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Nitric Oxide Pathway Other Products
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ALX-101-018 Revised 30-Jan-06
L-Glutamic acid
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PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY L-Amino Acids
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ALX-101-018-G001   1 g 12.00 USD Add To Cart
Product Specification
FORMULA: C5H9NO4
MW: 147.1
CAS NUMBER: 56-86-0
MERCK INDEX: 14: 4469
RTECS: LZ9700000
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
Excitatory Amino Acids • Nitric Oxide Pathway Other Products
 
 
ALX-270-112 Revised 16-Jun-08
Pentoxifylline
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SYNONYMS Trental
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-270-112-G001   1 g 15.00 USD Add To Cart
ALX-270-112-G005   5 g 35.00 USD Add To Cart
Product Specification
FORMULA: C13H18N4O3
MW: 278.3
CAS NUMBER: 6493-05-6
MERCK INDEX: 14: 7136
SOURCE/HOST: Isolated from Penicillium expansum.
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Phosphodiesterase inhibitor. Blocks the synthesis of TNF-α. Improves blood flow by decreasing blood viscosity.
Product Specific Literature References
Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality: P. Noel, et al.; Life Sci. 47, 1023 (1990) Abstract
Pentoxifylline inhibits the expression of tissue factor mRNA in endotoxin-activated human monocytes: V. Ollivier, et al.; FEBS Lett. 322, 231 (1993) Abstract
Pentoxifylline: C.P. Samlaska & E.A. Winfield; J. Am. Acad. Dermatol. 30, 603 (1994), Review Abstract
Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism: K. Prasad & P. Lee; Atherosclerosis 192, 313 (2007) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products • TNF-alpha & TNF Receptors Other Products • Nitric Oxide Pathway Other Products
 
 
ALX-340-004 Revised 18-Aug-08
Arachidonic acid
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SYNONYMS 5Z,8Z,11Z,14Z-Eicosatetraenoic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Arachidonic Acid / Related Products
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ALX-340-004-M100   100 mg 147.00 USD Add To Cart
Product Specification
FORMULA: C20H32O2
MW: 304.5
CAS NUMBER: 506-32-1
MERCK INDEX: 14: 765
RTECS: CE6675000
CONCENTRATION: 100mg/ml
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol containing 0.1% BHT.
SOLUBILITY: 100mg/ml soluble in DMSO or dimethyl formamide; sparingly soluble in basic aqueous buffers (1.7mg/ml). To prevent oxidation, the solvent should be purged with an inert gas.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING: Protect from light and oxygen.
HAZARD: TOXIC.

Product Description
Precursor to a large family of eicosanoids. Activator for several protein kinase C (PKC) isotypes.
Product Specific Literature References
Arachidonic acid metabolism: P. Needleman, et al.; Ann. Rev. Biochem. 55, 69 (1986) Abstract
Kinetic analysis of the Ca2+-dependent, membrane-bound, macrophage phospholipase A2 and the effects of arachidonic acid: M.D. Lister, et al.; J. Biol. Chem. 263, 7506 (1988) Abstract; Full Text
Characterization of the L-arginine:nitric oxide pathway in human platelets: M.W. Radomski, et al.; Br. J. Pharmacol. 101, 325 (1990) Abstract
The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor: A.J.R. Habenicht, et al.; Nature 345, 634 (1990) Abstract
The control of free arachidonic acid levels: R.D. Burgoyne & A. Morgan; TIBS 15, 365 (1990) Abstract
A unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets: F. Chevy, et al.; Lipids 26, 1080 (1991) Abstract
Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids: J.W. Han, et al.; Science 252, 576 (1991) Abstract
Arachidonic acid as a second messenger. Interactions with a GTP-binding protein of human neutrophils: S.B. Abramson, et al.; J. Immunol. 147, 231 (1991) Abstract
The immediate activator of the NADPH oxidase is arachidonate not phosphorylation: Henderson, et al.; Eur. J. Biochem. 211, 157 (1993) Abstract
Nitric oxide and arachidonic acid modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia: G. Khurana & M.R. Bennett; Br. J. Pharmacol. 109, 480 (1993) Abstract
Arachidonic acid-induced Ca2+ release from isolated sarcoplasmic reticulum: C. Dettbarn & P. Palade; Biochem. Pharmacol. 45, 1301 (1993) Abstract
Covalent binding of arachidonate to G protein alpha subunits of human platelets: H. Hallak, et al.; J. Biol. Chem. 269, 4713 (1994) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PKC Activators • Nitric Oxide Pathway Other Products • Fatty Acids
 
 
ALX-370-007 Revised 09-Sep-08
Corticosterone
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SYNONYMS (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
Reichstein's Substance H
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Glucocorticoids & Glucocorticoid Receptors / Related Products
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ALX-370-007-M050   50 mg 18.00 USD Add To Cart
Product Specification
FORMULA: C21H30O4
MW: 346.5
CAS NUMBER: 50-22-6
MERCK INDEX: 14: 2538
RTECS: GM7650000
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow solid.
SOLUBILITY: Soluble in 100% ethanol (50mg/ml) or dioxane (20mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE TERATOGENIC. IRRITANT.

Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Nitric Oxide Pathway Other Products
 
 
ALX-400-023 Revised 19-Apr-06
Gadolinium (III) chloride . hexahydrate
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PRODUCT LINE Immunology
PRODUCT CATEGORY Monocytes & Macrophages Other Products
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ALX-400-023-M100   100 mg 15.00 USD Add To Cart
ALX-400-023-M500   500 mg 25.00 USD Add To Cart
Product Specification
FORMULA: GdCl3 . 6H2O
MW: 263.6 . 108.1
CAS NUMBER: 13450-84-5
MERCK INDEX: 14: 4326
PURITY: ≥99%
APPEARANCE: White crystals or chunks.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Packaged under inert gas. Hygroscopic.
HAZARD: IRRITANT.
Product Description
Inhibits macrophages.
Product Specific Literature References
Inhibition of macrophages with gadolinium chloride abrogates ozone- induced pulmonary injury and inflammatory mediator production: K.J. Pendino, et al.; Am. J. Respir. Cell Mol. Biol. 13, 125 (1995) Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
 
 
ALX-430-020 Revised 13-Nov-08
Zaprinast
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SYNONYMS 1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one
M&B 22,948
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
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ALX-430-020-M010   10 mg 30.00 USD Add To Cart
ALX-430-020-M050   50 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C13H13N5O2
MW: 271.3
CAS NUMBER: 37762-06-4
PURITY: ≥98%
APPEARANCE: White to tan powder.
SOLUBILITY: Soluble in 1M sodium hydroxide, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.11mg/ml), DMSO (10mg/ml) or 100% ethanol (5 mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Phosphodiesterase (PDE) inhibitor.
Product Specific Literature References
Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948: P.G. Gillespie and J.A. Beavo; Mol. Pharmacol. 36, 773 (1989) Abstract
Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors: J.A. Beavo & D.H. Reifsnyder; TIPS 11, 150 (1990) Abstract
The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung: F. Burns, et al.; Biochem. J. 283, 487 (1992) Abstract
Cyclic nucleotide phosphodiesterases from frog atrial fibers: isolation and drug sensitivities: C. Lugnier, et al.; Am. J. Physiol. 262, H654 (1992) Abstract
Zaprinast increases cyclic GMP levels in plasma and in aortic tissue of rats: R.L. Dundore, et al.; Eur. J. Pharmacol. 249, 293 (1993) Abstract
Reversal of nitroglycerin tolerance in vitro by the cGMP- phosphodiesterase inhibitor zaprinast: E.D. Pagani, et al.; Eur. J. Pharmacol. 243, 141 (1993) Abstract
The nitric oxide--cyclic GMP pathway and synaptic depression in rat hippocampal slices: C.L. Boulton, et al.; Eur. J. Neurosci. 6, 1528 (1994) Abstract
The PDE inhibitor zaprinast enhances NO-mediated protection against vascular leakage in reperfused lungs: H. Schutte, et al.; Am. J. Physiol. Lung Cell Mol. Physiol. 279, L496 (2000) Abstract; Full Text
Phosphodiesterase 5 inhibitor, zaprinast, selectively increases cerebral blood flow in the ischemic penumbra in the rat brain: F. Gao, et al.; Neurol. Res. 27, 638 (2005) Abstract
Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35: Y. Taniguchi, et al.; FEBS Lett. 580, 5003 (2006) Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
 
 
ALX-430-021 Revised 17-Jan-05
N-Acetyl-N-acetoxy-4-chlorobenzenesulphonamide
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PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Pathway Other Products
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ALX-430-021-M005   5 mg 40.00 USD Add To Cart
Product Specification
FORMULA: C10H10ClNO5S
MW: 291.7
PURITY: ≥98%
APPEARANCE: White crystals.
SOLUBILITY: Soluble in DMSO or DMF; slightly soluble in methanol; not soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Nitroxyl (HNO) releasing compound in neutral solution. Release of nitric oxide was not detected. Potent vasorelaxant. Powerful inhibitor of aldehyde dehydrogenase.
Product Specific Literature References
Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase: M.J.C. Lee, et al.; J. Med. Chem. 35, 3648 (1992) Abstract
N,O-diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties: J.M. Fukuto, et al.; BBRC 187, 1367 (1992) Abstract
 
 
ALX-440-008 Revised 30-Oct-06
L-Biopterin
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SYNONYMS 6-Biopterin
2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone
2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine
L-erythro-6-(1,2-Dihydroxypropyl)pterin
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Pathway Other Products
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ALX-440-008-M025   25 mg 90.00 USD Add To Cart
ALX-440-008-M100   100 mg 270.00 USD Add To Cart
Product Specification
FORMULA: C9H11N5O3
MW: 237.2
CAS NUMBER: 22150-76-1
MERCK INDEX: 14: 1229
RTECS: UO3506000
PURITY: ≥98%
APPEARANCE: White to pale yellow powder.
SOLUBILITY: Soluble in 1 N sodium hydroxide or 1N hydrogen chloride; very slightly soluble in water (0.7mg/ml) (ultrasonication). To obtain concentrated solutions, ammonium hydroxide should be added.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 2 years after receipt when stored at -20°C.
HANDLING: Protect from light.
HAZARD: IRRITANT.

 
 
ALX-440-009 Revised 20-Nov-06
7,8-Dihydro-L-biopterin
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PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Pathway Other Products
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ALX-440-009-M010   10 mg 38.00 USD Add To Cart
ALX-440-009-M050   50 mg 152.00 USD Add To Cart
Product Specification
FORMULA: C9H13N5O3
MW: 239.2
CAS NUMBER: 6779-87-9
PURITY: ≥98%
APPEARANCE: Light yellow powder.
SOLUBILITY: Slightly soluble in water (2mg/ml, 22°C, ultrasonication).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Solutions should be prepared by oxygen free water and stored at -20°C immediately. Product is unstable in acidic solutions.
HANDLING: Hygroscopic.

 
 
ALX-450-001 Revised 23-Jul-08
A23187 (free acid)
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SYNONYMS Calcium Ionophore A23187
Calcimycin
Antibiotic A23187
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Ionophores
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ALX-450-001-M001   1 mg 28.00 USD Add To Cart
ALX-450-001-M005   5 mg 65.00 USD Add To Cart
ALX-450-001-5001   5x1 mg 80.00 USD Add To Cart
ALX-450-001-M010   10 mg 92.00 USD Add To Cart
ALX-450-001-M025   25 mg 195.00 USD Add To Cart
ALX-450-001-M050   50 mg 350.00 USD Add To Cart
Product Specification
FORMULA: C29H37N3O6
MW: 523.6
CAS NUMBER: 52665-69-7
MERCK INDEX: 14: 1639
RTECS: DM4676000
SOURCE/HOST: Isolated from Streptomyces chartreusis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methylene chloride; slightly soluble in water. Solubilize in DMSO or ethanol prior to preparing aqueous solutions of very low concentrations.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: In aqueous systems product may aggregate over time.
HANDLING: Protect from light. In aqueous systems, the product aggregates over time.
HAZARD: IRRITANT.

Product Description
Antibiotic possessing weak in vitro antimicrobial activity against gram positive bacteria and fungi. Divalent cation ionophore commonly used to increase intracellular Ca2+ levels in intact cells.
Product Specific Literature References
A23187: a divalent cation ionophore: P. W. Reed & H. A. Lardy; J. Biol. Chem. 247, 6970 (1972) Abstract
Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria: D.T. Wong, et al.; Arch. Biochem. Biophys. 156, 578 (1973) Abstract
Biological applications of ionophores: B.C. Pressman; Annu. Rev. Biochem. 45, 501 (1976), (Review) Abstract
Molecular mechanisms of endothelium-mediated vasodilation: R.R. Fiscus; Semin. Thromb. Hemost. 14 Suppl, 12 (1988), (Review) Abstract
Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species: 1740, 481 (2005): T. Przygodzki, et al.; Biochim. Biophys. Acta 1740, 481 (2005) Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products • Respiratory Chain Other Products • Antibiotics - ATPase Inhibitors