALX-804-495 Revised 22-Dec-06
Monoclonal Antibody to Pin1 (8C10)
Add to Clipboard
SYNONYMS anti-Peptidyl-prolyl cis-trans Isomerase Pin1 MAb (8C10)
anti-PPIase Pin1 (8C10) MAb
anti-Peptidyl-prolyl cis-trans Isomerase NIMA-interacting 1 MAb (8C10)
anti-PPIase NIMA-interacting 1 (8C10) MAb
anti-Rotamase Pin1 MAb (8C10)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Alzheimer Research Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-495-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
CLONE: 8C10
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15min, RT).
IMMUNOGEN: Recombinant human peptidyl-prolyl cis-trans isomerase (PPIase) Pin1.
SPECIFICITY: Recognizes human, mouse and dog Pin1. Detects a band of ~16 kDa by Western blot.
APPLICATION: Western Blot (0.5µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4'000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL INCLUDED: Yes (Prod. No. ALX-840-030).
General Information
Pin1, a member of the parvulin family of peptidyl-prolyl-cis-trans-isomerases (PPIases), specifically isomerizes only the phosphorylated  Ser/Thr-Pro bonds in certain proteins like Bcl-2, Cdc25C, Cdc27, p53 and Tau. Binding of Pin1 to p53 stimulates the DNA binding activity and transactivation function of p53. Pin1 also regulates the expression of cyclin D1 and is strikingly overexpressed in a subset of human tumors like breast cancer and oral squamous cell carcinoma.
Further Categories Containing This Product:
Stress & Heat Shock Proteins Other Products • Antiviral Signalling / Related Products • p53 Other Products • Monoclonal Antibodies
 
 
© 2008 ALEXIS Corporation, Privacy Policy, Disclaimer, Feedbackheader picture © micronaut.ch, another CS2 website

Catalogs / Brochures

E-Newsletter

 

Shopping Cart [0]

 

Distributors

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.