ALEXIS Biochemicals: Chartreusin

ALX-380-073

Revised 12-Oct-07

Chartreusin
SYNONYMS	Lambdamycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-073-M005		5 mg	50.00 USD
ALX-380-073-M025		25 mg	200.00 USD

Product Specification

FORMULA:	C₃₂H₃₂O₁₄
MW:	640.6
CAS NUMBER:	6377-18-0
MERCK INDEX:	14: 2045
SOURCE/HOST:	Isolated from Streptomyces chartreusis.
PURITY:	≥98%
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in acetone; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	TOXIC.

Product Description

Antitumor antibiotic which inhibits topoisomerase II. Induces single-strand scission in DNA in the presence of reducing agents.

Product Specific Literature References

Chartreusin, a New Antibiotic Produced by Streptomyces chartreusis, a New Species: B. E. Leach, et al.; J. Am. Chem. Soc. 75, 4011 (1953)
Chartreusin, a glycosidic antitumour antibiotic from Streptomyces: J.A. Beisler; Prog. Med. Chem. 19, 247 (1982), (Review) Abstract
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico & B.H. Long; Eur. J. Cancer 14, 1985 (1993) Abstract
Chartreusin, elsamicin A and related anti-cancer antibiotics: J. Portugal; Curr. Med. Chem. Anticancer Agents 3, 411 (2003), Review Abstract

Further Categories Containing This Product:

Antibiotics - Topoisomerase Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (DNA Interaction & Gene Regulation)

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