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ALX-850-075 Revised 23-Apr-08
CD40L, Soluble (mouse) (recombinant) Set
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SYNONYMS CD154, Soluble (mouse) (recombinant) Set
TNFSF 5, Soluble (mouse) (recombinant) Set
gp39, Soluble (mouse) (recombinant) Set
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD40 & CD40L [CD154] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-075-KI01   1 Set 495.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse CD40L (CD154) (aa 115-260) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: CD40L: 0.1mg/ml after reconstitution.
Enhancer: 1mg/ml after reconstitution.
KIT/SET CONTAINS: 10µg of CD40L, Soluble (mouse) (recombinant) (Prod. No. ALX-522-070) and 2x50µg of Enhancer for Ligands (Prod. No. ALX-804-034) which increases the biological activity of CD40L at least 1’000-fold.
PURITY: ≥90% (SDS-PAGE).
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute CD40L with 100µl sterile water and each vial of enhancer with 50µl of sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or carrier protein.
SPECIFICITY: CD40L binds to human and mouse CD40 in an ELISA assay.
APPLICATION: ELISA
Functional Application: Stimulates the proliferation of mouse B cells and dendritic cells. The activity of CD40L increases 1’000-fold (stimulation in the ng/ml range) in the presence of the cross-linking enhancer (Prod. No. ALX-804-034).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
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Product Specific Literature References
The persistent elimination of B cells responding to blood group A carbohydrates by synthetic group A carbohydrates and B-1 cell differentiation blockade: novel concept in preventing antibody-mediated rejection in ABO-incompatible transplantation: T. Irei, et al.; Blood 110, 4567 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION CD40L (Prod. No. ALX-522-070) and Enhancer for Ligands (Prod. No. ALX-804-034) should be incubated together for 30 min. at room temperature prior to cell application. Effects are typically best seen with 0.5-10µg/ml of CD40L together with 1-2µg/ml of enhancer. This may vary by cell type and experimental conditions.

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Receptor / Ligand + Enhancer Set • CD Kits & Sets
 
 
ALX-850-030 Revised 17-Apr-08
CD40L, Soluble (human) ELISA Kit
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SYNONYMS CD154, Soluble (human) ELISA Kit
TNFSF 5, Soluble (human) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD40 & CD40L [CD154] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-030-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.062ng/ml (range 0.16 to 10ng/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of soluble human CD40L (CD154) in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
HANDLING: Store controls at -20°C. Store rest of the kit at +4°C.
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
CD Kits & Sets • ELISA & EIA Kits
 
 
ALX-850-311 Revised 14-Apr-08
CD40L, Soluble (human) ELISA Kit (high sensitivity)
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SYNONYMS CD154, Soluble (human) ELISA Kit (high sensitivity)
TNFSF 5, Soluble (human) ELISA Kit (high sensitivity)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD40 & CD40L [CD154] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-311-KI01   1 Kit 682.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.005ng/ml (range 0.08 to 5ng/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of soluble human CD40L (CD154) in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
HANDLING: Store controls at -20°C. Store rest of the kit at +4°C.
Product Specific Literature References
CD40-ligand stimulates myelopoiesis by regulating flt3-ligand and thrombopoietin production in bone marrow stromal cells: A. Solanilla, et al.; Blood 95, 3758 (2000) Abstract
Levels of soluble CD40 ligand (CD154) in serum are increased in human immunodeficiency virus type 1-infected patients and correlate with CD4(+) T-cell counts: N.V. Sipsas, et al.; Clin. Diagn. Lab. Immunol. 9, 558 (2002) Abstract
Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis: J.F. Viallard, et al.; Blood 99, 2612 (2002) Abstract
Measurement of soluble P-selectin and soluble CD40 ligand in serum and plasma: J. Thom, et al.; J. Thromb. Haemost. 2, 2067 (2004) Abstract
Soluble CD40 ligand in acute and chronic heart failure: T. Ueland, et al.; Eur. Heart. J. 26, 1101 (2005) Abstract
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets: J.K. Damas, et al.; J. Immunol. 177, 2699 (2006) Abstract
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
ELISA & EIA Kits • CD Kits & Sets
 
 
ALX-522-110 Revised 27-Mar-08
MegaCD40L™, Soluble (human) (recombinant)
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SYNONYMS CD40L, Soluble (human) (recombinant):ACRP30headless (mouse)
CD154, Soluble (human) (recombinant):ACRP30headless (mouse)
TNFSF 5, Soluble (human) (recombinant):ACRP30headless (mouse)
gp39, Soluble (human) (recombinant):ACRP30headless (mouse)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD40 & CD40L [CD154] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-110-C010   10 µg 380.00 USD Add To Cart
Product Specification
MW: ~35-40kDa
SOURCE/HOST: Produced in CHO cells. The extracellular domain of human CD40L (CD154) (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
BIOLOGICAL ACTIVITY: Binds to human CD40. Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
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Product Description
MegaCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30/adiponectin. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to [CD40L+enhancer] combinations (Prod. No. ALX-850-064).
Product Specific Literature References
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex: N. Holler, et al.; Mol. Cell. Biol. 23, 1428 (2003) Abstract; Full Text
Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in Sezary syndrome: circumvention by hexameric soluble CD40L: L.E. French, et al.; Blood 105, 219 (2005) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P29965: CD40L (human)
Swiss-Prot link Q60994: ACRP30 (mouse) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-120 Revised 27-Mar-08
MegaCD40L™, Soluble (mouse) (recombinant)
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SYNONYMS CD40L, Soluble (mouse) (recombinant):ACRP30headless (mouse)
CD154, Soluble (mouse) (recombinant):ACRP30headless (mouse)
TNFSF 5, Soluble (mouse) (recombinant):ACRP30headless (mouse)
gp39, Soluble (mouse) (recombinant):ACRP30headless (mouse)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD40 & CD40L [CD154] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-120-C010   10 µg 380.00 USD Add To Cart
Product Specification
MW: ~35-40kDa
SOURCE/HOST: Produced in CHO cells. The extracellular domain of mouse CD40L (CD154) (aa 115-262) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
BIOLOGICAL ACTIVITY: Binds to mouse and human CD40. Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Description
MegaCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30/adiponectin. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L. It provides a simple and equally potent alternative to [CD40L+enhancer] combinations (Prod. No. ALX-850-075).
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P27548: CD40L (mouse)
Swiss-Prot link Q60994: ACRP30 (mouse) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-030 Revised 24-Mar-06
CD70, Soluble (mouse) (recombinant)
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SYNONYMS CD27L, Soluble (mouse) (recombinant)
TNFSF 7, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD27 & CD27L [CD70] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-030-C010   10 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~28kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse CD70 (CD27L) (aa 52-195) is fused at the N-terminus to a linker peptide (11 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds to human and mouse CD27.
APPLICATION: Can be used together with anti-FLAG® MAb to detect membrane-bound human and mouse CD27. rmsCD70 saturates its receptor at a concentration range of 0.06-60ng/ml.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
The CD27 ligand (CD27L, CD70) is a member of the tumor necrosis factor (TNF) family. CD27L is a type II, transmembrane protein. Engagement of CD27 by CD27L induces recruitment of TNF receptor-associated factor 2 (TRAF2) and TRAF3. CD27-CD70 interactions have been reported to be involved in several different immune mechanisms such as T, NK and B lymphocytes interactions and costimulation, early thymic differentiation, autoimmune and viral diseases and apoptosis. CD70 is a marker for mature B cells.
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link O55237: CD27L (mouse)
AfCS Signalling Gateway link A000547: CD27L (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-022 Revised 29-Nov-05
CD134 (human):Fc (human) (recombinant)
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SYNONYMS TNFRSF 4 (human):Fc (human) (recombinant)
OX40 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD134 [OX40] & CD134L [OX40L] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-022-C050   50 µg 368.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~72kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of human CD134 (OX40) (aa 29-214) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human and mouse CD134L (OX40L).
BIOLOGICAL ACTIVITY: Blocks T cell proliferation induced by CD134L.
APPLICATION: Can be used together with anti-human IgG1 PAb to detect membrane-bound human CD134L. Has been used to ameliorate graft-versus-host disease, experimental allergic encephalomyelitis and inflammatory bowel disease.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes: E. Biagi, et al.; Blood 105, 2436 (2005) Abstract
General Information
The CD134 receptor (OX40) is a member of the tumor necrosis factor receptor (TNF-R) family. CD134 is a type I transmembrane receptor. It contains 3 extracellular cysteine-rich motifs. CD134 is mainly expressed in activated lymphocytes. After interaction with its ligand CD134L (OX40L), CD134 interacts with TNF receptor-associated factor 2 (TRAF2), TRAF5 and mediate activation of nuclear factors NF-κB and AP1. CD134-CD134L have been reported to be involved in T cell selection, migration and induction of Th1 and Th2 cytokine pattern. Moreover, it is involved in anti-tumor immunity, cell adhesion and various auto-immune diseases.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P43489: CD134 (human) (precursor)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • CD Proteins
 
 
ALX-522-023 Revised 20-Jun-06
CD134L, Soluble (human) (recombinant)
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SYNONYMS OX40L, Soluble (human) (recombinant)
TNFSF 4, Soluble (human) (recombinant)
CD252, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD134 [OX40] & CD134L [OX40L] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-023-C010   10 µg 200.00 USD Add To Cart
ALX-522-023-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~30kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human CD134L (OX40L) (aa 52-183) is fused at the N-terminus to a linker peptide (11 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds to human CD134 (OX40).
BIOLOGICAL ACTIVITY: Activates T cell proliferation. Delays neutrophil apoptosis.
APPLICATION: Can be used together with anti-FLAG® MAb to detect membrane-bound human CD134 (OX40).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Functional expression of CD134 by neutrophils: R. Baumann, et al.; Eur. J. Immunol. 34, 2268 (2004) Abstract
Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand: J. Dannull, et al.; Blood 105, 3206 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P23510: CD134L (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses: I. Gramaglia, et al.; J. Immunol. 161, 6510 (1998) Abstract
CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells: H. Akiba, et al.; J. Immunol. 162, 7058 (1999) Abstract
CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles: T. Brocker, et al.; Eur. J. Immunol. 29, 1610 (1999) Abstract
OX40-Mediated cosignal enhances the maturation of naive human CD4+ T cells into high IL-4-producing effectors: G. Delespesse, et al.; Int. Arch. Allergy Immunol. 118, 384 (1999) Abstract
Functional expression of CD134 by neutrophils: R. Baumann, et al.; Eur. J. Immunol. 34, 2268 (2004) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • CD Proteins
 
 
ALX-522-043 Revised 24-Mar-06
CD134L, Soluble (mouse) (recombinant)
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SYNONYMS OX40L, Soluble (mouse) (recombinant)
TNFSF 4, Soluble (mouse) (recombinant)
CD252, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD134 [OX40] & CD134L [OX40L] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-043-C010   10 µg 200.00 USD Add To Cart
ALX-522-043-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: </