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Chemokines & Cytokines
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ALX-201-394 Revised 18-Mar-08
ANGPTL6 (Fibrinogen-like Domain) (human) (recombinant)
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SYNONYMS Angiopoietin-like Protein 6 (Fibrinogen-like Domain) (human) (recombinant)
AGF (Fibrinogen-like Domain) (human) (recombinant)
Angiopoietin-related Growth Factor (Fibrinogen-like Domain) (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-394-C010   10 µg 240.00 USD Add To Cart
ALX-201-394-C050   50 µg 710.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Mature human ANGPTL6 (angiopoietin-like protein 6; AGF) (aa 231-470) is fused at the N-terminus to a FLAG®-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot Link Q8NI99: Angiopoietin-related protein 6 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-201-368 Revised 04-Apr-07
ANGPTL7 (human) (recombinant)
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SYNONYMS Angiopoietin-like Protein 7 (human) (recombinant)
Cornea-derived Transcript 6 Protein (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-368-C010   10 µg 295.00 USD Add To Cart
ALX-201-368-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Human ANGPTL7 (angiopoietin-like protein 7) (aa 1-346) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION:   
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
Product Images
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General Information
Human ANGPTL7 is produced as a secreted glycoprotein with a molecular mass of 45kDa in SDS-PAGE analysis. Human mRNA is expressed in neural tissues, keratoconus cornea, trabecular meshwork, melanotic melanoma and uterus endometrial cancer, while mouse Angptl7 mRNA is expressed in four-cell embryos, synovial fibroblasts, thymus, uterus and testis. ANGPTL7 reduces tumor growth and aberrant blood vessel formation by inducing massive fibrosis in a mouse xenograft model [1]. It was reported that addition of ANGPTL7 results in a further increase in HSC activities. This suggests that ANGPTL7 may activate signal transduction pathways that cannot be activated by SCF, TPO, IGF-2 or FGF-1 [2]. Human ANGPTL7, characterized as potent target gene of WNT/ beta-catenin signalling pathway, is a pharmacogenomics target in the fields of oncology and regenerative medicine [3].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O43827: Angiopoietin-related protein 7 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
[1] The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea: R. Peek, et al.; J. Biol. Chem. 277, 686 (2002) Abstract; Full Text
[2] Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells: C.C. Zhang, et al.; Nat. Med. 12, 240 (2006) Abstract
[3] Comparative integromics on Angiopoietin family members: Y. Katoh and M. Katoh; Int. J. Mol. Med. 17, 1145 (2006) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-201-395 Revised 18-Mar-08
ANGPTL7 (Fibrinogen-like Domain) (human) (recombinant)
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SYNONYMS Angiopoietin-like Protein 7 (Fibrinogen-like Domain) (human) (recombinant)
Cornea-derived Transcript 6 Protein (Fibrinogen-like Domain) (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-395-C010   10 µg 250.00 USD Add To Cart
ALX-201-395-C050   50 µg 560.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Mature human ANGPTL7 (angiopoietin-like protein 7) (aa 126-346) is fused at the N-terminus to a FLAG®-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot Link O43827: Angiopoietin-related protein 7 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-035 Revised 02-Jul-08
MegaAPRIL™, Soluble (human) (recombinant)
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SYNONYMS APRIL, Soluble (human) (recombinant):ACRP30headless (human)
A-Proliferation-inducing Ligand (human) (recombinant):ACRP30headless (human)
TNFSF 13, Soluble (human) (recombinant):ACRP30headless (human)
CD256, Soluble (human) (recombinant):ACRP30headless (human)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY APRIL
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-035-3010   3x10 µg 460.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~34kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human APRIL (aa 88-233) is fused at the N-terminus to human ACRP30headless (aa 16-108) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human and mouse BCMA and TACI. Binds to proteoglycans.
BIOLOGICAL ACTIVITY: Stimulates proliferation of serum-starved NIH 3T3 cells. Stimulates B cell proliferation.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
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Product Specific Literature References
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL: M.B. Litinskiy, et al.; Nat. Immunol. 3, 822 (2002) Abstract
APRIL modulates B and T cell immunity: J.V. Stein, et al.; J. Clin. Invest. 109, 1587 (2002) Abstract; Full Text
Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL: B. He, et al.; J. Immunol. 172, 3268 (2004) Abstract; Full Text
Potential role of APRIL as autocrine growth factor for megakaryocytopoiesis: D. Bonci, et al.; Blood 104, 3169 (2004) Abstract; Full Text
BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway: A. Craxton, et al.; J. Exp. Med. 202, 1363 (2005) Abstract
APRIL and BAFF promote increased viability of replicating human B2 cells via mechanism involving cyclooxygenase 2: P.K. Mongini, et al.; J. Immunol. 176, 6736 (2006) Abstract; Full Text
TACI regulates IgA production by APRIL in collaboration with HSPG: D. Sakurai, et al.; Blood 109 , 2961 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link O75888: APRIL (human)
AfCS Signalling Gateway link A000305: APRIL (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth: M. Hahne, et al.; J. Exp. Med. 188, 1185 (1998) Abstract
Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI: S.A. Marsters, et al.; Curr. Biol. 10, 785 (2000) Abstract
A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth: P. Rennert, et al.; J. Exp. Med. 192, 1677 (2000) Abstract
Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS: Y. Wu, et al.; J. Biol. Chem. 275, 35478 (2000) Abstract
APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity: G. Yu, et al.; Nat. Immunol. 1, 252 (2000) Abstract
B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses: S. Xu & K.P. Lam; Mol. Cell. Biol. 21, 4067 (2001) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-270-443 Revised 05-May-08
AS601245
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SYNONYMS 1,3-Benzothiazol-2-yl-(2-{[2-(3-pyridinyl)ethyl]amino}-4-pyrimidinyl) acetonitrile
JNK Inhibitor V
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY JNK [SAPK1]/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-443-M001   1 mg 50.00 USD Add To Cart
ALX-270-443-M005   5 mg 150.00 USD Add To Cart
ALX-270-443-M025   25 mg 520.00 USD Add To Cart
Product Specification
FORMULA: C20H16N6S
MW: 372.5
CAS NUMBER: 345987-15-7
PURITY: ≥95% (HPLC)
APPEARANCE: White to yellow solid.
PURITY DETAIL: Sum of two isomers.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Hygroscopic. Packaged under inert gas. Protect from light.
HAZARD: HARMFUL.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Potent and cell permeable ATP competitive JNK inhibitor (hJNK1: IC50=150nM, hJNK2: IC50=220nM and hJNK3: IC50=70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice.
Product Specific Literature References
AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties: S. Carboni, et al.; J. Pharmacol. Exp. Ther. 310, 25 (2004) Abstract; Full Text
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase: P. Gaillard, et al.; J. Med. Chem. 48, 4596 (2005) Abstract
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • Anti-inflammatory Agents Other Products
 
 
ALX-380-208 Revised 03-Apr-08
Asterric acid
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SYNONYMS Dimethylosoic acid
TAN 1415A
WF 12880A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Angiogenesis Research
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ALX-380-208-M001   1 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C17H16O8
MW: 348.3
CAS NUMBER: 577-64-0
SOURCE/HOST: Isolated from Aspergillus terreus MST-FP1370.
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Antibiotic. Inhibitor of vascular endothelial growth factor (VEGF).
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 115. Metabolites of Penicillium frequentans Westling: isolation of sulochrin, asterric acid, (+)-bisdechlorogeodin and two new substituted anthraquinones, questin and questinol: A. Mahmoodian and C.E. Stickings; Biochem. J. 92, 369 (1964) Abstract; Full Text
Asterric acid, a new endothelin binding inhibitor: H. Ohashi, et al.; J. Antibiot. (Tokyo) 45, 1684 (1992) Abstract
Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs: H.J. Lee, et al.; J. Antibiot. (Tokyo) 55, 552 (2002) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • VEGFs & VEGF-Rs Other Products
 
 
ALX-522-025 Revised 23-Jun-08
BAFF, Soluble (human) (recombinant)
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SYNONYMS BlyS, Soluble (human) (recombinant)
TALL-1, Soluble (human) (recombinant)
THANK, Soluble (human) (recombinant)
zTNF4, Soluble (human) (recombinant)
TNFSF 13B/20, Soluble (human) (recombinant)
CD257, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-025-C010   10 µg 365.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~28kDa (SDS-PAGE).
SOURCE/HOST: Produced in E. coli. The extracellular domain of human BAFF (aa 83-285) is fused at the N-terminus to a linker peptide (6 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human and mouse (weak) BCMA, TACI and BAFF-R.
BIOLOGICAL ACTIVITY: Mediates splenocyte survival. Induces monocyte survival.
APPLICATION: Detection of receptors of human soluble BAFF on target cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
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Product Specific Literature References
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population: J.S. Thompson, et al.; J. Exp. Med. 192, 129 (2000) Abstract; Full Text
BAFF mediates survival of peripheral immature B lymphocytes: M. Batten, et al.; J. Exp. Med. 192, 1453 (2000) Abstract; Full Text
Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen: P. Schneider, et al.; J. Exp. Med. 194, 1691 (2001) Abstract
T cell costimulation by the TNF ligand BAFF: B. Huard, et al.; J. Immunol. 167, 6225 (2001) Abstract
Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival: A.J. Novak, et al.; Blood 100, 2973 (2002) Abstract; Full Text
BAFF is a survival and maturation factor for mouse B cells: A.G. Rolink, et al.; Eur. J. Immunol. 32, 2004 (2002) Abstract
Expression of BLyS and its Receptors in B-Cell Non-Hodgkin Lymphoma: Correlation with Disease Activity and Patient Outcome: A.J. Novak, et al.; Blood 104, 2247 (2004) Abstract
TACI is mutant in common variable immunodeficiency and IgA deficiency: E. Castigli, et al.; Nat. Genet. 37, 829 (2005) Abstract
A role for BLyS in the activation of innate immune cells: S.K. Chang, et al.; Blood 108, 2687 (2006) Abstract; Full Text
Viral Double-Stranded RNA Triggers Ig Class Switching by Activating Upper Respiratory Mucosa B Cells through an Innate TLR3 Pathway Involving BAFF: W. Xu, et al.; J. Immunol. 181, 276 (2008) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9Y275: BAFF (human)
AfCS Signalling Gateway link A000383: BAFF (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production: L.G. Xu & H.B. Shu; J. Immunol. 169, 6883 (2002) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-052 Revised 02-May-07
BAFF, Soluble (mouse) (recombinant)
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SYNONYMS BLyS, Soluble (mouse) (recombinant)
TALL-1, Soluble (mouse) (recombinant)
THANK, Soluble (mouse) (recombinant)
zTNF4, Soluble (mouse) (recombinant)
TNFSF 13B/20, Soluble (mouse) (recombinant)
CD257, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-052-C010   10 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~17kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse BAFF (aa 127-309) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or other carrier protein.
SPECIFICITY: Binds to human (weak) and mouse BCMA, TACI and BAFF-R.
BIOLOGICAL ACTIVITY: Mediates splenocyte survival.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Act1, a negative regulator in CD40- and BAFF-mediated B cell survival: Y. Qian, et al.; Immunity 21, 575 (2004) Abstract
BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway: A. Craxton, et al.; J. Exp. Med. 202, 1363 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9WU72: BAFF (mouse)
AfCS Signalling Gateway link A000383: BAFF (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
APO-54N-022 Revised 01-Apr-08
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