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ALX-350-290 Revised 19-Oct-07
Debromohymenialdisine
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SYNONYMS DBH
4-(2-Amino-4-oxo-2-imidazolin-5-ylidene)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-290-C100   100 µg 90.00 USD Add To Cart
Product Specification
FORMULA: C11H11N5O2
MW: 245.2
CAS NUMBER: 125118-55-0
SOURCE/HOST: Isolated from sponge Stylotella aurantium.
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Inhibitor of G2 DNA damage checkpoint (IC50=8µM) and check point kinases 1 (Chk1) (IC50=3µM) and 2 (Chk2) (IC50=3.5µM) [1,3]. Unlike other checkpoint inhibitors DBH does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related protein. Also inhibits MAP kinase kinase 1 (MEK-1) (IC50=881nM) but is not as potent as 10Z-hymenialdisine (Prod. No. ALX-350-289) (IC50=6nM) [2].
Product Specific Literature References
[1] Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine: D. Curman, et al.; J. Biol. Chem. 276, 17914 (2001) Abstract; Full Text
[2] Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002) Abstract
[3] G2 checkpoint abrogators as anticancer drugs: T. Kawabe; Mol. Cancer Ther. 3, 513 (2004) Abstract
Further Categories Containing This Product:
MAPK Pathway Inhibitors • Chk1 & Chk2/Related Products • Alkaloids • Natural Products for Cell Cycle Research
 
 
ALX-370-002 Revised 19-Sep-06
Dexamethasone
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SYNONYMS 9α-Fluoro-16α-methylprednisolone
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Glucocorticoids & Glucocorticoid Receptors/Related Products
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ALX-370-002-G001   1 g 45.00 USD Add To Cart
ALX-370-002-M250   250 mg 22.00 USD Add To Cart
Product Specification
FORMULA: C22H29FO5
MW: 392.5
CAS NUMBER: 50-02-2
MERCK INDEX: 14: 2943
RTECS: TU3980000
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol. Slightly soluble in acetone or chloroform. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL. MAY BE TERATOGENIC.

Product Description
Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Glucocorticoid with anti-inflammatory activity. Inhibits the induction of nitric oxide synthases (NOS).
Product Specific Literature References
Inhibition of the induction of nitric oxide synthase by glucocorticoids: yet another explanation for their anti-inflammatory effects?: S. Moncada & R.M.J. Palmer; TIPS 12, 130 (1991), (Review) Abstract
Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells: K.J. O'Connor & S. Moncada; Biochim. Biophys. Acta 1097, 227 (1991) Abstract
Nitric oxide mediates tumor necrosis factor-alpha cytotoxicity in endothelial cells: C. Estrada, et al.; BBRC 186, 475 (1992) Abstract
Dexamethasone inhibits the expression of an inducible nitric oxide synthase in infarcted rabbit myocardium: R.R. Dudek, et al.; BBRC 202, 1120 (1994) Abstract
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes: T. Grombacher, et al.; Carcinogenesis 17, 2329 (1996) Abstract
Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone: T. Biswas, et al.; Oncogene 18, 525 (1999) Abstract
Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases: M.G. Cifone, et al.; Blood 93, 2282 (1999) Abstract; Full Text
Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2: M.S. Montani, et al.; Cell Death Differ 6, 79 (1999) Abstract
Dexamethasone inhibits the phosphorylation of retinoblastoma protein in the suppression of human vascular smooth muscle cell proliferation: T.D. Reil, et al.; J. Surg. Res. 92, 108 (2000) Abstract
Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells: M. Matsumura, et al.; Life Sci. 69, 1067 (2001) Abstract
Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages: R. Korhonen, et al.; Mol. Pharmacol. 62, 698 (2002) Abstract; Full Text
Molecular mechanisms underlying dexamethasone inhibition of iNOS expression and activity in C6 glioma cells: J. Shinoda, et al.; Glia 42, 68 (2003) Abstract
Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-kappaB activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line: A.L. Vital, et al.; Mediators Inflamm. 12, 71 (2003) Abstract
Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles: S.C. Schafer, et al.; Am. J. Physiol. Heart Circ. Physiol. 288, H436 (2005) Abstract; Full Text
Related Products
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • GITR & GITRL Other Products • RANK & RANKL/OPG Other Products • Antitumor Agents (Hormone-related) • Chemopreventive Agents Other Products • DNA & RNA Methyl & Alkyl Transferases/Related Products • Cell Cycle Other Products
 
 
ALX-480-050 Revised 17-Jul-07
6-Dimethylaminopurine
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SYNONYMS N6,N6-Dimethyladenine
6-DMAP
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-480-050-M100   100 mg 15.00 USD Add To Cart
Product Specification
FORMULA: C7H9N5
MW: 163.2
CAS NUMBER: 938-55-6
PURITY: ≥97%
APPEARANCE: Crystalline.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Non-selective inhibitor of cdc2 and other kinases.
Product Specific Literature References
Inhibition of cyclin-dependent kinases by purine analogues: J. Vesley, et al.; Eur. J. Biochem. 224, 771 (1994)
 
 
ALX-270-438 Revised 06-Dec-06
Dimethylenastron
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SYNONYMS 7,7-Dimethyl-4-(3-hydroxyphenyl)-5-oxo-3,4,5,6,7,8-hexahydroquinazolin-2(1H)-thione
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Cycle Blockers & Inhibitors/Related Products
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ALX-270-438-M001   1 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C16H18N2O2S
MW: 302.4
CAS NUMBER: 863774-58-7
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (10mg/ml) or methanol (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at -20°C in the dark.
HANDLING: Protect from light.
HAZARD: HARMFUL.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Potent, cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=200nM) by binding to the mitotic kinesin Eg5.
Product Specific Literature References
Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5: M. Gartner, et al.; ChemBioChem. 6, 1173 (2005) Abstract
Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5: N. Sunder-Plassmann, et al.; Bioorg. Med. Chem. 13, 6094 (2005) Abstract
Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells: C. Muller, et al.; Cancer Chemother. Pharmacol. 59, 157 (2007) Abstract
Further Categories Containing This Product:
Kinesin & Kinesin-like Proteins/Related Products
 
 
ALX-201-278 Revised 19-Mar-08
DNA Ligase I (human) (recombinant)
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SYNONYMS DNA Ligase 1 (human) (recombinant)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Replication Other Products
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ALX-201-278-C010   10 µg 260.00 USD Add To Cart
Product Specification
MW: ~102kDa. Note: The mobility of DNA ligase I in a PAA gel is not corresponding to its MW; it runs at ~125kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 0.6mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 20mM HEPES-KOH, pH 7.5, containing 30mM sodium chloride, 1mM EDTA, 1mM DTT and 30% glycerol.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -80°C
USE/STABILITY: Enzyme is freshly produced upon customer request and is stable for ~2 weeks at -80°C. Very prone to degradation even in the absence of proteases. Freeze in liquid nitrogen for long term storage.
HANDLING: After opening, prepare aliquots and store in liquid nitrogen. Avoid freeze/thaw cycles.
Product Specific Literature References
The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair: A. Gembka, et al.; Nucleic Acids Res. 35, 2596 (2007) Abstract; Full Text
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Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • DNA Repair Other Products
 
 
ALX-380-115 Revised 03-Apr-08
Echinosporin
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SYNONYMS NSC357683
XK 213
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-115-M001   1 mg 90.00 USD Add To Cart
ALX-380-115-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C10H9NO5
MW: 223.2
CAS NUMBER: 79127-35-8
RTECS: JW5313000
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in dimethyl formamide, methanol or water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for at least 3 months when stored at -20°C.
HAZARD: HARMFUL.

Product Description
Antitumor antibiotic. Inhibits cell cycle at the G(2)/M phase and induces apoptosis.
Product Specific Literature References
A new antibiotic echinosporin (XK-213) - producing organism, isolation and characterization: T. Sato, et al.; J. Antibiot. 35, 266 (1982) Abstract
Antitumor activity of echinosporin: M. Morimoto and R. Imai; J. Antibiot. 38, 490 (1985) Abstract
Approaches to the total synthesis of the antitumor antibiotic echinosporin: M. A. Kinsella; J. Org. Chem. 55, 105 (1990)
Applications of an asymmetric [2 + 2]-photocycloaddition. Total synthesis of (-)-echinosporin. Construction of an advanced 11-deoxyprostaglandin intermediate: A. B. Smith; JACS 114, 2567 (1992)
Biosynthesis of the antibiotic echinosporin by a novel branch of the shikimate pathway: A. Dubeler; Eur. J. Org. Chem. 2002, 983 (2002)
Echinosporins as new cell cycle inhibitors and apoptosis inducers from marine-derived Streptomyces albogriseolus: C.B. Cui, et al.; Fitoterapia 78, 238 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Antibiotics for Cell Cycle Research
 
 
ALX-270-389 Revised 17-Jul-07
Elbfluorene
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SYNONYMS 3-Acetyl-6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b]pyridine
1-Aza-9-oxafluorene 5b
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Repair Other Products
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ALX-270-389-M001   1 mg 75.00 USD Add To Cart
ALX-270-389-M005   5 mg 300.00 USD Add To Cart
Product Specification
FORMULA: C19H13NO3
MW: 303.3
PURITY: ≥95% (HPLC)
APPEARANCE: Off-white to brownish powder.
SOLUBILITY: Soluble in DMSO. Insoluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Selective inhibitor of CDK1/cyclin B (IC50=4.2µM) with some P-glycoprotein-modulating properties (inhibitory activity ratio 1.26 at 7µM). Weakly inhibits CDK5/p25 (6% inhibition at 10µM) with no effect on CDK2/cyclin E and CDK4/cyclin D1 (IC50>100µM).
Product Specific Literature References
Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties: K. Brachwitz, et al.; J. Med. Chem. 46, 876 (2003) Abstract
Further Categories Containing This Product:
CDK & Cyclin Inhibitors
 
 
ALX-350-092 Revised 03-Apr-08
Emetine . dihydrochloride
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SYNONYMS 6’,7’,10,11-Tetramethoxyemetan . 2HCl
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - DNA Replication Inhibitors
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ALX-350-092-M050   50 mg 10.00 USD Add To Cart
Product Specification
FORMULA: C29H40N2O4 . 2HCl
MW: 480.7 . 73.0
CAS NUMBER: 316-42-7
MERCK INDEX: 14: 3559
SOURCE/HOST: Isolated from ground roots of Uragoga ipecacuanha.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Hygroscopic.
HAZARD: TOXIC.

Product Description
Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Antiamebic.
Product Specific Literature References
Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells: A.P. Grollman; J. Biol. Chem. 243, 4089 (1968) Abstract
Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A:: A: T. Schweighoffer, et al.; Histochemistry 96, 93 (1991) Abstract
Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation: W.C. Burhans, et al.; EMBO J. 10, 4351 (1991) Abstract
Role of newly synthesized MHC class II molecules in antigen-specific antigen presentation by B cells: T. Kokuho, et al.; Immunobiology 193, 42 (1995) Abstract
Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells: Y.D. Zhou, et al.; J. Nat. Prod. 68, 947 (2005) Abstract
The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells: M. Moller, et al.; Oncol. Rep. 18, 737 (2007) Abstract
Characteristics of apoptosis induction by the alkaloid emetine in human tumour cell lines: M. Moller & M. Wink; Planta Med. 73, 1389 (2007) Abstract
Further Categories Containing This Product:
Other Toxins • Hypoxia-inducible Factor [HIF]/Related Products • Alkaloids • Parasitic Diseases Other Products • Adrenergics & Adrenergic Receptors/Related Products • DNA Replication Inhibitors • Translation Inhibitors • Natural Products - Other Anti-infective Agents • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products for Neurological Research
 
 
ALX-270-263 Revised 03-Apr-08
(-)-Epigallocatechin gallate
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SYNONYMS EGCG
(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-263-M010   10 mg 20.00 USD Add To Cart
ALX-270-263-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C22H18O11
MW: 458.4
CAS NUMBER: 989-51-5
MERCK INDEX: 14: 3526
SOURCE/HOST: Isolated from green tea.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in 100% ethanol, dimethyl formamide or DMSO; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions in DMSO are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Keep under inert gas. Protect from light.

Product Description
Antitumor reagent. Antioxidant. Protects cells from lipid peroxidation and DNA damage induced by reactive free radicals. Inhibits inducible nitric oxide synthase (iNOS; NOS II). Chemopreventive anticancer agent. Induces apoptosis in human cancer cell lines. Inhibits MAP kinase mediated signalling pathways. Inhibits angiogenesis. Inhibits telomerase and DNA methyltransferase. Anti-inflammatory agent.
Product Specific Literature References
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin: M.T. Huang, et al.; Carcinogenesis 13, 947 (1992) Abstract
Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1 alpha mRNA and protein expression in SENCAR mice by green tea polyphenols: S.K. Katiyar, et al.; J. Invest. Dermatol. 105, 394 (1995) Abstract
Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate: S. Liao, et al.; Cancer Lett. 96, 239 (1995) Abstract
Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach: T. Yamane, et al.; Cancer Res. 55, 2081 (1995) Abstract
(-)-Epigallocatechin gallate, a polyphenolic tea antioxidant, inhibits peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine: E.S. Fiala, et al.; Experientia 52, 922 (1996) Abstract
Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells: N. Ahmad, et al.; J. Natl. Cancer Inst. 89, 1881 (1997) Abstract
Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea: M.M. Chan, et al.; Biochem. Pharmacol. 54, 1281 (1997) Abstract
(-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB: Y.L. Lin & J.K. Lin; Mol. Pharmacol. 52, 465 (1997) Abstract
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins: I. Naasani, et al.; BBRC 249, 391 (1998) Abstract
Epigallocatechin suppression of proliferation of vascular smooth muscle cells: correlation with c-jun and JNK: L.H. Lu, et al.; Br. J. Pharmacol. 124, 1227 (1998) Abstract
ESR study on the structure-antioxidant activity relationship of tea catechi