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Interleukins & Interleukin Receptors / Related Products
You are here: Product Lines > Chemokines & Cytokines > Interleukins & Interleukin Receptors / Related Products
 
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ALX-201-361 Revised 01-Oct-08
IL-33 (mouse) (recombinant) (His)
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SYNONYMS Interleukin-33 (mouse) (recombinant) (His)
NF-HEV (mouse) (recombinant) (His)
IL-1F11 (mouse) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-361-C010   10 µg 295.00 USD Add To Cart
ALX-201-361-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Recombinant mouse IL-33 (aa 109-266) is fused at the C-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing
150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SPECIFICITY: Binds to human ST2.
BIOLOGICAL ACTIVITY: Activates ST2-dependent NF-κB pathway.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q2YEJ4: Interleukin-33 (mouse) (recombinant)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-125 Revised 01-Oct-08
IL-33 (rat) (recombinant)
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SYNONYMS Interleukin-33 (rat) (recombinant)
NF-HEV (rat) (recombinant)
IL-1F11 (rat) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-125-C010   10 µg 290.00 USD Add To Cart
Product Specification
MW: ~16kDa
SOURCE/HOST: Produced in E. coli. Untagged rat IL-33 (aa 109-264).
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
Nuclear Interleukin-33 Is Generally Expressed in Resting Endothelium but Rapidly Lost upon Angiogenic or Proinflammatory Activation: A.M. Küchler, et al.; Am. J. Pathol. Epub ahead of print, (2008) Abstract
General Information
IL-33 is a new member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1RL1) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-κB and MAPK pathways. The human IL-33 protein is expressed with a prodomain (aa 1-111) which is cleaved by caspase-1 to produce the 18kDa mature protein (112-270).
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q66H70: Interleukin-33 (rat)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005) Abstract
IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system: S. Sanada, et al.; J. Clin. Invest. 117, 1538 (2007) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Interleukin-33 [IL-33] & Receptors / Related Products
 
 
ALX-350-328 Revised 07-Apr-08
(+)-Madindoline A
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SYNONYMS MadA
MDL-A
[(2R), 3aR, 8aS]-8-[4-(n-Butyl)-2,5-dimethyl-1, 3-dioxo-2-(4-cyclopentyl)methyl]-3, 3a, 8,8a-tetrahydro-3a-hydroxy-2H-furo[2,3-b] indole
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin & Interleukin Receptors Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-328-MC05   0.5 mg 330.00 USD Add To Cart
ALX-350-328-M001   1 mg 580.00 USD Add To Cart
Product Specification
FORMULA: C22H27NO4
MW: 370.2
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Light yellow needles
SOLUBILITY: Soluble in methanol or 100% ethanol; insoluble in hexane.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Madindolines are noncytotoxic indole alkaloids originally isolated from a fermentation broth of Streptomyces nitrosporeus K93-071. (+)-Madindoline A (MadA; MDL-A) and (+)-madindoline B (MadB; MDL-B) are diastereomers with MadA being the more potent compound. MadA binds competitively but noncovalently to the extracellular domain of the membrane glycoprotein gp130 and inhibits the homodimerization of the trimeric IL-6/IL-6R/gp130 or the IL-11/gp130 complex, thus inhibiting activation of the JAK/STAT signal transduction pathway. MadA inhibits IL-6 and IL-11-induced osteoclastogenesis in vitro in a dose dependent manner and postmenopausal osteoporosis in vivo, by a mechanism different from that of 17β-estradiol. IL-6 activity is known to cause various diseases such as cancer cachexia, Castleman’s disease, Crohn’s disease, rheumatoid arthritis, hypercalcemia, and multiple myeloma. Madindolines are no longer available from natural sources due to mutation of the originating bacterial strain. Thus, synthetic routes have been developed to produce madindolines. Recently analogs of madindolines have been synthesized as potent IL-6 inhibitors.
Product Specific Literature References
Madindoline, a novel inhibitor of IL-6 activity from Streptomyces sp. K93-0711. I. Taxonomy, fermentation, isolation and biological activities: M. Hayashi, et al.; J. Antibiot. 49, 1091 (1996) Abstract
Madindolines, novel inhibitors of IL-6 activity from streptomyces sp. K93-0711. II. Physico-chemical properties and structural elucidation: S.Takamatsu, et. al.; J. Antibiot. 50, 1069 (1997) Abstract
Binding of madindoline A to the extracellular domain of gp130: A.Z. Saleh, et al.; Biochemistry 44, 10822 (2005) Abstract
Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130: C. Lutticken, et al.; Science 263, 89 (1994) Abstract
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130: M. Hayashi, et al.; PNAS 99, 14728 (2002) Abstract
Mechanisms of experimental cancer cachexia. Local involvement of IL-1 in colon-26 tumor: G. Strassmann, et.al.; J. Immunol. 150, 2341 (1993) Abstract
Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman’s disease: K. Yoshizaki, et al.; Blood 74, 1360 (1989) Abstract
Inhibition of IL-6 for the treatment of inflammatory diseases: N. Nishimoto & T. Kishimoto; Curr. Opin. Pharmacol. 4, 386 (2004) Abstract
Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis: N. Takagi, et al.; Arthritis Rheum. 41, 2117 (1998) Abstract
Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo: J. de la Mata, et al.; J. Clin. Invest. 95, 2846 (1995) Abstract
Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells: X.G. Zhang, et al.; Blood 76, 2599 (1990) Abstract
Synthesis of (+)-madindoline A and (+)-madindoline B: L. Wan & M.A. Tius; Org. Lett. 9, 647 (2007) Abstract
Design, synthesis, and biological activities of madindoline analogues: D. Yamamoto, et al.; Bioorg. Med. Chem. Lett. 16, 2807 (2006) Abstract
Efficient total synthesis of novel bioactive microbial metabolites: T. Sunazuka, et al.; Acc. Chem. Res. 41, 302 (2008) Abstract
General Information
MANUFACTURER Manufactured by the Kitasato Institute, Tokyo.
Further Categories Containing This Product:
Bone Metabolism Other Products • Natural Products - Other Signal Transduction Pathway Modulators • Alkaloids
 
 
ALX-804-461 Revised 01-Oct-08
Monoclonal Antibody to IL-1 Receptor Type II (human) (MNC2)
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SYNONYMS anti-IL-1RII (human) MAb (MNC2)
anti-CD121b (human) MAb (MNC2)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptor Antibodies
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ALX-804-461-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MNC2
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Purified antibody in PBS containing 0.1% sodium azide.
IMMUNOGEN: Recombinant human IL-1RII (interleukin-1 receptor type II; CD121b).
SPECIFICITY: Recognizes human IL-1RII.
APPLICATION: ELISA (capture)
Flow Cytometry (excellent)
Immunohistochemistry
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors / Related Products • CD Antibodies • Monoclonal Antibodies
 
 
ALX-804-338 Revised 28-Nov-07
Monoclonal Antibody to IL-1F1 (mouse) (Flo1)
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SYNONYMS anti-Interleukin-1 Family Member 1 (mouse) MAb (Flo1)
anti-IL-1α (mouse) MAb (Flo1)
anti-Interleukin-1α (mouse) MAb (Flo1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Antibodies
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ALX-804-338-C100   100 µg 259.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: Flo1
ISOTYPE: Mouse IgG1
IMMUNOGEN: Mouse IL-1F1 (IL-1α).
SPECIFICITY: Recognizes mouse IL-1F1.
APPLICATION: ELISA
Functional Application (neutralizing)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
Functional discrimination between interleukin 6 and interleukin 1: M. Helle, et al.; Eur. J. Immunol. 18, 1535 (1988) Abstract
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors / Related Products • Monoclonal Antibodies
 
 
ALX-804-462 Revised 02-Mar-06
Monoclonal Antibody to IL-1ra3 (human) (MND1)
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SYNONYMS anti-icIL-1raII (human) MAb (MND1)
anti-IL-1 Receptor Agonist Type II (intracellular isoform) (human) MAb (MND1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin & Interleukin Receptors Other Products
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ALX-804-462-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MND1
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Purified antibody in PBS containing 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to a partial sequence (ADLYEEGGGGGGEGEDNADSK) of human IL-1ra3.
SPECIFICITY: Recognizes human IL-1ra3.
APPLICATION: Immunohistochemistry
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Characterization of type II intracellular IL-1 receptor antagonist (IL-1ra3): a depot IL-1ra: M. Muzio, et al.; Eur. J. Immunol. 29, 781 (1999) Abstract
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors / Related Products • Monoclonal Antibodies
 
 
ALX-804-337 Revised 30-Aug-07
Monoclonal Antibody to IL-2 (mouse) (JES6-5H4)
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SYNONYMS anti-Interleukin-2 (mouse) MAb (JES6-5H4)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-337-C100   100 µg 259.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: JES6-5H4
ISOTYPE: Rat IgG2b
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4 containing 0.1% sodium azide.
IMMUNOGEN: Recombinant mouse IL-2 (interleukin-2).
SPECIFICITY: Recognizes mouse IL-2.
APPLICATION: ELISA
Flow Cytometry
Immunohistochemistry (frozen sections)
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples: J.S. Abrams, et al.; Immunol. Rev. 127, 5 (1992) Abstract
Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. Cytokine detection by immunoassay and intracellular immunostaining: B. Sander, et al.; J. Immunol. Methods 166, 201 (1993) Abstract
Increase in orthotopic murine corneal transplantation rejection rate with anterior synechiae: S. Yamagami & T. Tsuru; Invest. Ophthalmol. Vis. Sci. 40, 2422 (1999) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-726 Revised 02-Oct-08
Monoclonal Antibody to IL-33 (human) (IL33305B)
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SYNONYMS anti-Interleukin-33 (human) MAb (IL33305B)
anti-NF-HEV (human) MAb (IL33305B)
anti-IL-1F11 (human) MAb (IL333305B)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-726-C050   50 µg 195.00 USD Add To Cart
ALX-804-726-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: IL33305B
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human IL-33 (interleukin-33).
SPECIFICITY: Recognizes human IL-33. Does not cross-react with mouse IL-33.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Western Blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Immunoprecipitation
Functional Application (Neutralization)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 1-2 weeks when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products • Polyclonal Antibodies
 
 
ALX-804-728 Revised 02-Oct-08
Monoclonal Antibody to IL-33 (IL33026B)
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SYNONYMS anti-Interleukin-33 MAb (IL33026B)
anti-NF-HEV MAb (IL33026B)
anti-IL-1F11 MAb (IL33026B)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-728-C050   50 µg 195.00 USD Add To Cart
ALX-804-728-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: IL33026B
ISOTYPE: Mouse IgG1κ
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human IL-33 (interleukin-33).
SPECIFICITY: Recognizes human and mouse IL-33.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Western Blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 1-2 weeks when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products • Polyclonal Antibodies
 
 
ALX-804-727 Revised 02-Oct-08
Monoclonal Antibody to IL-33 (IL33068A)
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SYNONYMS anti-Interleukin-33 MAb (IL33068A)
anti-NF-HEV MAb (IL33068A)
anti-IL-1F11 MAb (IL33068A)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-727-C050   50 µg 195.00 USD Add To Cart
ALX-804-727-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: IL33068A