• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
GITR & GITRL / Related Products
You are here: Product Lines > Chemokines & Cytokines > TNF & TNF Receptor Superfamily / Related Products > GITR & GITRL / Related Products
 
Toolbar - View Selection
 
Items 19 of 19
ALX-550-516 Revised 21-May-08
Compound A
Add to Clipboard
SYNONYMS CpdA
2-((4-Acetophenyl)-2-chloro-N-methyl)ethylammonium chloride
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-516-M005   5 mg 40.00 USD Add To Cart
ALX-550-516-M025   25 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C11H14ClNO2 . HCl
MW: 227.7 . 36.5
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or water.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stock solutions in ethanol are stable for up to 1 month when stored at -80°C.
HANDLING: Protect from moisture. After reconstitution, prepare aliquots and store at -80°C.

Product Description
Cell permeable, nonsteroidal glucocorticoid receptor modulator with high binding affinity. Exerts anti-inflammatory potential by down-modulating TNF-induced pro-inflammatory gene expression, such as IL-6 and E-selectin. Unlike dexamethasone (Prod. No. ALX-370-002) it does not enhance glucocorticoid response element (GRE)-driven gene expression or induce glucocorticoid receptor (GR) binding to GRE-dependent genes in vivo.
Product Specific Literature References
A fully dissociated compound of plant origin for inflammatory gene repression: K. De Bosscher, et al.; PNAS 102, 15827 (2005) Abstract
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis: P. Dewint, et al.; J. Immunol. 180, 2608 (2008) Abstract
Related Products
Further Categories Containing This Product:
GITR & GITRL Other Products • RANK & RANKL / OPG Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • Glucocorticoids & Glucocorticoid Receptors / Related Products • Antitumor Agents (Hormone-related) • DNA & RNA Methyl & Alkyl Transferases / Related Products • Other Natural Products - DNA Regulation / Transcription • Natural Products - Chemopreventive Agents • Natural Products - Nitric Oxide Pathway Modulators • Natural Products for Cell Cycle Research
 
 
ALX-370-002 Revised 19-Sep-06
Dexamethasone
Add to Clipboard
SYNONYMS 9α-Fluoro-16α-methylprednisolone
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Glucocorticoids & Glucocorticoid Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-370-002-M250   250 mg 22.00 USD Add To Cart
ALX-370-002-G001   1 g 45.00 USD Add To Cart
Product Specification
FORMULA: C22H29FO5
MW: 392.5
CAS NUMBER: 50-02-2
MERCK INDEX: 14: 2943
RTECS: TU3980000
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol. Slightly soluble in acetone or chloroform. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL. MAY BE TERATOGENIC.

Product Description
Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Glucocorticoid with anti-inflammatory activity. Inhibits the induction of nitric oxide synthases (NOS).
Product Specific Literature References
Inhibition of the induction of nitric oxide synthase by glucocorticoids: yet another explanation for their anti-inflammatory effects?: S. Moncada & R.M.J. Palmer; TIPS 12, 130 (1991), (Review) Abstract
Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells: K.J. O'Connor & S. Moncada; Biochim. Biophys. Acta 1097, 227 (1991) Abstract
Nitric oxide mediates tumor necrosis factor-alpha cytotoxicity in endothelial cells: C. Estrada, et al.; BBRC 186, 475 (1992) Abstract
Dexamethasone inhibits the expression of an inducible nitric oxide synthase in infarcted rabbit myocardium: R.R. Dudek, et al.; BBRC 202, 1120 (1994) Abstract
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes: T. Grombacher, et al.; Carcinogenesis 17, 2329 (1996) Abstract
Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone: T. Biswas, et al.; Oncogene 18, 525 (1999) Abstract
Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases: M.G. Cifone, et al.; Blood 93, 2282 (1999) Abstract; Full Text
Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2: M.S. Montani, et al.; Cell Death Differ 6, 79 (1999) Abstract
Dexamethasone inhibits the phosphorylation of retinoblastoma protein in the suppression of human vascular smooth muscle cell proliferation: T.D. Reil, et al.; J. Surg. Res. 92, 108 (2000) Abstract
Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells: M. Matsumura, et al.; Life Sci. 69, 1067 (2001) Abstract
Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages: R. Korhonen, et al.; Mol. Pharmacol. 62, 698 (2002) Abstract; Full Text
Molecular mechanisms underlying dexamethasone inhibition of iNOS expression and activity in C6 glioma cells: J. Shinoda, et al.; Glia 42, 68 (2003) Abstract
Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-kappaB activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line: A.L. Vital, et al.; Mediators Inflamm. 12, 71 (2003) Abstract
Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles: S.C. Schafer, et al.; Am. J. Physiol. Heart Circ. Physiol. 288, H436 (2005) Abstract; Full Text
Related Products
Further Categories Containing This Product:
GITR & GITRL Other Products • RANK & RANKL / OPG Other Products • Antitumor Agents (Hormone-related) • DNA & RNA Methyl & Alkyl Transferases / Related Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • Chemopreventive Agents Other Products • Cell Cycle Other Products
 
 
ALX-522-061 Revised 31-Aug-06
GITR (human):Fc (human) (recombinant)
Add to Clipboard
SYNONYMS Glucocorticoid-induced TNFR-related Protein (human):Fc (human) (recombinant)
AITR (human):Fc (human) (recombinant)
Activation-inducible TNFR Family Receptor (human):Fc (human) (recombinant)
TNFRSF 18 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-061-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~47kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of human GITR (AITR) (aa 26-161) is fused to the Fc portion of human IgG1.
QUANTITY: 50µg
CONCENTRATION: 1mg/ml.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human GITRL (AITRL).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9Y5U5: GITR (human) (precursor)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-024 Revised 31-Aug-06
GITR (mouse):Fc (human) (recombinant)
Add to Clipboard
SYNONYMS Glucocorticoid-induced TNFR-related Protein (mouse):Fc (human) (recombinant)
TNFRSF 18 (mouse):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-024-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~45kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of mouse GITR (aa 20-152) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds mouse GITRL.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Soluble glucocorticoid-induced TNF receptor (sGITR) induces inflammation in mice: H. H. Shin, et al.; Exp. Mol. Med. 35, 358 (2003) Abstract; Full Text
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells: M. Tone, et al.; PNAS 100, 15059 (2003) Abstract
Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) stimulates osteoclast differentiation in response to receptor activator of NF-kappaB ligand (RANKL) in osteoclast cells: H.H. Shin, et al.; Bone 36, 832 (2005) Abstract
Proinflammatory role of glucocorticoid-induced TNF receptor-related gene in acute lung inflammation: S. Cuzzocrea, et al.; J. Immunol. 177, 631 (2006) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O35714: GITR (mouse) (precursor)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-320 Revised 04-Sep-08
GITRL, Soluble (human) (recombinant)
Add to Clipboard
SYNONYMS Glucocorticoid-induced TNF Receptor Ligand, Soluble (human) (recombinant)
AITRL, Soluble (human) (recombinant)
Activation-inducible TNF-related Ligand, Soluble (human) (recombinant)
TNFSF 18, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-320-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human GITRL (AITRL) (aa 50-177) is fused at the N-terminus to a FLAG®-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized from 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test).
RECONSTITUTION: Reconstitute with an appropriate buffer.
ACTIVITY: Binds to human GITR (AITR).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY:

Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9UNG2: Tumor necrosis factor ligand superfamily member 18 (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-307 Revised 22-May-06
GITRL, Soluble (mouse) (recombinant)
Add to Clipboard
SYNONYMS TNFSF 18, Soluble (mouse) (recombinant)
Glucocorticoid-induced TNF Receptor Ligand, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-307-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 10mM glycine, pH 10.0.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
SPECIFICITY: Binds to mouse GITR.
APPLICATION: rmsGITRL can be used for GITR-mediated NF-κB activation.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells: K.Y. Yu, et al.; BBRC 310, 433 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q7TS55: GITR Ligand (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-308 Revised 31-Aug-06
GITRL, Soluble (mouse) (recombinant) (His)
Add to Clipboard
SYNONYMS TNFSF 18, Soluble (mouse) (recombinant) (His)
Glucocorticoid-induced TNF Receptor Ligand, Soluble (mouse) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-308-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The extracellular domain of mouse GITRL (aa 45-173) is fused at the C-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 10mM glycin, pH 10.0.
ENDOTOXIN CONTENT: <1EU/mg protein (LAL test; Bio Whittaker).
SPECIFICITY: Binds to mouse GITR.
APPLICATION: rmsGITRL can be used for GITR-mediated NF-κB activation.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) stimulates osteoclast differentiation in response to receptor activator of NF-kappaB ligand (RANKL) in osteoclast cells: H.H. Shin, et al.; Bone 36, 832 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q7TS55: GITR Ligand (mouse)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-327 Revised 04-Sep-08
GITRL (human) (recombinant) (His)
Add to Clipboard
SYNONYMS Glucocorticoid-induced TNF Receptor Ligand (human) (recombinant) (His)
AITRL (human) (recombinant) (His)
Activation-inducible TNF-related Ligand (human) (recombinant) (His)
TNFSF 18 (human) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-327-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The extracellular domain of human GITRL (AITRL) is fused at the N-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS, pH 8.2 containing 150 mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test).
ACTIVITY: Binds to human GITR (AITR).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9UNG2: Tumor necrosis factor ligand superfamily member 18 (human)
MANUFACTURER Manufactured by Adipogen, Inc.
General Literature References
Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand: B. Kwon, et al.; J. Biol. Chem. 274, 6056 (1999) Abstract; Full Text
Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR: A.L. Gurney, et al.; Curr. Biol. 9, 215 (1999) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-804-516 Revised 31-Oct-06
Monoclonal Antibody to GITR (mouse) (MGIT 02)
Add to Clipboard
SYNONYMS anti-TNFRSF 18 (mouse) MAb (MGIT 02)
anti-Glucocorticoid-induced TNFR-related Protein (mouse) MAb (MGIT 02)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-516-C050   50 µg 220.00 USD Add To Cart
ALX-804-516-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: MGIT 02
ISOTYPE: Rat IgG2a
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant mouse GITR.
SPECIFICITY: Recognizes both natural and recombinant mouse GITR. Does not cross-react with human GITR (AITR).
APPLICATION: ELISA (direct and indirect: 1:5'000-1:10'000)
Flow Cytometry (excellent) (1:1'000)
Western Blot (1:2'000-1:5'000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature.)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information