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Mitochondrial Pathway
You are here: Product Lines > Cell Death / Apoptosis / Autophagy > Mitochondrial Pathway
 
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ALX-201-125 Revised 10-Feb-05
Prothymosin α (1-99) (human) (recombinant)
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SYNONYMS ProTα (1-99) (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Prothymosin alpha
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-125-C050   50 µg 210.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Corresponding to the caspase-3 cleavage product of prothymosin α (ProTα) isolated from apoptotic human cells (no affinity-tags, no added additional (linker) sequences). Purified from overproducing bacterial strains by a phenol extraction procedure, DEAE chromatography, and ethanol precipitation [1].
CONCENTRATION: 1.5mg/ml
PURITY: ≥90%
FORMULATION: Liquid. 50µg dissolved in sterile water.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
[1] Overproduction in Escherichia coli, purification and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Eur. J. Biochem. 231, 639 (1995) Abstract
[2] Sensing prothymosin alpha origin, mutations and conformation with monoclonal antibodies: E.A. Sukhacheva, et al.; J. Immunol. Methods 266, 185 (2002) Abstract
[3] Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Exp. Cell Res. 284, 209 (2003) Abstract
[4] Cytochrome c is transformed from anti- to pro-oxidant when interacting with truncated oncoprotein prothymosin alpha: O.V. Markova, et al.; Biochim. Biophys. Acta 1557, 109 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION The exact length of the human protein is 109 aa corresponding to the NCBl data base entries AAH34921 and TNHUA. The N-terminal M is absent in the mature protein (otherwise, it would be 110). ProTα is acetylated at the N-terminal S. MALDI-MS data for the recombinant ProTα isolated from bacteria show that the protein is partially acetylated.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-126 Revised 10-Feb-05
Prothymosin α (1-109) (human) (recombinant)
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SYNONYMS ProTα (1-109) (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Prothymosin alpha
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-126-C050   50 µg 210.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Native sequence representing mature prothymosin α (ProTα) isolated from human cells (no affinity-tags, no additional added (linker) sequences). Purified from overproducing bacterial strains by a phenol extraction procedure, DEAE chromatography, and ethanol precipitation [1].
CONCENTRATION: 2.5mg/ml
PURITY: ≥90%
FORMULATION: Liquid. 50µg dissolved in sterile water.
BIOLOGICAL ACTIVITY: Stimulates mouse thymocytes comparable to native ProTα [1].
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
[1] Overproduction in Escherichia coli, purification and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Eur. J. Biochem. 231, 639 (2003) Abstract
[2] Sensing prothymosin alpha origin, mutations and conformation with monoclonal antibodies: E.A. Sukhacheva, et al.; J. Immunol. Methods 266, 185 (2002) Abstract
[3] Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha: A.G. Evstafieva, et al.; J. Exp. Cell Res. 284, 209 (2003) Abstract
[4] Cytochrome c is transformed from anti- to pro-oxidant when interacting with truncated oncoprotein prothymosin alpha: O.V. Markova, et al.; Biochim. Biophys. Acta 1557, 109 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION The exact length of the human protein is 109 aa corresponding to the NCBl data base entries AAH34921 and TNHUA. The N-terminal M is absent in the mature protein (otherwise, it would be 110). ProTα is acetylated at the N-terminal S. MALDI-MS data for the recombinant ProTα isolated from bacteria show that the protein is partially acetylated.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-165-067 Revised 16-May-06
PUMA (135-154) (cell permeable)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Noxa & PUMA / Related Products
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ALX-165-067-1   1 Vial 240.00 USD Add To Cart
Product Specification
SEQUENCE: REIGAQLRRMADDLNAQYER-GG-rrrqrrkkr-G-amide
FORMULA: C158H276N68O45S
MW: 3897.4
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
POSITIVE CONTROL: Prod. No. ALX-168-010
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
Product Specific Literature References
BH3-Only proteins-essential initiators of apoptotic cell death: D.C. Huang and A. Strasser; Cell 103, 839 (2000) Abstract
Related Products
Further Categories Containing This Product:
Peptides
 
 
ALX-350-360 Revised 28-May-08
Rotenone
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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ALX-350-360-G001   1 g 45.00 USD Add To Cart
ALX-350-360-G005   5 g 125.00 USD Add To Cart
Product Specification
FORMULA: C23H22O6
MW: 394.4
CAS NUMBER: 83-79-4
MERCK INDEX: 14: 8271
RTECS: DJ2800000
SOURCE/HOST: Synthetic. Originally isolated from Lonchocarpus sp. or Derris sp.
PURITY: ≥98% (Assay)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Insecticide. Inhibitor of mitochondrial electron transport. Specifically inhibits NAD-linked substrate oxidation at the oxygen side of NADH dehydrogenase (EC50=10pmol/mg). Inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding.
Product Specific Literature References
Metabolism of rotenone in vitro by tissue homogenates from mammals and insects: J.I. Fukami, et al.; Science 155, 713 (1967) Abstract
[3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study: D.S. Higgins, Jr. & J.T. Greenamyre; J. Neurosci. 16, 3807 (1996) Abstract; Full Text
Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures: C.M. Testa, et al.; Brain Res. Mol. Brain Res. 134, 109 (2005) Abstract; Full Text
Fatality after deliberate ingestion of the pesticide rotenone: a case report: D.M. Wood, et al.; Crit Care 9, R280 (2005) Abstract; Full Text
Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons: Q. Jiang, et al.; J. Biol. Chem. 281, 29391 (2006) Abstract
Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells: J. Jin, et al.; BMC Neurosci. 8, 67 (2007) Abstract; Full Text
Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding: P. Srivastava & D. Panda; FEBS J. 274, 4788 (2007) Abstract
Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson’s Disease: M. Marella, et al.; PLoS ONE 3, e1433 (2008) Abstract; Full Text
Further Categories Containing This Product:
MPTP [Mitochondrial Transition Pore] / Related Products • Respiratory Chain Other Products • Natural Products for Cytoskeletal Research • Apoptosome Other Products • Pesticides / Related Products
 
 
ALX-350-076 Revised 16-Jun-08
Sanguinarine chloride
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SYNONYMS Pseudochelerythrine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
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ALX-350-076-M005   5 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C20H14NO4Cl
MW: 367.8
CAS NUMBER: 5578-73-4
MERCK INDEX: 14: 8356
RTECS: VP5220000
SOURCE/HOST: Isolated from the leaves and stems of Macleaya cordata and M. microcarpa.
PURITY: ≥98% (HPLC)
APPEARANCE: Orange solid.
SOLUBILITY: Soluble in methanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: HARMFUL.

Product Description
Na+/K+-and Mg2+-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. Modulates the Bcl-2 family. Shows antiplaque activity in humans.
Product Specific Literature References
Sanguinarine, inhibitor of Na-K dependent ATP'ase: K.D. Straub & P. Carver; BBRC 62, 913 (1975) Abstract
Isoquinoline alkaloids. Inhibitory actions on cation-dependent ATP-phosphohydrolases: L.R. Meyerson, et al.; Neurochem. Res. 3, 239 (1978) Abstract
Sanguinarine, a new antiplaque agent: retention and plaque specificity: G.L. Southard, et al.; J. Am. Dent. Assoc. 108, 338 (1984) Abstract
Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion: E. Debiton, et al.; Cancer Chemother. Pharmacol. 51, 474 (2003) Abstract
Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes: V.M. Adhami, et al.; Clin. Cancer Res. 9, 3176 (2003) Abstract
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006) Abstract
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol. 364, 538 (2006) Abstract
Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt: M.H. Han, et al.; Anticancer Drugs 18, 913 (2007) Abstract
Metabolism of sanguinarine: the facts and the myths: Z. Dvorak & V. Simanek; Curr. Drug Metab. 8, 173 (2007), Review Abstract
Further Categories Containing This Product:
Bcl-2 Family Modulators • Na+ / K+-ATPase / Related Products • Natural Products - Antioxidants • Natural Products - Anti-inflammatory Agents • Alkaloids • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-270-294 Revised 03-May-06
Ubiquinone-5
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SYNONYMS Coenzyme Q1
2,3-Dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Coenzymes & Vitamins Other Products
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ALX-270-294-M002   2 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C14H18O4
MW: 250.3
CAS NUMBER: 727-81-1
PURITY: ≥95% (HPLC)
APPEARANCE: Orange-red to red liquid.
SOLUBILITY: Soluble in acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Counteracts inhibitory effects on mitochondrial permeability transition pore (MPTP) of decylubiquinone (Prod. No. ALX-270-293) and ubiquinone-10 (Prod. No. ALX-270-295).
Further Categories Containing This Product:
MPTP [Mitochondrial Transition Pore] / Related Products
 
 
ALX-270-295 Revised 03-May-06
Ubiquinone-10
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SYNONYMS Coenzyme Q2
2,3-Dimethoxy-5-methyl-geranyl-1,4-benzoquinone
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Coenzymes & Vitamins Other Products
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ALX-270-295-M002   2 mg 125.00 USD Add To Cart
Product Specification
FORMULA: C19H26O4
MW: 318.4
CAS NUMBER: 606-06-4
PURITY: ≥90% (HPLC)
APPEARANCE: Red liquid.
SOLUBILITY: Soluble in acetone.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of the mitochondrial permeability transition pore (MPTP). This inhibitory effect can be counteracted by ubiquinone-5 (Prod. No. ALX-270-294).
Further Categories Containing This Product:
MPTP [Mitochondrial Transition Pore] / Related Products
 
 
ALX-270-483 Revised 07-Apr-08
WP1066
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SYNONYMS 3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Apoptosis Inducers)
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ALX-270-483-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C17H14BrN3O
MW: 356.2
CAS NUMBER: 857064-38-1
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (>5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR.

Product Description

Cell permeable STAT3 inhibitor. Activates Bax. Shows potent anticancer effect on malignant glioma cells. Induces apoptosis and inhibits the growth of tumors. Acts as a potent immune adjuvant by upregulating CD80 and CD86 and inducing proliferation of effector T cells.
Product Specific Literature References
A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients: S.F. Hussain, et al.; Cancer Res. 67, 9630 (2007) Abstract
A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo: A. Iwamaru, et al.; Oncogene 26, 2435 (2007) Abstract
Further Categories Containing This Product:
Bax / Related Products • JAK / STAT Signalling Pathway Other Products • T Cell Regulation Other Products • Immunomodulators Other Products
 
 
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