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TNF & TNF Receptor Superfamily/Related Products
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ALX-201-376 Revised 28-Jan-08
CD137L, Soluble (mouse) (recombinant) (His)
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SYNONYMS 4-1BBL, Soluble (mouse) (recombinant) (His)
TNFSF 9, Soluble (mouse) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-376-C010   10 µg 140.00 USD Add To Cart
ALX-201-376-C050   50 µg 390.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The extracellular domain of mouse CD137L (4-1BBL) (aa 106-309) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS-HCl, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY:

Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P41274: CD137L (mouse)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • CD Proteins
 
 
ALX-522-032 Revised 25-Feb-08
CD137L, Soluble (human) (recombinant)  - Replaced by Prod. No. ALX-522-111
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PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L/Related Products
Ordering Information
not sold in USA
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins/Fusion Proteins
 
 
ALX-522-111 Revised 27-Mar-08
CD137L, Soluble (human) (recombinant)
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SYNONYMS 4-1BBL, Soluble (human) (recombinant)
TNFSF 9, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-111-C010   10 µg 140.00 USD Add To Cart
ALX-522-111-3010 SuperPack 3x10 µg 260.00 USD Add To Cart
Product Specification
MW: ~27kDa
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human CD137L (aa 49-254) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS and 5% trehalose.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human CD137 (4-1BB).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Description
Biologically active CD137L (4-1BBL; TNFSF 9) comprising the whole extracellular tail domain (aa 49-93), which is important for the cross-linking of the protein that is essential for its biological activity [1].
Product Specific Literature References
[1] Production of recombinant human trimeric CD137L (4-1BBL). Cross-linking is essential to its T cell co-stimulation activity: C. Rabu, et al.; J. Biol. Chem. 280, 41472 (2005) Abstract; Full Text
General Information
The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P41274: CD137L (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • CD Proteins
 
 
ALX-270-171 Revised 30-Jun-08
Chlorpromazine . hydrochloride
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SYNONYMS 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-171-G001   1 g 22.00 USD Add To Cart
ALX-270-171-G005   5 g 66.00 USD Add To Cart
Product Specification
FORMULA: C17H19ClN2S . HCl
MW: 318.9 . 36.5
CAS NUMBER: 69-09-0
MERCK INDEX: 14: 2185
RTECS: SO1750000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D2 antagonist. H1 antagonist. Inhibits TNF-α production. Potent PLA2 inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity: H.B. Collier; Clin. Biochem. 7, 331 (1974) Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins: D.R. Marshak, et al.; Biochemistry 24, 144 (1985) Abstract
Selective inhibition of group II phospholipase A2 by quercetin: M. Lindahl & C. Tagesson; Inflammation 17, 573 (1993) Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge: M. Palacios, et al.; BBRC 196, 280 (1993) Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice: H. Yamamoto; Toxicol. Lett. 66, 73 (1993) Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice: M.G. Netea, et al.; J. Infect. Dis. 171, 393 (1995) Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase: A. Boveris, et al.; Methods Enzymol. 359, 328 (2002) Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine: S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys. 430, 170 (2004) Abstract
Further Categories Containing This Product:
Phosphodiesterases/Related Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • TNF-alpha & TNF Receptors Other Products • PLA2 Inhibitors • Chemopreventive Agents Other Products • Dopaminergics & Dopamine Receptors/Related Products
 
 
ALX-550-516 Revised 21-May-08
Compound A
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SYNONYMS CpdA
2-((4-Acetophenyl)-2-chloro-N-methyl)ethylammonium chloride
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-550-516-M005   5 mg 40.00 USD Add To Cart
ALX-550-516-M025   25 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C11H14ClNO2 . HCl
MW: 227.7 . 36.5
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or water.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stock solutions in ethanol are stable for up to 1 month when stored at -80°C.
HANDLING: Protect from moisture. After reconstitution, prepare aliquots and store at -80°C.

Product Description
Cell permeable, nonsteroidal glucocorticoid receptor modulator with high binding affinity. Exerts anti-inflammatory potential by down-modulating TNF-induced pro-inflammatory gene expression, such as IL-6 and E-selectin. Unlike dexamethasone (Prod. No. ALX-370-002) it does not enhance glucocorticoid response element (GRE)-driven gene expression or induce glucocorticoid receptor (GR) binding to GRE-dependent genes in vivo.
Product Specific Literature References
A fully dissociated compound of plant origin for inflammatory gene repression: K. De Bosscher, et al.; PNAS 102, 15827 (2005) Abstract
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis: P. Dewint, et al.; J. Immunol. 180, 2608 (2008) Abstract
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Further Categories Containing This Product:
GITR & GITRL Other Products • Glucocorticoids & Glucocorticoid Receptors/Related Products • RANK & RANKL/OPG Other Products • DNA & RNA Methyl & Alkyl Transferases/Related Products • Antitumor Agents (Hormone-related) • NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products for Cell Cycle Research • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Chemopreventive Agents • Other Natural Products - DNA Regulation/Transcription
 
 
ALX-522-055 Revised 24-Mar-05
DcR3 (human):Fc (human) (recombinant)
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SYNONYMS Decoy Receptor 3 (human):Fc (human) (recombinant)
TNFRSF 6B (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY HVEM & LIGHT/LT-betaR/DcR3/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-055-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~58kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human DcR3 (decoy receptor 3) (aa 1-246) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water.
SPECIFICITY: Binds human LIGHT. Does not bind human FasL.
APPLICATION: Detection of human LIGHT and TL1A (VEGI) in combination with PAb to human IgG1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Specific Literature References
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer: R.M. Pitti, et al.; Nature 396, 699 (1998) Abstract
A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis: K.Y. Yu, et al.; J. Biol. Chem. 274, 13733 (1999) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O95407: DcR3 (human) (precursor)
AfCS Signalling Gateway link A000758: DcR3 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis: W. Roth, et al.; Cancer Res. 61, 2759 (2001) Abstract
Modulation of dendritic cell differentiation and maturation by decoy receptor 3: T.L. Hsu, et al.; J. Immunol. 168, 4846 (2002) Abstract
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Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-370-002 Revised 19-Sep-06
Dexamethasone
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SYNONYMS 9α-Fluoro-16α-methylprednisolone
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Glucocorticoids & Glucocorticoid Receptors/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-370-002-M250   250 mg 22.00 USD Add To Cart
ALX-370-002-G001   1 g 45.00 USD Add To Cart
Product Specification
FORMULA: C22H29FO5
MW: 392.5
CAS NUMBER: 50-02-2
MERCK INDEX: 14: 2943
RTECS: TU3980000
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol. Slightly soluble in acetone or chloroform. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL. MAY BE TERATOGENIC.

Product Description
Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Glucocorticoid with anti-inflammatory activity. Inhibits the induction of nitric oxide synthases (NOS).
Product Specific Literature References
Inhibition of the induction of nitric oxide synthase by glucocorticoids: yet another explanation for their anti-inflammatory effects?: S. Moncada & R.M.J. Palmer; TIPS 12, 130 (1991), (Review) Abstract
Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells: K.J. O'Connor & S. Moncada; Biochim. Biophys. Acta 1097, 227 (1991) Abstract
Nitric oxide mediates tumor necrosis factor-alpha cytotoxicity in endothelial cells: C. Estrada, et al.; BBRC 186, 475 (1992) Abstract
Dexamethasone inhibits the expression of an inducible nitric oxide synthase in infarcted rabbit myocardium: R.R. Dudek, et al.; BBRC 202, 1120 (1994) Abstract
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes: T. Grombacher, et al.; Carcinogenesis 17, 2329 (1996) Abstract
Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone: T. Biswas, et al.; Oncogene 18, 525 (1999) Abstract
Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases: M.G. Cifone, et al.; Blood 93, 2282 (1999) Abstract; Full Text
Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2: M.S. Montani, et al.; Cell Death Differ 6, 79 (1999) Abstract
Dexamethasone inhibits the phosphorylation of retinoblastoma protein in the suppression of human vascular smooth muscle cell proliferation: T.D. Reil, et al.; J. Surg. Res. 92, 108 (2000) Abstract
Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells: M. Matsumura, et al.; Life Sci. 69, 1067 (2001) Abstract
Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages: R. Korhonen, et al.; Mol. Pharmacol. 62, 698 (2002) Abstract; Full Text
Molecular mechanisms underlying dexamethasone inhibition of iNOS expression and activity in C6 glioma cells: J. Shinoda, et al.; Glia 42, 68 (2003) Abstract
Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-kappaB activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line: A.L. Vital, et al.; Mediators Inflamm. 12, 71 (2003) Abstract
Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles: S.C. Schafer, et al.; Am. J. Physiol. Heart Circ. Physiol. 288, H436 (2005) Abstract; Full Text
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Further Categories Containing This Product:
GITR & GITRL Other Products • RANK & RANKL/OPG Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • Antitumor Agents (Hormone-related) • Chemopreventive Agents Other Products • DNA & RNA Methyl & Alkyl Transferases/Related Products • Cell Cycle Other Products
 
 
ALX-522-040 Revised 24-Mar-05
DR3 (human):Fc (human) (recombinant)
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SYNONYMS Apo-3 (human):Fc (human) (recombinant)
LARD (human):Fc (human) (recombinant)
TRAMP (human):Fc (human) (recombinant)
TR3 (human):Fc (human) (recombinant)
WSL-1 (human):Fc (human) (recombinant)
TNFRSF 12 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TWEAK & FN14/DR3/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-040-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~55kDa (under reducing conditions).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of human DR3 (aa 25-199) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human TL1A.
APPLICATION: Can be used together with anti-human IgG1 PAb to detect TL1A.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C. After reconstitution, it is recommended to make appropriate aliquots and to store them at -20°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
The DR3 receptor (WSL-1, Apo-3, LARD, TRAMP, TR3) is a member of the tumor necrosis factor receptor (TNF-R) family. DR3 is a type I transmembrane receptor. It is 339 aa long and contains 4 extracellular cysteine-rich motifs in its extracellular domain, while its cytoplasmic region contains a death domain. DR3 is abundantly expressed on thymocytes and T and B lymphocytes. Overexpression of DR3 mediates activation of nuclear factor NF-κB and induces apoptosis. Besides the induction of apoptosis, DR3 has been reported to regulate negative selection during thymocyte development.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q93038: DR3 (human) (precursor)
AfCS Signalling Gateway link A000786: DR3 (mouse)
MANUFACTURER

Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-019 Revised 24-Mar-05
DR6 (human):Fc (human) (recombinant)
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SYNONYMS Death Receptor-6 (human):Fc (human) (recombinant)
TNFRSF 21 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY DR6/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-019-C050   50 µg 360.00 USD