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Chemokines & Cytokines
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ALX-270-066 Revised 07-Apr-08
Lavendustin C
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SYNONYMS Compound 5
5-(N-2,5-Dihydroxybenzyl)aminosalicylic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-270-066-M001   1 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C14H13NO5
MW: 275.3
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Potent inhibitor of protein tyrosine kinases and Ca2+/calmodulin-dependent kinase II. Acts also as an inhibitor of EGFR tyrosine kinase and pp60c-src kinase.
Product Specific Literature References
Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus: T. Onoda, et al.; J. Nat. Prod. 52, 1252 (1989) Abstract
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors: T.J. O'Dell, et al.; Nature 353, 558 (1991) Abstract
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity: I. Takahashi, et al.; BBRC 165, 1207 (1989) Abstract
Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor: H.M. Burt, et al.; J. Leukoc. Biol. 55, 112 (1994) Abstract
Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway: D. Lidington, et al.; J. Cell Physiol. 185, 117 (2000) Abstract
Related Products
Further Categories Containing This Product:
CAM Kinase Inhibitors • EGFR Kinase Inhibitors • Lipopolysaccharides [LPS] / Related Products • Tyrosine Kinase Inhibitors
 
 
ALX-350-084 Revised 07-Apr-08
Lavendustin C methyl ester
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SYNONYMS Compound 5 methyl ester
5-Amino-N-(2,5-dihydroxybenzyl)methyl salicylate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-084-M001   1 mg 50.00 USD Add To Cart
ALX-350-084-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C15H15NO5
MW: 289.3
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Inhibitor of EGFR tyrosine kinase with improved bioavailability over lavendustin C (Prod. No. ALX-270-066).
Product Specific Literature References
Synthesis and structure-activity studies of a series of [(hydroxybenzyl)amino]salicylates as inhibitors of EGF receptor- associated tyrosine kinase activity: H. Chen, et al.; J. Med. Chem. 36, 4094 (1993) Abstract
Structure-activity relationships in a series of 5-[(2,5- dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions: H. Chen, et al.; J. Med. Chem. 37, 845 (1994) Abstract
Related Products
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • EGFR Kinase Inhibitors
 
 
ALX-201-034 Revised 02-May-06
Leptin (human) (recombinant)
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SYNONYMS OB Gene Product (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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ALX-201-034-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~16kDa.
MERCK INDEX: 14: 5443
SOURCE/HOST: Produced in E. coli. Homologous to human serum leptin.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized from sterile filtered solution in 10mM sodium citrate, pH 4.0.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein.
RECONSTITUTION: Reconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing 0.1% HSA or BSA.
BIOLOGICAL ACTIVITY: Induces proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and freeze in liquid nitrogen.
General Information
Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. It targets the central nervous system, particularly hypothalamus, affecting food intake. Leptin levels are high in most obese individuals. Studies have shown that it may also influence reproductive function.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P41159: Leptin (human) (precursor)
General Literature References
Leptin and the regulation of body weight in mammals: J.M. Friedman and J.L. Halaas; Nature 395, 763 (1998), review Abstract
Mutation screening and identification of a sequence variation in the human ob gene coding region: R.V. Considine, et al.; BBRC 220, 735 (1996) Abstract
Serum immunoreactive leptin concentrations in normal-weight and obese humans  : R.V. Considine, et al. ; New Engl. J. Med. 334, 292 (1996) Abstract
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects  : M. Maffei, et al.; Nature Medicine 1, 1155 (1995) Abstract
Effects of the obese gene product on body weight regulation in ob/ob mice  : M.A. Pelleymounter, et al. ; Science 269, 540 (1995) Abstract
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity  : R.V. Considine, et al. ; J. Clin. Invest 95, 2986 (1995) Abstract
Overexpression of the obese (ob) gene in adipose tissue of the human subjects  : F. Lönnqvist, et al. ; Nature Medicine 1, 950 (1995) Abstract
Positional cloning of the mouse obese gene and its human homologue  : Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-035 Revised 18-May-06
Leptin (mouse) (recombinant)
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SYNONYMS OB Gene Product (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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ALX-201-035-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~16kDa.
MERCK INDEX: 14: 5443
SOURCE/HOST: Produced in E. coli. Homologous to mouse serum leptin.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized from 0.0045mM sodium bicarbonate.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein.
RECONSTITUTION: Reconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing a carrier protein.
BIOLOGICAL ACTIVITY: Induces proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. Studies have shown that it may also influence reproductive function. Mice with ob/ob genotype develop a form of diabetes similar to type II in humans.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link 41160: Leptin (mouse) (precursor)
AfCS Signalling Gateway link A001397: Leptin (mouse)
General Literature References
Positional cloning of the mouse obese gene and its human homologue: Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Effects of the obese gene product on body weight regulation in ob/ob mice: M.A. Pelleymounter, et al.; Science 269, 540 (1995) Abstract
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects: M. Maffei, et al.; Nature Med. 1, 1155 (1995) Abstract
Weight-reducing effects of the plasma protein encoded by the obese gene: J.L. Halaas, et al.; Science 269, 543 (1995) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-231 Revised 18-Mar-08
Leptin (rat) (recombinant)
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SYNONYMS OB Gene Product (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-231-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~16kDa.
MERCK INDEX: 14: 5443
SOURCE/HOST: Produced in E. coli. Homologous to rat serum leptin.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized from 0.0045mM sodium bicarbonate.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein.
RECONSTITUTION: Reconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing a carrier protein.
BIOLOGICAL ACTIVITY: Induces proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. It targets the central nervous system, particularly hypothalamus, affecting food intake. Leptin levels are high in most obese individuals. Studies have shown that it may also influence reproductive function.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P50596: Leptin (rat) (precursor)
General Literature References
Leptin and the regulation of body weight in mammals: J.M. Friedman and J.L. Halaas; Nature 395, 763 (1998), review Abstract
Mutation screening and identification of a sequence variation in the human ob gene coding region: R.V. Considine, et al.; BBRC 220, 735 (1996) Abstract
Serum immunoreactive leptin concentrations in normal-weight and obese humans  : R.V. Considine, et al. ; New Engl. J. Med. 334, 292 (1996) Abstract
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects  : M. Maffei, et al.; Nature Medicine 1, 1155 (1995) Abstract
Effects of the obese gene product on body weight regulation in ob/ob mice  : M.A. Pelleymounter, et al. ; Science 269, 540 (1995) Abstract
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity  : R.V. Considine, et al. ; J. Clin. Invest 95, 2986 (1995) Abstract
Overexpression of the obese (ob) gene in adipose tissue of the human subjects  : F. Lönnqvist, et al. ; Nature Medicine 1, 950 (1995) Abstract
Positional cloning of the mouse obese gene and its human homologue  : Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-850-050 Revised 24-Feb-05
Leptin (human) EIA Kit
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SYNONYMS OB Gene Product (human) EIA Kit
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-050-KI01   1 Kit 376.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.2ng/ml
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the direct assay of human leptin in serum or plasma.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
Positional cloning of the mouse obese gene and its human homologue: Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity: R.V. Considine, et al.; J. Clin. Invest. 95, 2986 (1995) Abstract
Weight-reducing effects of the plasma protein encoded by the obese gene: J.L. Halaas, et al.; Science 269, 543 (1995) Abstract
Effects of the obeses gene product on body weight regulation in ob/ob mice: M.A. Pelleymounter, et al.; Science 269, 540 (1995) Abstract
Serum immunoreactive-leptin concentrations in normal-weight and obese humans: R. Considine, et al.; New Engl. J. Med. 334, 292 (1996) Abstract
Mutation screening and identification of a sequence variation in the human obesity: R.V. Considine, et al.; BBRC 220, 735 (1996) Abstract
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-850-044 Revised 25-Sep-08
Leptin (human) ELISA Kit
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SYNONYMS OB Gene Product (human) ELISA Kit
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-044-KI01   1 Kit 344.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.17ng/ml (range 1 to 50ng/ml)
QUANTITY: For 96 wells (~80 tests)
APPLICATION: For the quantitative determination of human leptin in serum, plasma and cell culture supernatant. Weakly cross-reacts with dog and goat leptin. Does not cross-react with mouse and rat sera.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
Decreased plasma orexin-A levels in obese individuals: J.A. Adam, et al.; Int. J. Obes. Relat. Metab. Disord. 26, 274 (2002) Abstract
Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity: M. Haluzik, et al.; J. Hum. Hypertens. 16, 41 (2002) Abstract
Gender differences in factors influencing insulin resistance in elderly hyperlipemic non-diabetic subjects: R. Lichnovska, et al.; Cardiovasc. Diabetol. 14, 4 (2002) Abstract; Full Text
Exon 6 and 2 peroxisome proliferator-activated receptor-gamma polymorphisms in polycystic ovary syndrome: F. Orio, Jr., et al.; J. Clin. Endocrinol. Metab. 88, 5887 (2003) Abstract; Full Text
Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin: U. Meier & A.M. Gressner; Clin. Chem. 50, 1511 (2004) Abstract; Full Text
Serum leptin in the development of insulin resistance and other disorders in the metabolic syndrome: R. Lichnovska, et al.; Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub. 149, 119 (2005) Abstract; Full Text
Conjugated linoleic acid impairs endothelial function: J.S. Taylor, et al.; Arterioscler. Thromb. Vasc. Biol. 26, 307 (2006) Abstract; Full Text
General Information
MANUFACTURER Manufactured by BioVendor.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-850-317 Revised 25-Sep-08
Leptin (mouse/rat) ELISA Kit
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-317-KI01   1 Kit 461.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SENSITIVITY: 30pg/ml for mouse and 50pg/ml for rat leptin (range 100 to 4’000pg/ml).
QUANTITY: For 96 wells (~80 tests)
APPLICATION: For the quantitative determination of mouse and rat leptin in plasma, serum and cell culture supernatant. Cross-reacts strongly with human and weakly with hamster leptin.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by BioVendor.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-850-296 Revised 26-Sep-08
Leptin Receptor (human) ELISA Kit
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SYNONYMS OB-R (human) ELISA Kit
CD295 (human) ELISA Kit
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-296-KI01   1 Kit 696.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.4ng/ml (range 2 to 100ng/ml)
QUANTITY: For 96 wells (~80 tests)
APPLICATION: For the quantitative determination of human leptin receptor in serum, plasma and cell culture supernatant. Weakly cross-reacts with mouse, dog, horse and pig leptin receptor. Does not cross-react with rat serum.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 6 months when stored at +4°C.
Product Specific Literature References
Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans: J.L. Chan, et al.; Diabetes 51, 2105 (2002) Abstract
Mutations in the human leptin and leptin receptor genes as models of serum leptin receptor regulation: N. Lahlou, et al.; Diabetes 51, 1980 (2002) Abstract
Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin: M. Laimer, et al.; Obes. Res. 10, 597 (2002) Abstract
Soluble leptin receptor and insulin resistance as determinant of sleep apnea: D. Manzella, et al.; Int. J. Obes. Relat. Metab. Disord. 26, 370 (2002) Abstract
Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum: P. Monteleone, et al.; Mol. Psychiatry 7, 641 (2002) Abstract
Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans: V. Ogier, et al.; Int. J. Obes. Relat. Metab. Disord. 26, 496 (2002) Abstract
Soluble leptin receptors and serum leptin in end-stage renal disease: relationship with inflammation and body composition: R. Pecoits-Filho, et al.; Eur. J. Clin. Invest. 32, 811 (2002) Abstract
Circulating concentrations of soluble leptin receptor: influence of menstrual cycle and diet therapy: H. Shimizu, et al.; Nutrition 18, 309 (2002) Abstract
Leptin and soluble leptin receptor levels in obese and weight-losing individuals: F.M. van Dielen, et al.; J. Clin. Endocrinol. Metab. 87, 1708 (2002) Abstract
Leptin, soluble leptin receptor, and transforming growth factor-beta1 levels in minimal change nephrotic syndrom: N. Buyan, et al.; Pediatr. Nephrol. 18, 1009 (2003) Abstract
Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns: A. Gavrila, et al.; J. Clin. Endocrinol. Metab. 88, 2838 (2002) Abstract; Full Text
Relationships between the serum levels of soluble leptin receptor and free and bound leptin in non-pregnant women of reproductive age and women undergoing controlled ovarian hyperstimulation: N. Kado, et al.; Hum. Reprod. 18, 715 (2003) Abstract; Full Text
Changes in circulating leptin, leptin receptor, and gonadal hormones from infancy until advanced age in humans: D.R. Mann, et al.; J. Clin. Endocrinol. Metab. 88, 3339 (2003) Abstract; Full Text
Serum ghrelin levels in obese patients: the relationship to serum leptin levels and soluble leptin receptors levels: M. Rosicka, et al.; Physiol. Res. 52, 61 (2003) Abstract; Full Text
Soluble leptin receptor and soluble receptor-bound fraction of leptin in the metabolic syndrome: A. Sandhofer, et al.; Obes. Res. 11, 760 (2003) Abstract; Full Text
Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans: M. Yannakoulia, et al.; J. Clin. Endocrinol. Metab. 88, 1730 (2003) Abstract; Full Text
Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS) In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS patients: K. Chatzantoni, et al.; J. Autoimm. 23, 169 (2004) Abstract
Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity: M. Misra, et al.; J. Clin. Endocrinol. Metab. 89, 3486 (2004) Abstract; Full Text
Serum leptin, soluble leptin receptor, free leptin index and bone mineral density in patients with primary biliary cirrhosis: F. Szalay, et al.; Eur. J. Gastroenterol. Hepatol. 17, 923 (2005)