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ALX-270-171
Revised 30-Jun-08
Chlorpromazine . hydrochloride
SYNONYMS
2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-171-G001
1 g
22.00 USD
ALX-270-171-G005
5 g
66.00 USD
Product Specification
FORMULA:
C
17
H
19
ClN
2
S . HCl
MW:
318.9 . 36.5
CAS NUMBER:
69-09-0
MERCK INDEX:
14:
2185
RTECS:
SO1750000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D
2
antagonist. H
1
antagonist. Inhibits TNF-α production. Potent PLA
2
inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity:
H.B. Collier; Clin. Biochem.
7
, 331 (1974)
Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins:
D.R. Marshak, et al.; Biochemistry
24
, 144 (1985)
Abstract
Selective inhibition of group II phospholipase A2 by quercetin:
M. Lindahl & C. Tagesson; Inflammation
17
, 573 (1993)
Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge:
M. Palacios, et al.; BBRC
196
, 280 (1993)
Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice:
H. Yamamoto; Toxicol. Lett.
66
, 73 (1993)
Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice:
M.G. Netea, et al.; J. Infect. Dis.
171
, 393 (1995)
Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase:
A. Boveris, et al.; Methods Enzymol.
359
, 328 (2002)
Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine:
S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys.
430
, 170 (2004)
Abstract
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products
•
Chemopreventive Agents Other Products
•
PLA2 Inhibitors
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Dopaminergics & Dopamine Receptors / Related Products
•
Phosphodiesterases / Related Products
ALX-270-182
Revised 02-Jun-06
S-Ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea . hydrochloride
SYNONYMS
ETPI . HCl
TFPI . HCl
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-182-M005
5 mg
40.00 USD
ALX-270-182-M025
25 mg
160.00 USD
Product Specification
FORMULA:
C
10
H
11
SN
2
F
3
. HCl
MW:
248.3 . 36.5
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (50mg/ml), methanol, 100% ethanol (33mg/ml), DMSO (33mg/ml) or dimethyl formamide (33mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Selective inhibitor of neuronal nitric oxide synthase (nNOS; NOS I) relative to inducible nitric oxide synthase (iNOS; NOS II) (115-fold) and endothelial nitric oxide synthase (eNOS; NOS III) (29-fold).
Product Specific Literature References
Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity:
B.G. Shearer, et al.; J. Med. Chem.
40
, 1901 (1997)
Abstract
ALX-270-199
Revised 03-Jul-07
3-Bromo-7-nitroindazole . sodium salt
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-270-199-M005
5 mg
35.00 USD
ALX-270-199-M025
25 mg
95.00 USD
Product Specification
FORMULA:
C
7
H
3
BrN
3
O
2
. Na
MW:
241.0 . 23.0
PURITY:
≥97%
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO or methanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic. Protect from light.
HAZARD:
TOXIC.
Product Description
Salt form of 3-bromo-7-nitroindazole (Prod. No.
ALX-270-009
). Potent inhibitor of rat cerebellar nitric oxide synthase (nNOS/NOS I). More potent than 7-nitroindazole (Prod. No.
ALX-270-004
).
Product Specific Literature References
7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase:
P.A. Bland-Ward & P.K. Moore; Life Sci.
57
, PL131 (1995)
Abstract
Evidence for involvement of the neuronal isoform of nitric oxide synthase during induction of long-term potentiation and long-term depression in the rat dentate gyrus in vitro:
J. Wu, et al.; Neuroscience
78
, 393 (1997)
Abstract
Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy:
D.B. Vaupel, et al.; Eur. J. Pharmacol.
324
, 11 (1997)
Abstract
3-bromo-7-nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs maternal aggression and citrulline immunoreactivity in prairie voles:
S.C. Gammie, et al.; Brain Res.
870
, 80 (2000)
Abstract
Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism:
C.S. Raman, et al.; Biochemistry
40
, 13448 (2001)
Abstract
Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat:
M. Cavas & J.F. Navarro; Prog. Neuropsychopharmacol. Biol. Psychiatry
30
, 56 (2006)
Abstract
ALX-270-200
Revised 17-Oct-07
7-Nitroindazole . sodium salt
SYNONYMS
7-NiNa
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-200-M005
5 mg
25.00 USD
ALX-270-200-M025
25 mg
75.00 USD
ALX-270-200-M100
100 mg
225.00 USD
Product Specification
FORMULA:
C
7
H
4
N
3
O
2
. Na
MW:
162.2 . 23.0
PURITY:
≥98%
APPEARANCE:
Orange to red solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light and moisture.
HAZARD:
TOXIC. MAY BE TERATOGENIC. MAY BE MUTAGENIC.
Product Description
A more soluble salt form of 7-nitroindazole. Its higher solubility in artificial cerebrospinal fluid (CSF) permits its use as an inhibitor of nitric oxide synthase (NOS) in rat brain tissue. Provides a useful tool for the study of nitric oxide (NO) activity in the brain. See also 3-bromo-7-nitroindazole . sodium salt (Prod. No.
ALX-270-199
).
Product Specific Literature References
Increased striatal dopamine efflux in vivo following inhibition of cerebral nitric oxide synthase by the novel monosodium salt of 7-nitro indazole
:
M.T. Silva, et al.; Br. J. Pharmacol.
114
, 257 (1995)
Abstract
ALX-270-203
Revised 11-Jan-07
N-ω-Propyl-L-arginine
SYNONYMS
N
5
-[Imino(propylamino)methyl]-L-ornithine
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-270-203-M005
5 mg
72.00 USD
ALX-270-203-M025
25 mg
180.00 USD
Product Specification
FORMULA:
C
9
H
20
N
4
O
2
MW:
216.3
CAS NUMBER:
137361-05-8
PURITY:
≥98%
APPEARANCE:
White to off-white solid
SOLUBILITY:
Soluble in PBS, 100% ethanol, DMSO or dimethyl formamide.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least one year when stored at -20 °C.
Product Description
Potent and selective inhibitor of neuronal nitric oxide synthase (nNOS; NOS I) relative to inducible nitric oxide synthase (iNOS; NOS II) (3158-fold) and endothelial nitric oxide synthase (eNOS; NOS III) (149-fold).
Product Specific Literature References
Potent and selective inhibition of neuronal nitric oxide synthase by N-omega-propyl-L-arginine:
H.Q. Zhang, et al.; J. Med. Chem.
40
, 3869 (1997)
Abstract
Mechanism of inactivation of neuronal nitric oxide synthase by N-allyl-L-arginine:
H.Q. Zhang, et al.; JACS
119
, 10888 (1997)
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase:
H. Huang, et al.; J. Med. Chem.
42
, 3147 (1999)
Abstract
Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases:
Y. Lee, et al.; Bioorg. Med. Chem.
7
, 1097 (1999)
Abstract
Cellular and enzymatic studies of N(omega)-propyl-l-arginine and S-ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea as reversible, slowly dissociating inhibitors selective for the neuronal nitric oxide synthase isoform:
G.R. Cooper, et al.; Arch. Biochem. Biophys.
375
, 183 (2000)
Abstract
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes:
R. Boer, et al.; Mol. Pharmacol.
58
, 1026 (2000)
Abstract
;
Full Text
Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms:
R. Fedorov, et al.; J. Biol. Chem.
278
, 45818 (2003)
Abstract
;
Full Text
Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms:
R. Fedorov, et al.; J. Biol. Chem.
278
, 45818 (2003)
Abstract
;
Full Text
The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle:
C. Gowda, et al.; Nitric Oxide
11
, 17 (2004)
Abstract
The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice:
D. Klamer, et al.; Eur. J. Pharmacol.
503
, 103 (2004)
Abstract
ALX-270-211
Revised 07-Jun-06
2-Imino-4-methylpiperidine . acetate
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
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ALX-270-211-M005
5 mg
30.00 USD
ALX-270-211-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
6
H
12
N
2
. CH
3
COOH
MW:
112.2 . 60.2
CAS NUMBER:
165383-72-2
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in PBS, 100% ethanol, methanol, DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Specific inhibitor of inducible nitric oxide synthase (iNOS; NOS II).
ALX-270-216
Revised 04-Aug-08
Vinyl-L-NIO
SYNONYMS
N
5
-(1-Imino-3-butenyl)-L-ornithine
L-VNIO
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
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ALX-270-216-M005
5 mg
70.00 USD
ALX-270-216-M025
25 mg
245.00 USD
Product Specification
FORMULA:
C
9
H
17
N
3
O
2
. 2HCl
MW:
199.3 . 73.0
PURITY:
≥95%
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Very hygroscopic.
Product Description
Very selective and potent neuronal nitric oxide synthase (nNOS/NOS I) inhibitor.
Product Specific Literature References
N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase:
B. R. Babu & O.W. Griffith; J. Biol. Chem.
273
, 8882 (1998)
Abstract
;
Full Text
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes:
R. Boer, et al.; Mol. Pharmacol.
58
, 1026 (2000)
Abstract
;
Full Text
Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines:
L.E. Bretscher, et al.; J. Biol. Chem.
278
, 46789 (2003)
Abstract
;
Full Text
Myocardial effects of nitric oxide, NO. Clinical and experimental evidence:
C. Heymes, et al.; Bull. Acad. Natl. Med.
189
, 893 (2005), [Article in French]
Abstract
Neuronal nitric-oxide synthase inhibition facilitates adrenergic neurotransmission in rat mesenteric resistance arteries:
Y. Hatanaka, et al.; J. Pharmacol. Exp. Ther.
316
, 490 (2006)
Abstract
Ischemia/reperfusion-induced death of cardiac myocytes: possible involvement of nitric oxide in the coordination of ATP supply and demand during ischemia:
K. Kawahara, et al.; J. Mol. Cell Cardiol.
40
, 35 (2006)
Abstract
Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2.Lewis rats:
L.M. Yamaleyeva, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol.
292
, R819 (2007)
Abstract
General Literature References
Design of isoform-selective inhibitors of nitric oxide synthase:
B.R. Babu & O.W. Griffith; Curr. Opin. Chem. Biol.
2
, 491 (1998)
Abstract
ALX-270-252
Revised 03-Mar-05
MEG . sodium succinate
SYNONYMS
Mercaptoethylguanidine . sodium succinate
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
Size:
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ALX-270-252-M010
10 mg
95.00 USD
Product Specification
FORMULA:
C
3
H
10
N
3
S . C
4
H
4
O
4
Na
MW:
120.2 . 139.1
PURITY:
≥90%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Keep under inert gas. Keep cool and dry. Protect from moisture.
Product Description
Inhibitor of inducible nitric oxide synthase (iNOS; NOS II). Peroxynitrite scavenger.
Product Specific Literature References
Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform:
G.J. Southan, et al.; Br. J. Pharmacol.
117
, 619 (1996)
Abstract
The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity:
B. Zingarelli, et al.; Br. J. Pharmacol.
120
, 357 (1997)
Abstract
Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage:
C. Szabó, et al.; J. Biol. Chem.
272
, 9030 (1997)
Abstract
;
Full Text
Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation:
S. Cuzzocrea, et al.; Free Radic. Biol. Med.
24
, 450 (1998)
Abstract
Protective effects of MEG, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat [published erratum appears in Br. J. Pharmacol. 123, 741 (1998)]:
Z. Lohinai, et al.; Br. J. Pharmacol.
123
, 353 (1998)
Abstract
Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats:
B. Zingarelli, et al.; J. Pharmacol. Exp. Ther.
287
, 1048 (1998)
Abstract
Modulation of peroxynitrite- and hypochlorous acid-induced inactivation of alpha1-antiproteinase by mercaptoethylguanidine:
M. Whiteman, et al.; Br. J. Pharmacol.
126
, 1646 (1999)
Abstract
Further Categories Containing This Product:
Peroxynitrite / Scavengers / Detection
ALX-270-254
Revised 22-Sep-08
Carnosol
SYNONYMS
1,3,4,9,10,10aS-Hexahydro-5,6-dihydroxy-1,1-dimethyl-7-isopropyl-2
H
-9S,4aR-(epoxymethano)phenanthren-12-one
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antioxidants
Ordering Information
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ALX-270-254-M001
1 mg
60.00 USD
ALX-270-254-M005
5 mg
269.00 USD
Product Specification
FORMULA:
C
20
H
26
O
4
MW:
330.4
CAS NUMBER:
5957-80-2
SOURCE/HOST:
Isolated from
Rosmarinus officinalis.
PURITY:
≥96%
APPEARANCE:
White to beige solid.
SOLUBILITY:
Soluble in 100% ethanol (8mg/ml), DMSO (250mg/ml) or dimethyl formamide (35mg/ml); sparingly soluble in aqueous PBS, pH 7.2 (<30μg/ml).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:
Protect from light.
Product Description
Naturally occurring phenolic compound with antioxidant and anti-inflammatory properties. Suppresses nitric oxide (NO) production and inducible nitric oxide synthase (iNOS; NOS II) gene expression by inhibiting NF-κB activation. Inhibits lipid peroxidation. Antimicrobial. Anticarcinogenic. Inhibits cyclooxygenase-2 (COX-2).
Product Specific Literature References
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid:
O.I. Aruoma, et al.; Xenobiotica
22
, 257 (1992)
Abstract
Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production:
M.M. Chan, et al.; Cancer Lett.
96
, 23 (1995)
Abstract
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis:
H. Haraguchi, et al.; Planta Med.
61
, 333 (1995)
Abstract
Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation:
K. Singletary, et al.; Cancer Lett.
104
, 43 (1996)
Abstract
Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention:
K. Macé, et al.; Arch. Toxicol. Suppl.
20
, 227 (1998)
Abstract
Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages:
A.H. Lo, et al.; Carcinogenesis
23
, 983 (2002)
Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma:
O. Rau, et al.; Planta Med.
72
, 881 (2006)
Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis:
K. Horiuchi, et al.; Biol. Pharm. Bull.
30
, 287 (2007)
Abstract
Further Categories Containing This Product:
Natural Products - Chemopreventive Agents
•
Active Substances from Fruit and Vegetables
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Natural Products - NF-kB Pathway Inhibitors
•
Natural Products - Anti-inflammatory Agents
•
Lipid Peroxidation
•
Natural Products - Nitric Oxide Pathway Modulators
•
COX Inhibitors
