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Antibiotics - Antifungal
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ALX-380-137 Revised 05-Jan-09 New product
Acetomycin
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SYNONYMS NSC350598
3-Acetyl-5-(acetyloxy)dihydro-3,4-dimethyl-2(3H)furanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-137-M001   1 mg 85.00 USD Add To Cart
ALX-380-137-M005   5 mg 255.00 USD Add To Cart
Product Specification
FORMULA: C10H14O5
MW: 214.2
CAS NUMBER: 510-18-9
SOURCE/HOST: Isolated from Streptomyces ramulosus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystals.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Antibiotic with antibacterial, antifungal and antiprotozoal activity. Cytotoxic against several tumor cell lines in vitro.
Product Specific Literature References
The structure of acetomycin. Spectroscopic characterization and X-ray analysis of a bromo derivative: H. Uhr, et al.; J. Antibiot. (Tokyo) 38, 1684 (1985) Abstract
Biological effects of acetomycin. I. Activity against tumor cells in vitro and in vivo: S.W. Mamber, et al.; J. Antibiot. (Tokyo) 40, 73 (1987) Abstract
Biological effects of acetomycin. II. Inactivation by esterases in vitro: S.W. Mamber, et al.; J. Antibiot. (Tokyo) 40, 77 (1987) Abstract
The structure and absolute configuration of acetomycin: F.H. Cano, et al.; Acta Crystallogr. C. 44, 919 (1988) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-350-325 Revised 25-Jun-07
Altenusin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-350-325-M001   1 mg 110.00 USD Add To Cart
ALX-350-325-M005   5 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C15H14O6
MW: 290.3
CAS NUMBER: 31186-12-6
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antifungal penicillide. Non-competitive, specific neutral sphingomyelinase (N-SMase) and strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light chain kinase inhibitor. Exhibits anti-HIV-1 integrase activity.
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 103. Metabolites of Alternaria tenuis Auct.: Culture filtrate products: T. Rosett, et al.; Biochem. J. 67, 390 (1957) Full Text
Studies in the biosynthesis of fungal metabolites. 4. Alternariol monomethyl ether and its relation to other phenolic metabolites of Alternaria tenuis: R. Thomas; Biochem. J. 80, 234 (1961) Abstract; Full Text
Metabolites of some Alternaria species. The structures of altenusin and dehydroaltenusin: R. G. Coombe, et al.; Aus. J. Chem. 23, 2343 (1970)
Host-specific toxins and chemical structures from alternaria species: S. Nishimura, et al.; Ann. Rev. Phytopathol. 21, 87 (1983)
The metabolites of Talaromycesflavus: Part 1. Metabolites of the organic extracts : W. A. Ayer, et al.; Can. J. Chem. 68, 2085 (1990)
Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur: S. Nakanishi, et al.; Biosci. Biotechnol. Biochem. 59, 1333 (1995) Abstract
Alutenusin, a specific neutral sphingomyelinase inhibitor, produced by Penicillium sp. FO-7436: R. Uchida, et al.; J. Antibiot. 52, 572 (1999) Abstract
Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites: S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol. 30, 721 (2003) Abstract
Fungal metabolites as potent protein kinase inhibitors: Identification of a novel metabolite and novel activities of known metabolites : M. Oyama, et al.; Lett. Drug Design Discov. 1, 24 (2004)
New penicillide derivatives isolated from Penicillium simplicissimum: S. I. Komai, et al.; J. Nat. Med. 60, 185 (2006)
HIV-1 integrase inhibitors: 2003-2004 update: R. Dayam, et al.; Med. Res. Rev. 26, 271 (2006) Abstract
Further Categories Containing This Product:
Myosin Light Chain Kinase Inhibitors • Tyrosine Kinase Inhibitors • Antibiotics - Antiviral / Anti-HIV
 
 
ALX-380-122 Revised 03-Apr-08
Asperlactone
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SYNONYMS 5-(1-Hydroxyethyl)-3-(3-methyloxiranyl)-2(5H)-furanone
5-(1-Hydroxyethyl)-3-(2,3-epoxypropyl)butenolide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-122-M001   1 mg 60.00 USD Add To Cart
ALX-380-122-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C9H12O4
MW: 184.2
CAS NUMBER: 76375-62-7
SOURCE/HOST: Isolated from Aspergillus ochraceus.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow oil.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from moisture.

Product Description
Antibiotic with nematicidal, insecticidal, antibacterial and antifungal activity.
Product Specific Literature References
New polyketide metabolites from Aspergillus melleus: structural and stereochemical studies: M.J. Garson, et al.; J.C.S. Perkin Trans. I 1984, 1021 (1984)
Biosynthesis of fungal metabolites: asperlactone and its relationship to other metabolites of Aspergillus melleus: R.G. Brereton, et al.; J.C.S. Perkin Trans. I 1984, 1027 (1984)
17O NMR in biosynthetic studies: aspyrone, asperlactone and isoasperlactone, metabolites of Aspergillus melleus: J. Staunton & A.C. Sutkowski; J.C.S. Chem. Commun. 1991, 1106 (1991)
Effect of fungal metabolites and some derivatives against Tribolium castaneum (Herbst) and Nezara viridula (L.): M. Balcells, et al.; Pestic. Sci. 45, 319 (1995)
Aspyrone, a nematicidal compound isolated from the fungus, Aspergillus melleus: Y. Kimura, et al.; Biosci. Biotech. Biochem. 60, 1375 (1996)
Bactericidal and fungicidal activity of Aspergillus ochraceus metabolites and some derivatives: M. Torres, et al.; Pestic. Sci. 53, 9 (1998)
Characterization and regulation of new secondary metabolites from Aspergillus ochraceus M18 obtained by UV mutagenesis: G. Awad, et al.; Can. J. Microbiol. 51, 59 (2005) Abstract; Full Text
 
 
ALX-380-121 Revised 20-Nov-08
Aspyrone
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SYNONYMS 5,6-Dihydro-5-hydroxy-6-methyl-3-(3-methyloxiranyl)-2H-pyran-2-one
3-(1,2-Epoxypropyl)-5,6-dihydro-5-hydroxy-6-methyl-2H-pyran-2-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-121-M001   1 mg 60.00 USD Add To Cart
ALX-380-121-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C9H12O4
MW: 184.2
CAS NUMBER: 17398-00-4
SOURCE/HOST: Isolated from Aspergillus ochraceus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from moisture.

Product Description
Antibiotic with nematicidal, insecticidal, antibacterial and antifungal activity. Related to aspinonene (Prod. No. ALX-380-132).
Product Specific Literature References
A new metabolite of Aspergillus melleus: S.D. Mills & W.B. Turner; J. Chem. Soc. (C) 1967, 2242 (1967)
Production of 3-(1,2-Epoxypropyl)-5,6-dihydro-5-hydroxy-6-methylpyran-2-one by Aspergillus ochraceus Wilhelm: J.H. Moore, et al.; J. Agr. Food Chem. 22, 697 (1974) Abstract
J.S.E. Holker, et al.; J.C.S. Perkin Trans. I 1981, 1397 (1981)
17O NMR in biosynthetic studies: aspyrone, asperlactone and isoasperlactone, metabolites of Aspergillus melleus: J. Staunton & A.C. Sutkowski; J.C.S. Chem. Commun. 1991, 1106 (1991)
Biosynthesis of aspyrone, a metabolite of Aspergillus melleus: advanced precursor studies to identify the product of the polyketide synthase: J. Staunton & A.C. Sutkowski; J.C.S. Chem. Commun. 1991, 1108 (1991)
The polyketide synthase (PKS) of aspyrone biosynthesis: evidence for the enzyme bound intermediates from incorporation studies with N-acetylcysteamine thioesters in intact cells of Aspergillus melleus: J. Staunton & A.C. Sutkowski; J.C.S. Chem. Commun. 1991, 1110 (1991)
Effect of fungal metabolites and some derivatives against Tribolium castaneum (Herbst) and Nezara viridula (L.): M. Balcells, et al.; Pestic. Sci. 45, 319 (1995)
Synthesis of chiral aspyrone, a multi-functional dihydropyranone antibiotic: T. Sugiyama, et al.; Biosci. Biotech. Biochem. 59, 1921 (1995) Abstract
Aspyrone, a nematicidal compound isolated from the fungus, Aspergillus melleus: Y. Kimura, et al.; Biosci. Biotech. Biochem. 60, 1375 (1996)
Bactericidal and fungicidal activity of Aspergillus ochraceus metabolites and some derivatives: M. Torres, et al.; Pestic. Sci. 53, 9 (1998)
Related Products
 
 
ALX-380-108 Revised 03-Apr-08
Atpenin A5
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SYNONYMS 3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-108-C250   250 µg 90.00 USD Add To Cart
Product Specification
FORMULA: C15H21Cl2NO5
MW: 366.2
CAS NUMBER: 119509-24-9
RTECS: CJ8800000
SOURCE/HOST: Produced by Penicillium sp.
PURITY: ≥85% (HPLC)
APPEARANCE: Colorless oil.
SOLUBILITY: Soluble in DMSO, methanol or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antibiotic. Potent and specific inhibitor of mitochondrial complex II (succinate-ubiquinone oxidoreductase).
Product Specific Literature References
Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties: S. Omura, et al.; J. Antibiot. 41, 1769 (1988) Abstract
The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp: H. Kumagai, et al.; J. Antibiot. 43, 1553 (1990) Abstract
Mechanism of action of atpenin B on Raji cells: K. Oshino, et al.; J. Antibiot. 43, 1064 (1990) Abstract
Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase): H. Miyadera, et al.; PNAS 100, 473 (2003) Abstract
Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction: R. Horsefield, et al.; J. Biol. Chem. 281, 7309 (2006) Abstract; Full Text
General Information
MANUFACTURER Fungal strain courtesy of the Kitasato Institute, Tokyo.
Further Categories Containing This Product:
Respiratory Chain Other Products
 
 
ALX-380-240 Revised 03-Apr-08
Aureothricin
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SYNONYMS Propionylpyrrothione
Farcinicin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-240-MC05   0.5 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C9H10N2O2S2
MW: 242.3
CAS NUMBER: 574-95-8
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS4782.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Antibiotic. More hydrophobic analog of the antibiotic thiolutin (Prod. No. ALX-380-200) with selective antitumor activity. Potent inhibitor of bacterial and yeast RNA polymerases and of fungal mannan and glucan formation.
Product Specific Literature References
Studies on a common hydrolysis product of thiolutin and aureothricin: W.D. Celmer & I.A. Solomons; Antibiot. Annu. 622, (1953)
Anticancer properties of dithiolopyrrolones: J.M. Webster, et al.; US Patent 6,020,360, (2000)
Related Products
Further Categories Containing This Product:
Other Antibiotics - DNA Regulation / Transcription • Antitumor Antibiotics • RNA Polymerases / Related Products
 
 
ALX-380-209 Revised 13-Nov-07
Bafilomycin C1
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SYNONYMS L-681,110A1
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
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ALX-380-209-M001   1 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C39H60O12
MW: 720.4
CAS NUMBER: 88979-61-7
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5338.
PURITY: ≥95% (HPLC)
APPEARANCE: White to tan solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide oder DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: May undergo transformation to methyl ketal on long term storage in methanol. We recommend to use fresh solutions.
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description

Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Shows antibacterial, antifungal, insecticidal and antihelmintic activity. Potential antiosteoporotic agent in treating bone lytic diseases.
Product Specific Literature References
Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984) Abstract
Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993) Abstract
Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995) Abstract
Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis: J. Xu, et al.; Histol. Histopathol. 222, 443 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal • H+-ATPase / Related Products • Bone Metabolism Other Products
 
 
ALX-380-241 Revised 21-May-08
Blasticidin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-241-M001   1 mg 370.00 USD Add To Cart
Product Specification
FORMULA: C58H107NO23
MW: 1186.5 (free acid)
CAS NUMBER: 100513-53-9
RTECS: EC4897000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS4079.
PURITY: ≥98% (HPLC)
APPEARANCE:

Yellow tan solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or methanol; fairly soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Antibiotic. Shows broad spectrum antifungal and antibacterial activity. Specific inhibitor of aflatoxin production by Aspergillus parasiticus.
Product Specific Literature References
Blasticidin, a new anti-phytopathogenic fungal substance: K. Fukunaga, et al.; Bull. Agr. Chem. Soc. Jpn. 19, 181 (1955)
Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus: S. Sakuda, et al.; J. Antibiot. 53, 1265 (2000) Abstract
Further Categories Containing This Product:
Natural Products with Antibiotic Activity • Natural Products - Antifungal Agents
 
 
ALX-380-089 Revised 29-Jul-08
Blasticidin S . hydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - DNA Replication Inhibitors
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ALX-380-089-M100   100 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C17H26N8O5 . HCl
MW: 422.4 . 36.5
CAS NUMBER: 3513-03-9
MERCK INDEX: 14: 1316
SOURCE/HOST: Isolated from Streptomyces griseochromogenes.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water; insoluble in organic solvents.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.
HAZARD: VERY TOXIC.

Product Description
Antibiotic. Inhibitor of DNA and protein synthesis.
Product Specific Literature References
Blasticidin S, a new antibiotic: S. Takeuchi, et al.; J. Antibiot. (Tokyo) 11, 1 (1958) Abstract
The blasticidin S resistance gene (bsr) selectable in a single copy state in the Bacillus subtilis chromosome: M. Itaya, et al.; J. Biochem. 107, 799 (1990) Abstract
Cloning and characterization of the gene encoding a blasticidin S acetyltransferase from Streptoverticillum sp: J.A. Perez-Gonzalez, et al.; Gene 86, 129 (1990) Abstract
Blasticidin S-resistance gene (bsr): a novel selectable marker for mammalian cells: M. Izumi, et al.; Exp. Cell Res. 197, 229 (1991) Abstract
Cloning of the blasticidin S deaminase gene (BSD) from Aspergillus terreus and its use as a selectable marker for Schizosaccharomyces pombe and Pyricularia oryzae: M. Kimura, et al.; Mol. Gen. Genet. 242, 121 (1994) Abstract
Blasticidin S deaminase gene from Aspergillus terreus (BSD): a new drug resistance gene for transfection of mammalian cells: M. Kimura, et al.; Biochim. Biophys. Acta 1219, 653 (1994) Abstract
Further Categories Containing This Product:
DNA Replication Inhibitors • Reporter Gene Markers / Related Products • Translation Inhibitors • Antibiotics - Antifungal
 
 
ALX-350-019 Revised 16-Oct-08
(+)-Brefeldin A
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SYNONYMS BFA
Ascotoxin
Decumbin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-350-019-M005   5 mg 80.00 USD Add To Cart
ALX-350-019-M010   10 mg 130.00 USD Add To Cart
ALX-350-019-M025   25 mg 270.00 USD Add To Cart
ALX-350-019-M050   50 mg