ALEXIS Biochemicals: Streptozotocin

You are here: Product Lines > Natural Products / Antibiotics > Antibiotics > Antibiotics for Cancer Research > Antitumor Antibiotics

ALX-804-624

Revised 20-Jun-05

Monoclonal Antibody to Doxorubicin (MAD11)
SYNONYMS	anti-DXR MAb (MAD11) anti-14-Hydroxydaunomycin MAb (MAD11) anti-Adriamycin MAb (MAD11)
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-624-C100		100 µg	320.00 USD

Product Specification

CLONE:	MAD11
ISOTYPE:	Mouse IgG2
CONCENTRATION:
FORMULATION:	Liquid. Purified antibody containing 150mM sodium chloride and 0.02% sodium azide, pH 7.4.
IMMUNOGEN:	Doxorubicin-BSA.
SPECIFICITY:	Recognizes anthracycline compounds including doxorubicin analogs and derivatives.
APPLICATION:	ELISA Immunohistochemistry Functional Application: In vivo antidotic effect.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	Do not freeze.

Product Specific Literature References

Monoclonal antibodies against doxorubicin: A. Balsari, et al.; Int. J. Cancer 42, 798 (1988) Abstract
A new monoclonal antibody recognizing anthracyclinic molecule: A. Balsari, et al.; Anticancer Res. 10, 129 (1990) Abstract
Anti-drug monoclonal antibodies antagonize toxic effect more than anti-tumor activity of doxorubicin: A. Balsari, et al.; Int. J. Cancer 47, 889 (1991) Abstract
An anti-doxorubicin monoclonal antibody modulates kinetic and dynamic characteristics of the drug: A. Sardini, et al.; Int. J. Cancer 50, 617 (1992) Abstract
Protection against doxorubicin-induced alopecia in rats by liposome-entrapped monoclonal antibodies: A.L. Balsari, et al.; FASEB J. 8, 226 (1994) Abstract
Effect of a bifunctional monoclonal antibody directed against a tumor marker and doxorubicin on the growth of epidermoid vulvar carcinoma grafted in athymic mice: D. Morelli, et al.; Cell Biophys. 24-25, 119 (1994) Abstract
Relevance of antibody valency in EGF receptor modulation: D. Morelli, et al.; Scand. J. Immunol. 39, 453 (1994) Abstract
Oral administration of anti-doxorubicin monoclonal antibody prevents chemotherapy-induced gastrointestinal toxicity in mice: D. Morelli, et al.; Cancer Res. 56, 2082 (1996) Abstract
Apoptosis of hair follicle cells during doxorubicin-induced alopecia in rats: R. Cece, et al.; Lab. Invest. 75, 601 (1996) Abstract
Intratibial injection of an anti-doxorubicin monoclonal antibody prevents drug-induced myelotoxicity in mice: D. Morelli, et al.; Br. J. Cancer 75, 656 (1997) Abstract
Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice: A. Balsari, et al.; Br. J. Cancer 85, 1964 (2001) Abstract
Role of proliferation in HER2 status predicted response to doxorubicin: M. Campiglio, et al.; Int. J. Cancer 105, 568 (2003) Abstract

Further Categories Containing This Product:

Cancer Other Products • Topoisomerases Other Products • Antibiotics - Topoisomerase Inhibitors • Monoclonal Antibodies

ALX-380-233

Revised 08-Apr-08

Neoantimycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-233-MC05		0.5 mg	360.00 USD

Product Specification

FORMULA:	C₃₆H₄₆N₂O₁₂
MW:	698.8
CAS NUMBER:	22862-63-1
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS4461.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Antibiotic. Displays potent nematocidal and antitumor activity.

Product Specific Literature References

The structure of neoantimycin: L. Caglioti, et al.; Tetrahedron 25, 2193 (1969) Abstract

ALX-380-088

Revised 30-Jul-08

Netropsin . dihydrochloride
SYNONYMS	4-([((Aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-3-carboxamide
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-088-M005		5 mg	40.00 USD

Product Specification

FORMULA:	C₁₈H₂₆N₁₀O₃ . 2HCl
MW:	430.5 . 73.0
CAS NUMBER:	63770-20-7 (hydrochloride)
RTECS:	DW2973000
SOURCE/HOST:	Isolated from Streptomyces netropsis.
PURITY:	≥93% (HPLC)
APPEARANCE:	Faint yellow powder.
SOLUBILITY:	Soluble in alcohols or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	HARMFUL.

Product Description

Nucleic acid binding ligand. Binds to A-T-rich regions of the minor groove of DNA.

Product Specific Literature References

Netropsin, a New Antibiotic Produced by a Streptomyces: A.C. Finlay et al.; J. Am. Chem. Soc. 73, 341 (1951)
Efficient Total Syntheses of the Oligopeptide Antibiotics Netropsin and Distamycin: J.W. Lown et al.; J. Org. Chem. 50, 3774 (1985)
Sequence and structural selectivity of nucleic acid binding ligands: J. Ren & J.B. Chaires; Biochemistry 38, 16067 (1999) Abstract
Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2: K. Bielawski, et al.; Acta Biochim. Pol. 47, 855 (2000) Abstract
Recent developments in sequence selective minor groove DNA effectors: B.S. Reddy, et al.; Curr. Med. Chem. 8, 475 (2001), (Review) Abstract

Further Categories Containing This Product:

Other Antibiotics - DNA Regulation / Transcription • Antibiotics - Antiviral / Anti-HIV

ALX-380-037

Revised 20-Jun-08

Oligomycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-037-M005		5 mg	50.00 USD
ALX-380-037-M010		10 mg	95.00 USD

Product Specification

MW:	789.3
CAS NUMBER:	1404-19-9
MERCK INDEX:	14: 6833
RTECS:	RK3325000
SOURCE/HOST:	Isolated from Streptomyces diastatochromogens.
PURITY:	≥90% (mixture of oligomycin A, B, and C (~65% oligomycin A))
APPEARANCE:	White to faint yellow powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol (10mg/ml) or acetone (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL. MAY BE MUTAGENIC.

Product Description

Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F₁), preventing phosphoryl group transfer. Induces apoptosis.

Product Specific Literature References

Inhibition of the Na(+)-Ca++ exchanger enhances anoxia and glucopenia- induced [3H]aspartate release in hippocampal slices: S. Amoroso, et al.; J. Pharmacol. Exp. Ther. 264, 515 (1993) Abstract
Cyclosporin A suppression of uncoupling in liver mitochondria of ground squirrel during arousal from hibernation: N.N. Brustovetsky, et al.; FEBS Lett. 315, 233 (1993) Abstract
The lipophilic weak base (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4- piperidinopyridine (AU-1421) is a potent protonophore type cationic uncoupler of oxidative phosphorylation in mitochondria: H. Nagamune, et al.; Biochim. Biophys. Acta 1141, 231 (1993) Abstract
Mitochondrial respiratory chain inhibitors induce apoptosis: E.J. Wolvetang, et al.; FEBS Lett. 339, 40 (1994) Abstract
Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program: J. Zhuang, et al.; J. Biol. Chem. 273, 15628 (1998) Abstract; Full Text
Apoptosis in factor-dependent haematopoietic cells is linked to calcium- sensitive mitochondrial rearrangements and cytoskeletal modulation: J. Garland, et al.; Br. J. Haematol. 109, 221 (2000) Abstract
Properties of DNA fragmentation activity generated by ATP depletion: N. Nakamura & Y. Wada; Cell Death Differ. 7, 477 (2000) Abstract

Further Categories Containing This Product:

ALX-380-036

Revised 10-Dec-07

Oligomycin A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-036-M005		5 mg	140.00 USD

Product Specification

FORMULA:	C₄₅H₇₄O₁₁
MW:	791.1
CAS NUMBER:	579-13-5
MERCK INDEX:	14: 6833
RTECS:	RK3328000
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5339.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	MAY BE MUTAGENIC. HARMFUL.

Product Description

Major component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F₁F₀), preventing phosphoryl group transfer. Induces apoptosis. Induces autophagy in the IPLB-LdFB insect cell line.

Product Specific Literature References

Production and isolation of the antibiotic, oligomycin: J. Visser, et al.; J. Biochem. Microbiol. Technol. Egr. 2, 31 (1960) Abstract
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000) Abstract; Full Text
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2000) Abstract; Full Text
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004) Abstract
Oligomycin A induces autophagy in the IPLB-LdFB insect cell line: G. Tettamanti, et al.; Cell Tissue Res. 326, 179 (2006) Abstract

Further Categories Containing This Product:

Antibiotics - ATPase Inhibitors • H+-ATPase / Related Products • Respiratory Chain Other Products • Antibiotics - Antifungal • Antitumor Antibiotics

ALX-380-038

Revised 10-Dec-07

Oligomycin B
SYNONYMS	28-Oxooligomycin A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-038-M005		5 mg	140.00 USD

Product Specification

FORMULA:	C₄₅H₇₂O₁₂
MW:	805.1
CAS NUMBER:	11050-94-5
MERCK INDEX:	14: 6833
RTECS:	RK3330000
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5339.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL. MAY BE MUTAGENIC.

Product Description

Minor component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F₁F₀), preventing phosphoryl group transfer. Induces apoptosis.

Product Specific Literature References

Further Categories Containing This Product:

ALX-380-039

Revised 10-Dec-07

Oligomycin C
SYNONYMS	12-Deoxyoligomycin A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-039-M001		1 mg	330.00 USD

Product Specification

FORMULA:	C₄₅H₇₄O₁₀
MW:	775.1
CAS NUMBER:	11052-72-5
MERCK INDEX:	14: 6833
RTECS:	RK3335000
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5339.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	MAY BE MUTAGENIC. HARMFUL.

Product Description

Minor component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F₁F₀), preventing phosphoryl group transfer. Induces apoptosis.

Product Specific Literature References

Production and isolation of the antibiotic, oligomycin: J. Visser, et al.; J. Biochem. Microbiol. Technol. Engr. 2, 31 (1960) Abstract
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000) Abstract; Full Text
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2002) Abstract; Full Text
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004) Abstract

Further Categories Containing This Product:

ALX-380-235

Revised 20-Jun-08

Piericidin A
SYNONYMS	Piericidin A1 Shaoguanmycin B Antibiotic MT 1882-I Antibiotic SN 198E Antibiotic IT 143D
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-235-M002		2 mg	140.00 USD

Product Specification

FORMULA:	C₂₅H₃₇NO₄
MW:	415.6
CAS NUMBER:	2738-64-9
RTECS:	YD4588000
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5364.
PURITY:	≥95% (HPLC)
APPEARANCE:	Pale yellow oil.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	VERY TOXIC.

Product Description

Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (complex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78, and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.

Product Specific Literature References

Piericidin A: a new inhibitor of mitochondrial electron transport: C. Hall, et al.; BBRC 25, 373 (1966) Abstract
Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase: T. Friedrich, et al.; Eur. J. Biochem. 219, 691 (1994) Abstract
The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors: E. Darrouzet, et al.; FEBS Lett. 431, 34 (1998) Abstract; Full Text
Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I: I. Prieur, et al.; Biochim. Biophys. Acta 1504, 173 (2001) Abstract
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator: J.H. Hwang, et al.; J. Cell. Physiol. 215, 243 (2008) Abstract

Further Categories Containing This Product:

Respiratory Chain Other Products

ALX-380-127

Revised 30-Jun-08

Polyketomycin
SYNONYMS	Antibiotic K99-5147
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-127-M001		1 mg	100.00 USD

Product Specification

FORMULA:	C₄₄H₄₈O₁₈
MW:	864.9
CAS NUMBER:	200625-47-4
SOURCE/HOST:	Isolated from Streptomyces sp.
PURITY:	≥98% (HPLC)
APPEARANCE:	Orange to dark brown solid.
SOLUBILITY:	Soluble in DMSO, methanol or acetone.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Tetracyclic quinone glycoside. Displays antibacterial, antimalarial and antitumor activity.

Product Specific Literature References

Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities: I. Momose, et al.; J. Antibiot. 51, 21 (1998) Abstract
Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. II. Structure determination: I. Momose, et al.; J. Antibiot. 51, 26 (1998) Abstract
Biosynthesis of polyketomycin produced by Streptomyces diastatochromogenes Tü 6028: T. Paululat, et al.; J. Antibiot. 52, 96 (1999) Abstract
In vitro antimalarial activities of the microbial metabolites: K. Otoguro, et al.; J. Antibiot. 56, 322 (2003) Abstract
Synthesis of the polyketomycin disaccharide: D.S. Micalizzi, et al.; Tetrahedron: Asymmetry 14, 3183 (2003)

Further Categories Containing This Product:

Antitumor Antibiotics • Antibiotics - Antimalarial

ALX-480-083

Revised 05-Jun-07

Puromycin aminonucleoside
SYNONYMS	3'-Amino-3'-deoxy-N,N-dimethyl-adenosine
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-083-M010		10 mg	50.00 USD