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Cell Cycle
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ALX-850-308 Revised 23-Nov-05
QuickCount™ Cell Quantification Kit
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Proliferation & Cytotoxicity Assays
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ALX-850-308-KI01   1 Kit 200.00 USD Add To Cart
Product Specification
KIT/SET CONTAINS: 2x75ml of lysis buffer and 2x0.075ml of dye reagent.
APPLICATION: For assessing the number of cells present in a wide range of cell concentrations.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +20°C
USE/STABILITY: Store dye reagent at -20°C.
Product Description
Suited for high throughput screening and includes protocols for adherent and suspended cells. Flexible to use. Can be optimized in formats ranging from 96 wells to cuvettes. Nonradioactive. Can also be used in time course studies to measure cell proliferation, and for the quantification of double stranded DNA in a sample of plasmid, lamda or genomic DNA. Excitation at 355nm and Emission at 460nm.
Further Categories Containing This Product:
Quantification Kits
 
 
ALX-201-233 Revised 22-Jun-07
Rad9/Rad1/Hus1 (human) (recombinant)
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SYNONYMS 9-1-1 Complex (human) (recombinant)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY DNA Damage Checkpoint Other Products
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ALX-201-233-C005   5 µg 240.00 USD Add To Cart
Product Specification
MW: 106kDa (heterotrimer of 43, 31 and 32kDa)
SOURCE/HOST: Produced in baculovirus.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (by SDS-PAGE).
FORMULATION: Liquid. In 25mM Tris, pH 8.0, containing 20% glycerol, 100mM sodium chloride and 1mM β-mercaptoethanol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Product Specific Literature References
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair: M. Toueille, et al.; Nucl. Acids Res. 32, 3316 (2004) Abstract; Full Text
The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery: E. Smirnova, et al.; Biochem. J. 389, 13 (2005) Abstract
General Literature References
Regulation of the DNA replication fork: a way to fight genomic instability: M. Toueille and U. Hubscher; Chromosoma 113, 113 (2004) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • DNA Replication Other Products
 
 
ALX-380-092 Revised 03-Jul-08
Radicicol
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SYNONYMS Monorden
1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-092-M001   1 mg 75.00 USD Add To Cart
ALX-380-092-M005   5 mg 295.00 USD Add To Cart
Product Specification
FORMULA: C18H17ClO6
MW: 364.8
CAS NUMBER: 12772-57-5
MERCK INDEX: 14: 6253
RTECS: RR1105000
SOURCE/HOST: Isolated from Humicola fuscoatra.
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Antifungal macrocyclic lactone antibiotic with antimalarial activity. Potent inhibitor of HSP90. Binds more strongly to HSP90 (nanomolar affinity) than to Grp94. Also binds to yeast HSP90, E. coli HtpG and TRAP-1. Non-competitive inhibitor of ATP citrate lyase. Anti-angiogenic. Specifically inhibits the interaction between HIF-1α/Arnt heterodimer and the hypoxia-responsive element (HRE), reducing VEGF expression. Protein tyrosine kinase inhibitor, e.g. p60v-src (IC50=0.27nM). Inhibitor of cyclooxygenase-2 (COX-2) expression (IC50=27nM) without affecting COX-1 expression in LPS-stimulated macrophages. Induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. Suppressor of NIH 3T3 cell transformation by diverse oncogenes such as mos, ras and src in part by blocking the key signal transduction intermediates such as MAP kinase and GAP-associated p62. Inhibitor of AP-1-, NF-κB- and serum response factor (SRF)-mediated transcription (e.g. expression of iNOS). Represses the transcriptional function of the estrogen receptor. Inhibits archeal growth and DNA topoisomerase VI (a Topo IIB family topoisomerase). Blocks replication of negative-strand RNA viruses.
Product Specific Literature References
Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol: H.J. Kwon, et al.; Cancer Res. 52, 6926 (1992) Abstract
Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis: T. Oikawa, et al.; Eur. J. Pharmacol. 241, 221 (1993) Abstract
Radicicol, a protein tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis: P. Chanmugam, et al.; J. Biol. Chem. 270, 5418 (1995) Abstract; Full Text
Suppression of RAS and MOS transformation by radicicol: J.F. Zhao, et al.; Oncogene 11, 161 (1995) Abstract
Induction of differentiation of HL-60 cells by the anti-fungal antibiotic, radicicol: Y. Shimada, et al.; J. Antibiot. 48, 824 (1995) Abstract
Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells: I. Pillay, et al.; Cell Growth Differ. 7, 1487 (1996) Abstract
Radicicol leads to selective depletion of Raf kinase and disrupts K-Ras-activated aberrant signaling pathway: S. Soga, et al.; J. Biol. Chem. 273, 822 (1998) Abstract; Full Text
Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites: Y. Tanaka, et al.; J. Antibiot. 51, 153 (1998) Abstract
Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol: S.V. Sharma, et al.; Oncogene 16, 2369 (1998) Abstract
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin: S.M. Roe, et al.; J. Med. Chem. 42, 260 (1999) Abstract
T.W. Schulte, et al.; Mol. Endocrinol. 13, 1435 (1999) Abstract; Full Text
Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-kappaB/Rel in lipopolysaccharide-stimulated macrophages: Y.J. Jeon, et al.; J. Pharmacol. Exp. Ther. 294, 548 (2000) Abstract; Full Text
Radicicol binds and inhibits mammalian ATP citrate lyase: S.W. Ki, et al.; J. Biol. Chem. 275, 39231 (2000) Abstract; Full Text
Radicicol suppresses transformation and restores tropomyosin-2 expression in both ras- and MEK-transformed cells without inhibiting the Raf/MEK/ERK signaling cascade: P.N. Kim, et al.; Cell Growth Differ. 12, 543 (2001) Abstract; Full Text
Radicicol-sensitive peptide binding to the N-terminal portion of GRP94: S. Vogen, et al.; J. Biol. Chem. 277, 40742 (2002) Abstract; Full Text
Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol: E. Hur, et al.; Mol. Pharmacol. 62, 975 (2002) Abstract; Full Text
Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90: M.O. Lee, et al.; Mol. Cell Endocrinol. 188, 47 (2002) Abstract
Development of radicicol analogues: S. Soga, et al.; Curr. Cancer Drug Targets 3, 359 (2003) Abstract
Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor: K. Harashima, et al.; Int. J. Radiat. Biol. 81, 63 (2005) Abstract
Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol: D. Gadelle, et al.; Nucleic Acid Res. 33, 2310 (2005) Abstract
Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site: M.K. Hadden, et al.; Curr. Top. Med. Chem. 6, 1173 (2006), Review Abstract
The topoisomerase II-Hsp90 complex: a new chemotherapeutic target?: C.R. Barker, et al.; Int. J. Cancer 118, 2685 (2006) Abstract
Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol: K.D. Corbett & J.M. Berger; Nucleic Acids Res. 34, 4269 (2006) Abstract
Chemistry and biology of resorcylic acid lactones: N. Winssinger & S. Barluenga; Chem. Commun. (Camb.) 22 (2007) Abstract
Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses: J.H. Connor, et al.; Virology 362, 109 (2007) Abstract
Further Categories Containing This Product:
HSP90 / HtpG / Related Products • Tyrosine Kinase Inhibitors • Antibiotics - Topoisomerase Inhibitors • Antitumor Agents (Hormone-related) • Estrogen & Estrogen Receptors / Related Products • Malaria / Related Products • Antibiotics - Antimalarial • Antibiotics for Cell Cycle Research • Antibiotics - NF-kB Inhibitors • Antibiotics - Nitric Oxide Pathway Modulators • Antibiotics for Angiogenesis Research • Antibiotics - Protein Kinase Inhibitors • RNA Polymerases / Related Products • Cell Cycle Blockers & Inhibitors / Related Products • NF-kB Pathway Inhibitors
 
 
ALX-270-346 Revised 28-May-08
Ratjadone A (synthetic)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cell Cycle Research
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ALX-270-346-C002   2 µg 150.00 USD Add To Cart
Product Specification
FORMULA: C28H40O5
MW: 456.6
CAS NUMBER: 163564-92-9
SOURCE/HOST: Synthetic.
PURITY: ≥95%
FORMULATION: Liquid. Solution in methanol.
SOLUBILITY: Soluble in methanol (20mg/ml) or aqueous buffers (<100µM).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Sensitive to acids and bases. Unstable in acidic buffer systems (pH<6). Stable in substance as oil and in solution in methanol at -20°C.
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Represents a new class of natural compounds, which inhibit proliferation in eukaryotes by blocking nuclear export. As potent as leptomycin B (Prod. No. ALX-380-100) and specific for G1/S checkpoint. Cytotoxic secondary metabolite (IC50=50pg/ml in mouse cell line L929) that arrests tumor cells in the G1 phase at remarkably low concentrations (50pg/ml in HeLa cell line KB3.1). Inhibits the binding between the nuclear export signal (NES) of proteins and the chromosome maintenance region protein (CRM1). Anticancer compound. Belongs to the family of orphan ligands which include polyketides like leptomycin B, callystatin A and other related compounds.
Product Specific Literature References
Antibiotics from gliding bacteria, LXIII. Ratjadone: a new antifungal metabolite from Sorangium cellulosum: D. Schummer, et al.; Liebigs Ann. 685 (1995)
Ratjadon: a new antifungal compound from Sorangium cellulosum (myxobacteria) production, physio-chemical and biological properties: J. Gerth, et al.; J. Antibiot. 48, 973 (1995) Abstract
The chemistry and biology of ratjadone: M. Kalesse, et al.; ChemBioChem. 9, 709 (2001) Abstract
The chemistry and biology of the leptomycin family: M. Kalesse & M. Christmann; Synthesis 8, 981 (2002) Abstract
Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms: T. Meissner, et al.; FEBS Lett. 576, 27 (2004)
Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export: S. Strunze, et al.; Mol. Biol. Cell 16, 2999 (2005) Abstract
Further Categories Containing This Product:
Nuclear Envelope & Nuclear Transport • Antitumor Agents (Anti-proliferative) • Antitumor Antibiotics • Antibiotics - Antifungal • Cell Cycle Blockers & Inhibitors / Related Products
 
 
ALX-270-369 Revised 28-May-08
Ratjadone C (native)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cell Cycle Research
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ALX-270-369-C005   5 µg 180.00 USD Add To Cart
Product Specification
FORMULA: C28H40O5
MW: 456.6
SOURCE/HOST: Isolated from Sorangium cellulosum.
PURITY: ≥95%
FORMULATION: Liquid. Solution in methanol (5µg in 1ml).
SOLUBILITY: Soluble in methanol (>50mg/ml). Sparingly soluble in aqueous buffers (up to 10µg/ml in PBS).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Acid and base sensitive. Unstable in acidic and alkaline buffer systems (pH <6 or >7). Stable in methanolic solution at -20°C.
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Cytotoxic secondary metabolite that inhibits cell growth of mammalian cell lines in the picomolar range (IC50=0.2ng/ml with L929 mouse cells) including multidrug resistant (MDR) HeLa cells (IC50=0.1ng/ml with KB-V1). Like leptomycin B (Prod. No. ALX-380-100), ratjadone C binds covalently to the nuclear export protein CRM1. It inhibits cargo protein binding to the leucine-rich nuclear export sequence and thereby blocks nuclear export.
Product Specific Literature References
Antibiotics from gliding bacteria, LXIII. Ratjadone: a new antifungal metabolite from Sorangium cellulosum: D. Schummer, et al.; Liebigs Ann. 685 (1995)
Ratjadon: a new antifungal compound from Sorangium cellulosum (myxobacteria) production, physico-chemical and biological properties: K. Gerth, et al.; J. Antibiot. (Tokyo) 48, 973 (1995) Abstract
The chemistry and biology of the leptomycin family: M. Kalesse & M. Christmann; Synthesis 8, 981 (2002) Abstract
Ratjadones inhibit nuclear export by blocking CRM1/exportin 1: M. Koster, et al.; Exp. Cell. Res. 286, 321 (2003) Abstract
Further Categories Containing This Product:
Nuclear Envelope & Nuclear Transport • Antitumor Agents (Anti-proliferative) • Antitumor Antibiotics • Antibiotics - Antifungal • Cell Cycle Blockers & Inhibitors / Related Products
 
 
ALX-201-296 Revised 15-Oct-08 New product
Replication Protein A (human) (recombinant)
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SYNONYMS RP-A (human) (recombinant)
Replication Factor A (human) (recombinant)
RF-A (human) (recombinant)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Repair Other Products
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ALX-201-296-C005   5 µg 260.00 USD Add To Cart
Product Specification
MW: ~118kDa (heterotrimer with subunits of 70, 32/34 and 14kDa)
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 0.16mg/ml
PURITY: ≥98% (SDS-PAGE).
FORMULATION: Liquid. In 20mM TRIS, pH 8.0, containing 10% (v/v) glycerol, 2mM EDTA and 1mM DTT.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for more then 2 year when stored at  -80°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Recombinant replication protein A: expression, complex formation, and functional characterization: L.A. Henricksen, et al.; J. Biol. Chem. 269, 11121 (1994) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot links
P27694: RFA1 (human)
P15927: RFA2 (human)
P35244: RFA3 (human)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • DNA Replication Other Products
 
 
ALX-380-216 Revised 20-Jun-08
Reveromycin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cell Cycle Research
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ALX-380-216-MC01   0.1 mg 150.00 USD Add To Cart
ALX-380-216-MC25   0.25 mg 320.00 USD Add To Cart
Product Specification
SEQUENCE: 134615-37-5
FORMULA: C36H52O11
MW: 660.8
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5344.
PURITY: ≥99% (HPLC)
APPEARANCE: White to tan solid.
SOLUBILITY: Soluble in ethyl acetate, 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Unstable in acidic conditions.

Product Description
Antibiotic. Dominant analog of the reveromycin complex. Inhibitor of the mitogenic activity of epidermal growth factor (EGF). G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Displays antiproliferative as well as potent antifungal activity. Induces apoptosis in osteoclasts thus inhibiting bone resorption.
Product Specific Literature References
Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties: H. Takahashi, et al.; J. Antibiot. (Tokyo) 45, 1409 (1992) Abstract
Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities: H. Takahashi, et al.; J. Antibiot. (Tokyo) 45, 1414 (1992) Abstract
Chemical modification of reveromycin A and its biological activities: T. Shimizu, et al.; Bioorg. Med. Chem. Lett. 12, 3363 (2002) Abstract
Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A: Y. Miyamoto, et al.; J. Biol. Chem. 277, 28810 (2002) Abstract; Full Text
Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an antiosteoclastic activity: H. Muguruma, et al.; Clin. Cancer Res. 11, 8822 (2005) Abstract; Full Text
Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts: J.T. Woo, et al.; PNAS 103, 4729 (2006) Abstract; Full Text
Molecular pathogenesis and its therapeutic modalities of lung cancer metastasis to bone: S. Sone and S. Yano; Cancer Metastasis Rev. 26, 685 (2007) Abstract
Regulation of osteoclast polarization: N. Takahashi, et al.; Odontology 95, 1 (2007), (Review) Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors • Bone Metabolism Other Products • Antibiotics - Antifungal • Cell Cycle Blockers & Inhibitors / Related Products • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
ALX-380-217 Revised 08-Apr-08
Reveromycin B
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cell Cycle Research
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ALX-380-217-MC25   0.25 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C36H52O11
MW: 660.8
CAS NUMBER: 144860-68-4
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5344.
PURITY: ≥90% (HPLC)
APPEARANCE: White to tan solid.
SOLUBILITY: Soluble in ethyl acetate, 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Unstable in acidic conditions.

Product Description
Antibiotic. Much less active analog of reveromycin A (Prod. No. ALX-380-216), which is a G1 phase cell cycle inhibitor and induces apoptosis in osteoclasts. Useful negative control in resolving the mode of action of this class.
Product Specific Literature References
Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties: H. Takahashi, et al.; J. Antibiot. (Tokyo) 45, 1409 (1992) Abstract
Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities: H. Takahashi, et al.; J. Antibiot. (Tokyo) 45, 1414 (1992) Abstract
Further Categories Containing This Product:
Bone Metabolism Other Products • EGFR Kinase Inhibitors • Antibiotics - Antifungal • Cell Cycle Blockers & Inhibitors / Related Products • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
ALX-380-218 Revised 08-Apr-08
Reveromycin C
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cell Cycle Research
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ALX-380-218-MC25   0.25 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C37H54O11
MW: 674.8
CAS NUMBER: 144860-69-5
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5344.
PURITY: ≥95% (HPLC)
APPEARANCE: White to tan solid.
SOLUBILITY: Soluble in ethyl acetate, 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Unstable in acidic conditions.

Product Description
Antibiotic. Minor component of the reveromycin complex with similar biological profile as reveromycin A (Prod. No. ALX-380-216), which is a G1 phase cell cycle inhibitor and induces apoptosis in osteoclasts. Generally more potent than reveromycin A. Inhibitor of the mitogenic activity of epidermal growth factor (EGF).
Product Specific Literature References
Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties: H. Takahashi, et al.; J. Antibiot. (Tokyo) 45, 1409 (1992) Abstract
Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities: H. Takahashi, et al.; J. Antibiot. (Tokyo) 45, 1414 (1992)