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Chemokines & Cytokines
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ALX-804-843 Revised 16-Aug-07
Monoclonal Antibody to EDA-A1 (Renzo-1)
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SYNONYMS anti-Ectodysplasin-A1 MAb (Renzo-1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY EDA & EDAR, Troy / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-843-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Renzo-1
ISOTYPE: Mouse IgG2b
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human EDA-A1 (ectodysplasin-A1) extracellular domain (aa 245-391) (Prod. No ALX-522-038).
SPECIFICITY: Recognizes human and mouse EDA-A1 and EDA-A2.
CROSSREACTIVITY PROTEINS: EDA-A2
APPLICATION: ELISA
Immunohistochemistry (paraffin sections)
Immunoprecipitation (1:100)
Western Blot (1:1‘000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
POSITIVE CONTROL: Prod. No. ALX-522-038
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A: P. Schneider, et al.; J. Biol. Chem. 276, 18819 (2001) Abstract
Related Products
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • Monoclonal Antibodies
 
 
ALX-804-839 Revised 03-May-07
Monoclonal Antibody to EDA-A1 (Renzo-2)
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SYNONYMS anti-Ectodysplasin-A1 MAb (Renzo-2)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY EDA & EDAR, Troy / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-839-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Renzo-2
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human EDA-A1 (ectodysplasin-A1) extracellular domain (aa 245-391) (Prod. No ALX-522-038).
SPECIFICITY: Recognizes human and mouse EDA-A1 and EDA-A2.
CROSSREACTIVITY PROTEINS: EDA-A2
APPLICATION: ELISA
Immunoprecipitation (1:100)
Flow Cytometry
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Prod. No. ALX-522-038
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A: P. Schneider, et al.; J. Biol. Chem. 276, 18819 (2001) Abstract
Related Products
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • Monoclonal Antibodies
 
 
ALX-804-064 Revised 05-Feb-08
Monoclonal Antibody to EGF Receptor (human) (13G8)
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SYNONYMS anti-Epidermal Growth Factor Receptor (human) MAb (13G8)
anti-EGFR (human) MAb (13G8)
anti-HER-1 (human) MAb (13G8)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-064-C100   100 µg 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 13G8
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN: Synthetic peptide corresponding to aa 1165-1186 of EGF receptor (epidermal growth factor receptor).
SPECIFICITY: Recognizes the C-terminus of human EGF receptor (aa 1165-1186). Recognition is independent of phosphorylation of Tyr1173.
APPLICATION: Immunocytochemistry: 0.1-1µg/ml
Immunoprecipitation
Luminex
Western Blot: (1µg/ml µg/ml for HRPO/ECL detection). Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and freeze in liquid nitrogen.
POSITIVE CONTROL: Yes (Prod. No. ALX-840-030).
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-572 Revised 04-Jul-05
Monoclonal Antibody to EGF Receptor (human) (MGR1)
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SYNONYMS anti-EGF Receptor (human) MAb (MGR1)
anti-Epidermal Growth Factor Receptor (human) MAb (MGR1)
anti-EGFR (human) MAb (MGR1)
anti-HER-1 (human) MAb (MGR1)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Antibodies
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ALX-804-572-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MGR1
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. In 150mM sodium chloride, pH 7.4, containing 0.02% sodium azide.
IMMUNOGEN: A431 vulva epidermoid carcinoma cell line.
SPECIFICITY: Recognizes the EGF binding site of the extracellular domain of human EGFR (epidermal growth factor receptor; HER-1).
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections)
Immunoprecipitation
Western Blot: Only in not reduced condition and with a sample buffer containing 0.1% SDS. Detects a band of ~145kDa.
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Do not freeze.
Product Specific Literature References
Characterization of a monoclonal antibody directed against the epidermal growth factor receptor binding site: R. Pellegrini, et al.; Cancer Immunol. Immunother. 34, 37 (1991) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-161 Revised 05-Jun-07
Monoclonal Antibody to EGF Receptor (non-phosphorylated) (20G3)
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SYNONYMS anti-Epidermal Growth Factor Receptor (non-phosphorylated) MAb (20G3)
anti-EGFR (non-phosphorylated) MAb (20G3)
anti-HER-1 (non-phosphorylated) MAb (20G3)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-161-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 20G3
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 2x PBS containing 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN: Synthetic peptide corresponding to human EGF receptor (epidermal growth factor receptor) Tyr1173 phosporylation site.
SPECIFICITY: Recognizes non-activated human and mouse EGF receptor (dephosphorylated at Tyr1173) and cross-reacts with the 1170NAEYLRV peptide motif. Does not cross-react with the activated human and mouse EGF receptor phosphorylated at Tyr1173. Activated EGF receptor (phosphorylated at Tyr1173) can be detected in parallel using Prod. No. ALX-804-160, which specifically recognizes the phosphorylated peptide motif.
APPLICATION: Immunoprecipitation (1-1µg/106 vandate treated A431 cells)
Immunocytochemistry (0.1-1µg/ml)
Luminex
Western Blot (1µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL INCLUDED: yes
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-390 Revised 05-Jun-07
Monoclonal Antibody to EGF Receptor (phosphorylated) (pSer1047) (1H9)
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SYNONYMS anti-Epidermal Growth Factor Receptor (phosphorylated) (pSer1047) MAb (1H9)
anti-EGFR (phosphorylated) (pSer1047) MAb (1H9)
anti-HER-1 (phosphorylated) (pSer1047) MAb (1H9)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-390-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
CLONE: 1H9
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min, RT).
IMMUNOGEN: Synthetic peptide corresponding to a portion of human EGF receptor (epidermal growth factor receptor) phosphorylated at Ser1047.
SPECIFICITY: Recognizes human, mouse and dog Ser1047-phosphorylated EGF receptor. Does not cross-react with unphosphorylated EGF receptor or other unrelated serine-phosphorylated proteins.
APPLICATION: Immunocytochemistry (0.1-1µg/ml)
Luminex
Western Blot (0.5µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Included (Prod. No. ALX-840-025).
Further Categories Containing This Product:
Phospho-specific Antibodies • Monoclonal Antibodies
 
 
ALX-804-160 Revised 20-Sep-07
Monoclonal Antibody to EGF Receptor (phosphorylated) (Tyr1173) (9H2)
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SYNONYMS anti-Epidermal Growth Factor Receptor (phosphorylated) (Tyr1173) MAb (9H2)
anti-EGFR (phosphorylated) (Tyr1173) MAb (9H2)
anti-HER-1 (phosphorylated) (Tyr1173) MAb (9H2)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-160-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
CLONE: 9H2
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS containing 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min, RT).
IMMUNOGEN: Synthetic peptide corresponding to a portion of human EGF receptor (epidermal growth factor receptor) phosphorylated at Tyr1173.
SPECIFICITY: Recognizes the major autophosphorylation site N1170AEpYLRV of human, mouse and dog EGF receptor. Does not cross-react with the non-phosphorylated human, mouse, rat and dog EGF receptor or with unrelated Tyr-phosphorylated proteins. Non-activated EGF receptor (dephosphorylated at Tyr1173) can be detected in parallel using Prod. No. ALX-804-161 that specifically recognizes the non-phosphorylated peptide motif.
APPLICATION: Immunocytochemistry (0.1-1µg/ml)
Immunohistochemistry (paraffin sections, frozen sections)
Immunoprecipitation
Luminex
Western Blot: (0.5µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and freeze in liquid nitrogen.
POSITIVE CONTROL INCLUDED: yes
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Further Categories Containing This Product:
Phospho-specific Antibodies • Monoclonal Antibodies
 
 
ALX-804-119 Revised 03-Nov-05
Monoclonal Antibody to Fas (DD) (human) (3D5)
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SYNONYMS anti-APO-1 (DD) (human) (3D5)
anti-CD95 (DD) (human) (3D5)
anti-TNFRSF 6 (DD) (human) MAb (3D5)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Fas Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-119-R200   200 µl 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 3D5
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. In 50% glycerol containing 1mM sodium azide.
IMMUNOGEN: Recombinant human Fas (CD95; APO-1) cytoplasmic domain.
SPECIFICITY: Recognizes human Fas death domain (DD).
APPLICATION: Western Blot (1:500; total cell lysates)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Activation-induced aggregation and processing of the human Fas antigen. Detection with cytoplasmic domain-specific antibodies: T. Kamitani, et al.; J. Biol. Chem. 272, 22307 (1997) Abstract; Full Text
Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms: E.L. Henderson, et al.; Circulation 99, 96 (1999) Abstract; Full Text
Fas aggregation does not correlate with Fas-mediated apoptosis: Y. Lee & E. Shacter; J. Immunol. 167, 82 (2001) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-038 Revised 23-Jul-08
Monoclonal Antibody to Fas (human) (2R2)
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SYNONYMS anti-CD95 (human) MAb (2R2)
anti-APO-1 (human) MAb (2R2)
anti-TNFRSF 6 MAb (human) (2R2)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Fas Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-038-C100   100 µg 340.00 USD Add To Cart
ALX-805-038B-C100 Biotin 100 µg 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 2R2
ISOTYPE: Mouse IgG3
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE).
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: 2R2: Liquid. In PBS containing 1% BSA. Contains no preservatives.
2R2-Biotin: Liquid. In PBS.
IMMUNOGEN: Mouse L cells stably overexpressing human Fas (CD95; APO-1).
SPECIFICITY: Recognizes human Fas.
APPLICATION: 2R2:
Flow Cytometry
Functional Application (induces apoptosis - no cross-linking required).
- Can be used in DISC (death-inducing signalling complex assays): Co-immunoprecipitates FADD and caspase-8 after receptor activation.

2R2-Biotin:
Flow Cytometry
Immunocytochemistry
Immunohistochemistry (frozen sections, paraffin sections)
- Recommended working dilutions are 1:200-1:1000.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
Product Images
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Product Specific Literature References
Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis: D. Ferrari, et al.; J. Exp. Med. 188, 979 (1998) Abstract; Full Text
Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction: S. Wesselborg, et al.; Blood 93, 3053 (1999) Abstract; Full Text
IL-10 induces apoptosis in human monocytes involving the CD95 receptor/ligand pathway: M. Schmidt, et al.; Eur. J. Immunol. 30, 1769 (2000) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION IHC (PS) Antigen Retrieval: we recommend using a citric acid solution together with microwave retrieval (5 x 5 minutes at high intensity).
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-022 Revised 06-Jan-09
Monoclonal Antibody to Fas (human) (APO-1-1)
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SYNONYMS anti-CD95 (human) MAb (APO-1-1)
anti-APO-1 (human) MAb (APO-1-1)
anti-TNFRSF 6 (human) MAb (APO-1-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Fas Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-022-C100 Purified 100 µg 259.00 USD Add To Cart
ALX-805-022B-T100 Biotin 100 tests 308.00 USD Add To Cart
ALX-805-022F-T100 FITC 100 tests 308.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: APO-1-1