• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
TNF & TNF Receptor Superfamily / Related Products
You are here: Product Lines > Chemokines & Cytokines > TNF & TNF Receptor Superfamily / Related Products
 
Toolbar - View Selection
 
 Items 1-20 of 269 Page 1 of 14 Select Page: 1 2 3 4 5 6 7 8 9 10  >>  
ALX-201-073 Revised 20-Nov-08
KillerTRAIL™, Soluble (human) (recombinant)
Add to Clipboard
SYNONYMS Apo-2L, Soluble (human) (recombinant)
TNFSF 10, Soluble (human) (recombinant)
CD253, Soluble (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-073-C020   20 µg 360.00 USD Add To Cart
ALX-201-073-3020 SuperPack 3x20 µg 720.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: Produced in E. coli. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide.
CONCENTRATION: 0.5mg/ml   
PURITY: ≥99% (SDS-PAGE)
PURITY DETAIL: Affinity purified. Sterile filtered.
FORMULATION: Liquid. In 20mM HEPES, pH 7.9, 120mM sodium chloride, 0.01% Tween 20, 1% sucrose and 1mM DTT.
ENDOTOXIN CONTENT: ≤0.004EU/μg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: For a special storage and dilution buffer see KillerTRAIL™ Storage and Dilution Buffer (Prod. No. ALX-505-005).
SPECIFICITY: Binds to human and mouse TRAIL receptors and osteoprotegerin (OPG).
BIOLOGICAL ACTIVITY: Induces apoptosis in a concentration range of 10-100ng/ml.
Note: Does not require a cross-linking enhancer for its potent biological activity. For cell lines that require extensive cross-linking of the TRAIL-Rs for killing (e.g. Jurkat) use SuperKillerTRAIL™ (Prod. No. ALX-201-115).
SPECIFIC ACTIVITY: ED50: 20ng/ml (BJAB cells)
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The cytokines tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papilloma: J.R. Basile, et al.; J. Biol. Chem. 276, 22522 (2001) Abstract; Full Text
The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines: Q. Liao, et al.; FEBS Lett. 503, 151 (2001) Abstract
TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors: M. Plasilova, et al.; Leukemia 16, 67 (2002) Abstract; Full Text
TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections: J. Sträter, et. al.; Gastroenterology 122, 659 (2002) Abstract
Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1: M. MacFarlane, et al.; Cell Death Differ. 12, 773 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P50591: TRAIL (human)
AfCS Signalling Gateway link A002862: TRAIL (mouse)
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-115 Revised 20-Nov-08
SuperKillerTRAIL™, Soluble (human) (recombinant)
Add to Clipboard
SYNONYMS Apo-2L, Soluble (human) (recombinant) (CC-mutant)
TNFSF 10, Soluble (human) (recombinant) (CC-mutant)
CD253, Soluble (human) (recombinant) (CC-mutant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-115-C010   10 µg 360.00 USD Add To Cart
ALX-201-115-3010 SuperPack 3x10 µg 720.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide. The active multimeric conformation is stabilized by an inserted mutation allowing an additional CC-bridge.
CONCENTRATION: 0.5mg/ml.
PURITY: ≥98% (SDS-PAGE)
PURITY DETAIL: Affinity purified. Sterile filtered.
FORMULATION: Liquid. In 20mM HEPES, pH 7.9, containing 120mM NaCl, 0.01% Tween 20, 1% sucrose, 1mM DTT.
ENDOTOXIN CONTENT: <0.02EU/µg purified protein (LAL test; Bio Whittaker).
SPECIFICITY: Binds to human TRAIL receptors.
BIOLOGICAL ACTIVITY: Induces apoptosis at concentrations of >1ng/ml. Note: Does not require a cross-linking enhancer for its potent biological activity. Shows superior activity on human cell lines that require extensive cross-linking of TRAIL-Rs for killing (e.g. Jurkat).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Once thawed it is recommended to prepare appropriate aliquots and to store them at -80°C. In order to retain full activity don’t dilute higher than to a concentration of 0.1mg/ml, prepare 20µl aliquots and store at -80°C. For a special storage and dilution buffer see Prod. No. ALX-505-005. Working dilution: 2-100ng/ml.
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway: Y. Wang, et al.; Cancer Cell 5, 501 (2004) Abstract
Sulforaphane targets pancreatic tumor-initiating cells by NF-{kappa}B-induced anti-apoptotic signaling: G. Kallifatidis, et al.; Gut Epub ahead of print, (2008) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P50591: TRAIL (human)
AfCS Signalling Gateway link A002862: TRAIL (mouse)
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-123 Revised 06-Jun-08
KillerTRAIL™, Soluble (human) (recombinant) (BULK)
Add to Clipboard
SYNONYMS Apo-2L, Soluble (human) (recombinant)
TNFSF 10, Soluble (human) (recombinant)
CD253, Soluble (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-123-C500   500 µg 1'400.00 USD Add To Cart
Inquire
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: Produced in E. coli. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide.
CONCENTRATION: 0.5mg/ml.
PURITY: ≥99% (SDS-PAGE)
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In 20mM HEPES, pH 7.9, containing 120mM sodium chloride, 0.01% Tween 20, 1% sucrose, 1mM DTT.
ENDOTOXIN CONTENT: <0.2EU/µg protein (LAL test; Bio Whittaker).
RECONSTITUTION: For a special storage and dilution buffer see KillerTRAIL™ Storage and Dilution Buffer (Prod. No. ALX-505-005).
SPECIFICITY: Binds to human and mouse TRAIL receptors and osteoprotegerin (OPG).
BIOLOGICAL ACTIVITY: Induces apoptosis in a concentration range of 10-100ng/ml.
Note: This protein does not require a cross-linking enhancer for its potent biological activity. For cell lines that require extensive cross-linking of the TRAIL-Rs for killing (e.g. Jurkat) use SuperKillerTRAIL™ (Prod. No. ALX-201-115).
SPECIFIC ACTIVITY: ED50: 20ng/ml (BJAB cells)
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein J.R. Basile, et al.; J. Biol. Chem. 276, 22522 (2001) Abstract; Full Text
The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines: Q. Liao, et al.; FEBS Lett. 503, 151 (2001) Abstract; Full Text
TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors: M. Plasilova, et al.; Leukemia 16, 67 (2002) Abstract
TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections: J. Sträter, et al.; Gastroenterology 122, 659 (2002) Abstract
Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1: M. MacFarlane, et al.; Cell Death Differ. 12, 773 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P50591: TRAIL (human)
AfCS Signalling Gateway link A002862: TRAIL (mouse)
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-130 Revised 13-Dec-07
SuperKillerTRAIL™, Soluble (mouse) (recombinant)
Add to Clipboard
SYNONYMS Apo-2L, Soluble (mouse) (recombinant) (CC-mutant)
TNFSF 10, Soluble (mouse) (recombinant) (CC-mutant)
CD253, Soluble (mouse) (recombinant) (CC-mutant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-130-C020   20 µg 360.00 USD Add To Cart
ALX-201-130-3020 SuperPack 3x20 µg 720.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: Produced in E. coli. The extracellular domain of mouse TRAIL (aa 99-291) is fused at the N-terminus to a His-tag and a linker peptide. The active multimeric conformation is stabilized by an inserted mutation allowing an additional CC-bridge.
CONCENTRATION: 0.5mg/ml.
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Affinity purified. Sterile filtered.
FORMULATION: Liquid. In 20mM HEPES, pH 7.4, 300mM sodium chloride, 0.01% Tween 20, 1% sucrose, 1mM DTT.
ENDOTOXIN CONTENT: <0.02EU/µg purified protein (LAL test; Bio Whittaker).
SPECIFICITY: Binds to mouse and less potently to human TRAIL receptors.
BIOLOGICAL ACTIVITY: Induces apoptosis at concentrations of >10ng/ml as tested on human tumor cells. This effect can be efficiently blocked by recombinant mouse TRAIL receptors (Prod. No. ALX-522-067 (rmTRAIL-R2:Fc), ALX-522-066 (rmDcTRAIL-R1:Fc), ALX-522-068 (rmDcTRAIL-R2:Fc)). Note: This protein does not require a cross-linker (enhancer) for its potent biological activity.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Once thawed it is recommended to prepare appropriate aliquots and to store them at -80°C. For a special storage and dilution buffer see Prod. No. ALX-505-005.
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P50591: TRAIL (human)
AfCS Signalling Gateway link A002862: TRAIL (mouse)
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-307 Revised 22-May-06
GITRL, Soluble (mouse) (recombinant)
Add to Clipboard
SYNONYMS TNFSF 18, Soluble (mouse) (recombinant)
Glucocorticoid-induced TNF Receptor Ligand, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-307-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 10mM glycine, pH 10.0.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
SPECIFICITY: Binds to mouse GITR.
APPLICATION: rmsGITRL can be used for GITR-mediated NF-κB activation.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells: K.Y. Yu, et al.; BBRC 310, 433 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q7TS55: GITR Ligand (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-308 Revised 31-Aug-06
GITRL, Soluble (mouse) (recombinant) (His)
Add to Clipboard
SYNONYMS TNFSF 18, Soluble (mouse) (recombinant) (His)
Glucocorticoid-induced TNF Receptor Ligand, Soluble (mouse) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-308-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The extracellular domain of mouse GITRL (aa 45-173) is fused at the C-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 10mM glycin, pH 10.0.
ENDOTOXIN CONTENT: <1EU/mg protein (LAL test; Bio Whittaker).
SPECIFICITY: Binds to mouse GITR.
APPLICATION: rmsGITRL can be used for GITR-mediated NF-κB activation.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) stimulates osteoclast differentiation in response to receptor activator of NF-kappaB ligand (RANKL) in osteoclast cells: H.H. Shin, et al.; Bone 36, 832 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q7TS55: GITR Ligand (mouse)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-320 Revised 04-Sep-08
GITRL, Soluble (human) (recombinant)
Add to Clipboard
SYNONYMS Glucocorticoid-induced TNF Receptor Ligand, Soluble (human) (recombinant)
AITRL, Soluble (human) (recombinant)
Activation-inducible TNF-related Ligand, Soluble (human) (recombinant)
TNFSF 18, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-320-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human GITRL (AITRL) (aa 50-177) is fused at the N-terminus to a FLAG®-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized from 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test).
RECONSTITUTION: Reconstitute with an appropriate buffer.
ACTIVITY: Binds to human GITR (AITR).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY:

Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9UNG2: Tumor necrosis factor ligand superfamily member 18 (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-321 Revised 28-Jan-08
CD137L, Soluble (mouse) (recombinant)
Add to Clipboard
SYNONYMS 4-1BBL, Soluble (mouse) (recombinant)
TNFSF 9, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-321-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse CD137L (4-1BBL) (aa 104-309) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY:

Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P41274: CD137L (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-327 Revised 04-Sep-08
GITRL (human) (recombinant) (His)
Add to Clipboard
SYNONYMS Glucocorticoid-induced TNF Receptor Ligand (human) (recombinant) (His)
AITRL (human) (recombinant) (His)
Activation-inducible TNF-related Liga